MX2012000267A - Derivados de pirazoles, y su preparacion y su uso en terapeutica. - Google Patents
Derivados de pirazoles, y su preparacion y su uso en terapeutica.Info
- Publication number
- MX2012000267A MX2012000267A MX2012000267A MX2012000267A MX2012000267A MX 2012000267 A MX2012000267 A MX 2012000267A MX 2012000267 A MX2012000267 A MX 2012000267A MX 2012000267 A MX2012000267 A MX 2012000267A MX 2012000267 A MX2012000267 A MX 2012000267A
- Authority
- MX
- Mexico
- Prior art keywords
- therapeutic use
- preparation
- pyrazole derivatives
- relates
- pyrazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/38—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by doubly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a derivados de pirazol de fórmula general (I), donde X es cloro o flúor. La invención también se refiere a un método para preparar el mismo y a su uso terapéutico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0903270A FR2947546B1 (fr) | 2009-07-03 | 2009-07-03 | Derives de pyrazoles, leur preparation et leur application en therapeutique |
PCT/FR2010/051394 WO2011001122A2 (fr) | 2009-07-03 | 2010-07-02 | Dérivés de pyrazoles, leur préparation et leur application en thérapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012000267A true MX2012000267A (es) | 2012-04-30 |
Family
ID=41695643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012000267A MX2012000267A (es) | 2009-07-03 | 2010-07-02 | Derivados de pirazoles, y su preparacion y su uso en terapeutica. |
Country Status (31)
Country | Link |
---|---|
US (1) | US8367715B2 (es) |
EP (1) | EP2448924B1 (es) |
JP (1) | JP5680640B2 (es) |
KR (1) | KR20120037967A (es) |
CN (1) | CN102471280B (es) |
AR (1) | AR077371A1 (es) |
AU (1) | AU2010267824A1 (es) |
BR (1) | BR112012000104A2 (es) |
CA (1) | CA2767096A1 (es) |
CL (1) | CL2012000013A1 (es) |
CO (1) | CO6480992A2 (es) |
CR (1) | CR20110701A (es) |
DO (1) | DOP2012000001A (es) |
EA (1) | EA020364B1 (es) |
EC (2) | ECSP12011659A (es) |
FR (1) | FR2947546B1 (es) |
HK (1) | HK1169387A1 (es) |
IL (1) | IL217300A0 (es) |
MA (1) | MA33500B1 (es) |
MX (1) | MX2012000267A (es) |
MY (1) | MY155829A (es) |
NI (1) | NI201200001A (es) |
NZ (1) | NZ597578A (es) |
PE (1) | PE20120917A1 (es) |
SG (1) | SG177463A1 (es) |
TN (1) | TN2011000658A1 (es) |
TW (1) | TWI471312B (es) |
UA (1) | UA106500C2 (es) |
UY (1) | UY32757A (es) |
WO (1) | WO2011001122A2 (es) |
ZA (1) | ZA201200027B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2908409B1 (fr) | 2006-11-10 | 2009-01-09 | Sanofi Aventis Sa | Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation |
US9394256B2 (en) * | 2012-01-09 | 2016-07-19 | X-Chem, Inc. | Benzhydrol-pyrazole derivatives having kinase inhibitory activity and uses thereof |
AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
ES2914072T3 (es) | 2014-08-18 | 2022-06-07 | Eisai R&D Man Co Ltd | Sal de derivado de piridina monocíclico y su cristal |
CN107619388A (zh) * | 2016-07-13 | 2018-01-23 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
CN107840842A (zh) | 2016-09-19 | 2018-03-27 | 北京天诚医药科技有限公司 | 炔代杂环化合物、其制备方法及其在医药学上的应用 |
CN111712245A (zh) | 2018-03-28 | 2020-09-25 | 卫材R&D管理有限公司 | 用于肝细胞癌的治疗剂 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6331541B1 (en) * | 1998-12-18 | 2001-12-18 | Soo S. Ko | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
