UA106500C2 - Похідні піразолів, спосіб їх одержання та застосування в терапії - Google Patents

Похідні піразолів, спосіб їх одержання та застосування в терапії

Info

Publication number
UA106500C2
UA106500C2 UAA201201093A UAA201201093A UA106500C2 UA 106500 C2 UA106500 C2 UA 106500C2 UA A201201093 A UAA201201093 A UA A201201093A UA A201201093 A UAA201201093 A UA A201201093A UA 106500 C2 UA106500 C2 UA 106500C2
Authority
UA
Ukraine
Prior art keywords
derivatives
pyrazol
therapy
producing
relates
Prior art date
Application number
UAA201201093A
Other languages
English (en)
Russian (ru)
Inventor
Пьер-Ив Абекасси
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи filed Critical Санофи
Publication of UA106500C2 publication Critical patent/UA106500C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Винахід стосується похідних піразолів загальної формули (І), у якій X означає хлор або фтор.Винахід також стосується способу їх одержання і застосування в терапії.
UAA201201093A 2009-07-03 2010-07-02 Похідні піразолів, спосіб їх одержання та застосування в терапії UA106500C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0903270A FR2947546B1 (fr) 2009-07-03 2009-07-03 Derives de pyrazoles, leur preparation et leur application en therapeutique
PCT/FR2010/051394 WO2011001122A2 (fr) 2009-07-03 2010-07-02 Dérivés de pyrazoles, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
UA106500C2 true UA106500C2 (uk) 2014-09-10

Family

ID=41695643

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201201093A UA106500C2 (uk) 2009-07-03 2010-07-02 Похідні піразолів, спосіб їх одержання та застосування в терапії

Country Status (31)

Country Link
US (1) US8367715B2 (uk)
EP (1) EP2448924B1 (uk)
JP (1) JP5680640B2 (uk)
KR (1) KR20120037967A (uk)
CN (1) CN102471280B (uk)
AR (1) AR077371A1 (uk)
AU (1) AU2010267824A1 (uk)
BR (1) BR112012000104A2 (uk)
CA (1) CA2767096A1 (uk)
CL (1) CL2012000013A1 (uk)
CO (1) CO6480992A2 (uk)
CR (1) CR20110701A (uk)
DO (1) DOP2012000001A (uk)
EA (1) EA020364B1 (uk)
EC (2) ECSP12011659A (uk)
FR (1) FR2947546B1 (uk)
HK (1) HK1169387A1 (uk)
IL (1) IL217300A0 (uk)
MA (1) MA33500B1 (uk)
MX (1) MX2012000267A (uk)
MY (1) MY155829A (uk)
NI (1) NI201200001A (uk)
NZ (1) NZ597578A (uk)
PE (1) PE20120917A1 (uk)
SG (1) SG177463A1 (uk)
TN (1) TN2011000658A1 (uk)
TW (1) TWI471312B (uk)
UA (1) UA106500C2 (uk)
UY (1) UY32757A (uk)
WO (1) WO2011001122A2 (uk)
ZA (1) ZA201200027B (uk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2908409B1 (fr) 2006-11-10 2009-01-09 Sanofi Aventis Sa Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
AU2013208104B2 (en) * 2012-01-09 2017-11-23 X-Chem, Inc. Benzhydrol-pyrazole derivatives having kinase inhibitory activity and uses thereof
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
BR112017002268B1 (pt) 2014-08-18 2022-11-08 Eisai R&D Management Co., Ltd Sal de derivado de piridina monocíclica e cristal do mesmo
CN107619388A (zh) * 2016-07-13 2018-01-23 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
CN107840842A (zh) 2016-09-19 2018-03-27 北京天诚医药科技有限公司 炔代杂环化合物、其制备方法及其在医药学上的应用
MX2020008610A (es) 2018-03-28 2020-09-21 Eisai R&D Man Co Ltd Agente terapeutico para carcinoma hepatocelular.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331541B1 (en) * 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
GB0317127D0 (en) * 2003-07-22 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
KR20070107707A (ko) * 2005-01-21 2007-11-07 아스텍스 테라퓨틱스 리미티드 피라졸 키나제 억제제와 추가 항종양제의 조합물
KR20130141706A (ko) * 2005-12-02 2013-12-26 바이엘 헬스케어 엘엘씨 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에 유용한 치환된 4-아미노-피롤로트리아진 유도체
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
EP1959947A2 (en) * 2005-12-15 2008-08-27 Cytokinetics, Inc. Certain chemical entities, compositions and methods
FR2908409B1 (fr) * 2006-11-10 2009-01-09 Sanofi Aventis Sa Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
US20100168182A1 (en) * 2006-12-11 2010-07-01 Irm Llc Compounds and compositions as kinase inhibitors

