JP2007533752A5 - - Google Patents
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- Publication number
- JP2007533752A5 JP2007533752A5 JP2007509585A JP2007509585A JP2007533752A5 JP 2007533752 A5 JP2007533752 A5 JP 2007533752A5 JP 2007509585 A JP2007509585 A JP 2007509585A JP 2007509585 A JP2007509585 A JP 2007509585A JP 2007533752 A5 JP2007533752 A5 JP 2007533752A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- thiophen
- thiazol
- amino
- ylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 5
- 125000004861 4-isopropyl phenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- NXTGYHATIFGITI-UHFFFAOYSA-N 3-[[4-[4-(2-methylpropyl)phenyl]-1,3-thiazol-2-yl]-(thiophen-2-ylmethyl)amino]propanoic acid Chemical compound C1=CC(CC(C)C)=CC=C1C1=CSC(N(CCC(O)=O)CC=2SC=CC=2)=N1 NXTGYHATIFGITI-UHFFFAOYSA-N 0.000 claims 3
- -1 4-trifluoromethylphenyl 4-tert-butylphenyl 4-isobutylphenyl 1-naphthyl 4-ethoxyphenyl 4-isobutoxyphenyl biphenyl-3-yl Chemical group 0.000 claims 3
- KWMRBXXPVSCWNZ-UHFFFAOYSA-N 3-[[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]-(thiophen-2-ylmethyl)amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C1=CSC(N(CCC(O)=O)CC=2SC=CC=2)=N1 KWMRBXXPVSCWNZ-UHFFFAOYSA-N 0.000 claims 2
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- XACTZCKPVYVENO-UHFFFAOYSA-N 3-[[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]-(3-thiophen-2-ylpropyl)amino]propanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C1=CSC(N(CCCC=2SC=CC=2)CCC(O)=O)=N1 XACTZCKPVYVENO-UHFFFAOYSA-N 0.000 claims 1
- RDMLOXWOYWGKEK-UHFFFAOYSA-N 3-[[4-[4-(2-methylpropyl)phenyl]-1,3-thiazol-2-yl]-(thiophen-2-ylmethyl)amino]propanoic acid;hydrochloride Chemical compound Cl.C1=CC(CC(C)C)=CC=C1C1=CSC(N(CCC(O)=O)CC=2SC=CC=2)=N1 RDMLOXWOYWGKEK-UHFFFAOYSA-N 0.000 claims 1
- AXWLHIHHYWOTMM-UHFFFAOYSA-N 5-[[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]-(thiophen-2-ylmethyl)amino]pentanoic acid Chemical compound C1=CC(C(C)C)=CC=C1C1=CSC(N(CCCCC(O)=O)CC=2SC=CC=2)=N1 AXWLHIHHYWOTMM-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- CXTREVCLAXUGDL-UHFFFAOYSA-M sodium;3-[[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]-(thiophen-2-ylmethyl)amino]propanoate Chemical compound [Na+].C1=CC(C(C)C)=CC=C1C1=CSC(N(CCC([O-])=O)CC=2SC=CC=2)=N1 CXTREVCLAXUGDL-UHFFFAOYSA-M 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56388204P | 2004-04-20 | 2004-04-20 | |
| US60/563,882 | 2004-04-20 | ||
| PCT/US2005/013386 WO2005103022A1 (en) | 2004-04-20 | 2005-04-20 | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007533752A JP2007533752A (ja) | 2007-11-22 |
| JP2007533752A5 true JP2007533752A5 (https=) | 2011-09-01 |
| JP4879165B2 JP4879165B2 (ja) | 2012-02-22 |
Family
ID=34971867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007509585A Expired - Fee Related JP4879165B2 (ja) | 2004-04-20 | 2005-04-20 | メラノコルチン受容体の調節因子としての置換チアゾール及びピリミジン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7820704B2 (https=) |
| EP (1) | EP1753735A1 (https=) |
| JP (1) | JP4879165B2 (https=) |
| CN (1) | CN1946703A (https=) |
| AU (1) | AU2005236055B2 (https=) |
| BR (1) | BRPI0510095A (https=) |
| CA (1) | CA2562075C (https=) |
| IL (1) | IL178597A0 (https=) |
| MX (1) | MXPA06012130A (https=) |