GB0317127D0 (en) * | 2003-07-22 | 2003-08-27 | Astex Technology Ltd | Pharmaceutical compounds |
MX2007008809A (es) * | 2005-01-21 | 2007-09-07 | Astex Therapeutics Ltd | Combinaciones de inhibidores de pirazol cinasa y otros agentes antitumor. |
BRPI0619146A2 (pt) * | 2005-12-02 | 2011-09-13 | Bayer Pharmaceuticals Corp | derivados de 4-amino-pirroltriazina substituìda úteis no tratamento de disordens e doenças hiperproliferativas associadas com angiogênesis |
US20070208000A1 (en) * | 2005-12-15 | 2007-09-06 | Morgan Bradley P | Certain chemical entities, compositions and methods |
WO2007075377A2 (en) * | 2005-12-15 | 2007-07-05 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
FR2908409B1 (fr) * | 2006-11-10 | 2009-01-09 | Sanofi Aventis Sa | Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation |
EP2102190A1 (en) * | 2006-12-11 | 2009-09-23 | Irm Llc | Compounds and compositions as kinase inhibitors |
-
2009
- 2009-07-03 FR FR0903270A patent/FR2947546B1/fr not_active Expired - Fee Related
-
2010
- 2010-07-02 AU AU2010267824A patent/AU2010267824A1/en not_active Abandoned
- 2010-07-02 TW TW99121891A patent/TWI471312B/zh not_active IP Right Cessation
- 2010-07-02 MY MYPI2011006394A patent/MY155829A/en unknown
- 2010-07-02 MX MX2012000267A patent/MX2012000267A/es active IP Right Grant
- 2010-07-02 NZ NZ597578A patent/NZ597578A/xx not_active IP Right Cessation
- 2010-07-02 SG SG2011097821A patent/SG177463A1/en unknown
- 2010-07-02 BR BR112012000104A patent/BR112012000104A2/pt not_active IP Right Cessation
- 2010-07-02 EA EA201270128A patent/EA020364B1/ru not_active IP Right Cessation
- 2010-07-02 EP EP10742179.4A patent/EP2448924B1/fr active Active
- 2010-07-02 AR ARP100102366A patent/AR077371A1/es unknown
- 2010-07-02 JP JP2012518123A patent/JP5680640B2/ja not_active Expired - Fee Related
- 2010-07-02 WO PCT/FR2010/051394 patent/WO2011001122A2/fr active Application Filing
- 2010-07-02 UA UAA201201093A patent/UA106500C2/uk unknown
- 2010-07-02 CA CA2767096A patent/CA2767096A1/fr not_active Abandoned
- 2010-07-02 PE PE2012000008A patent/PE20120917A1/es not_active Application Discontinuation
- 2010-07-02 KR KR1020127002905A patent/KR20120037967A/ko not_active Application Discontinuation
- 2010-07-02 MA MA34592A patent/MA33500B1/fr unknown
- 2010-07-02 CN CN201080036552.8A patent/CN102471280B/zh not_active Expired - Fee Related
- 2010-07-02 UY UY0001032757A patent/UY32757A/es not_active Application Discontinuation
-
2011
- 2011-12-21 CR CR20110701A patent/CR20110701A/es unknown
- 2011-12-22 TN TNP2011000658A patent/TN2011000658A1/fr unknown
- 2011-12-23 US US13/336,253 patent/US8367715B2/en active Active
- 2011-12-29 IL IL217300A patent/IL217300A0/en unknown
-
2012
- 2012-01-02 DO DO2012000001A patent/DOP2012000001A/es unknown
- 2012-01-03 EC ECSP12011659 patent/ECSP12011659A/es unknown
- 2012-01-03 ZA ZA2012/00027A patent/ZA201200027B/en unknown
- 2012-01-03 CL CL2012000013A patent/CL2012000013A1/es unknown
- 2012-01-03 CO CO12000505A patent/CO6480992A2/es active IP Right Grant
- 2012-01-03 EC EC2012011569A patent/ECSP12011569A/es unknown
- 2012-01-05 NI NI201200001A patent/NI201200001A/es unknown
- 2012-10-08 HK HK12109827.6A patent/HK1169387A1/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |