|
CN100562516C
(zh)
|
2001-12-27 |
2009-11-25 |
第一制药株式会社 |
β-淀粉样蛋白产生和分泌的抑制剂
|
|
GB0218041D0
(en)
*
|
2002-08-02 |
2002-09-11 |
Merck Sharp & Dohme |
Chemical process
|
|
GB0223039D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
GB0313772D0
(en)
*
|
2003-06-13 |
2003-07-23 |
Merck Sharp & Dohme |
Therapeutic treatment
|
|
CA2526487A1
(en)
|
2003-06-30 |
2005-01-06 |
Daiichi Pharmaceutical Co., Ltd. |
Heterocyclic methyl sulfone derivative
|
|
MXPA06001558A
(es)
|
2003-08-08 |
2006-05-15 |
Schering Corp |
Inhibidores de amina ciclica bace-1 que poseen un sustituyente heterociclico.
|
|
ES2323068T3
(es)
|
2003-08-08 |
2009-07-06 |
Schering Corporation |
Inhibidores de bace-1 de aminas ciclicas con un sustituyente de benzamida.
|
|
GB0323258D0
(en)
|
2003-10-04 |
2003-11-05 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
AR047666A1
(es)
*
|
2004-02-20 |
2006-02-01 |
Merck Sharp & Dohme |
Sintesis estereoselectiva del acido ciclohexanopropanoico 4,4-disubstituido
|
|
EP1781625B1
(en)
|
2004-07-22 |
2010-12-15 |
Schering Corporation |
Substituted amide beta secretase inhibitors
|
|
US8114886B2
(en)
|
2005-04-08 |
2012-02-14 |
Daiichi Sankyo Company, Limited |
Pyridylmethylsulfone derivative
|
|
WO2006123182A2
(en)
|
2005-05-17 |
2006-11-23 |
Merck Sharp & Dohme Limited |
Cyclohexyl sulphones for treatment of cancer
|
|
WO2007092435A2
(en)
|
2006-02-07 |
2007-08-16 |
Wyeth |
11-beta hsd1 inhibitors
|
|
WO2007103114A2
(en)
|
2006-03-07 |
2007-09-13 |
The Brigham & Women's Hospital, Inc. |
Notch inhibition in the treatment or prevention of atherosclerosis
|
|
US9567396B2
(en)
|
2006-03-07 |
2017-02-14 |
Evonik Degussa Gmbh |
Notch inhibition in the prevention of vein graft failure
|
|
CA2676715A1
(en)
|
2007-02-12 |
2008-08-21 |
Merck & Co., Inc. |
Piperazine derivatives for treatment of ad and related conditions
|
|
TW200920362A
(en)
|
2007-09-11 |
2009-05-16 |
Daiichi Sankyo Co Ltd |
Alkylsulfone derivatives
|
|
KR101595238B1
(ko)
|
2007-12-21 |
2016-02-18 |
리간드 파마슈티칼스 인코포레이티드 |
선택적 안드로겐 수용체 조절제(ｓａｒｍ) 및 이의 용도
|
|
EP2236494B1
(en)
*
|
2007-12-26 |
2016-08-31 |
Msd K.K. |
Sulfonyl substituted 6-membered ring derivative
|
|
WO2009128057A2
(en)
|
2008-04-18 |
2009-10-22 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al |
Psycho-pharmaceuticals
|
|
WO2010114780A1
(en)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
|
US8859776B2
(en)
|
2009-10-14 |
2014-10-14 |
Merck Sharp & Dohme Corp. |
Substituted piperidines that increase p53 activity and the uses thereof
|
|
EP2493497A4
(en)
|
2009-11-01 |
2013-07-24 |
Brigham & Womens Hospital |
NOTCH INHIBITION IN THE TREATMENT AND PROPHYLAXIS OF ADIPOSITAS AND METABOLISM SYNDROME
|
|
US8999957B2
(en)
|
2010-06-24 |
2015-04-07 |
Merck Sharp & Dohme Corp. |
Heterocyclic compounds as ERK inhibitors
|
|
CA2805265A1
(en)
|
2010-08-02 |
2012-02-09 |
Merck Sharp & Dohme Corp. |
Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
|
|
WO2012024170A2
(en)
|
2010-08-17 |
2012-02-23 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
WO2012030685A2
(en)
|
2010-09-01 |
2012-03-08 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
|
US9242981B2
