MX2012012905A - Hidroxialquilbencilpirazoles y su uso para tratamiento de enfermedades hiperproliferativas y angiogenicas. - Google Patents
Hidroxialquilbencilpirazoles y su uso para tratamiento de enfermedades hiperproliferativas y angiogenicas.Info
- Publication number
- MX2012012905A MX2012012905A MX2012012905A MX2012012905A MX2012012905A MX 2012012905 A MX2012012905 A MX 2012012905A MX 2012012905 A MX2012012905 A MX 2012012905A MX 2012012905 A MX2012012905 A MX 2012012905A MX 2012012905 A MX2012012905 A MX 2012012905A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- diseases
- hyperproliferative
- angiogenic diseases
- hydroxyalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente solicitud se refiere a derivados de 1-[3-(hidroxialquil) bencil]-IH-pirazol novedosos, a procedimientos para su preparación, a su uso para el tratamiento y/o la prevención de enfermedades y a su uso para la producción de medicamentos para el tratamiento yio la prevención de enfermedades, más particularmente para el tratamiento y/o la prevención de enfermedades hiperproliferativas y angiogénicas y para las enfermedades provocadas por la adaptación metabólica a estados hipóxicos. Dichos tratamientos pueden llevarse a cabo en forma de monoterapia o también en combinación con otros medicamentos o medidas terapéuticas adicionales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10004854 | 2010-05-08 | ||
PCT/EP2011/057019 WO2011141325A1 (de) | 2010-05-08 | 2011-05-03 | Hydroxyalkylbenzyl- pyrazole und ihre verwendung zur behandlung von hyperproliferativen und angiogenen erkrankungen |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012012905A true MX2012012905A (es) | 2012-12-17 |
Family
ID=44243203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012012905A MX2012012905A (es) | 2010-05-08 | 2011-05-03 | Hidroxialquilbencilpirazoles y su uso para tratamiento de enfermedades hiperproliferativas y angiogenicas. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP2569309A1 (es) |
JP (1) | JP2013530139A (es) |
KR (1) | KR20130108998A (es) |
CN (1) | CN103003266A (es) |
AU (1) | AU2011252222A1 (es) |
BR (1) | BR112012028652A2 (es) |
CA (1) | CA2798374A1 (es) |
IL (1) | IL222850A0 (es) |
MX (1) | MX2012012905A (es) |
RU (1) | RU2012152800A (es) |
WO (1) | WO2011141325A1 (es) |
ZA (1) | ZA201209298B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2888256A4 (en) * | 2012-08-24 | 2016-02-17 | Univ Texas | HETEROCYCLIC HIF ACTIVITY MODULATORS FOR THE TREATMENT OF DISEASES |
NZ704799A (en) | 2012-08-24 | 2018-06-29 | Univ Texas | Heterocyclic modulators of hif activity for treatment of disease |
EP2888253A4 (en) | 2012-08-24 | 2016-01-06 | Univ Texas | HETEROCYCLIC MODULATORS OF HIF FACTOR ACTIVITY USED FOR THE TREATMENT OF DISEASES |
ES2726648T3 (es) | 2014-02-25 | 2019-10-08 | Univ Texas | Sales de moduladores heterocíclicos de la actividad del HIF para el tratamiento de enfermedades |
CN107235873B (zh) * | 2017-07-04 | 2018-11-06 | 中节能万润股份有限公司 | 一种美司钠的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004228057A1 (en) | 2003-04-03 | 2004-10-21 | Merck & Co., Inc. | Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5 |
WO2005030121A2 (en) | 2003-06-30 | 2005-04-07 | Hif Bio, Inc. | Compounds, compositions and methods |
WO2007065010A2 (en) | 2005-12-02 | 2007-06-07 | Hif Bio, Inc. | Anti-angiogenesis compounds |
WO2008141731A2 (en) | 2007-05-18 | 2008-11-27 | Bayer Healthcare Ag | Inhibitors of hypoxia inducible factor (hif) useful for treating hyper-proliferative disorders and diseases associated with angiogenesis |
EP2356113B1 (de) * | 2008-11-14 | 2015-01-07 | Bayer Intellectual Property GmbH | Heterocyclisch substituierte aryl-verbindungen als hif-inhibitoren |
DE102008057344A1 (de) * | 2008-11-14 | 2010-05-20 | Bayer Schering Pharma Aktiengesellschaft | Aminoalkyl-substituierte Aryl-Verbindungen und ihre Verwendung |
