ATE355839T1 - 1,4,5-substituierte 1,2-dihydro-pyrazol-3-one and 3-alkoxy-1h-pyrazole derivate als tnf-alpha und interleukin senkende wirkstoffe zur behandlung von entzündungen - Google Patents

1,4,5-substituierte 1,2-dihydro-pyrazol-3-one and 3-alkoxy-1h-pyrazole derivate als tnf-alpha und interleukin senkende wirkstoffe zur behandlung von entzündungen

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Publication number
ATE355839T1
ATE355839T1 AT03755794T AT03755794T ATE355839T1 AT E355839 T1 ATE355839 T1 AT E355839T1 AT 03755794 T AT03755794 T AT 03755794T AT 03755794 T AT03755794 T AT 03755794T AT E355839 T1 ATE355839 T1 AT E355839T1
Authority
AT
Austria
Prior art keywords
disease
hiv
inflammation
treatment
syndrome
Prior art date
Application number
AT03755794T
Other languages
English (en)
Inventor
Celia Dominguez
Dawei Zhang
Kelvin K C Sham
Guo-Qiang Cao
Original Assignee
Amgen Inc
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Publication date
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Publication of ATE355839T1 publication Critical patent/ATE355839T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Immunology (AREA)
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AT03755794T 2002-09-09 2003-09-08 1,4,5-substituierte 1,2-dihydro-pyrazol-3-one and 3-alkoxy-1h-pyrazole derivate als tnf-alpha und interleukin senkende wirkstoffe zur behandlung von entzündungen ATE355839T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40917602P 2002-09-09 2002-09-09

Publications (1)

Publication Number Publication Date
ATE355839T1 true ATE355839T1 (de) 2007-03-15

Family

ID=31978728

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03755794T ATE355839T1 (de) 2002-09-09 2003-09-08 1,4,5-substituierte 1,2-dihydro-pyrazol-3-one and 3-alkoxy-1h-pyrazole derivate als tnf-alpha und interleukin senkende wirkstoffe zur behandlung von entzündungen

Country Status (11)

Country Link
US (1) US6967254B2 (de)
EP (1) EP1542680B1 (de)
JP (1) JP2006501263A (de)
AT (1) ATE355839T1 (de)
AU (1) AU2003273295B2 (de)
CA (1) CA2497007A1 (de)
DE (1) DE60312342T2 (de)
ES (1) ES2283811T3 (de)
MX (1) MXPA05002513A (de)
PL (1) PL379544A1 (de)
WO (1) WO2004022055A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1812071A2 (de) * 2004-10-13 2007-08-01 PTC Therapeutics, Inc. Verbindungen zur nonsense-unterdrückung und verwendung dieser verbindungen für die herstellung eines medikaments zur behandlung somatischer mutationsbedingter erkrankungen
TW200639163A (en) * 2005-02-04 2006-11-16 Genentech Inc RAF inhibitor compounds and methods
AU2006295340B2 (en) 2005-08-05 2010-11-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
EP1933714B1 (de) * 2005-09-21 2020-03-18 The Regents of The University of California Systeme und zusammensetzungen für die lokale darstellung und behandlung von schmerzen
US9187455B2 (en) * 2009-02-23 2015-11-17 Hoffmann-La Roche Inc. Substituted pyridazines as PDE10A inhibitors
DE102011055815A1 (de) * 2011-11-29 2013-05-29 Aicuris Gmbh & Co. Kg Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
JPS4935278B1 (de) * 1970-09-26 1974-09-20
CA994338A (en) 1973-09-25 1976-08-03 Merck Sharp And Dohme (I.A.) Corp. U.S.A. (Doing Business As Laboratoire S Merck Frosst Laboratories) Compositions containing heterocyclic bronchodilating agents
JPS5821251B2 (ja) * 1978-08-28 1983-04-28 旭化成株式会社 乾式画像形成材料
IL86926A (en) * 1987-07-13 1992-07-15 Sterling Drug Inc Diphenyl-1h-pyrazole-1-alkanamides,their preparation and antiarrhythmic compositions containing them
US4898880A (en) * 1989-03-22 1990-02-06 Sterling Drug Inc. N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmic agents, compositions and use
US5191084A (en) * 1991-05-01 1993-03-02 American Home Products Corporation Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents
US5559137A (en) * 1994-05-16 1996-09-24 Smithkline Beecham Corp. Compounds
US6096753A (en) 1996-12-05 2000-08-01 Amgen Inc. Substituted pyrimidinone and pyridone compounds and methods of use
US6514977B1 (en) * 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
WO1998052937A2 (en) 1997-05-22 1998-11-26 G.D. Searle And Co. 4-aryl-3(5)-heteroaryl substituted pyrazoles as p38 kinase
WO1998052941A1 (en) * 1997-05-22 1998-11-26 G.D. Searle And Co. PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
JP2002504909A (ja) * 1997-06-13 2002-02-12 スミスクライン・ビーチャム・コーポレイション 新規な置換ピラゾールおよびピラゾリン化合物
JP2002510679A (ja) * 1998-04-08 2002-04-09 アボット・ラボラトリーズ ピラゾールサイトカイン産生阻害剤
US6548529B1 (en) 1999-04-05 2003-04-15 Bristol-Myers Squibb Company Heterocyclic containing biphenyl aP2 inhibitors and method
CA2379421A1 (en) * 1999-08-27 2001-03-08 Abbott Laboratories Sulfonylphenylpyrazole compounds useful as cox-2 inhibitors
US6566357B1 (en) * 2001-09-20 2003-05-20 The Procter & Gamble Co. Spirocyclic-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US6677337B2 (en) * 2002-03-19 2004-01-13 The Procter & Gamble Company 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines

Also Published As

Publication number Publication date
DE60312342T2 (de) 2007-07-12
US6967254B2 (en) 2005-11-22
JP2006501263A (ja) 2006-01-12
WO2004022055B1 (en) 2005-01-13
AU2003273295B2 (en) 2007-03-22
MXPA05002513A (es) 2005-05-27
ES2283811T3 (es) 2007-11-01
PL379544A1 (pl) 2006-10-02
CA2497007A1 (en) 2004-03-18
DE60312342D1 (de) 2007-04-19
AU2003273295A1 (en) 2004-03-29
EP1542680B1 (de) 2007-03-07
WO2004022055A1 (en) 2004-03-18
EP1542680A1 (de) 2005-06-22
US20040058918A1 (en) 2004-03-25

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