JOP20110347B1 - صوديوم 1h- بيرازول-5-أولات مستبدل - Google Patents

صوديوم 1h- بيرازول-5-أولات مستبدل

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Publication number
JOP20110347B1
JOP20110347B1 JOP/2011/0347A JOP20110347A JOP20110347B1 JO P20110347 B1 JOP20110347 B1 JO P20110347B1 JO P20110347 A JOP20110347 A JO P20110347A JO P20110347 B1 JOP20110347 B1 JO P20110347B1
Authority
JO
Jordan
Prior art keywords
olate
pyrazol
diseases
substituted sodium
prophylaxis
Prior art date
Application number
JOP/2011/0347A
Other languages
English (en)
Inventor
Militzer Hans-Christian
Koep Stefan
Gries Jorg
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Application granted granted Critical
Publication of JOP20110347B1 publication Critical patent/JOP20110347B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

يتعلق الطلب الحالي بمركب sodium 1-[6-(morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-olate، بعمليات لتحضيره، باستخدامه لمعالجة و/أو الوقاية من أمراض وباستخدامه لتحضير أدوية لمعالجة و/أو الوقاية من أمراض، تحديدا أمراض الأوعية الدموية القلبية والأمراض الدموية وأمراض الكُلى، وكذلك لتعزيز التئام الجروح.
JOP/2011/0347A 2010-11-18 2011-11-17 صوديوم 1h- بيرازول-5-أولات مستبدل JOP20110347B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102010044131A DE102010044131A1 (de) 2010-11-18 2010-11-18 Substituiertes Natrium-1H-pyrazol-5-olat

Publications (1)

Publication Number Publication Date
JOP20110347B1 true JOP20110347B1 (ar) 2021-08-17

Family

ID=44999768

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2011/0347A JOP20110347B1 (ar) 2010-11-18 2011-11-17 صوديوم 1h- بيرازول-5-أولات مستبدل

Country Status (45)

Country Link
US (2) US8653074B2 (ar)
EP (1) EP2640718B8 (ar)
JP (1) JP5918779B2 (ar)
KR (2) KR20180023043A (ar)
CN (2) CN103270031B (ar)
AP (1) AP3429A (ar)
AR (1) AR083887A1 (ar)
AU (1) AU2011331305B2 (ar)
BR (1) BR112013012223B1 (ar)
CA (1) CA2818002C (ar)
CL (1) CL2013001390A1 (ar)
CO (1) CO6741155A2 (ar)
CR (1) CR20130196A (ar)
CU (1) CU20130072A7 (ar)
CY (1) CY1120375T1 (ar)
DE (1) DE102010044131A1 (ar)
DK (1) DK2640718T3 (ar)
DO (1) DOP2013000096A (ar)
EA (1) EA023103B1 (ar)
EC (1) ECSP13012627A (ar)
ES (1) ES2675580T3 (ar)
GT (1) GT201300125A (ar)
HK (2) HK1188782A1 (ar)
HR (1) HRP20180993T1 (ar)
HU (1) HUE038024T2 (ar)
IL (1) IL226192A (ar)
JO (1) JOP20110347B1 (ar)
LT (1) LT2640718T (ar)
MA (1) MA34671B1 (ar)
MX (1) MX347670B (ar)
MY (1) MY167219A (ar)
NZ (1) NZ610614A (ar)
PE (2) PE20140391A1 (ar)
PL (1) PL2640718T3 (ar)
PT (1) PT2640718T (ar)
RS (1) RS57599B1 (ar)
SG (1) SG189975A1 (ar)
SI (1) SI2640718T1 (ar)
TN (1) TN2013000215A1 (ar)
TR (1) TR201806652T4 (ar)
TW (1) TWI516485B (ar)
UA (1) UA112422C2 (ar)
UY (1) UY33736A (ar)
WO (1) WO2012065967A1 (ar)
ZA (1) ZA201304430B (ar)

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WO2018149929A1 (en) * 2017-02-16 2018-08-23 Bayer Pharma Aktiengesellschaft Combination of reporter gene assays and transcriptional analysis
EP3888684A1 (en) * 2020-03-31 2021-10-06 Bayer Animal Health GmbH Composition having improved voluntary acceptance

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DE102010044131A1 (de) 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituiertes Natrium-1H-pyrazol-5-olat

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IL226192A0 (en) 2013-07-31
SG189975A1 (en) 2013-06-28
PE20140391A1 (es) 2014-03-29
US9533972B2 (en) 2017-01-03
US20120129857A1 (en) 2012-05-24
TWI516485B (zh) 2016-01-11
TN2013000215A1 (en) 2014-11-10
KR101984317B1 (ko) 2019-05-30
BR112013012223B1 (pt) 2021-06-29
CR20130196A (es) 2013-08-06
GT201300125A (es) 2017-07-26
DOP2013000096A (es) 2013-06-15
US8653074B2 (en) 2014-02-18
PE20180324A1 (es) 2018-02-13
ES2675580T3 (es) 2018-07-11
MX347670B (es) 2017-05-03
HK1188782A1 (en) 2014-05-16
AP3429A (en) 2015-09-30
TW201307328A (zh) 2013-02-16
EA201390703A1 (ru) 2013-12-30
MY167219A (en) 2018-08-14
MA34671B1 (fr) 2013-11-02
EP2640718B1 (de) 2018-03-28
CN103270031A (zh) 2013-08-28
AU2011331305B2 (en) 2016-06-02
CL2013001390A1 (es) 2014-04-04
AR083887A1 (es) 2013-03-27
CA2818002C (en) 2019-01-15
DK2640718T3 (da) 2018-07-16
AP2013006922A0 (en) 2013-06-30
HRP20180993T1 (hr) 2018-08-10
WO2012065967A1 (de) 2012-05-24
HK1210776A1 (en) 2016-05-06
MX2013004797A (es) 2013-06-28
JP2014500877A (ja) 2014-01-16
PL2640718T3 (pl) 2018-08-31
DE102010044131A1 (de) 2012-05-24
KR20180023043A (ko) 2018-03-06
US20130310381A1 (en) 2013-11-21
CO6741155A2 (es) 2013-08-30
EA023103B1 (ru) 2016-04-29
PT2640718T (pt) 2018-07-04
CN104650047A (zh) 2015-05-27
HUE038024T2 (hu) 2018-09-28
CU20130072A7 (es) 2013-09-27
ZA201304430B (en) 2014-12-23
CA2818002A1 (en) 2012-05-24
EP2640718B8 (de) 2018-06-27
IL226192A (en) 2016-06-30
AU2011331305A1 (en) 2013-06-06
JP5918779B2 (ja) 2016-05-18
ECSP13012627A (es) 2013-07-31
LT2640718T (lt) 2018-07-10
UA112422C2 (uk) 2016-09-12
CN103270031B (zh) 2015-06-17
UY33736A (es) 2012-06-29
RS57599B1 (sr) 2018-11-30
EP2640718A1 (de) 2013-09-25
CY1120375T1 (el) 2019-07-10
SI2640718T1 (en) 2018-08-31
BR112013012223A2 (pt) 2020-03-10
TR201806652T4 (tr) 2018-06-21
NZ610614A (en) 2015-05-29
KR20130131335A (ko) 2013-12-03

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