JP2005522492A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005522492A5 JP2005522492A5 JP2003583416A JP2003583416A JP2005522492A5 JP 2005522492 A5 JP2005522492 A5 JP 2005522492A5 JP 2003583416 A JP2003583416 A JP 2003583416A JP 2003583416 A JP2003583416 A JP 2003583416A JP 2005522492 A5 JP2005522492 A5 JP 2005522492A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- methyl
- pyridin
- substituted
- trimethoxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims description 14
- -1 cyclic amine compound Chemical class 0.000 claims description 12
- 239000004480 active ingredient Substances 0.000 claims description 9
- 150000004677 hydrates Chemical class 0.000 claims description 6
- 239000012830 cancer therapeutic Substances 0.000 claims description 4
- 238000001415 gene therapy Methods 0.000 claims description 4
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims description 4
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 30
- 125000001072 heteroaryl group Chemical group 0.000 claims 28
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 24
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 18
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 12
- 125000002252 acyl group Chemical group 0.000 claims 12
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 12
- 125000004414 alkyl thio group Chemical group 0.000 claims 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims 12
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 12
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 11
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 6
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 6
- NLGSNZVQUOCQJN-UHFFFAOYSA-N n-(1,3-benzodioxol-5-yl)-n,1-bis[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidin-4-amine Chemical compound COC1=C(OC)C(OC)=CC(C=2N=CC=C(CN(C3CCN(CC=4C=C(N=CC=4)C=4C=C(OC)C(OC)=C(OC)C=4)CC3)C=3C=C4OCOC4=CC=3)C=2)=C1 NLGSNZVQUOCQJN-UHFFFAOYSA-N 0.000 claims 6
- WCQNPRXILHBFLX-UHFFFAOYSA-N n-(3,5-dimethoxyphenyl)-n,1-bis[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidin-4-amine Chemical compound COC1=CC(OC)=CC(N(CC=2C=C(N=CC=2)C=2C=C(OC)C(OC)=C(OC)C=2)C2CCN(CC=3C=C(N=CC=3)C=3C=C(OC)C(OC)=C(OC)C=3)CC2)=C1 WCQNPRXILHBFLX-UHFFFAOYSA-N 0.000 claims 6
- HLFPVNRCIWSFNV-UHFFFAOYSA-N n-(4-methoxyphenyl)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-n-[[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]methyl]piperidin-4-amine Chemical compound C1=CC(OC)=CC=C1N(C1CCN(CC=2C=C(N=CC=2)C=2C=C(OC)C(OC)=C(OC)C=2)CC1)CC1=CN=CC(C=2C=C(OC)C(OC)=C(OC)C=2)=C1 HLFPVNRCIWSFNV-UHFFFAOYSA-N 0.000 claims 6
- FCMRKIJWSJURDE-UHFFFAOYSA-N n-(4-methoxyphenyl)-n,1-bis[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidin-4-amine Chemical group C1=CC(OC)=CC=C1N(C1CCN(CC=2C=C(N=CC=2)C=2C=C(OC)C(OC)=C(OC)C=2)CC1)CC1=CC=NC(C=2C=C(OC)C(OC)=C(OC)C=2)=C1 FCMRKIJWSJURDE-UHFFFAOYSA-N 0.000 claims 6
- AVFGUYNXNVEQFK-UHFFFAOYSA-N n-methyl-n,1-bis[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidin-4-amine Chemical compound COC1=C(OC)C(OC)=CC(C=2N=CC=C(CN(C)C3CCN(CC=4C=C(N=CC=4)C=4C=C(OC)C(OC)=C(OC)C=4)CC3)C=2)=C1 AVFGUYNXNVEQFK-UHFFFAOYSA-N 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- OOAMKQROPFDCBV-UHFFFAOYSA-N n-(4-methylsulfanylphenyl)-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]-n-[[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]methyl]piperidin-4-amine Chemical compound COC1=C(OC)C(OC)=CC(C=2C=C(CN(C3CCN(CC=4C=C(N=CC=4)C=4C=C(OC)C(OC)=C(OC)C=4)CC3)C=3C=CC(SC)=CC=3)C=NC=2)=C1 OOAMKQROPFDCBV-UHFFFAOYSA-N 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 3
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37167502P | 2002-04-12 | 2002-04-12 | |
| US41257102P | 2002-09-23 | 2002-09-23 | |
| PCT/JP2003/004602 WO2003086397A1 (en) | 2002-04-12 | 2003-04-11 | Medicine for treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005522492A JP2005522492A (ja) | 2005-07-28 |
| JP2005522492A5 true JP2005522492A5 (https=) | 2006-01-05 |
Family
ID=29254452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583416A Pending JP2005522492A (ja) | 2002-04-12 | 2003-04-11 | 癌治療薬 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050176764A1 (https=) |
| EP (1) | EP1494670A1 (https=) |
| JP (1) | JP2005522492A (https=) |