Also Published As

Publication number Publication date
ZA201200027B (en) 2013-03-27
EP2448924B1 (fr) 2013-09-04
US20120270918A1 (en) 2012-10-25
TW201107298A (en) 2011-03-01
ECSP12011569A (es) 2012-02-29
FR2947546B1 (fr) 2011-07-01
MY155829A (en) 2015-12-15
NZ597578A (en) 2013-11-29
AU2010267824A1 (en) 2012-02-16
EP2448924A2 (fr) 2012-05-09
MA33500B1 (fr) 2012-08-01
CR20110701A (es) 2012-03-06
HK1169387A1 (en) 2013-01-25
SG177463A1 (en) 2012-02-28
DOP2012000001A (es) 2012-01-31
CA2767096A1 (fr) 2011-01-06
US8367715B2 (en) 2013-02-05
FR2947546A1 (fr) 2011-01-07
TWI471312B (zh) 2015-02-01
MX2012000267A (es) 2012-04-30
TN2011000658A1 (fr) 2013-05-24
PE20120917A1 (es) 2012-08-17
BR112012000104A2 (pt) 2016-03-15
JP2012531466A (ja) 2012-12-10
JP5680640B2 (ja) 2015-03-04
WO2011001122A2 (fr) 2011-01-06
ECSP12011659A (es) 2012-03-30
IL217300A0 (en) 2012-02-29
CN102471280B (zh) 2014-08-06
EA020364B1 (ru) 2014-10-30
WO2011001122A3 (fr) 2011-02-24
CO6480992A2 (es) 2012-07-16
AR077371A1 (es) 2011-08-24
CN102471280A (zh) 2012-05-23
EA201270128A1 (ru) 2012-07-30
UY32757A (es) 2011-01-31
CL2012000013A1 (es) 2012-09-14
NI201200001A (es) 2012-03-30
KR20120037967A (ko) 2012-04-20

Similar Documents

Publication Publication Date Title
UA106500C2 (uk) Похідні піразолів, спосіб їх одержання та застосування в терапії
MY158257A (en) Forms of rifaximin and uses thereof
MX2009009786A (es) Inhibidores de la via de hedgehog.
UA97794C2 (uk) Цитотоксичні агенти, які включають похідні томайміцину, і їх терапевтичне застосування
UA89787C2 (uk) Фторглікозидні похідні піразолів, лікарський засіб, що містить їх, і їх застосування
MX2011009369A (es) 2-mercaptoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
EA024630B9 (ru) Производные пиразола как ингибиторы ионных каналов, активируемых высвобождением кальция (crac)
UA108442C2 (uk) Індазоли
HK1138840A1 (en) Azabiphenylaminobenzoic acid derivatives as dhodh inhibitors
MX2012014017A (es) Derivados de heteroaril imidazolona como inhibidores de jak.
UA102251C2 (uk) Похідні амінодигідротіазину як інгібітори васе для лікування хвороби альцгеймера
UA108743C2 (uk) Похідні хіназолін-4(3н)-ону для застосування як інгібіторів рі3-кінази
UA99485C2 (uk) Хіназоліндіонові похідні, їх одержання і їх застосування в терапії
TN2011000199A1 (en) Sulfoximine-substituted anilinopyrimidine derivatives as cdk inhibitors, the production thereof, and use as medicine
JO2682B1 (en) Derivatives of alkynil-8.1-naphthayridone, preparations thereof and therapeutic use thereof
IN2015DN01151A (uk)
TW200700064A (en) Novel compounds
MX2011008825A (es) 3-aminoisoxazolopiridinas sustituidas como moduladores de kcnq2/3.
WO2011107608A8 (en) Heterocyclic amides as rock inhibitors
MX2011008662A (es) 2-mercapto-3-aminopiridinas sustituidas como moduladores de kcnq2/3.
MX2011009338A (es) 3-amino-2-mercaptoquinolinas sustituidas como moduladores de kcnq2/3.
MX339460B (es) Derivados de benzazol como ligandos del receptor h4 de histamina.
IN2012DN03379A (uk)
MX2011012507A (es) Piperidinas sustituidas.
MY151228A (en) Derivatives of 2-oxoalkyl-1-piperazin-2-one, preparation method thereof and therapeutic use of same