JP2008502309A5 - - Google Patents
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- JP2008502309A5 JP2008502309A5 JP2006538540A JP2006538540A JP2008502309A5 JP 2008502309 A5 JP2008502309 A5 JP 2008502309A5 JP 2006538540 A JP2006538540 A JP 2006538540A JP 2006538540 A JP2006538540 A JP 2006538540A JP 2008502309 A5 JP2008502309 A5 JP 2008502309A5
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- Prior art keywords
- monoclonal antibody
- seq
- antibody
- cells
- chir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51733703P | 2003-11-04 | 2003-11-04 | |
| US60/517,337 | 2003-11-04 | ||
| US52557903P | 2003-11-26 | 2003-11-26 | |
| US60/525,579 | 2003-11-26 | ||
| US56571004P | 2004-04-27 | 2004-04-27 | |
| US60/565,710 | 2004-04-27 | ||
| PCT/US2004/037152 WO2005044854A2 (en) | 2003-11-04 | 2004-11-04 | Antagonist anti-cd40 monoclonal antibodies and methods for their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010277537A Division JP2011072317A (ja) | 2003-11-04 | 2010-12-13 | アンタゴニスト抗cd40モノクローナル抗体およびそれらを使用するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008502309A JP2008502309A (ja) | 2008-01-31 |
| JP2008502309A5 true JP2008502309A5 (enExample) | 2011-02-10 |
| JP5019881B2 JP5019881B2 (ja) | 2012-09-05 |
Family
ID=34577667
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538514A Expired - Fee Related JP4765039B2 (ja) | 2003-11-04 | 2004-11-04 | Cd40抗原を発現する癌に対する治療方法。 |
| JP2006538540A Expired - Lifetime JP5019881B2 (ja) | 2003-11-04 | 2004-11-04 | アンタゴニスト抗cd40モノクローナル抗体およびそれらを使用するための方法 |
| JP2006538513A Expired - Lifetime JP4746552B2 (ja) | 2003-11-04 | 2004-11-04 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗cd40抗体の使用 |
| JP2010277537A Withdrawn JP2011072317A (ja) | 2003-11-04 | 2010-12-13 | アンタゴニスト抗cd40モノクローナル抗体およびそれらを使用するための方法 |
| JP2011033969A Withdrawn JP2011126900A (ja) | 2003-11-04 | 2011-02-18 | Cd40抗原を発現する癌に対する治療方法。 |
| JP2011040922A Withdrawn JP2011105769A (ja) | 2003-11-04 | 2011-02-25 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗cd40抗体の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538514A Expired - Fee Related JP4765039B2 (ja) | 2003-11-04 | 2004-11-04 | Cd40抗原を発現する癌に対する治療方法。 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006538513A Expired - Lifetime JP4746552B2 (ja) | 2003-11-04 | 2004-11-04 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗cd40抗体の使用 |
| JP2010277537A Withdrawn JP2011072317A (ja) | 2003-11-04 | 2010-12-13 | アンタゴニスト抗cd40モノクローナル抗体およびそれらを使用するための方法 |
| JP2011033969A Withdrawn JP2011126900A (ja) | 2003-11-04 | 2011-02-18 | Cd40抗原を発現する癌に対する治療方法。 |
| JP2011040922A Withdrawn JP2011105769A (ja) | 2003-11-04 | 2011-02-25 | 自己免疫疾患および炎症性疾患ならびに臓器移植拒絶の処置のためのアンタゴニスト抗cd40抗体の使用 |
Country Status (22)
| Country | Link |
|---|---|
| EP (6) | EP2248830A1 (enExample) |
| JP (6) | JP4765039B2 (enExample) |
| KR (2) | KR101403910B1 (enExample) |
| CN (2) | CN1938045B (enExample) |
| AT (3) | ATE447412T1 (enExample) |
| AU (3) | AU2004287482B2 (enExample) |
| CA (3) | CA2544948A1 (enExample) |
| CY (3) | CY1110231T1 (enExample) |
| DE (3) | DE602004028505D1 (enExample) |
| DK (4) | DK1682178T3 (enExample) |
| EC (2) | ECSP066607A (enExample) |
| ES (3) | ES2333971T3 (enExample) |
| HR (2) | HRP20100066T1 (enExample) |
| IL (1) | IL175225A (enExample) |
| MA (1) | MA28331A1 (enExample) |
| PL (4) | PL1682178T3 (enExample) |
| PT (4) | PT1694360E (enExample) |
| RS (2) | RS53073B (enExample) |
| SG (1) | SG148143A1 (enExample) |
| SI (3) | SI1682178T1 (enExample) |
| WO (3) | WO2005044306A2 (enExample) |
| ZA (1) | ZA200604419B (enExample) |
Families Citing this family (83)
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| US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| EP2248830A1 (en) * | 2003-11-04 | 2010-11-10 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-CD40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection |
| WO2005044307A2 (en) * | 2003-11-04 | 2005-05-19 | Chiron Corporation | Methods of therapy for b cell-related cancers |
| US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
| US20050281815A1 (en) * | 2004-02-26 | 2005-12-22 | Dani Eshel | CD40 splice variants and their uses |
| HRP20130852T1 (en) * | 2005-05-18 | 2013-10-25 | Novartis Ag | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
| WO2006125143A2 (en) * | 2005-05-18 | 2006-11-23 | Novartis Ag | Methods for diagnosis and treatment of proliferative disorders mediated by cd40 signaling |
| ES2776657T3 (es) | 2005-06-14 | 2020-07-31 | Amgen Inc | Formulaciones de proteínas autotamponantes |
| CN101351478A (zh) * | 2005-11-01 | 2009-01-21 | 诺华有限公司 | 抗cd40抗体的应用 |