| AU (1) | AU2003222449A1 (https=) |
| MY (1) | MY134200A (https=) |
| TW (1) | TW200407141A (https=) |
| WO (1) | WO2003086397A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20060040986A1 (en) * | 2002-12-06 | 2006-02-23 | Kowa Co., Ltd. | Erythropoietin production accelerator |
| CA2518318A1 (en) | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP4634303B2 (ja) * | 2003-10-10 | 2011-02-16 | 興和株式会社 | 血管新生抑制薬 |
| US7521462B2 (en) | 2004-02-27 | 2009-04-21 | Eli Lilly And Company | 4-Amino-piperidine derivatives as monoamine uptake inhibitors |
| JP2008524246A (ja) | 2004-12-16 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| WO2006082834A1 (ja) * | 2005-02-02 | 2006-08-10 | Kowa Co., Ltd. | ケラチノサイト増殖に起因する疾患の予防・治療剤 |
| US7642253B2 (en) | 2005-05-11 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EA200800321A1 (ru) | 2005-07-14 | 2008-06-30 | Такеда Сан Диего, Инк. | Ингибиторы гистондеацетилазы |
| WO2008044337A1 (en) * | 2006-10-13 | 2008-04-17 | Kowa Co., Ltd. | γ-GLOBIN INDUCER |
| EP2520561B1 (en) | 2007-06-08 | 2016-02-10 | MannKind Corporation | IRE-1A Inhibitors |
| WO2010080864A1 (en) | 2009-01-12 | 2010-07-15 | Array Biopharma Inc. | Piperidine-containing compounds and use thereof |
| EP2895474B1 (en) * | 2012-09-17 | 2019-12-11 | Duke University | Smoothened receptor modulators and methods of use thereof |
| UY36391A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| US20190298705A1 (en) * | 2016-06-08 | 2019-10-03 | Glaxosmithkline Intellectual Property Development Limited | Chemical Compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3808921B2 (ja) * | 1995-11-20 | 2006-08-16 | 興和株式会社 | 細胞接着阻害剤 |
| US6605620B1 (en) * | 2001-08-30 | 2003-08-12 | Kowa Co., Ltd. | Cyclic amine compounds and pharmaceutical composition containing the same |
| US6867221B2 (en) * | 2001-08-30 | 2005-03-15 | Kowa Co., Ltd. | Cyclic amine compounds and pharmaceutical composition containing the same |
| US6395753B1 (en) * | 2001-08-30 | 2002-05-28 | Kowa Co., Ltd. | Cyclic amine compounds and pharmaceutical composition containing the same |
-
2003
- 2003-04-08 MY MYPI20031300A patent/MY134200A/en unknown
- 2003-04-09 TW TW092108179A patent/TW200407141A/zh unknown
- 2003-04-11 WO PCT/JP2003/004602 patent/WO2003086397A1/en not_active Ceased
- 2003-04-11 US US10/510,759 patent/US20050176764A1/en not_active Abandoned
- 2003-04-11 AU AU2003222449A patent/AU2003222449A1/en not_active Abandoned
- 2003-04-11 EP EP03717559A patent/EP1494670A1/en not_active Withdrawn
- 2003-04-11 JP JP2003583416A patent/JP2005522492A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005522492A5 (https=) | ||
| RU2397168C2 (ru) | Производные тиофена в качестве ингибиторов снк 1 | |
| RU2004121161A (ru) | Замещенные 2-тио-3,5-дициано-4-фенил-6-аминопиридины и их применение | |
| RU2420522C2 (ru) | Новый класс ингибиторов гистондеацетилаз | |
| JP2005501120A5 (https=) | ||
| RU2004135066A (ru) | Ингибиторы деацетилазы гистонов | |
| JP2006515858A5 (https=) | ||
| CA2376305A1 (en) | Sulfonamide and sulfamide substituted imidazoquinolines | |
| JP2005511547A5 (https=) | ||
| RU2007107189A (ru) | Производные арилпиридина | |
| RU2001111023A (ru) | Новые производные n-(иминометил)аминов, их получение, их использование в качестве лекарственных средств и содержащие их фармацевтические композиции | |
| RU2009115653A (ru) | Производные 5-замещенного хиназолинона, содержащие их композиции и способы их применения | |
| NZ590355A (en) | Stat3 inhibitor containing quinolinecarboxamide derivative as active ingredient | |
| JP2015510886A5 (https=) | ||
| JP2007016035A5 (https=) | ||
| RU2006116889A (ru) | Производные n-гетероциклилметилбензамидов, их получение и их применение в терапии | |
| RU2004119406A (ru) | 5-сульфанил-4н-1,2,4-триазольные производные и их применение в качестве лекарственного препарата | |
| JP2012530765A5 (https=) | ||
| JPH10279578A5 (https=) | ||
| EA200700901A1 (ru) | Производные 2-амидо-4-фенилтиазола, их получение и применение в терапии | |
| RU2010107603A (ru) | Производные n-(2-тиазолил)амида для лечения ожирения, диабетов и сердечно-сосудистых заболеваний | |
| JP2005511594A5 (https=) | ||
| JP2009520791A5 (https=) | ||
| JP2005527521A5 (https=) | ||
| JP2007514639A5 (https=) |