JP2005533104A5 - - Google Patents
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- JP2005533104A5 JP2005533104A5 JP2004521488A JP2004521488A JP2005533104A5 JP 2005533104 A5 JP2005533104 A5 JP 2005533104A5 JP 2004521488 A JP2004521488 A JP 2004521488A JP 2004521488 A JP2004521488 A JP 2004521488A JP 2005533104 A5 JP2005533104 A5 JP 2005533104A5
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- JP
- Japan
- Prior art keywords
- composition
- compound
- composition according
- och
- cooh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000203 mixture Substances 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- KXZOIWWTXOCYKR-UHFFFAOYSA-M diclofenac potassium Chemical compound [K+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KXZOIWWTXOCYKR-UHFFFAOYSA-M 0.000 claims 1
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 claims 1
- 239000000890 drug combination Substances 0.000 claims 1
- 229960001680 ibuprofen Drugs 0.000 claims 1
- 229960000681 leflunomide Drugs 0.000 claims 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 1
- -1 malononitrile amide Chemical class 0.000 claims 1
- 229960002009 naproxen Drugs 0.000 claims 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 1
- 229960003940 naproxen sodium Drugs 0.000 claims 1
- CDBRNDSHEYLDJV-FVGYRXGTSA-M naproxen sodium Chemical compound [Na+].C1=C([C@H](C)C([O-])=O)C=CC2=CC(OC)=CC=C21 CDBRNDSHEYLDJV-FVGYRXGTSA-M 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/195,824 US6727272B1 (en) | 2002-07-15 | 2002-07-15 | Leflunomide analogs for treating rheumatoid arthritis |
| PCT/US2003/019956 WO2004006834A2 (en) | 2002-07-15 | 2003-06-25 | Leflunomide analogs for treating rheumatoid arthritis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010108822A Division JP2010168402A (ja) | 2002-07-15 | 2010-05-10 | 慢性関節リウマチを処置するためのレフルノミド類似体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005533104A JP2005533104A (ja) | 2005-11-04 |
| JP2005533104A5 true JP2005533104A5 (https=) | 2006-06-29 |
Family
ID=30115011
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004521488A Ceased JP2005533104A (ja) | 2002-07-15 | 2003-06-25 | 慢性関節リウマチを処置するためのレフルノミド類似体 |
| JP2010108822A Pending JP2010168402A (ja) | 2002-07-15 | 2010-05-10 | 慢性関節リウマチを処置するためのレフルノミド類似体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010108822A Pending JP2010168402A (ja) | 2002-07-15 | 2010-05-10 | 慢性関節リウマチを処置するためのレフルノミド類似体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6727272B1 (https=) |
| EP (1) | EP1539143A4 (https=) |
| JP (2) | JP2005533104A (https=) |
| AU (1) | AU2003251611A1 (https=) |
| WO (1) | WO2004006834A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0903345B1 (de) * | 1997-08-08 | 2000-10-04 | Aventis Pharma Deutschland GmbH | Kristallform von 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)-anilid |
| US7125902B2 (en) * | 2004-05-28 | 2006-10-24 | Unitech Pharmaceuticals, Inc. | Methods, compounds, and diagnostics for cancer treatment |
| WO2006002422A2 (en) | 2004-06-24 | 2006-01-05 | Novartis Vaccines And Diagnostics Inc. | Compounds for immunopotentiation |
| US20060024376A1 (en) * | 2004-07-30 | 2006-02-02 | The University Of Chicago | Methods and compositions for reducing toxicity associated with leflunomide treatment |
