CY1110361T1 - Φαρμακευτικες συνθεσεις ως αναστολεις διπεπτιδυλικης πεπτιδασης iv (dpp-iv) - Google Patents

Φαρμακευτικες συνθεσεις ως αναστολεις διπεπτιδυλικης πεπτιδασης iv (dpp-iv)

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Publication number
CY1110361T1
CY1110361T1 CY20071101364T CY071101364T CY1110361T1 CY 1110361 T1 CY1110361 T1 CY 1110361T1 CY 20071101364 T CY20071101364 T CY 20071101364T CY 071101364 T CY071101364 T CY 071101364T CY 1110361 T1 CY1110361 T1 CY 1110361T1
Authority
CY
Cyprus
Prior art keywords
dpp
diplomatic
pharmaceutical compositions
diabetes
pulp analysis
Prior art date
Application number
CY20071101364T
Other languages
English (en)
Inventor
David Madar
Zhonghua Pei
Daisy Pireh
Stevan W Djuric
Paul E Wiedeman
Hong Yong
Melissa J Michmerhuizen
Hana Kopecka
Xiaofeng Li
Kenton Longenecker
Hing L Sham
Kent D Stewart
Bruce G Szczepankiewicz
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/659,860 external-priority patent/US20040121964A1/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CY1110361T1 publication Critical patent/CY1110361T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με ενώσεις του τύπου Ι οι οποίες αναστέλλουν την διπεπτιδυλική πεπτιδάση IV (DPP-IV) και είναι χρήσιμες για την πρόληψη ή την αγωγή του διαβήτη, ειδικά του διαβήτη τύπου ΙΙ, όπως επίσης της υπεργλυκαιμίας, του Συνδρόμου Χ, της υπερινσουλιναιμίας, της παχυσαρκίας, της αθηροσκλήρωσης, και διαφόρων ανοσορρυθμιστικών νόσων. Ή φαρμακευτικώς αποδεκτά άλατα ή προφάρμακα αυτών, όπου τα X, R, R1, R2 και R3 έχουν τους ορισμούς που δίνονται στην περιγραφή.
CY20071101364T 2002-09-19 2007-10-23 Φαρμακευτικες συνθεσεις ως αναστολεις διπεπτιδυλικης πεπτιδασης iv (dpp-iv) CY1110361T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24683102A 2002-09-19 2002-09-19
US10/659,860 US20040121964A1 (en) 2002-09-19 2003-09-11 Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
EP03774478A EP1560811B9 (en) 2002-09-19 2003-09-15 Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-iv (dpp-iv)

Publications (1)

Publication Number Publication Date
CY1110361T1 true CY1110361T1 (el) 2015-04-29

Family

ID=32033228

Family Applications (1)

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Country Status (21)

Country Link
EP (1) EP1560811B9 (el)
JP (1) JP4712387B2 (el)
KR (1) KR101072236B1 (el)
CN (1) CN101676264A (el)
AT (1) ATE368647T1 (el)
AU (1) AU2003282800B2 (el)
BR (1) BR0314582A (el)
CA (2) CA2497725C (el)
CY (1) CY1110361T1 (el)
DE (1) DE60315336T2 (el)
DK (1) DK1560811T3 (el)
ES (1) ES2290511T3 (el)
HK (1) HK1082733A1 (el)
IL (1) IL167434A (el)
MX (1) MXPA05003091A (el)
NZ (1) NZ538567A (el)
PL (1) PL374732A1 (el)
PT (1) PT1560811E (el)
TW (1) TWI320406B (el)
WO (1) WO2004026822A2 (el)
ZA (1) ZA200502218B (el)

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CN101676264A (zh) 2010-03-24
JP4712387B2 (ja) 2011-06-29
TW200417545A (en) 2004-09-16
MXPA05003091A (es) 2005-05-27
JP2006503057A (ja) 2006-01-26
ZA200502218B (en) 2005-11-30
WO2004026822A3 (en) 2004-05-06
ES2290511T3 (es) 2008-02-16
EP1560811B9 (en) 2008-03-05
CA2497725A1 (en) 2004-04-01
AU2003282800B2 (en) 2009-10-29
DE60315336D1 (de) 2007-09-13
PL374732A1 (en) 2005-10-31
DK1560811T3 (da) 2007-12-10
DE60315336T2 (de) 2008-05-08
KR101072236B1 (ko) 2011-10-12
ATE368647T1 (de) 2007-08-15
KR20050043981A (ko) 2005-05-11
CA2497725C (en) 2012-04-10
EP1560811A2 (en) 2005-08-10
AU2003282800A1 (en) 2004-04-08
BR0314582A (pt) 2005-08-09
IL167434A (en) 2010-12-30
NZ538567A (en) 2007-04-27
HK1082733A1 (en) 2006-06-16
EP1560811B1 (en) 2007-08-01
TWI320406B (en) 2010-02-11
WO2004026822A2 (en) 2004-04-01
PT1560811E (pt) 2007-11-14
CA2768674A1 (en) 2004-04-01

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