PE20180324A1 - 1h-pirazol-5-olato sodico sustituido - Google Patents

1h-pirazol-5-olato sodico sustituido

Info

Publication number
PE20180324A1
PE20180324A1 PE2017002012A PE2017002012A PE20180324A1 PE 20180324 A1 PE20180324 A1 PE 20180324A1 PE 2017002012 A PE2017002012 A PE 2017002012A PE 2017002012 A PE2017002012 A PE 2017002012A PE 20180324 A1 PE20180324 A1 PE 20180324A1
Authority
PE
Peru
Prior art keywords
pirazole
substitute
compound
anemia
olate
Prior art date
Application number
PE2017002012A
Other languages
English (en)
Inventor
Hans Christian Militzer
Jorg Gries
Stefan Koep
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of PE20180324A1 publication Critical patent/PE20180324A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P27/02—Ophthalmic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cardiology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

Esta referido al compuesto 1-[6-(morfolin-4-il)pirimidin-4-il]-4-(1H-1,2,3- triazol-1-il)-1H-pirazol-5-olato sodico de formula (II), procedimientos para su preparacion. Este compuesto es adecuado para incrementar el hematocrito; puede usarse solo o en combinacion con otros principios activos; siendo util para enfermedades cardiovasculares, especialmente insuficiencia cardiaca, angina de pecho; y hematologicas, como por ejemplo, anemia idiopatica, anemias concomitantes de una enfermedad tumoral, especialmente una anemia inducida por quimioterapia; enfermedades renales, como tambien para ayudar a la curacion de heridas
PE2017002012A 2010-11-18 2011-11-15 1h-pirazol-5-olato sodico sustituido PE20180324A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102010044131A DE102010044131A1 (de) 2010-11-18 2010-11-18 Substituiertes Natrium-1H-pyrazol-5-olat

Publications (1)

Publication Number Publication Date
PE20180324A1 true PE20180324A1 (es) 2018-02-13

Family

ID=44999768

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2017002012A PE20180324A1 (es) 2010-11-18 2011-11-15 1h-pirazol-5-olato sodico sustituido
PE2013000943A PE20140391A1 (es) 2010-11-18 2011-11-15 1h-pirazol-5-olato sodico sustituido

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2013000943A PE20140391A1 (es) 2010-11-18 2011-11-15 1h-pirazol-5-olato sodico sustituido

Country Status (45)

Country Link
US (2) US8653074B2 (es)
EP (1) EP2640718B8 (es)
JP (1) JP5918779B2 (es)
KR (2) KR20180023043A (es)
CN (2) CN104650047A (es)
AP (1) AP3429A (es)
AR (1) AR083887A1 (es)
AU (1) AU2011331305B2 (es)
BR (1) BR112013012223B1 (es)
CA (1) CA2818002C (es)
CL (1) CL2013001390A1 (es)
CO (1) CO6741155A2 (es)
CR (1) CR20130196A (es)
CU (1) CU20130072A7 (es)
CY (1) CY1120375T1 (es)
DE (1) DE102010044131A1 (es)
DK (1) DK2640718T3 (es)
DO (1) DOP2013000096A (es)
EA (1) EA023103B1 (es)
EC (1) ECSP13012627A (es)
ES (1) ES2675580T3 (es)
GT (1) GT201300125A (es)
HK (2) HK1188782A1 (es)
HR (1) HRP20180993T1 (es)
HU (1) HUE038024T2 (es)
IL (1) IL226192A (es)
JO (1) JOP20110347B1 (es)
LT (1) LT2640718T (es)
MA (1) MA34671B1 (es)
MX (1) MX347670B (es)
MY (1) MY167219A (es)
NZ (1) NZ610614A (es)
PE (2) PE20180324A1 (es)
PL (1) PL2640718T3 (es)
PT (1) PT2640718T (es)
RS (1) RS57599B1 (es)
SG (1) SG189975A1 (es)
SI (1) SI2640718T1 (es)
TN (1) TN2013000215A1 (es)
TR (1) TR201806652T4 (es)
TW (1) TWI516485B (es)
UA (1) UA112422C2 (es)
UY (1) UY33736A (es)
WO (1) WO2012065967A1 (es)
ZA (1) ZA201304430B (es)

