JP2011504485A5 - - Google Patents
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- Publication number
- JP2011504485A5 JP2011504485A5 JP2010534558A JP2010534558A JP2011504485A5 JP 2011504485 A5 JP2011504485 A5 JP 2011504485A5 JP 2010534558 A JP2010534558 A JP 2010534558A JP 2010534558 A JP2010534558 A JP 2010534558A JP 2011504485 A5 JP2011504485 A5 JP 2011504485A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- amine
- fluorobut
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98963407P | 2007-11-21 | 2007-11-21 | |
| PCT/IB2008/003124 WO2009066152A2 (en) | 2007-11-21 | 2008-11-19 | Haloallylamine inhibitors of ssao/vap-1 and uses therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011504485A JP2011504485A (ja) | 2011-02-10 |
| JP2011504485A5 true JP2011504485A5 (https=) | 2011-05-26 |
Family
ID=40667907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534558A Pending JP2011504485A (ja) | 2007-11-21 | 2008-11-19 | Ssao/vap−1のハロアリルアミン阻害剤およびその用途 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8426587B2 (https=) |
| EP (1) | EP2222160B1 (https=) |
| JP (1) | JP2011504485A (https=) |
| CN (1) | CN101917845A (https=) |
| AU (1) | AU2008327615B2 (https=) |
| CA (1) | CA2706465A1 (https=) |
| NZ (1) | NZ585528A (https=) |
| SG (1) | SG186008A1 (https=) |
| WO (1) | WO2009066152A2 (https=) |
| ZA (1) | ZA201003596B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11724982B2 (en) | 2014-10-10 | 2023-08-15 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA112154C2 (uk) | 2009-09-08 | 2016-08-10 | Біоті Терапіс Корп. | Застосування повністю людського анти-vap-1-антитіла для лікування фіброзних станів |
| FI20115234A0 (fi) | 2011-03-08 | 2011-03-08 | Biotie Therapies Corp | Uusia pyridatsinoni- ja pyridoniyhdisteitä |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP3438087A1 (en) | 2012-05-02 | 2019-02-06 | Boehringer Ingelheim International GmbH | Substituted 3-haloallylamine inhibitors of ssao and uses thereof |
| WO2014199171A1 (en) | 2013-06-12 | 2014-12-18 | Proximagen Limited | New therapeutic uses of enzyme inhibitors |
| WO2015189534A1 (en) | 2014-06-12 | 2015-12-17 | Proximagen Limited | Vap-1 inhibitors for treating muscular dystrophy |
| HK1256174A1 (zh) | 2015-12-07 | 2019-09-13 | Benevolentai Cambridge Limited | 用於治疗疼痛的 vap-1 抑制剂 |
| JP6849197B2 (ja) * | 2016-02-12 | 2021-03-24 | ファーマクシス リミテッド | リジルオキシダーゼのインドールおよびアザインドールハロアリルアミン誘導体阻害剤およびその使用 |
| WO2018027892A1 (en) | 2016-08-12 | 2018-02-15 | Eli Lilly And Company | Amino pyrimidine ssao inhibitors |
| GB201617339D0 (en) | 2016-10-12 | 2016-11-23 | Lytix Biopharma As | Therapeutic compounds |
| BR112019005930A2 (pt) | 2016-10-19 | 2019-06-11 | Boehringer Ingelheim Int | combinações compreendendo um inibidor de ssao/vap-1 e um inibidor de sglt2, e usos das mesmas |
| WO2018148856A1 (en) | 2017-02-14 | 2018-08-23 | Eli Lilly And Company | Diazaspirodecanyl-pyrimidine compounds useful as ssao inhibitors |
| ES2965478T3 (es) * | 2017-03-01 | 2024-04-15 | Boehringer Ingelheim Int | Protodescarboxilación catalizada por metales de transición de derivados del ácido alfa-halo-acrílico |
| US20200069648A1 (en) * | 2017-03-02 | 2020-03-05 | Pharmaxis Ltd. | Haloallylamine pyrazole derivative inhibitors of lysyl oxidases and uses thereof |
| US20200087248A1 (en) * | 2017-04-28 | 2020-03-19 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Fluoroallylamine Derivative And Use Thereof |
| AU2018287777B2 (en) * | 2017-06-20 | 2020-05-21 | Shandong Danhong Pharmaceutical Co., Ltd. | SSAO inhibitor |