| NZ (1) | NZ550114A (https=) |
| WO (1) | WO2005103022A1 (https=) |
| ZA (1) | ZA200608225B (https=) |
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| DE10006453A1 (de) | 2000-02-14 | 2001-08-16 | Bayer Ag | Piperidylcarbonsäuren als Integrinantagonisten |
| JP2004501191A (ja) * | 2000-06-28 | 2004-01-15 | テバ ファーマシューティカル インダストリーズ リミティド | カルベジロール |
| EP1294704A1 (en) | 2000-06-29 | 2003-03-26 | Abbott Laboratories | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents |
| HUP0202719A3 (en) * | 2001-08-21 | 2006-01-30 | Pfizer Prod Inc | Pharmaceutical compositions for the treatment of female sexual dysfunctions |
| JP2005507932A (ja) | 2001-10-12 | 2005-03-24 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 肥満の処置のためのフェニル置換５−員窒素含有複素環 |
| RU2317292C2 (ru) * | 2001-11-08 | 2008-02-20 | Орто-Макнейл Фармасьютикал, Инк. | Новые производные 1,2,4-тиадиазола в качестве модуляторов рецепторов меланокортина |
| AU2002349705A1 (en) | 2001-12-03 | 2003-06-17 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
| US20030158199A1 (en) | 2002-01-25 | 2003-08-21 | Kylix, B.V. | Novel compounds for inhibition of Tie-2 |
| AU2003216274A1 (en) * | 2002-02-11 | 2003-09-04 | Neurocrine Biosciences, Inc. | Pyrrole derivatives as ligands of melanocortin receptors |
| MXPA04008379A (es) * | 2002-02-28 | 2004-11-26 | Hoffmann La Roche | Derivados de tiazol como antagonistas del receptor de neuropeptido y (npy). |
| UA79755C2 (en) * | 2002-04-16 | 2007-07-25 | Bayer Pharmaceuticals Corp | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
| CA2488725A1 (en) | 2002-07-03 | 2004-01-15 | Su Qian | Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism |
| RU2324685C2 (ru) * | 2002-08-07 | 2008-05-20 | Ф.Хоффманн-Ля Рош Аг | Производные тиазола, способ их получения и применение, фармацевтическая композиция, обладающая свойствами антагонистов рецепторов npy |
| WO2004089918A1 (ja) | 2003-04-09 | 2004-10-21 | Japan Tobacco Inc. | 複素芳香５員環化合物及びその医薬用途 |
| US20050009891A1 (en) | 2003-07-09 | 2005-01-13 | Lee Francis Y. | Combination of SRC Kinase inhibitors and chemotherapeutic agents for the treatment of proliferative diseases |
| WO2006038594A1 (ja) | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | Ｎ型カルシウムチャネル阻害薬 |
-
2005
- 2005-04-20 AU AU2005236055A patent/AU2005236055B2/en not_active Ceased
- 2005-04-20 MX MXPA06012130A patent/MXPA06012130A/es active IP Right Grant
- 2005-04-20 NZ NZ550114A patent/NZ550114A/en not_active IP Right Cessation
- 2005-04-20 EP EP05757033A patent/EP1753735A1/en not_active Withdrawn
- 2005-04-20 US US11/110,499 patent/US7820704B2/en not_active Expired - Fee Related
- 2005-04-20 WO PCT/US2005/013386 patent/WO2005103022A1/en not_active Ceased
- 2005-04-20 CA CA2562075A patent/CA2562075C/en not_active Expired - Fee Related
- 2005-04-20 JP JP2007509585A patent/JP4879165B2/ja not_active Expired - Fee Related
- 2005-04-20 BR BRPI0510095-0A patent/BRPI0510095A/pt not_active IP Right Cessation
- 2005-04-20 CN CNA2005800125133A patent/CN1946703A/zh active Pending
-
2006
- 2006-10-03 ZA ZA2006/08225A patent/ZA200608225B/en unknown
- 2006-10-15 IL IL178597A patent/IL178597A0/en unknown
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