MX2007004484A - Compuestos de pirazol o triazol y su uso para la fabricacion de un medicamento para tratar las enfermedades relacionadas con la mutacion somatica. - Google Patents

Compuestos de pirazol o triazol y su uso para la fabricacion de un medicamento para tratar las enfermedades relacionadas con la mutacion somatica.

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Publication number
MX2007004484A
MX2007004484A MX2007004484A MX2007004484A MX2007004484A MX 2007004484 A MX2007004484 A MX 2007004484A MX 2007004484 A MX2007004484 A MX 2007004484A MX 2007004484 A MX2007004484 A MX 2007004484A MX 2007004484 A MX2007004484 A MX 2007004484A
Authority
MX
Mexico
Prior art keywords
pyrazole
medicament
manufacture
related diseases
somatic mutation
Prior art date
Application number
MX2007004484A
Other languages
English (en)
Inventor
Hongyu Ren
Guangming Chen
Neil Almstead
Gary M Karp
Ellen Welch
Richard Wilde
Jeffrey A Campbell
Original Assignee
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ptc Therapeutics Inc filed Critical Ptc Therapeutics Inc
Publication of MX2007004484A publication Critical patent/MX2007004484A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C07F9/65306—Five-membered rings containing two nitrogen atoms

Abstract

La presente invencion se refiere a metodos, compuestos, y composiciones para tratar o prevenir enfermedades asociadas con mutaciones sin sentido en un ARNm mediante la administracion de los compuestos o composiciones de la presente invencion; en particular, la presente invencion se refiere a metodos, compuestos, y composiciones para suprimir la terminacion de la traduccion prematura asociada con una mutacion sin sentido en un ARNm.
MX2007004484A 2004-10-13 2005-10-13 Compuestos de pirazol o triazol y su uso para la fabricacion de un medicamento para tratar las enfermedades relacionadas con la mutacion somatica. MX2007004484A (es)

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US61763404P 2004-10-13 2004-10-13
US61767004P 2004-10-13 2004-10-13
US61765304P 2004-10-13 2004-10-13
US61763304P 2004-10-13 2004-10-13
US61765504P 2004-10-13 2004-10-13
US62417004P 2004-11-03 2004-11-03
PCT/US2005/036761 WO2006044502A2 (en) 2004-10-13 2005-10-13 Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases

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MX2007004484A MX2007004484A (es) 2004-10-13 2005-10-13 Compuestos de pirazol o triazol y su uso para la fabricacion de un medicamento para tratar las enfermedades relacionadas con la mutacion somatica.
MX2007004487A MX2007004487A (es) 2004-10-13 2005-10-13 Compuestos para supresion sin sentido, y metodos para su uso.
MX2007004479A MX2007004479A (es) 2004-10-13 2005-10-13 Compuestoss para supresion sin sentido y metodos para su uso.

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EP (13) EP2316452A1 (es)
JP (3) JP2008515985A (es)
KR (3) KR20070065429A (es)
AU (3) AU2005295727A1 (es)
BR (2) BRPI0516110A (es)
CA (5) CA2583177A1 (es)
IL (3) IL182461A0 (es)
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