CA2544948A1 - Methods of therapy for cancers expressing the cd40 antigen - Google Patents

Methods of therapy for cancers expressing the cd40 antigen Download PDF

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Publication number
CA2544948A1
CA2544948A1 CA002544948A CA2544948A CA2544948A1 CA 2544948 A1 CA2544948 A1 CA 2544948A1 CA 002544948 A CA002544948 A CA 002544948A CA 2544948 A CA2544948 A CA 2544948A CA 2544948 A1 CA2544948 A1 CA 2544948A1
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CA
Canada
Prior art keywords
antibody
administered
antigen
dose
weeks
Prior art date
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Abandoned
Application number
CA002544948A
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English (en)
French (fr)
Inventor
Li Long
Mohammad Luqman
Asha Yabannavar
Isabel Zaror
Deborah Hurst
Daniel E. Lopes De Menezes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
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Individual
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34577667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2544948(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2544948A1 publication Critical patent/CA2544948A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
CA002544948A 2003-11-04 2004-11-04 Methods of therapy for cancers expressing the cd40 antigen Abandoned CA2544948A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US51733703P 2003-11-04 2003-11-04
US60/517,337 2003-11-04
US52557903P 2003-11-26 2003-11-26
US60/525,579 2003-11-26
US56571004P 2004-04-27 2004-04-27
US60/565,710 2004-04-27
PCT/US2004/036958 WO2005044294A2 (en) 2003-11-04 2004-11-04 Method of therapy for cancers expressing the cd40 antigen

Publications (1)

Publication Number Publication Date
CA2544948A1 true CA2544948A1 (en) 2005-05-19

Family

ID=34577667

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002544948A Abandoned CA2544948A1 (en) 2003-11-04 2004-11-04 Methods of therapy for cancers expressing the cd40 antigen
CA2544949A Expired - Fee Related CA2544949C (en) 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use
CA2544853A Expired - Fee Related CA2544853C (en) 2003-11-04 2004-11-04 Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases, and organ transplant rejection

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2544949A Expired - Fee Related CA2544949C (en) 2003-11-04 2004-11-04 Antagonist anti-cd40 monoclonal antibodies and methods for their use
CA2544853A Expired - Fee Related CA2544853C (en) 2003-11-04 2004-11-04 Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases, and organ transplant rejection

Country Status (22)

Country Link
EP (6) EP1682178B8 (enExample)
JP (6) JP4765039B2 (enExample)
KR (2) KR101403910B1 (enExample)
CN (2) CN1938045B (enExample)
AT (3) ATE473016T1 (enExample)
AU (3) AU2004287879C1 (enExample)
CA (3) CA2544948A1 (enExample)
CY (3) CY1110231T1 (enExample)
DE (3) DE602004028037D1 (enExample)
DK (4) DK1694360T3 (enExample)
EC (2) ECSP066607A (enExample)
ES (3) ES2435410T3 (enExample)
HR (2) HRP20100066T1 (enExample)
IL (1) IL175225A (enExample)
MA (1) MA28331A1 (enExample)
PL (4) PL2149585T3 (enExample)
PT (4) PT1682180E (enExample)
RS (2) RS53073B (enExample)
SG (1) SG148143A1 (enExample)
SI (3) SI1682180T1 (enExample)
WO (3) WO2005044854A2 (enExample)
ZA (1) ZA200604419B (enExample)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US8277810B2 (en) 2003-11-04 2012-10-02 Novartis Vaccines & Diagnostics, Inc. Antagonist anti-CD40 antibodies
US20070098718A1 (en) * 2003-11-04 2007-05-03 Chiron Methods of therapy for b cell-related cancers
AU2004287879C1 (en) * 2003-11-04 2011-05-26 Novartis Vaccines And Diagnostics, Inc. Antagonist anti-CD40 monoclonal antibodies and methods for their use
US20050281815A1 (en) * 2004-02-26 2005-12-22 Dani Eshel CD40 splice variants and their uses
EP2312315A1 (en) * 2005-05-18 2011-04-20 Novartis AG Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component
AU2006247067B2 (en) * 2005-05-18 2012-06-07 Novartis Ag Methods for diagnosis and treatment of proliferative disorders mediated by CD40 signaling
JP2008543839A (ja) 2005-06-14 2008-12-04 アムジェン インコーポレーテッド 自己緩衝タンパク質製剤
EP1945260B1 (en) * 2005-11-01 2012-10-24 Novartis AG Uses of anti-cd40 antibodies
WO2007053661A2 (en) * 2005-11-01 2007-05-10 Novartis Ag Uses of anti-cd40 antibodies
RU2442793C2 (ru) 2005-11-30 2012-02-20 Эбботт Лэборетриз АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ
PL1976877T5 (pl) 2005-11-30 2017-09-29 Abbvie Inc Przeciwciała monoklonalne przeciwko białku amyloidu beta oraz ich zastosowania
NZ600075A (en) 2005-12-09 2013-12-20 Amc Amsterdam Means and methods for influencing the stability of antibody producing cells
US9005974B2 (en) 2005-12-09 2015-04-14 Academish Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for influencing the stability of cells
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PL1694360T3 (pl) 2011-04-29
PL1682178T3 (pl) 2010-12-31
SI1682178T1 (sl) 2010-11-30
HK1095270A1 (en) 2007-05-04
AU2011201529B2 (en) 2012-11-01
JP2007510666A (ja) 2007-04-26
WO2005044306A3 (en) 2005-09-15
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AU2004287482B2 (en) 2011-04-14
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DE602004028037D1 (de) 2010-08-19
JP5019881B2 (ja) 2012-09-05
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EP1682178B1 (en) 2010-07-07
PT1694360E (pt) 2010-12-13
DK1682180T3 (da) 2010-01-11
ZA200604419B (en) 2008-06-25
PL2149585T3 (pl) 2014-01-31
CY1110803T1 (el) 2015-06-10
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KR101403910B1 (ko) 2014-06-09
ATE447412T1 (de) 2009-11-15
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EP1682178A2 (en) 2006-07-26
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EP2248830A1 (en) 2010-11-10
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CA2544853A1 (en) 2005-05-19
AU2004287879B2 (en) 2011-01-06
EP2255828A1 (en) 2010-12-01
SI1682180T1 (sl) 2010-03-31
SI1694360T1 (sl) 2010-12-31
DK1682178T3 (da) 2010-10-04
MA28331A1 (fr) 2006-12-01
EP1682180B1 (en) 2009-11-04
JP2011126900A (ja) 2011-06-30
ATE473016T1 (de) 2010-07-15
CN1938045B (zh) 2014-03-26
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DE602004028505D1 (de) 2010-09-16
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EP2149585A1 (en) 2010-02-03
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JP4746552B2 (ja) 2011-08-10
PT1682178E (pt) 2010-10-21
CN1905897A (zh) 2007-01-31
RS51230B (sr) 2010-12-31
SG148143A1 (en) 2008-12-31
CN1905897B (zh) 2012-09-05
ATE476448T1 (de) 2010-08-15
ES2333971T3 (es) 2010-03-03
EP2149585B1 (en) 2013-08-14
ECSP066607A (es) 2006-10-25
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