AR077371A1 - DERIVADOS DE PIRAZOL, SU PREPARACIoN Y SU APLICACIoN EN LA TERAPIA DEL CÁNCER - Google Patents

DERIVADOS DE PIRAZOL, SU PREPARACIoN Y SU APLICACIoN EN LA TERAPIA DEL CÁNCER

Info

Publication number
AR077371A1
AR077371A1 ARP100102366A ARP100102366A AR077371A1 AR 077371 A1 AR077371 A1 AR 077371A1 AR P100102366 A ARP100102366 A AR P100102366A AR P100102366 A ARP100102366 A AR P100102366A AR 077371 A1 AR077371 A1 AR 077371A1
Authority
AR
Argentina
Prior art keywords
application
derivatives
preparation
pirazol
cancer therapy
Prior art date
Application number
ARP100102366A
Other languages
English (en)
Inventor
Michel Tabart
Pascal Desmazeau
Pierre Yves Abecassis
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR077371A1 publication Critical patent/AR077371A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Derivados de pirazoles de la formula general (1) en la que: en donde X representa cloro o fluor en el estado de base o sal de adicion de ácido. Procedimiento de preparacion y aplicacion en terapéutica del cáncer. Reivindicacion 5: Compuesto de formula 1: en donde X representa cloro o fluor. Reivindicacion 6: Compuesto de formula 2: en donde X representa cloro o fluor.
ARP100102366A 2009-07-03 2010-07-02 DERIVADOS DE PIRAZOL, SU PREPARACIoN Y SU APLICACIoN EN LA TERAPIA DEL CÁNCER AR077371A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0903270A FR2947546B1 (fr) 2009-07-03 2009-07-03 Derives de pyrazoles, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR077371A1 true AR077371A1 (es) 2011-08-24

Family

ID=41695643

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102366A AR077371A1 (es) 2009-07-03 2010-07-02 DERIVADOS DE PIRAZOL, SU PREPARACIoN Y SU APLICACIoN EN LA TERAPIA DEL CÁNCER

Country Status (31)

Country Link
US (1) US8367715B2 (es)
EP (1) EP2448924B1 (es)
JP (1) JP5680640B2 (es)
KR (1) KR20120037967A (es)
CN (1) CN102471280B (es)
AR (1) AR077371A1 (es)
AU (1) AU2010267824A1 (es)
BR (1) BR112012000104A2 (es)
CA (1) CA2767096A1 (es)
CL (1) CL2012000013A1 (es)
CO (1) CO6480992A2 (es)
CR (1) CR20110701A (es)
DO (1) DOP2012000001A (es)
EA (1) EA020364B1 (es)
EC (2) ECSP12011659A (es)
FR (1) FR2947546B1 (es)
HK (1) HK1169387A1 (es)
IL (1) IL217300A0 (es)
MA (1) MA33500B1 (es)
MX (1) MX2012000267A (es)
MY (1) MY155829A (es)
NI (1) NI201200001A (es)
NZ (1) NZ597578A (es)
PE (1) PE20120917A1 (es)
SG (1) SG177463A1 (es)
TN (1) TN2011000658A1 (es)
TW (1) TWI471312B (es)
UA (1) UA106500C2 (es)
UY (1) UY32757A (es)
WO (1) WO2011001122A2 (es)
ZA (1) ZA201200027B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2908409B1 (fr) 2006-11-10 2009-01-09 Sanofi Aventis Sa Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
JP6131272B2 (ja) * 2012-01-09 2017-05-17 エックス−アールエックス，インコーポレーテッド キナーゼ阻害活性を有するベンズヒドロール−ピラゾール誘導体及びその使用
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
CN106660997B (zh) 2014-08-18 2019-05-21 卫材R&D管理有限公司 单环吡啶衍生物的盐及其晶体
CN107619388A (zh) * 2016-07-13 2018-01-23 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
CN107840842A (zh) 2016-09-19 2018-03-27 北京天诚医药科技有限公司 炔代杂环化合物、其制备方法及其在医药学上的应用
CA3091153A1 (en) 2018-03-28 2019-10-03 Eisai R&D Management Co., Ltd. Therapeutic agent for hepatocellular carcinoma

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331541B1 (en) * 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
GB0317127D0 (en) * 2003-07-22 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
KR20070107707A (ko) * 2005-01-21 2007-11-07 아스텍스 테라퓨틱스 리미티드 피라졸 키나제 억제제와 추가 항종양제의 조합물
US8143393B2 (en) * 2005-12-02 2012-03-27 Bayer Healthcare Llc Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
US20070197505A1 (en) * 2005-12-15 2007-08-23 Morgan Bradley P Certain chemical entities, compositions and methods
FR2908409B1 (fr) * 2006-11-10 2009-01-09 Sanofi Aventis Sa Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
MX2009006170A (es) * 2006-12-11 2009-06-19 Irmc Llc Compuestos y composiciones como inhibidores de cinasa.

Also Published As

Publication number Publication date
US8367715B2 (en) 2013-02-05
CO6480992A2 (es) 2012-07-16
MA33500B1 (fr) 2012-08-01
EP2448924B1 (fr) 2013-09-04
TN2011000658A1 (fr) 2013-05-24
TW201107298A (en) 2011-03-01
NZ597578A (en) 2013-11-29
JP2012531466A (ja) 2012-12-10
ECSP12011569A (es) 2012-02-29
ECSP12011659A (es) 2012-03-30
MX2012000267A (es) 2012-04-30
DOP2012000001A (es) 2012-01-31
TWI471312B (zh) 2015-02-01
KR20120037967A (ko) 2012-04-20
PE20120917A1 (es) 2012-08-17
JP5680640B2 (ja) 2015-03-04
IL217300A0 (en) 2012-02-29
EA020364B1 (ru) 2014-10-30
SG177463A1 (en) 2012-02-28
UY32757A (es) 2011-01-31
WO2011001122A3 (fr) 2011-02-24
WO2011001122A2 (fr) 2011-01-06
HK1169387A1 (en) 2013-01-25
CN102471280A (zh) 2012-05-23
EP2448924A2 (fr) 2012-05-09
MY155829A (en) 2015-12-15
UA106500C2 (uk) 2014-09-10
CR20110701A (es) 2012-03-06
BR112012000104A2 (pt) 2016-03-15
FR2947546A1 (fr) 2011-01-07
CL2012000013A1 (es) 2012-09-14
ZA201200027B (en) 2013-03-27
US20120270918A1 (en) 2012-10-25
FR2947546B1 (fr) 2011-07-01
EA201270128A1 (ru) 2012-07-30
CA2767096A1 (fr) 2011-01-06
AU2010267824A1 (en) 2012-02-16
CN102471280B (zh) 2014-08-06
NI201200001A (es) 2012-03-30

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