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EP3197442B1 (en) 2014-09-26 2019-07-03 The Cleveland Clinic Foundation Treating and preventing disease with tma and tmao lowering agents
CL2015003047A1 (es) * 2015-10-15 2016-06-17 Univ Chile Método ex vivo para detectar precozmente injuria renal aguda en pacientes críticos, que comprende la mediciom en una muestra de tres proteinas como biomarcadores, factor de crecimiento fibroblástico 23, klotho y eritropoyetina
WO2018149929A1 (en) * 2017-02-16 2018-08-23 Bayer Pharma Aktiengesellschaft Combination of reporter gene assays and transcriptional analysis
EP3888684A1 (en) * 2020-03-31 2021-10-06 Bayer Animal Health GmbH Composition having improved voluntary acceptance

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DE102010044131A1 (de) 2010-11-18 2012-05-24 Bayer Schering Pharma Aktiengesellschaft Substituiertes Natrium-1H-pyrazol-5-olat

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IL226192A0 (en) 2013-07-31
RS57599B1 (sr) 2018-11-30
HUE038024T2 (hu) 2018-09-28
IL226192A (en) 2016-06-30
KR20130131335A (ko) 2013-12-03
CA2818002C (en) 2019-01-15
CN103270031B (zh) 2015-06-17
AU2011331305A1 (en) 2013-06-06
BR112013012223A2 (pt) 2020-03-10
JP2014500877A (ja) 2014-01-16
EP2640718A1 (de) 2013-09-25
TN2013000215A1 (en) 2014-11-10
CU20130072A7 (es) 2013-09-27
CL2013001390A1 (es) 2014-04-04
KR20180023043A (ko) 2018-03-06
HK1188782A1 (en) 2014-05-16
MX347670B (es) 2017-05-03
CN103270031A (zh) 2013-08-28
CA2818002A1 (en) 2012-05-24
AP2013006922A0 (en) 2013-06-30
PE20140391A1 (es) 2014-03-29
CN104650047A (zh) 2015-05-27
PT2640718T (pt) 2018-07-04
MX2013004797A (es) 2013-06-28
WO2012065967A1 (de) 2012-05-24
ZA201304430B (en) 2014-12-23
US20130310381A1 (en) 2013-11-21
UY33736A (es) 2012-06-29
SI2640718T1 (en) 2018-08-31
EP2640718B1 (de) 2018-03-28
ECSP13012627A (es) 2013-07-31
CR20130196A (es) 2013-08-06
JOP20110347B1 (ar) 2021-08-17
AP3429A (en) 2015-09-30
PL2640718T3 (pl) 2018-08-31
KR101984317B1 (ko) 2019-05-30
MA34671B1 (fr) 2013-11-02
DK2640718T3 (da) 2018-07-16
SG189975A1 (en) 2013-06-28
EP2640718B8 (de) 2018-06-27
US9533972B2 (en) 2017-01-03
LT2640718T (lt) 2018-07-10
HK1210776A1 (en) 2016-05-06
US20120129857A1 (en) 2012-05-24
BR112013012223B1 (pt) 2021-06-29
DOP2013000096A (es) 2013-06-15
TWI516485B (zh) 2016-01-11
CY1120375T1 (el) 2019-07-10
NZ610614A (en) 2015-05-29
EA023103B1 (ru) 2016-04-29
TR201806652T4 (tr) 2018-06-21
JP5918779B2 (ja) 2016-05-18
AU2011331305B2 (en) 2016-06-02
EA201390703A1 (ru) 2013-12-30
AR083887A1 (es) 2013-03-27
ES2675580T3 (es) 2018-07-11
US8653074B2 (en) 2014-02-18
DE102010044131A1 (de) 2012-05-24
GT201300125A (es) 2017-07-26
HRP20180993T1 (hr) 2018-08-10
UA112422C2 (uk) 2016-09-12
TW201307328A (zh) 2013-02-16
MY167219A (en) 2018-08-14
CO6741155A2 (es) 2013-08-30

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