JP2010527364A5 - - Google Patents
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- Publication number
- JP2010527364A5 JP2010527364A5 JP2010508499A JP2010508499A JP2010527364A5 JP 2010527364 A5 JP2010527364 A5 JP 2010527364A5 JP 2010508499 A JP2010508499 A JP 2010508499A JP 2010508499 A JP2010508499 A JP 2010508499A JP 2010527364 A5 JP2010527364 A5 JP 2010527364A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- alkyl
- amino
- hydrogen
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 ethoxy, hydroxy, 1- (hydroxy) ethyl Chemical group 0.000 claims 42
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 125000001153 fluoro group Chemical group F* 0.000 claims 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000006317 cyclopropyl amino group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- LLAPDLPYIYKTGQ-UHFFFAOYSA-N 1-aminoethyl Chemical group C[CH]N LLAPDLPYIYKTGQ-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 125000006525 methoxy ethyl amino group Chemical group [H]N(*)C([H])([H])C([H])([H])OC([H])([H])[H] 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93833307P | 2007-05-16 | 2007-05-16 | |
| US60/938,333 | 2007-05-16 | ||
| PCT/US2008/062799 WO2008144222A2 (en) | 2007-05-16 | 2008-05-07 | Triazolyl aminopyrimidine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527364A JP2010527364A (ja) | 2010-08-12 |
| JP2010527364A5 true JP2010527364A5 (https=) | 2011-06-16 |
| JP5204838B2 JP5204838B2 (ja) | 2013-06-05 |
Family
ID=39967594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508499A Expired - Fee Related JP5204838B2 (ja) | 2007-05-16 | 2008-05-07 | トリアゾリルアミノピリミジン化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8114872B2 (https=) |
| EP (1) | EP2155735A2 (https=) |
| JP (1) | JP5204838B2 (https=) |
| KR (1) | KR101131254B1 (https=) |
| CN (1) | CN101679396B (https=) |
| AR (1) | AR066472A1 (https=) |
| AU (1) | AU2008254318B2 (https=) |
| BR (1) | BRPI0811611A2 (https=) |
| CA (1) | CA2687474A1 (https=) |
| CL (1) | CL2008001322A1 (https=) |
| EA (1) | EA015574B1 (https=) |
| MX (1) | MX2009012233A (https=) |
| PE (1) | PE20090803A1 (https=) |
| TW (1) | TW200902012A (https=) |
| WO (1) | WO2008144222A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2349169T3 (es) | 2006-12-21 | 2010-12-28 | ELI LILLY & COMPANY | Compuestos de imidazolidinonil aminopirimidina para el tratamiento del cáncer. |
| DK2125794T3 (da) | 2006-12-21 | 2011-01-24 | Lilly Co Eli | Imidazolidinonylaminopyrimidin-forbindelser til behandling af cancer |
| US8063035B2 (en) | 2007-05-16 | 2011-11-22 | Eli Lilly And Company | Triazolyl aminopyrimidine compounds |
| CN101679396B (zh) | 2007-05-16 | 2012-06-06 | 伊莱利利公司 | 三唑基氨基嘧啶化合物 |
| CN105121411B (zh) | 2013-04-15 | 2017-10-10 | 杜邦公司 | 杀真菌酰胺 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4929726A (en) * | 1988-02-09 | 1990-05-29 | Georgia State University Foundation, Inc. | Novel diazines and their method of preparation |
| WO2004063192A1 (en) | 2003-01-10 | 2004-07-29 | Pharmacopeia Drug Discovery, Inc. | Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| US7521457B2 (en) * | 2004-08-20 | 2009-04-21 | Boehringer Ingelheim International Gmbh | Pyrimidines as PLK inhibitors |
| WO2006021548A1 (de) * | 2004-08-27 | 2006-03-02 | Boehringer Ingelheim International Gmbh | Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| EP1831207B1 (en) | 2004-12-17 | 2012-11-14 | Amgen Inc. | Aminopyrimidine compounds as plk inhibitors |
| TW200800201A (en) | 2005-11-18 | 2008-01-01 | Lilly Co Eli | Pyrimidinyl benzothiophene compounds |
| CA2644910C (en) | 2006-03-31 | 2014-01-28 | Abbott Laboratories | Indazole compounds |
| ES2349169T3 (es) | 2006-12-21 | 2010-12-28 | ELI LILLY & COMPANY | Compuestos de imidazolidinonil aminopirimidina para el tratamiento del cáncer. |
| US8063035B2 (en) * | 2007-05-16 | 2011-11-22 | Eli Lilly And Company | Triazolyl aminopyrimidine compounds |
| CN101679396B (zh) | 2007-05-16 | 2012-06-06 | 伊莱利利公司 | 三唑基氨基嘧啶化合物 |
-
2008
- 2008-05-07 CN CN2008800159078A patent/CN101679396B/zh not_active Expired - Fee Related
- 2008-05-07 KR KR1020097023738A patent/KR101131254B1/ko not_active Expired - Fee Related
- 2008-05-07 WO PCT/US2008/062799 patent/WO2008144222A2/en not_active Ceased
- 2008-05-07 CA CA2687474A patent/CA2687474A1/en not_active Abandoned
- 2008-05-07 JP JP2010508499A patent/JP5204838B2/ja not_active Expired - Fee Related
- 2008-05-07 EA EA200971067A patent/EA015574B1/ru not_active IP Right Cessation
- 2008-05-07 US US12/596,957 patent/US8114872B2/en not_active Expired - Fee Related
- 2008-05-07 AR ARP080101931A patent/AR066472A1/es unknown
- 2008-05-07 AU AU2008254318A patent/AU2008254318B2/en not_active Ceased
- 2008-05-07 BR BRPI0811611-3A2A patent/BRPI0811611A2/pt not_active IP Right Cessation
- 2008-05-07 MX MX2009012233A patent/MX2009012233A/es active IP Right Grant
- 2008-05-07 TW TW097116887A patent/TW200902012A/zh unknown
- 2008-05-07 CL CL2008001322A patent/CL2008001322A1/es unknown
- 2008-05-07 EP EP08755094A patent/EP2155735A2/en not_active Withdrawn
- 2008-05-07 PE PE2008000797A patent/PE20090803A1/es not_active Application Discontinuation
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