JP2004137288A5 - - Google Patents
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- Publication number
- JP2004137288A5 JP2004137288A5 JP2003422779A JP2003422779A JP2004137288A5 JP 2004137288 A5 JP2004137288 A5 JP 2004137288A5 JP 2003422779 A JP2003422779 A JP 2003422779A JP 2003422779 A JP2003422779 A JP 2003422779A JP 2004137288 A5 JP2004137288 A5 JP 2004137288A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- hydroxyamidine
- thiocarboxamide
- carboxamide
- formamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24443800P | 2000-10-31 | 2000-10-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539332A Division JP4340437B2 (ja) | 2000-10-31 | 2001-10-31 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004137288A JP2004137288A (ja) | 2004-05-13 |
| JP2004137288A5 true JP2004137288A5 (https=) | 2005-07-21 |
Family
ID=22922766
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539332A Expired - Lifetime JP4340437B2 (ja) | 2000-10-31 | 2001-10-31 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
| JP2003422779A Pending JP2004137288A (ja) | 2000-10-31 | 2003-12-19 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539332A Expired - Lifetime JP4340437B2 (ja) | 2000-10-31 | 2001-10-31 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US6784187B2 (https=) |
| EP (3) | EP1353909B1 (https=) |
| JP (2) | JP4340437B2 (https=) |
| AT (2) | ATE391712T1 (https=) |
| AU (2) | AU2002227135B2 (https=) |
| CA (1) | CA2426942C (https=) |
| DE (2) | DE60109960T2 (https=) |
| ES (3) | ES2572332T3 (https=) |
| WO (1) | WO2002036573A2 (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002227135B2 (en) * | 2000-10-31 | 2008-01-03 | Rensselaer Polytechnic Institute | 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
| US6974824B2 (en) * | 2001-01-08 | 2005-12-13 | Research Triangle Institute | Kappa opioid receptor ligands |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP2987788A1 (en) * | 2002-05-17 | 2016-02-24 | Taiwanj Pharmaceuticals Co., Ltd. | Opioid and opioid-like compounds and uses thereof |
| EP1602374A4 (en) * | 2003-03-07 | 2007-03-07 | Toray Industries | MEANS FOR TREATMENT OF MEDICAMENT / SUBSTANCE DEPENDENCE |
| US7381721B2 (en) | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US6992090B2 (en) | 2003-06-16 | 2006-01-31 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| US7589103B2 (en) | 2003-06-27 | 2009-09-15 | Janssen Pharmaceutica N.V. | Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators |
| EP1595541A1 (en) | 2004-05-12 | 2005-11-16 | Alcasynn Pharmaceuticals Gmbh | Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin |
| AU2005245403B2 (en) * | 2004-05-14 | 2012-04-19 | Janssen Pharmaceutica N.V. | Carboxamido opioid compounds |
| EP1910353A1 (en) | 2004-08-05 | 2008-04-16 | Janssen Pharmaceutica N.V. | Tricyclic delta- opioid modulators |
| AR053098A1 (es) | 2004-11-04 | 2007-04-25 | Toray Industries | Analgesico derivado de morfinano |
| ES2387737T3 (es) * | 2004-11-05 | 2012-10-01 | Rensselaer Polytechnic Institute | 4-Hidroxibenzomorfanos |
| JP2008525483A (ja) | 2004-12-22 | 2008-07-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式δ−オピオイド調節剤 |
| ATE432279T1 (de) | 2004-12-22 | 2009-06-15 | Janssen Pharmaceutica Nv | Tricyclische delta-opioid-modulatoren |
| KR20070104380A (ko) | 2005-01-06 | 2007-10-25 | 얀센 파마슈티카 엔.브이. | 트리사이클릭 δ-오피오이드 조절제 |
| WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| ATE490251T1 (de) | 2005-06-16 | 2010-12-15 | Janssen Pharmaceutica Nv | Tricyclische opioidmodulatoren |
| JP5266051B2 (ja) | 2005-07-21 | 2013-08-21 | レンセラール ポリテクニック インスティチュート | 大きい置換基を有する非フェノール性オピオイド |
| US7538110B2 (en) | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