| JP2009517339A (ja) * | 2005-11-01 | 2009-04-30 | ノバルティス アーゲー | 抗cd40抗体の使用 |
| CN117903302A (zh) | 2005-11-30 | 2024-04-19 | Abbvie 公司 | 抗-Aβ球聚体抗体,其相关产品,生产所述抗体的方法,所述抗体的应用以及使用方法 |
| PT1976877E (pt) | 2005-11-30 | 2014-04-29 | Abbvie Inc | Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações |
| ES2444465T5 (es) | 2005-12-09 | 2023-11-30 | Academisch Medisch Centrum Bij De Univ Van Amsterdam | Medios y procedimientos para influenciar la estabilidad de las células productoras de anticuerpos |
| US9005974B2 (en) | 2005-12-09 | 2015-04-14 | Academish Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| AR059066A1 (es) | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| NZ571757A (en) * | 2006-04-21 | 2012-01-12 | Novartis Ag | Antagonist anti-CD40 antibody pharmaceutical compositions comprising arginine-HCl and a citrate or citric acid buffer |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| JP5577098B2 (ja) * | 2006-12-21 | 2014-08-20 | アムジエン・インコーポレーテツド | ポリペプチドを含有する安定な緩衝化された製剤 |
| US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| US7951368B2 (en) | 2007-06-25 | 2011-05-31 | Amgen Inc. | Compositions of specific binding agents to hepatocyte growth factor |
| EP2222875B1 (en) * | 2007-11-07 | 2014-08-20 | Genentech, Inc. | Methods and compositions for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies |
| KR20100088621A (ko) * | 2007-11-09 | 2010-08-09 | 노파르티스 아게 | 항-cd40 항체의 용도 |
| JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
| BRPI1011394A8 (pt) | 2009-04-18 | 2018-06-26 | Genentech Inc | método para avaliação de responsividade de linforma de células b ao tratamento com anticorpos anti-cd40 |
| AU2010271583B2 (en) | 2009-07-15 | 2015-02-12 | Kling Biotherapeutics B.V. | Means and methods for producing high affinity antibodies |
| CN104744591B (zh) | 2010-04-15 | 2022-09-27 | Abbvie德国有限责任两合公司 | β淀粉样蛋白结合蛋白 |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| PT2635601T (pt) | 2010-11-04 | 2016-09-27 | Boehringer Ingelheim Int | Anticorpos anti-il-23 |
| AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| AU2016201742B2 (en) * | 2010-11-15 | 2017-11-02 | Novartis Ag | Silent Fc variants of anti-CD40 antibodies |
| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| PT2646466T (pt) * | 2010-12-02 | 2017-06-07 | Aimm Therapeutics Bv | Meios e métodos para produzir anticorpos de alta afinidade |
| WO2012111762A1 (ja) * | 2011-02-17 | 2012-08-23 | 協和発酵キリン株式会社 | 抗cd40抗体の高濃度製剤 |
| US9713636B2 (en) * | 2011-02-28 | 2017-07-25 | Napajen Pharma, Inc. | Nucleic acid/polysaccharide complex |
| PL2683406T3 (pl) | 2011-03-11 | 2019-11-29 | Beth Israel Deaconess Medical Ct Inc | Przeciwciała anty-cd40 i ich zastosowania |
| EP2699601B1 (en) * | 2011-04-21 | 2018-01-17 | Bristol-Myers Squibb Company | Antibody polypeptides that antagonize cd40 |
| IN2014CN03555A (enExample) | 2011-10-25 | 2015-07-03 | Onclave Therapeutics Ltd | |
| CA2855864A1 (en) * | 2011-11-17 | 2013-05-23 | Gundram Jung | Bi-specific antibodies for treating b-cell mediated autoimmune diseases or auto-reactive b-cells |
| EP4039275A1 (en) | 2012-05-03 | 2022-08-10 | Boehringer Ingelheim International GmbH | Anti-il-23p19 antibodies |
| US20140004131A1 (en) | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
| US9676861B2 (en) * | 2012-10-30 | 2017-06-13 | Apexigen, Inc. | Anti-CD40 antibodies and methods of use |
| CN105229029B (zh) | 2012-11-19 | 2020-07-14 | 巴利奥医药股份公司 | 结合到cd20和cd95的重组双特异性抗体 |
| KR20160034893A (ko) * | 2013-06-13 | 2016-03-30 | 패스트 포워드 파머슈티컬스 비.브이. | Cd40 시그널링 억제제 및 추가 화합물로서, 상기 추가 화합물은 담즙산, 담즙산 유도체, tgr5-수용체 아고니스트, fxr 아고니스트 또는 이들의 조합이고, 만성 염증의 치료용, 및 위장 암 또는 섬유증의 예방용인, cd40 시그널링 억제제 및 추가 화합물 |
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| WO2015134988A1 (en) | 2014-03-07 | 2015-09-11 | Bristol-Myers Squibb Company | Method of using antibody polypeptides that antagonize cd40 to treat ibd |
| CN106687125B (zh) | 2014-03-12 | 2021-12-14 | 耶达研究与开发有限公司 | 降低系统性调节性t细胞水平或活性来治疗cns疾病和损伤 |
| CN108025068A (zh) * | 2014-03-12 | 2018-05-11 | 耶达研究与开发有限公司 | 降低系统性调节性t细胞水平或活性来治疗cns的疾病和损伤 |
| US10519237B2 (en) | 2014-03-12 | 2019-12-31 | Yeda Research And Development Co. Ltd | Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS |
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| US11111284B2 (en) | 2014-08-21 | 2021-09-07 | The General Hospital Corporation | Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing |
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| CA3184366A1 (en) | 2020-06-29 | 2022-01-06 | Darby Rye Schmidt | Viruses engineered to promote thanotransmission and their use in treating cancer |
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