MX2012000267A - Derivados de pirazoles, y su preparacion y su uso en terapeutica. - Google Patents

Derivados de pirazoles, y su preparacion y su uso en terapeutica.

Info

Publication number
MX2012000267A
MX2012000267A MX2012000267A MX2012000267A MX2012000267A MX 2012000267 A MX2012000267 A MX 2012000267A MX 2012000267 A MX2012000267 A MX 2012000267A MX 2012000267 A MX2012000267 A MX 2012000267A MX 2012000267 A MX2012000267 A MX 2012000267A
Authority
MX
Mexico
Prior art keywords
therapeutic use
preparation
pyrazole derivatives
relates
pyrazole
Prior art date
Application number
MX2012000267A
Other languages
English (en)
Inventor
Michel Tabart
Pascal Desmazeau
Pierre-Yves Abecassis
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2012000267A publication Critical patent/MX2012000267A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a derivados de pirazol de fórmula general (I), donde X es cloro o flúor. La invención también se refiere a un método para preparar el mismo y a su uso terapéutico.
MX2012000267A 2009-07-03 2010-07-02 Derivados de pirazoles, y su preparacion y su uso en terapeutica. MX2012000267A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0903270A FR2947546B1 (fr) 2009-07-03 2009-07-03 Derives de pyrazoles, leur preparation et leur application en therapeutique
PCT/FR2010/051394 WO2011001122A2 (fr) 2009-07-03 2010-07-02 Dérivés de pyrazoles, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
MX2012000267A true MX2012000267A (es) 2012-04-30

Family

ID=41695643

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000267A MX2012000267A (es) 2009-07-03 2010-07-02 Derivados de pirazoles, y su preparacion y su uso en terapeutica.

Country Status (31)

Country Link
US (1) US8367715B2 (es)
EP (1) EP2448924B1 (es)
JP (1) JP5680640B2 (es)
KR (1) KR20120037967A (es)
CN (1) CN102471280B (es)
AR (1) AR077371A1 (es)
AU (1) AU2010267824A1 (es)
BR (1) BR112012000104A2 (es)
CA (1) CA2767096A1 (es)
CL (1) CL2012000013A1 (es)
CO (1) CO6480992A2 (es)
CR (1) CR20110701A (es)
DO (1) DOP2012000001A (es)
EA (1) EA020364B1 (es)
EC (2) ECSP12011659A (es)
FR (1) FR2947546B1 (es)
HK (1) HK1169387A1 (es)
IL (1) IL217300A0 (es)
MA (1) MA33500B1 (es)
MX (1) MX2012000267A (es)
MY (1) MY155829A (es)
NI (1) NI201200001A (es)
NZ (1) NZ597578A (es)
PE (1) PE20120917A1 (es)
SG (1) SG177463A1 (es)
TN (1) TN2011000658A1 (es)
TW (1) TWI471312B (es)
UA (1) UA106500C2 (es)
UY (1) UY32757A (es)
WO (1) WO2011001122A2 (es)
ZA (1) ZA201200027B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2908409B1 (fr) 2006-11-10 2009-01-09 Sanofi Aventis Sa Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
US9394256B2 (en) * 2012-01-09 2016-07-19 X-Chem, Inc. Benzhydrol-pyrazole derivatives having kinase inhibitory activity and uses thereof
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
ES2914072T3 (es) 2014-08-18 2022-06-07 Eisai R&D Man Co Ltd Sal de derivado de piridina monocíclico y su cristal
CN107619388A (zh) * 2016-07-13 2018-01-23 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
CN107840842A (zh) 2016-09-19 2018-03-27 北京天诚医药科技有限公司 炔代杂环化合物、其制备方法及其在医药学上的应用
CN111712245A (zh) 2018-03-28 2020-09-25 卫材R&D管理有限公司 用于肝细胞癌的治疗剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331541B1 (en) * 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
GB0317127D0 (en) * 2003-07-22 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
MX2007008809A (es) * 2005-01-21 2007-09-07 Astex Therapeutics Ltd Combinaciones de inhibidores de pirazol cinasa y otros agentes antitumor.
BRPI0619146A2 (pt) * 2005-12-02 2011-09-13 Bayer Pharmaceuticals Corp derivados de 4-amino-pirroltriazina substituìda úteis no tratamento de disordens e doenças hiperproliferativas associadas com angiogênesis
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
WO2007075377A2 (en) * 2005-12-15 2007-07-05 Cytokinetics, Inc. Certain chemical entities, compositions and methods
FR2908409B1 (fr) * 2006-11-10 2009-01-09 Sanofi Aventis Sa Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation
EP2102190A1 (en) * 2006-12-11 2009-09-23 Irm Llc Compounds and compositions as kinase inhibitors

Also Published As

Publication number Publication date
IL217300A0 (en) 2012-02-29
JP5680640B2 (ja) 2015-03-04
TN2011000658A1 (fr) 2013-05-24
CL2012000013A1 (es) 2012-09-14
PE20120917A1 (es) 2012-08-17
NZ597578A (en) 2013-11-29
TW201107298A (en) 2011-03-01
UA106500C2 (uk) 2014-09-10
JP2012531466A (ja) 2012-12-10
EP2448924A2 (fr) 2012-05-09
WO2011001122A3 (fr) 2011-02-24
WO2011001122A2 (fr) 2011-01-06
TWI471312B (zh) 2015-02-01
MY155829A (en) 2015-12-15
EA020364B1 (ru) 2014-10-30
ZA201200027B (en) 2013-03-27
FR2947546B1 (fr) 2011-07-01
UY32757A (es) 2011-01-31
US8367715B2 (en) 2013-02-05
CA2767096A1 (fr) 2011-01-06
KR20120037967A (ko) 2012-04-20
CO6480992A2 (es) 2012-07-16
ECSP12011659A (es) 2012-03-30
MA33500B1 (fr) 2012-08-01
US20120270918A1 (en) 2012-10-25
EP2448924B1 (fr) 2013-09-04
SG177463A1 (en) 2012-02-28
AR077371A1 (es) 2011-08-24
DOP2012000001A (es) 2012-01-31
CN102471280B (zh) 2014-08-06
EA201270128A1 (ru) 2012-07-30
NI201200001A (es) 2012-03-30
HK1169387A1 (en) 2013-01-25
ECSP12011569A (es) 2012-02-29
CN102471280A (zh) 2012-05-23
CR20110701A (es) 2012-03-06
AU2010267824A1 (en) 2012-02-16
FR2947546A1 (fr) 2011-01-07
BR112012000104A2 (pt) 2016-03-15

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