| US7291743B2 (en) * | 2005-03-29 | 2007-11-06 | Geneblue Corporation | Isoxazole derivatives and methods of treating nitric oxide mediated diseases |
| JPWO2007026737A1 (ja) * | 2005-08-31 | 2009-03-12 | 興和株式会社 | 関節リウマチの予防及び／又は治療法 |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| AR060358A1 (es) | 2006-04-06 | 2008-06-11 | Novartis Vaccines & Diagnostic | Quinazolinas para la inhibicion de pdk 1 |
| CN101563082A (zh) * | 2006-09-05 | 2009-10-21 | 窦德献 | 治疗免疫介导性皮肤病的组合物和方法 |
| EA200900472A1 (ru) * | 2006-09-22 | 2009-10-30 | Ранбакси Лабораторис Лимитед | Ингибиторы фосфодиэстеразы iv типа |
| US20080085912A1 (en) * | 2006-10-06 | 2008-04-10 | Unitech Pharmaceuticals, Inc. | Isoxazole derivatives and methods of treating diseases |
| EP2240475B1 (en) | 2007-12-20 | 2013-09-25 | Novartis AG | Thiazole derivatives used as pi 3 kinase inhibitors |
| US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| AR082418A1 (es) | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
| JP5820476B2 (ja) | 2010-08-24 | 2015-11-24 | アルギアックス ファルマコウティカルス ゲーエムベーハーＡＬＧＩＡＸ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＧｍｂＨ | レフルノミドおよびマロノニトリラマイドの新規の使用 |
| MX343706B (es) | 2011-01-31 | 2016-11-18 | Novartis Ag | Derivados heterocíclicos novedosos. |
| PT2771342T (pt) | 2011-10-28 | 2016-08-17 | Novartis Ag | Derivados de purina e o seu uso no tratamento de doença |
| WO2013173283A1 (en) | 2012-05-16 | 2013-11-21 | Novartis Ag | Dosage regimen for a pi-3 kinase inhibitor |
| CN105979947A (zh) | 2013-12-06 | 2016-09-28 | 诺华股份有限公司 | α-同工型选择性磷脂酰肌醇3-激酶抑制剂的剂量方案 |
| US10526279B2 (en) * | 2015-06-17 | 2020-01-07 | Biocon Limited | Process for the preparation of teriflunomide |
| RU2018119085A (ru) | 2015-11-02 | 2019-12-04 | Новартис Аг | Схема введения ингибитора фосфатидилинозитол-3-киназы |
| WO2018060833A1 (en) | 2016-09-27 | 2018-04-05 | Novartis Ag | Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib |
| CN108863970A (zh) * | 2017-08-14 | 2018-11-23 | 四川省中医药转化医学中心 | 新化合物及其在治疗炎症或炎症相关疾病方面的应用 |
| KR102696521B1 (ko) * | 2021-11-24 | 2024-08-20 | 한양대학교 에리카산학협력단 | 이속사졸 유도체 또는 이의 약학적으로 허용가능한 염 및 이의 용도 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1533347A (en) * | 1976-10-22 | 1978-11-22 | Pfizer Ltd | Anthelmintic compounds |
| FR2639636B1 (fr) * | 1988-11-30 | 1994-03-04 | Novapharme | Nouveaux composes heterocycliques a activite anticonvulsivante, procede de preparation et compositions therapeutiques les contenant |
| EP0418667B1 (de) * | 1989-09-22 | 1995-08-16 | BASF Aktiengesellschaft | Carbonsäureamide |
| US5814646A (en) * | 1995-03-02 | 1998-09-29 | Eli Lilly And Company | Inhibitors of amyloid beta-protein production |
| DE19702988A1 (de) | 1997-01-28 | 1998-07-30 | Hoechst Ag | Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika |
| US20030092706A1 (en) * | 2001-11-09 | 2003-05-15 | Johannes Barsig | Combination |
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2002
- 2002-07-15 US US10/195,824 patent/US6727272B1/en not_active Expired - Fee Related
-
2003
- 2003-06-25 WO PCT/US2003/019956 patent/WO2004006834A2/en not_active Ceased
- 2003-06-25 JP JP2004521488A patent/JP2005533104A/ja not_active Ceased
- 2003-06-25 EP EP03764320A patent/EP1539143A4/en not_active Withdrawn
- 2003-06-25 AU AU2003251611A patent/AU2003251611A1/en not_active Abandoned
-
2010
- 2010-05-10 JP JP2010108822A patent/JP2010168402A/ja active Pending