| TWI425945B (zh) * | 2007-05-28 | 2014-02-11 | Seldar Pharma Inc | 四氫異喹啉－１－酮衍生物或其鹽 |
| CN101827819B (zh) * | 2007-08-09 | 2013-06-12 | 伦斯勒理工学院 | 阿片样物质酰胺季铵盐 |
| JP5727374B2 (ja) * | 2008-07-21 | 2015-06-03 | レンセラール ポリテクニック インスティチュート | 大型置換基を有する非フェノール性アミンオピオイド |
| EP3170395A1 (en) * | 2009-03-19 | 2017-05-24 | Alkermes Pharma Ireland Limited | Morphinan derivatives with high oral bioavailability |
| US8624040B2 (en) | 2009-06-22 | 2014-01-07 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US9096518B2 (en) | 2009-06-22 | 2015-08-04 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| AU2010295464B2 (en) * | 2009-09-18 | 2015-11-26 | Merck Sharp & Dohme Corp. | Use of opioid receptor antagonist for gastrointestinal tract disorders |
| TR201908514T4 (tr) * | 2009-12-04 | 2019-07-22 | Alkermes Pharma Ireland Ltd | İlaç doz aşimi tedavi̇si̇ i̇çi̇n morfi̇nan türevleri̇ |
| US8546588B2 (en) * | 2010-02-26 | 2013-10-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2011106632A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8436175B2 (en) | 2010-03-22 | 2013-05-07 | Rensselaer Polytechnic Institute | Carboxamide bioisosteres of opiates |
| WO2011130163A1 (en) | 2010-04-12 | 2011-10-20 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| CA2804940C (en) | 2010-07-08 | 2017-03-07 | Alkermes Pharma Ireland Limited | Process for the synthesis of substituted morphinans |
| WO2012008984A1 (en) | 2010-07-16 | 2012-01-19 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| US8778960B2 (en) | 2010-08-23 | 2014-07-15 | Alkermes Pharma Ireland Limited | Methods for treating antipsychotic-induced weight gain |
| US8471026B2 (en) | 2010-08-26 | 2013-06-25 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012054332A1 (en) | 2010-10-18 | 2012-04-26 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012088015A2 (en) * | 2010-12-22 | 2012-06-28 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012138888A1 (en) | 2011-04-05 | 2012-10-11 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
| WO2013003720A1 (en) | 2011-06-29 | 2013-01-03 | Alkermes, Inc. | Peripherally acting opioid compounds |
| LT3153171T (lt) | 2011-12-15 | 2018-12-10 | Alkermes Pharma Ireland Limited | Samidorfanas (alks 33) derinyje su buprenorfinu, skirtas depresinių sutrikimų gydymui |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| CA2890655A1 (en) * | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| ES2770978T3 (es) | 2013-05-24 | 2020-07-06 | Alkermes Pharma Ireland Ltd | Análogos de morfanos y morfinanos y métodos de uso |
| EP3003311A2 (en) | 2013-05-24 | 2016-04-13 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| US9688638B2 (en) | 2013-11-27 | 2017-06-27 | Nektar Therapeutics | Opioid agonists and uses thereof |
| CA2948144A1 (en) * | 2014-05-06 | 2015-11-12 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
| SG11201708622UA (en) | 2015-02-02 | 2017-11-29 | Forma Therapeutics Inc | 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors |
| WO2016126726A1 (en) | 2015-02-02 | 2016-08-11 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors |
| EP3472131B1 (en) | 2016-06-17 | 2020-02-19 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH581624A5 (https=) | 1970-08-14 | 1976-11-15 | Sumitomo Chemical Co | |
| US3856795A (en) | 1972-04-25 | 1974-12-24 | American Home Prod | Process for preparation of secondary amines from tertiary amines |
| US4032529A (en) * | 1974-09-20 | 1977-06-28 | Sterling Drug Inc. | Aminomethanobenzazocine intermediates |
| US3957793A (en) | 1974-09-20 | 1976-05-18 | Sterling Drug Inc. | Hydroxyiminobenzazocines |
| US4205171A (en) | 1976-01-12 | 1980-05-27 | Sterling Drug Inc. | Aminomethanobenzazocines and nitromethanobenzazocines |
