JP2008519783A5 - - Google Patents
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- JP2008519783A5 JP2008519783A5 JP2007540535A JP2007540535A JP2008519783A5 JP 2008519783 A5 JP2008519783 A5 JP 2008519783A5 JP 2007540535 A JP2007540535 A JP 2007540535A JP 2007540535 A JP2007540535 A JP 2007540535A JP 2008519783 A5 JP2008519783 A5 JP 2008519783A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- hydrogen
- alkyl
- phenyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 60
- 229910052739 hydrogen Inorganic materials 0.000 claims 39
- 239000001257 hydrogen Substances 0.000 claims 39
- 150000002431 hydrogen Chemical group 0.000 claims 26
- 125000000217 alkyl group Chemical group 0.000 claims 25
- 229910052731 fluorine Inorganic materials 0.000 claims 25
- 229910052801 chlorine Inorganic materials 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 15
- 230000002265 prevention Effects 0.000 claims 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 14
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 12
- 229910052794 bromium Inorganic materials 0.000 claims 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 12
- 229910052740 iodine Inorganic materials 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 11
- 208000035475 disorder Diseases 0.000 claims 9
- -1 methoxy, ethoxy Chemical group 0.000 claims 9
- 210000000056 organ Anatomy 0.000 claims 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
- 208000028867 ischemia Diseases 0.000 claims 7
- 210000001519 tissue Anatomy 0.000 claims 7
- 206010019280 Heart failures Diseases 0.000 claims 6
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 6
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 6
- 238000001356 surgical procedure Methods 0.000 claims 6
- 206010016654 Fibrosis Diseases 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 210000003169 central nervous system Anatomy 0.000 claims 5
- 230000004761 fibrosis Effects 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 230000002093 peripheral effect Effects 0.000 claims 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 3
- 206010027476 Metastases Diseases 0.000 claims 3
- 230000009692 acute damage Effects 0.000 claims 3
- 230000032683 aging Effects 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 208000015114 central nervous system disease Diseases 0.000 claims 3
- 230000009693 chronic damage Effects 0.000 claims 3
- 210000002307 prostate Anatomy 0.000 claims 3
- 230000010410 reperfusion Effects 0.000 claims 3
- 208000003663 ventricular fibrillation Diseases 0.000 claims 3
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000003495 Coccidiosis Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 206010012335 Dependence Diseases 0.000 claims 2
- 208000007530 Essential hypertension Diseases 0.000 claims 2
- 208000010496 Heart Arrest Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 206010020850 Hyperthyroidism Diseases 0.000 claims 2
- 206010022562 Intermittent claudication Diseases 0.000 claims 2
- 206010023076 Isosporiasis Diseases 0.000 claims 2
- 206010023421 Kidney fibrosis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- 208000007536 Thrombosis Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 230000006793 arrhythmia Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000000747 cardiac effect Effects 0.000 claims 2
- 230000009787 cardiac fibrosis Effects 0.000 claims 2
- 231100000457 cardiotoxic Toxicity 0.000 claims 2
- 230000001451 cardiotoxic effect Effects 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 208000037976 chronic inflammation Diseases 0.000 claims 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims 2
- 230000036461 convulsion Effects 0.000 claims 2
- 230000003111 delayed effect Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 206010020718 hyperplasia Diseases 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 208000021156 intermittent vascular claudication Diseases 0.000 claims 2
- 230000037356 lipid metabolism Effects 0.000 claims 2
- 201000004792 malaria Diseases 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 208000031225 myocardial ischemia Diseases 0.000 claims 2
- 210000001428 peripheral nervous system Anatomy 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 210000001835 viscera Anatomy 0.000 claims 2
- DWQKZCIMVWJIBS-UHFFFAOYSA-N 4-(1,1-dioxo-1,2-thiazolidin-2-yl)-3-methylbenzoic acid Chemical compound CC1=CC(C(O)=O)=CC=C1N1S(=O)(=O)CCC1 DWQKZCIMVWJIBS-UHFFFAOYSA-N 0.000 claims 1
- 206010001497 Agitation Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- 206010020880 Hypertrophy Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 230000003712 anti-aging effect Effects 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- JFRGVHDKQGKGOJ-UHFFFAOYSA-N methyl 4-(1,1-dioxo-1,2-thiazolidin-2-yl)-3-methylbenzoate Chemical compound CC1=CC(C(=O)OC)=CC=C1N1S(=O)(=O)CCC1 JFRGVHDKQGKGOJ-UHFFFAOYSA-N 0.000 claims 1