(en)
|
2010-09-16 |
2016-01-26 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel ERK inhibitors
|
|
WO2012058210A1
(en)
|
2010-10-29 |
2012-05-03 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
|
|
EP2654748B1
(en)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
|
WO2013059302A1
(en)
|
2011-10-17 |
2013-04-25 |
Nationwide Children's Hospital, Inc. |
Products and methods for aortic abdominal aneurysm
|
|
EP2770987B1
(en)
|
2011-10-27 |
2018-04-04 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
|
WO2013165816A2
(en)
|
2012-05-02 |
2013-11-07 |
Merck Sharp & Dohme Corp. |
SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
|
|
WO2014052563A2
(en)
|
2012-09-28 |
2014-04-03 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
|
ME02925B
(me)
|
2012-11-28 |
2018-04-20 |
Merck Sharp & Dohme |
Kompozicije i postupci za liječenje kancera
|
|
TW201429969A
(zh)
|
2012-12-20 |
2014-08-01 |
Merck Sharp & Dohme |
作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
|
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
|
CN106061947B
(zh)
*
|
2014-01-06 |
2019-12-03 |
百时美施贵宝公司 |
环己基砜RORγ调节剂
|
|
EP3094323A4
(en)
|
2014-01-17 |
2017-10-11 |
Ligand Pharmaceuticals Incorporated |
Methods and compositions for modulating hormone levels
|
|
US10975084B2
(en)
|
2016-10-12 |
2021-04-13 |
Merck Sharp & Dohme Corp. |
KDM5 inhibitors
|
|
US10947234B2
(en)
|
2017-11-08 |
2021-03-16 |
Merck Sharp & Dohme Corp. |
PRMT5 inhibitors
|
|
EP3706747B1
(en)
|
2017-11-08 |
2025-09-03 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
|
WO2020016377A1
(en)
|
2018-07-19 |
2020-01-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Combination for treating cancer
|
|
WO2020033282A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
|
WO2020033288A1
(en)
|
2018-08-07 |
2020-02-13 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
|
EP3833669A4
(en)
|
2018-08-07 |
2022-05-11 |
Merck Sharp & Dohme Corp. |
PRMT5 INHIBITORS
|
|
US11981701B2
(en)
|
2018-08-07 |
2024-05-14 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
|
AU2020257397B2
(en)
|
2019-04-19 |
2026-02-26 |
Ligand Pharmaceuticals Inc. |
Crystalline forms and methods of producing crystalline forms of a compound
|
|
CN115003303B
(zh)
|
2019-12-17 |
2024-03-08 |
默沙东公司 |
Prmt5抑制剂
|
|
EP4076460B1
(en)
|
2019-12-17 |
2026-01-21 |
Merck Sharp & Dohme LLC |
1,4-dihydro-2h-spiro[isoquinoline-3,4'-piperidine derivatives as prmt5 inhibitors for the treatment of cancer
|
|
JP7589247B2
(ja)
|
2019-12-17 |
2024-11-25 |
メルク・シャープ・アンド・ドーム・エルエルシー |
Ｐｒｍｔ５阻害剤
|
|
US12595248B2
(en)
|
2019-12-17 |
2026-04-07 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
|
WO2022101481A1
(en)
|
2020-11-16 |
2022-05-19 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for predicting and treating uveal melanoma
|
|
JP2025511436A
(ja)
|
2022-09-02 |
2025-04-16 |
メルク・シャープ・アンド・ドーム・エルエルシー |
エキサテカン由来トポイソメラーゼ－１阻害薬医薬組成物及びその使用
|
|
CN120417935A
(zh)
|
2022-10-25 |
2025-08-01 |
默沙东有限责任公司 |
依喜替康衍生的adc接头-载荷及其药物组合物和用途
|
|
US20240207425A1
(en)
|
2022-12-14 |
2024-06-27 |
Merck Sharp & Dohme Llc |
Auristatin linker-payloads, pharmaceutical compositions, and uses thereof
|