| US4373139A (en) | 1979-04-30 | 1983-02-08 | Motorola, Inc. | Detectors |
| US4464378A (en) * | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
| US4374139A (en) * | 1981-11-09 | 1983-02-15 | Hoffmann-La Roche Inc. | Levorotatory N-substituted acylmorphinans useful as analgesic agents |
| US4649200A (en) * | 1986-05-08 | 1987-03-10 | Regents Of The University Of Minnesota | Substituted pyrroles with opioid receptor activity |
| US4939264A (en) | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| US5258386A (en) | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| US5607941A (en) | 1992-06-26 | 1997-03-04 | Boehringer Ingelheim Kg | Useful for treating neurodegenerative diseases |
| SE9103745D0 (sv) * | 1991-12-18 | 1991-12-18 | Wikstroem Haakan | Aryl-triflates and related compounds |
| AU3423493A (en) | 1991-12-31 | 1993-07-28 | Zymogenetics Inc. | Methods and compositions for reducing blood loss |
| EP0632041A1 (en) * | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| ATE229958T1 (de) * | 1996-01-10 | 2003-01-15 | Glaxosmithkline Spa | Heterocyclische kondensierte morphin-derivate |
| GB9709972D0 (en) * | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| AU2002227135B2 (en) | 2000-10-31 | 2008-01-03 | Rensselaer Polytechnic Institute | 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
| US20050222204A1 (en) | 2002-05-30 | 2005-10-06 | Mitch Charles H | Opioid receptor antagonists |
| ES2387737T3 (es) * | 2004-11-05 | 2012-10-01 | Rensselaer Polytechnic Institute | 4-Hidroxibenzomorfanos |
| JP5266051B2 (ja) * | 2005-07-21 | 2013-08-21 | レンセラール ポリテクニック インスティチュート | 大きい置換基を有する非フェノール性オピオイド |
-
2001
- 2001-10-31 AU AU2002227135A patent/AU2002227135B2/en not_active Expired
- 2001-10-31 EP EP01992702A patent/EP1353909B1/en not_active Expired - Lifetime
- 2001-10-31 AU AU2713502A patent/AU2713502A/xx active Pending
- 2001-10-31 AT AT03013544T patent/ATE391712T1/de not_active IP Right Cessation
- 2001-10-31 ES ES08004779T patent/ES2572332T3/es not_active Expired - Lifetime
- 2001-10-31 ES ES03013544T patent/ES2304477T3/es not_active Expired - Lifetime
- 2001-10-31 CA CA2426942A patent/CA2426942C/en not_active Expired - Lifetime
- 2001-10-31 DE DE60109960T patent/DE60109960T2/de not_active Expired - Lifetime
- 2001-10-31 ES ES01992702T patent/ES2239170T3/es not_active Expired - Lifetime
- 2001-10-31 WO PCT/US2001/045581 patent/WO2002036573A2/en not_active Ceased
- 2001-10-31 EP EP03013544A patent/EP1359146B1/en not_active Expired - Lifetime
- 2001-10-31 EP EP08004779.8A patent/EP1944292B9/en not_active Expired - Lifetime
- 2001-10-31 JP JP2002539332A patent/JP4340437B2/ja not_active Expired - Lifetime
- 2001-10-31 DE DE60133584T patent/DE60133584T2/de not_active Expired - Lifetime
- 2001-10-31 AT AT01992702T patent/ATE292625T1/de not_active IP Right Cessation
-
2002
- 2002-11-26 US US10/305,287 patent/US6784187B2/en not_active Expired - Lifetime
-
2003
- 2003-04-09 US US10/409,803 patent/US6887998B2/en not_active Expired - Lifetime
- 2003-12-19 JP JP2003422779A patent/JP2004137288A/ja active Pending
-
2004
- 2004-11-12 US US10/987,527 patent/US7265226B2/en not_active Expired - Lifetime
-
2005
- 2005-08-17 US US11/205,354 patent/US20060030580A1/en not_active Abandoned
-
2008
- 2008-10-10 US US12/249,238 patent/US7956187B2/en not_active Expired - Fee Related
-
2011
- 2011-05-09 US US13/103,599 patent/US8252929B2/en not_active Expired - Fee Related
-
2012
- 2012-07-24 US US13/556,650 patent/US8642615B2/en not_active Expired - Fee Related
-
2013
- 2013-12-19 US US14/134,264 patent/US20140275545A1/en not_active Abandoned
-
2016
- 2016-09-09 US US15/260,610 patent/US9932349B2/en not_active Expired - Lifetime