MA28331A1 - Anticorps monoclonaux anti-cd40 antagonistes et procedes d'utilisation associes - Google Patents

Anticorps monoclonaux anti-cd40 antagonistes et procedes d'utilisation associes

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Publication number
MA28331A1
MA28331A1 MA29078A MA29078A MA28331A1 MA 28331 A1 MA28331 A1 MA 28331A1 MA 29078 A MA29078 A MA 29078A MA 29078 A MA29078 A MA 29078A MA 28331 A1 MA28331 A1 MA 28331A1
Authority
MA
Morocco
Prior art keywords
methods
dosing regimen
antibody
treating
binding fragment
Prior art date
Application number
MA29078A
Other languages
English (en)
Inventor
Li Long
Mohammad Luqman
Asha Yabannavar
Isabel Zaror
Bao-Lu Chen
Xiaofeng Lu
Sang Hoon Lee
Deborah Hurst
Original Assignee
Novartis Vaccines & Diagnostic
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Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34577667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA28331(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Publication of MA28331A1 publication Critical patent/MA28331A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Des procédés de thérapie pour le traitement de maladies médiées par stimulation de la signalisation du CD40 sur des cellules exprimant le CD40 sont fournis. Les procédés comprennent l'administration d'une quantité thérapeutiquement efficace d'un anticorps anti-CD40 antagoniste ou son fragment de liaison à l'antigène à un patient ayant besoin de cela. L'anticorps anti-CD40 antagoniste ou son fragment de liaison à l'antigène est dépourvu d'activité agoniste significative, mais exhibe une activité antagoniste lorsque l'anticorps se lie à un antigène CD40 sur une cellule humaine exprimant le CD40. L¿activité antagoniste de l'anticorps anti-CD40 ou son fragment de liaison à l'antigène inhibe avantageusement la prolifération et/ou la différenciation des cellules humaines exprimant le CD40, telles que les cellules B.
MA29078A 2003-11-04 2006-06-05 Anticorps monoclonaux anti-cd40 antagonistes et procedes d'utilisation associes MA28331A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51733703P 2003-11-04 2003-11-04
US52557903P 2003-11-26 2003-11-26
US56571004P 2004-04-27 2004-04-27

Publications (1)

Publication Number Publication Date
MA28331A1 true MA28331A1 (fr) 2006-12-01

Family

ID=34577667

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29078A MA28331A1 (fr) 2003-11-04 2006-06-05 Anticorps monoclonaux anti-cd40 antagonistes et procedes d'utilisation associes

Country Status (23)

Country Link
EP (6) EP1682180B1 (fr)
JP (6) JP5019881B2 (fr)
KR (2) KR101125127B1 (fr)
CN (2) CN1938045B (fr)
AT (3) ATE447412T1 (fr)
AU (3) AU2004287482B2 (fr)
CA (3) CA2544853C (fr)
CY (3) CY1110231T1 (fr)
DE (3) DE602004028037D1 (fr)
DK (4) DK1682178T3 (fr)
EC (2) ECSP066607A (fr)
ES (3) ES2346977T3 (fr)
HK (4) HK1095270A1 (fr)
HR (2) HRP20100066T1 (fr)
IL (1) IL175225A (fr)
MA (1) MA28331A1 (fr)
PL (4) PL1694360T3 (fr)
PT (4) PT1682180E (fr)
RS (2) RS51230B (fr)
SG (1) SG148143A1 (fr)
SI (3) SI1694360T1 (fr)
WO (3) WO2005044294A2 (fr)
ZA (1) ZA200604419B (fr)

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HK1095270A1 (en) 2007-05-04
PL1682178T3 (pl) 2010-12-31
AU2004287482B2 (en) 2011-04-14
SI1682178T1 (sl) 2010-11-30
AU2004287879B2 (en) 2011-01-06
IL175225A0 (en) 2006-09-05
AU2004287879C1 (en) 2011-05-26
CA2544853C (fr) 2014-05-20
ATE473016T1 (de) 2010-07-15
CN1938045B (zh) 2014-03-26
WO2005044294A3 (fr) 2005-09-15
RS53073B (en) 2014-04-30
ECSP066607A (es) 2006-10-25
ATE447412T1 (de) 2009-11-15
DE602004028505D1 (de) 2010-09-16
AU2004287482A1 (en) 2005-05-19
SG148143A1 (en) 2008-12-31
KR101403910B1 (ko) 2014-06-09
JP2011126900A (ja) 2011-06-30
DE602004028037D1 (de) 2010-08-19
DK2149585T3 (da) 2013-10-21
PL1694360T3 (pl) 2011-04-29
CA2544948A1 (fr) 2005-05-19

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