JP2004137288A5 - - Google Patents
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- Publication number
- JP2004137288A5 JP2004137288A5 JP2003422779A JP2003422779A JP2004137288A5 JP 2004137288 A5 JP2004137288 A5 JP 2004137288A5 JP 2003422779 A JP2003422779 A JP 2003422779A JP 2003422779 A JP2003422779 A JP 2003422779A JP 2004137288 A5 JP2004137288 A5 JP 2004137288A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- hydroxyamidine
- thiocarboxamide
- carboxamide
- formamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Claims (2)
- 薬物依存症、アルコール依存症、ニコチン依存症を治療するための医薬の製造における、下記の化学式
Ａがカルボキサミド、チオカルボキサミド、ヒドロキシアミジン及びホルムアミドから選ばれ、そして
Ｒ17が、−ＣＨ2 −シクロプロピル、−ＣＨ2 ＣＨＣＨ2 、−ＣＨ2 ＣＨＣ（ＣＨ3 ）2 及び−ＣＨ3 からなる群より選択されるものである、
で表される化合物の使用。 - 痛みを治療又は予防するための医薬の製造における下記の化学式
Ａがカルボキサミド、チオカルボキサミド、ヒドロキシアミジン及びホルムアミドから選ばれ、
Ｒ3 が水素、低級アルキル、アルケニル、アリール、ヘテロシクリル、ベンジル及びヒドロキシアルキルから選ばれ、
Ｒ5 が低級アルキルであり、そして
Ｒ6 が低級アルキルである、
で表される化合物の使用。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24443800P | 2000-10-31 | 2000-10-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539332A Division JP4340437B2 (ja) | 2000-10-31 | 2001-10-31 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004137288A JP2004137288A (ja) | 2004-05-13 |
| JP2004137288A5 true JP2004137288A5 (ja) | 2005-07-21 |
Family
ID=22922766
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539332A Expired - Lifetime JP4340437B2 (ja) | 2000-10-31 | 2001-10-31 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
| JP2003422779A Pending JP2004137288A (ja) | 2000-10-31 | 2003-12-19 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539332A Expired - Lifetime JP4340437B2 (ja) | 2000-10-31 | 2001-10-31 | ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン |
Country Status (9)
| Country | Link |
|---|---|
| US (9) | US6784187B2 (ja) |
| EP (3) | EP1353909B1 (ja) |
| JP (2) | JP4340437B2 (ja) |
| AT (2) | ATE292625T1 (ja) |
| AU (2) | AU2002227135B2 (ja) |
| CA (1) | CA2426942C (ja) |
| DE (2) | DE60133584T2 (ja) |
| ES (3) | ES2239170T3 (ja) |
| WO (1) | WO2002036573A2 (ja) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60133584T2 (de) * | 2000-10-31 | 2009-06-04 | Rensselaer Polytechnic Institute | 4-arylpiperidine als opioidrezeptorbindende agenzien |
| US6974824B2 (en) * | 2001-01-08 | 2005-12-13 | Research Triangle Institute | Kappa opioid receptor ligands |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| JP5438250B2 (ja) * | 2002-05-17 | 2014-03-12 | ジェンケン バイオサイエンスィズ，インコーポレイテッド | オピオイド及びオピオイド様の化合物並びにそれらの使用 |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| CN1758912A (zh) * | 2003-03-07 | 2006-04-12 | 东丽株式会社 | 药物·物质依赖治疗药 |
| US7381721B2 (en) | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US6992090B2 (en) | 2003-06-16 | 2006-01-31 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| CN100513407C (zh) | 2003-06-27 | 2009-07-15 | 詹森药业有限公司 | 三环δ阿片样物质调节剂 |
| EP1595541A1 (en) | 2004-05-12 | 2005-11-16 | Alcasynn Pharmaceuticals Gmbh | Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin |
| AU2005245403B2 (en) * | 2004-05-14 | 2012-04-19 | Janssen Pharmaceutica N.V. | Carboxamido opioid compounds |
| EP1910353A1 (en) | 2004-08-05 | 2008-04-16 | Janssen Pharmaceutica N.V. | Tricyclic delta- opioid modulators |
| AR053098A1 (es) | 2004-11-04 | 2007-04-25 | Toray Industries | Analgesico derivado de morfinano |
| ATE557006T1 (de) * | 2004-11-05 | 2012-05-15 | Rensselaer Polytech Inst | 4-hydroxybenzomorphane |
| CN101119992A (zh) | 2004-12-22 | 2008-02-06 | 詹森药业有限公司 | 三环δ阿片样物质调节剂 |
| WO2006069276A2 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | TRICYCLIC ō-OPIOID MODULATORS |
| EP1846400A2 (en) | 2005-01-06 | 2007-10-24 | Janssen Pharmaceutica N.V. | Tricyclic delta-opioid modulators |
| WO2006126529A1 (ja) * | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| JP2008543866A (ja) | 2005-06-16 | 2008-12-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 三環式オピオイドモジュレーター |
| CA2615774C (en) * | 2005-07-21 | 2014-12-09 | Rensselaer Polytechnic Institute | Large substituent, non-phenolic opioids |
