RU2006116885A - Производные n-фенил(пиперидин-2-ил)метил-бензамида, способ получения указанных соединений и их применение в терапии - Google Patents

Производные n-фенил(пиперидин-2-ил)метил-бензамида, способ получения указанных соединений и их применение в терапии

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RU2006116885A
RU2006116885A RU2006116885/04A RU2006116885A RU2006116885A RU 2006116885 A RU2006116885 A RU 2006116885A RU 2006116885/04 A RU2006116885/04 A RU 2006116885/04A RU 2006116885 A RU2006116885 A RU 2006116885A RU 2006116885 A RU2006116885 A RU 2006116885A
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alkyl
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thiazoleazole
substituents selected
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Жиад ДАРГАЗАНЛИ (FR)
Жиад Даргазанли
Женевьев ЭСТЕНН-БУТУ (FR)
Женевьев Эстенн-Буту
Паскаль МАГА (FR)
Паскаль Мага
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Санофи-Авентис (Fr)
Санофи-Авентис
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (5)

1. Соединение, отвечающее общей формуле (I)
Figure 00000001
в которой R1 обозначает либо атом водорода, либо прямую или разветвленную группу (С1-С7)алкил, возможно замещенную одним или несколькими атомами фтора, либо группу (С3-С7)циклоалкил, либо группу (С3-7)циклоалкил(С1-3)алкил, либо группу фенил(С1-3)алкил, возможно замещенную одной или двумя группами метокси, либо группу (С2-4)алкенил, либо группу (С2-С4)алкинил;
Х обозначает атом водорода или один или несколько заместителей, выбранных из атомов галогена и групп: трифторметил, прямые или разветвленные (С1-С4)алкил и (С1-4)алкоксил;
R2 обозначает группу, выбранную из групп нафталенил, пиридинил, пиримидинил, пиразинил, пиридазинил, триазинил, инданил, инденил, хинолеинил, изохинолеинил, хиназолинил, хиноксалинил, фталазинил, тиенил, фурил, пирролил, имидазолил, пиразолил, оксазолил, тиазолил, изоксазолил, изотиазолил, тиадиазолил, оксадиазолил, триазолил, бензотиенил, бензофурил, бензимидазолил, бензотиазолил, индолил, изоиндолил, индазолил, бензоксазолил, бензизоксазолил, бензотриазолил, бензизотиазолил, дигидроиндолил, пирролопиридинил, фуропиридинил, тиенопиридинил, имидазопиридинил, оксазолопиридинил, тиазолопиридинил, пиразолопиридинил, изоксазолопиридинил, изотиазолопиридинил, тетрагидрохинолеинил, тетрагидроизохинолеинил, и возможно замещенную одним или несколькими заместителями, выбранными из атомов галогена и групп: (С1-С4)алкилы, (С1-С4)алкоксилы, тио(С1-4)алкилы или фенилы, возможно замещенные одним или несколькими заместителями, выбранными из атомов галогена и групп: трифторметил, (С1-С4)алкилы и (С1-4)алкоксилы, в форме свободного основания или аддитивной соли с кислотой.
2. Лекарственное средство, отличающееся тем, что оно представляет собой соединение по п.1.
3. Фармацевтическая композиция, отличающаяся тем, что она включает соединение по п.1, ассоциированное с эксципиентом.
4. Применение соединения согласно п.1 для получения лекарственного средства, предназначенного для лечения поведенческих расстройств, связанных с деменцией, психозов, различных форм тревог, приступов паники, фобий, компульсивных навязчивых состояний, различных форм депрессии, расстройств, связанных со злоупотреблением алкоголя или с прекращением принятия алкоголя, нарушений сексуального поведения, нарушений приема пищи и лечения мигрени.
5. Применение соединения по п.1 для получения лекарственного средства, предназначенного для лечения контрактур, боли, болезни Паркинсона и симптомов болезни Паркинсона, эпилепсий, смешанных форм и других эпилептических синдромов в сочетании с другим антиэпилептическим лечением, или в монотерапии, для лечения апное во сне и в качестве нейропротектора.
RU2006116885/04A 2003-10-17 2004-10-15 Производные n-фенил(пиперидин-2-ил)метил-бензамида и их применение в терапии RU2351588C2 (ru)

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FR0312140 2003-10-17
FR0312140A FR2861074B1 (fr) 2003-10-17 2003-10-17 Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique

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WO2005037792A1 (fr) 2005-04-28
IL174942A0 (en) 2006-08-20
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JP2007508358A (ja) 2007-04-05
BRPI0415504A (pt) 2006-12-12
CN1882540A (zh) 2006-12-20
EP1680402A1 (fr) 2006-07-19
KR20060094079A (ko) 2006-08-28
ZA200603937B (en) 2009-01-28
US20060223885A1 (en) 2006-10-05
NZ547164A (en) 2009-11-27
CA2542373A1 (fr) 2005-04-28
NO20062105L (no) 2006-05-10
FR2861074A1 (fr) 2005-04-22
RS20060318A (en) 2008-11-28
MA28101A1 (fr) 2006-08-01
RU2351588C2 (ru) 2009-04-10
US7750025B2 (en) 2010-07-06
FR2861074B1 (fr) 2006-04-07
AU2004281214B2 (en) 2010-07-08
IL174942A (en) 2011-03-31
US20100234424A1 (en) 2010-09-16

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