EP2202232A1 (en) | 2008-12-26 | 2010-06-30 | Laboratorios Almirall, S.A. | 1,2,4-oxadiazole derivatives and their therapeutic use |
US8389509B2 (en) | 2009-01-23 | 2013-03-05 | Bristol-Myers Squibb Company | Substituted pyrazole compounds |
-
2011
- 2011-05-03 MX MX2012012905A patent/MX2012012905A/es unknown
- 2011-05-03 CN CN2011800338366A patent/CN103003266A/zh active Pending
- 2011-05-03 BR BR112012028652A patent/BR112012028652A2/pt not_active IP Right Cessation
- 2011-05-03 RU RU2012152800/04A patent/RU2012152800A/ru not_active Application Discontinuation
- 2011-05-03 WO PCT/EP2011/057019 patent/WO2011141325A1/de active Application Filing
- 2011-05-03 CA CA2798374A patent/CA2798374A1/en not_active Abandoned
- 2011-05-03 KR KR1020127032070A patent/KR20130108998A/ko not_active Application Discontinuation
- 2011-05-03 EP EP11716947A patent/EP2569309A1/de not_active Withdrawn
- 2011-05-03 JP JP2013509504A patent/JP2013530139A/ja not_active Withdrawn
- 2011-05-03 AU AU2011252222A patent/AU2011252222A1/en not_active Abandoned
-
2012
- 2012-11-05 IL IL222850A patent/IL222850A0/en unknown
- 2012-12-07 ZA ZA2012/09298A patent/ZA201209298B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2011252222A1 (en) | 2012-12-06 |
CN103003266A (zh) | 2013-03-27 |
BR112012028652A2 (pt) | 2016-08-09 |
ZA201209298B (en) | 2014-05-28 |
KR20130108998A (ko) | 2013-10-07 |
RU2012152800A (ru) | 2014-06-20 |
IL222850A0 (en) | 2012-12-31 |
CA2798374A1 (en) | 2011-11-17 |
JP2013530139A (ja) | 2013-07-25 |
EP2569309A1 (de) | 2013-03-20 |
WO2011141325A1 (de) | 2011-11-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TN2012000531A1 (en) | Substituted heterocyclyl benzyl pyrazoles, and use thereof | |
MY160004A (en) | Heterocyclically substituted aryl compounds as hif inhibitors | |
TN2012000428A1 (en) | Bisaryl-bonded aryltriazolones and use thereof | |
EP2294184A4 (en) | TREATMENT OF EYE DISEASES AND EXCESSIVE NEOVASCULARIZATION WITH THE HELP OF COMBINED THERAPY | |
AU2011328009A8 (en) | Compounds and methods for treating pain | |
NZ720736A (en) | Antibody drug conjugates (adcs) with kinesin spindel protein (ksp) | |
MX2011007589A (es) | Tratamiento de un cancer usando una combinacion de bendamustine y un anticuerpo anti-cd20. | |
MX2014002171A (es) | Tratamientos de combinacion para hepatitis c. | |
MX2011008450A (es) | Agonistas y antagonistas del receptor s1p5, y metodos de uso de los mismos. | |
MX2010005631A (es) | Nuevos compuestos de hidrocarburo ciclicos para el tratamiento de enfermedades. | |
MX2010009623A (es) | Derivados de 1-bencil-3-hidroximetilindazol novedosos y su uso en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40. | |
MX2010009625A (es) | Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40. | |
TN2014000320A1 (en) | Substituted phenylimidazopyrazoles and use thereof | |
MX2010009624A (es) | Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1 y cx3cr1. | |
MX2012012905A (es) | Hidroxialquilbencilpirazoles y su uso para tratamiento de enfermedades hiperproliferativas y angiogenicas. | |
MY150931A (en) | Substituted oxazolidinones and their use | |
MX340585B (es) | Derivados de 5-metil-1-(naftalen-2-il)-1h-pirazol y su uso en potencializar el efecto de los analgesicos opioides. | |
MX2014001393A (es) | 3-(bifenil-3-il)-4-hidroxi-8-metoxi-1-azaespiro[4.5]dec-3-en-2-on as sustituidas. | |
MY164998A (en) | Isoquinolinone derivatives as nk3 antagonists | |
JOP20110347B1 (ar) | صوديوم 1h- بيرازول-5-أولات مستبدل | |
MX2013002208A (es) | Derivados de sulfonilpiperazina que interactuan con la proteina reguladora de glucocinasa para el tratamiento de diabetes. | |
UA106500C2 (uk) | Похідні піразолів, спосіб їх одержання та застосування в терапії | |
MX2009009332A (es) | Antagonista del receptor de mineralocorticoides para el tratamiento de endometriosis. | |
TN2010000266A1 (en) | Oxazolidinones for the treatment and/or prophylaxis of heart failure | |
WO2014138616A3 (en) | Pyrazole compounds and methods of use thereof |