| US7538110B2 (en) | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
| TWI425945B (zh) * | 2007-05-28 | 2014-02-11 | Seldar Pharma Inc | 四氫異喹啉－１－酮衍生物或其鹽 |
| MX2010001371A (es) | 2007-08-09 | 2010-03-10 | Rensselaer Polytech Inst | Carboxamidas opioides cuaternarias. |
| WO2010011619A1 (en) * | 2008-07-21 | 2010-01-28 | Rensselaer Polytechnic Institute | Large substituent, non-phenolic amine opioids |
| CA2754984C (en) * | 2009-03-19 | 2018-06-26 | Alkermes, Inc. | Morphinan derivatives with high oral bioavailability |
| US8624040B2 (en) | 2009-06-22 | 2014-01-07 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| CA2765678A1 (en) | 2009-06-22 | 2010-12-29 | Christopher Blackburn | Substituted hydroxamic acids and uses thereof |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| WO2011035142A1 (en) * | 2009-09-18 | 2011-03-24 | Adolor Corporation | Use of opioid receptor antagonist for gastrointestinal tract disorders |
| ME03468B (me) | 2009-12-04 | 2020-01-20 | Alkermes Pharma Ireland Ltd | Derivati morfinana za liječenje predoziranja lijekom |
| US20110212969A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2011106627A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| EP2550253B9 (en) | 2010-03-22 | 2016-09-21 | Rensselaer Polytechnic Institute | Morphinane derivatives containing a carboxamide group as opioid receptor ligands |
| WO2011130163A1 (en) | 2010-04-12 | 2011-10-20 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| CA2804940C (en) | 2010-07-08 | 2017-03-07 | Alkermes Pharma Ireland Limited | Process for the synthesis of substituted morphinans |
| JP5911484B2 (ja) | 2010-07-16 | 2016-04-27 | マリンクロッド エルエルシー | トール様受容体９のアンタゴニストとしての（＋）−モルフィナンおよびその治療的使用 |
| AU2011293502B2 (en) | 2010-08-23 | 2015-03-19 | Alkermes Pharma Ireland Limited | Methods for treating antipsychotic-induced weight gain |
| US8471026B2 (en) | 2010-08-26 | 2013-06-25 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US8765773B2 (en) | 2010-10-18 | 2014-07-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| WO2012088015A2 (en) * | 2010-12-22 | 2012-06-28 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| US9029543B2 (en) | 2011-04-05 | 2015-05-12 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
| EP2725908B1 (en) * | 2011-06-29 | 2017-05-31 | Alkermes, Inc. | Peripherally acting opioid compounds |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| KR101996108B1 (ko) | 2011-12-15 | 2019-10-01 | 엘커메스 파마 아일랜드 리미티드 | 부프레놀핀 및 뮤-오피오이드 수용체 길항물질의 조성물 |
| CA2890655A1 (en) * | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Benzomorphan analogs and the use thereof |
| WO2014190271A2 (en) | 2013-05-24 | 2014-11-27 | Alkermes Pharma Ireland Limted | Methods for treating depressive symptoms |
| AU2014268361B2 (en) | 2013-05-24 | 2018-09-06 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
| US9688638B2 (en) | 2013-11-27 | 2017-06-27 | Nektar Therapeutics | Opioid agonists and uses thereof |
| US9975854B2 (en) | 2014-05-06 | 2018-05-22 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
| AR103598A1 (es) | 2015-02-02 | 2017-05-24 | Forma Therapeutics Inc | Ácidos bicíclicos[4,6,0]hidroxámicos como inhibidores de hdac |
| ES2770123T3 (es) | 2015-02-02 | 2020-06-30 | Forma Therapeutics Inc | Acidos 3-alquil-4-amido-bicíclicos [4,5,0]hidroxámicos como inhibidores de HDAC |
| US10555935B2 (en) | 2016-06-17 | 2020-02-11 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors |
| US10745402B2 (en) | 2017-01-02 | 2020-08-18 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH581624A5 (ja) | 1970-08-14 | 1976-11-15 | Sumitomo Chemical Co | |
| US3856795A (en) | 1972-04-25 | 1974-12-24 | American Home Prod | Process for preparation of secondary amines from tertiary amines |
| US3957793A (en) | 1974-09-20 | 1976-05-18 | Sterling Drug Inc. | Hydroxyiminobenzazocines |
| US4032529A (en) * | 1974-09-20 | 1977-06-28 | Sterling Drug Inc. | Aminomethanobenzazocine intermediates |