- RTHZGZMREZPJRL-UHFFFAOYSA-N n-(diaminomethylidene)-4-(1,1-dioxo-1,2-thiazolidin-2-yl)-2-methyl-5-methylsulfonylbenzamide Chemical compound C1=C(C(=O)NC(N)=N)C(C)=CC(N2S(CCC2)(=O)=O)=C1S(C)(=O)=O RTHZGZMREZPJRL-UHFFFAOYSA-N 0.000 claims 1
- GNHBQRQBQXZITB-UHFFFAOYSA-N n-(diaminomethylidene)-4-(1,1-dioxo-4-phenyl-1,2-thiazolidin-2-yl)-2-methyl-5-methylsulfonylbenzamide Chemical compound C1=C(C(=O)NC(N)=N)C(C)=CC(N2S(CC(C2)C=2C=CC=CC=2)(=O)=O)=C1S(C)(=O)=O GNHBQRQBQXZITB-UHFFFAOYSA-N 0.000 claims 1
- ZEXSKAVDDIBBGH-UHFFFAOYSA-N n-(diaminomethylidene)-4-(1,1-dioxothiazinan-2-yl)-2-methyl-5-methylsulfonylbenzamide Chemical compound C1=C(C(=O)NC(N)=N)C(C)=CC(N2S(CCCC2)(=O)=O)=C1S(C)(=O)=O ZEXSKAVDDIBBGH-UHFFFAOYSA-N 0.000 claims 1
- LRNHWVUUAXXLSL-UHFFFAOYSA-N n-(diaminomethylidene)-4-(3,3-dimethyl-1,1-dioxo-1,2-thiazolidin-2-yl)-2-methyl-5-methylsulfonylbenzamide Chemical compound C1=C(C(=O)NC(N)=N)C(C)=CC(N2S(CCC2(C)C)(=O)=O)=C1S(C)(=O)=O LRNHWVUUAXXLSL-UHFFFAOYSA-N 0.000 claims 1
- YQJFRCKAROSGNN-UHFFFAOYSA-N n-(diaminomethylidene)-4-[4-(4-fluorophenyl)-1,1-dioxo-1,2-thiazolidin-2-yl]-2-methyl-5-methylsulfonylbenzamide Chemical compound C1=C(C(=O)NC(N)=N)C(C)=CC(N2S(CC(C2)C=2C=CC(F)=CC=2)(=O)=O)=C1S(C)(=O)=O YQJFRCKAROSGNN-UHFFFAOYSA-N 0.000 claims 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 claims 1
- 239000002831 pharmacologic agent Substances 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 0 CC(*)(C(*)(*)**1)N(c2c(*)c(*)c(C(I)=O)c(*)c2*)S1(=O)=O Chemical compound CC(*)(C(*)(*)**1)N(c2c(*)c(*)c(C(I)=O)c(*)c2*)S1(=O)=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004054847A DE102004054847A1 (de) | 2004-11-13 | 2004-11-13 | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| PCT/EP2005/011595 WO2006050830A1 (de) | 2004-11-13 | 2005-10-29 | Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008519783A JP2008519783A (ja) | 2008-06-12 |
| JP2008519783A5 true JP2008519783A5 (https=) | 2008-12-11 |
Family
ID=35502583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540535A Ceased JP2008519783A (ja) | 2004-11-13 | 2005-10-29 | 置換ベンゾイルグアニジン類、それらの製造法及び医薬又は診断薬としての使用、並びにそれらを含む医薬 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7772262B2 (https=) |
| EP (1) | EP1812412B1 (https=) |
| JP (1) | JP2008519783A (https=) |
| DE (2) | DE102004054847A1 (https=) |
| WO (1) | WO2006050830A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011527677A (ja) * | 2008-07-08 | 2011-11-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｎｈｅ−１阻害剤として有用なピロリジニル及びピペリジニル化合物 |
| SI2384318T1 (en) | 2008-12-31 | 2018-03-30 | Ardelyx, Inc. | MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| MX366293B (es) | 2012-08-21 | 2019-07-04 | Ardelyx Inc | Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal. |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| LT2983667T (lt) | 2013-04-12 | 2019-07-10 | Ardelyx, Inc. | Nhe3 rišantys junginiai ir fosfato pernešimo slopinimo būdai |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CA3049678A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
| EA201991676A1 (ru) | 2017-01-09 | 2020-01-30 | Арделикс, Инк. | Ингибиторы nhe-опосредованного антипорта |
| CN118440135A (zh) | 2017-08-04 | 2024-08-06 | 阿德利克斯股份有限公司 | 用于治疗高钾血症的甘草次酸衍生物 |
| KR20260004570A (ko) | 2019-02-07 | 2026-01-08 | 알데릭스, 인코포레이티드 | 고칼륨혈증 치료에 사용하기 위한 글리시레틴산 유도체 |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59305042D1 (de) * | 1992-09-22 | 1997-02-20 | Hoechst Ag | Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika |
| JP2002530325A (ja) * | 1998-11-26 | 2002-09-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 非インスリン依存型真性糖尿病の治療へのベンゾイルグアニジンの使用 |
| DE10155075A1 (de) * | 2001-11-09 | 2003-05-22 | Merck Patent Gmbh | Cyclische Sulfonamide |
| DE10226462A1 (de) * | 2002-06-13 | 2003-12-24 | Aventis Pharma Gmbh | Fluorierte Cycloalkyl-derivatisierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| US7205318B2 (en) * | 2003-03-18 | 2007-04-17 | Bristol-Myers Squibb Company | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors |
| US7371743B2 (en) * | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
-
2004
- 2004-11-13 DE DE102004054847A patent/DE102004054847A1/de not_active Withdrawn
-
2005
- 2005-10-29 DE DE502005003873T patent/DE502005003873D1/de not_active Expired - Lifetime
- 2005-10-29 JP JP2007540535A patent/JP2008519783A/ja not_active Ceased
- 2005-10-29 WO PCT/EP2005/011595 patent/WO2006050830A1/de not_active Ceased
- 2005-10-29 EP EP05806565A patent/EP1812412B1/de not_active Expired - Lifetime
-
2007
- 2007-05-14 US US11/748,166 patent/US7772262B2/en not_active Expired - Fee Related
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