| WO2019024924A1 (zh) * | 2017-08-04 | 2019-02-07 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其在医药上的应用 |
| CN109810041B (zh) * | 2017-11-21 | 2023-08-15 | 药捷安康(南京)科技股份有限公司 | 卤代烯丙基胺类ssao/vap-1抑制剂及其应用 |
| CN109988109B (zh) * | 2017-12-29 | 2020-12-29 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的胺类化合物及其用途 |
| KR20190110740A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| KR20190110736A (ko) | 2018-03-21 | 2019-10-01 | 주식회사유한양행 | 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| WO2020006177A1 (en) * | 2018-06-29 | 2020-01-02 | Blade Therapeutics, Inc. | Vascular adhesion protein-1 (vap-1) modulators and therapeutic uses thereof |
| KR20200004036A (ko) * | 2018-07-03 | 2020-01-13 | 주식회사유한양행 | (e)-(2-(클로로메틸)-3-플루오로알릴)카바메이트 유도체의 제조방법 |
| CN112533897B (zh) | 2018-08-03 | 2023-07-14 | 法玛西斯有限公司 | 赖氨酰氧化酶的卤代烯丙胺砜衍生抑制剂及其用途 |
| CN110938059A (zh) | 2018-09-25 | 2020-03-31 | 上海轶诺药业有限公司 | 胺基脲敏感性胺氧化酶抑制剂制备及其应用 |
| CN113164454A (zh) | 2018-09-28 | 2021-07-23 | 奥克塞拉有限公司 | Vap-1的抑制剂 |
| MX2021003731A (es) | 2018-09-28 | 2021-08-05 | Acucela Inc | Inhibidores de vap-1. |
| AU2019365213A1 (en) * | 2018-10-24 | 2021-06-03 | Metacrine, Inc. | SSAO inhibitors and uses thereof |
| TWI835945B (zh) | 2018-12-14 | 2024-03-21 | 南韓商柳韓洋行股份有限公司 | 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物 |
| TW202039486A (zh) | 2018-12-14 | 2020-11-01 | 南韓商柳韓洋行股份有限公司 | 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物 |
| BR112021013429A2 (pt) | 2019-01-11 | 2021-10-19 | Nanjing Transthera Biosciences Co., Ltd. | Composto, composição farmacêutica, e, uso do composto |
| WO2020233583A1 (zh) * | 2019-05-20 | 2020-11-26 | 广东东阳光药业有限公司 | 抑制ssao/vap-1的异喹啉酮类化合物及其用途 |
| AU2020317374A1 (en) * | 2019-07-25 | 2022-02-03 | Pharmaxis Ltd. | Difluorohaloallylamine sulfone derivative inhibitors of lysyl oxidases, methods of preparation, and uses thereof |
| MX2022005199A (es) * | 2019-10-29 | 2022-08-04 | Eccogene Shanghai Co Ltd | Inhibidores de ssao y uso de los mismos. |
| CN112876419A (zh) * | 2019-11-29 | 2021-06-01 | 四川科伦博泰生物医药股份有限公司 | 烯丙胺衍生物及其制备方法和用途 |
| US12578335B2 (en) * | 2020-02-05 | 2026-03-17 | Syntara Limited | Bioprobes for lysyl oxidases and uses thereof |
| CN115916337B (zh) * | 2020-06-26 | 2025-04-15 | 法玛西斯有限公司 | 卤代烯丙基胺双胺氧化酶抑制剂 |
| JP2023539639A (ja) | 2020-08-25 | 2023-09-15 | イーライ リリー アンド カンパニー | Ssao阻害剤の多形 |
| CN114621189B (zh) * | 2020-12-14 | 2024-01-02 | 上海拓界生物医药科技有限公司 | 一种内酰胺类衍生物及其用途 |
| CN114621190B (zh) * | 2020-12-14 | 2023-12-05 | 上海拓界生物医药科技有限公司 | 一种烯丙基胺类衍生物及其用途 |
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-
2008
- 2008-11-19 JP JP2010534558A patent/JP2011504485A/ja active Pending
- 2008-11-19 CA CA2706465A patent/CA2706465A1/en not_active Abandoned
- 2008-11-19 US US12/742,915 patent/US8426587B2/en not_active Expired - Fee Related
- 2008-11-19 SG SG2012084919A patent/SG186008A1/en unknown
- 2008-11-19 WO PCT/IB2008/003124 patent/WO2009066152A2/en not_active Ceased
- 2008-11-19 EP EP08851514.3A patent/EP2222160B1/en not_active Not-in-force
- 2008-11-19 CN CN200880125037XA patent/CN101917845A/zh active Pending
- 2008-11-19 NZ NZ585528A patent/NZ585528A/xx not_active IP Right Cessation
- 2008-11-19 AU AU2008327615A patent/AU2008327615B2/en not_active Ceased
-
2010
- 2010-05-20 ZA ZA2010/03596A patent/ZA201003596B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11724982B2 (en) | 2014-10-10 | 2023-08-15 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
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