| US4205171A (en) | 1976-01-12 | 1980-05-27 | Sterling Drug Inc. | Aminomethanobenzazocines and nitromethanobenzazocines |
| US4373139A (en) | 1979-04-30 | 1983-02-08 | Motorola, Inc. | Detectors |
| US4464378A (en) * | 1981-04-28 | 1984-08-07 | University Of Kentucky Research Foundation | Method of administering narcotic antagonists and analgesics and novel dosage forms containing same |
| US4374139A (en) * | 1981-11-09 | 1983-02-15 | Hoffmann-La Roche Inc. | Levorotatory N-substituted acylmorphinans useful as analgesic agents |
| US4649200A (en) * | 1986-05-08 | 1987-03-10 | Regents Of The University Of Minnesota | Substituted pyrroles with opioid receptor activity |
| US4939264A (en) | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| US5258386A (en) | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| US5607941A (en) | 1992-06-26 | 1997-03-04 | Boehringer Ingelheim Kg | Useful for treating neurodegenerative diseases |
| SE9103745D0 (sv) * | 1991-12-18 | 1991-12-18 | Wikstroem Haakan | Aryl-triflates and related compounds |
| EP0624095B2 (en) | 1991-12-31 | 2005-07-20 | Zymogenetics, Inc. | Methods and compositions for reducing blood loss |
| EP0632041A1 (en) * | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| JP2000503019A (ja) | 1996-01-10 | 2000-03-14 | スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ | 複素環縮合モルフィノイド誘導体（ｉｉ） |
| GB9709972D0 (en) * | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
| GB9912411D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| DE60133584T2 (de) | 2000-10-31 | 2009-06-04 | Rensselaer Polytechnic Institute | 4-arylpiperidine als opioidrezeptorbindende agenzien |
| WO2003101963A1 (en) | 2002-05-30 | 2003-12-11 | Eli Lilly And Company | Opioid receptor antagonists |
| ATE557006T1 (de) * | 2004-11-05 | 2012-05-15 | Rensselaer Polytech Inst | 4-hydroxybenzomorphane |
| CA2615774C (en) * | 2005-07-21 | 2014-12-09 | Rensselaer Polytechnic Institute | Large substituent, non-phenolic opioids |
-
2001
- 2001-10-31 DE DE60133584T patent/DE60133584T2/de not_active Expired - Lifetime
- 2001-10-31 EP EP01992702A patent/EP1353909B1/en not_active Expired - Lifetime
- 2001-10-31 AT AT01992702T patent/ATE292625T1/de not_active IP Right Cessation
- 2001-10-31 JP JP2002539332A patent/JP4340437B2/ja not_active Expired - Lifetime
- 2001-10-31 AU AU2002227135A patent/AU2002227135B2/en not_active Expired
- 2001-10-31 CA CA2426942A patent/CA2426942C/en not_active Expired - Lifetime
- 2001-10-31 ES ES01992702T patent/ES2239170T3/es not_active Expired - Lifetime
- 2001-10-31 WO PCT/US2001/045581 patent/WO2002036573A2/en active IP Right Grant
- 2001-10-31 ES ES03013544T patent/ES2304477T3/es not_active Expired - Lifetime
- 2001-10-31 AU AU2713502A patent/AU2713502A/xx active Pending
- 2001-10-31 EP EP08004779.8A patent/EP1944292B9/en not_active Expired - Lifetime
- 2001-10-31 ES ES08004779T patent/ES2572332T3/es not_active Expired - Lifetime
- 2001-10-31 DE DE60109960T patent/DE60109960T2/de not_active Expired - Lifetime
- 2001-10-31 EP EP03013544A patent/EP1359146B1/en not_active Expired - Lifetime
- 2001-10-31 AT AT03013544T patent/ATE391712T1/de not_active IP Right Cessation
-
2002
- 2002-11-26 US US10/305,287 patent/US6784187B2/en not_active Expired - Lifetime
-
2003
- 2003-04-09 US US10/409,803 patent/US6887998B2/en not_active Expired - Lifetime
- 2003-12-19 JP JP2003422779A patent/JP2004137288A/ja active Pending
-
2004
- 2004-11-12 US US10/987,527 patent/US7265226B2/en not_active Expired - Lifetime
-
2005
- 2005-08-17 US US11/205,354 patent/US20060030580A1/en not_active Abandoned
-
2008
- 2008-10-10 US US12/249,238 patent/US7956187B2/en not_active Expired - Fee Related
-
2011
- 2011-05-09 US US13/103,599 patent/US8252929B2/en not_active Expired - Lifetime
-
2012
- 2012-07-24 US US13/556,650 patent/US8642615B2/en not_active Expired - Lifetime
-
2013
- 2013-12-19 US US14/134,264 patent/US20140275545A1/en not_active Abandoned
-
2016
- 2016-09-09 US US15/260,610 patent/US9932349B2/en not_active Expired - Lifetime
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