CY1110231T1 - Anti-cd40 μονοκλωνικα αντισωματα antαγωνιστες και μεθοδοι για τη χρηση αυτων - Google Patents
Anti-cd40 μονοκλωνικα αντισωματα antαγωνιστες και μεθοδοι για τη χρηση αυτωνInfo
- Publication number
- CY1110231T1 CY1110231T1 CY20101100045T CY101100045T CY1110231T1 CY 1110231 T1 CY1110231 T1 CY 1110231T1 CY 20101100045 T CY20101100045 T CY 20101100045T CY 101100045 T CY101100045 T CY 101100045T CY 1110231 T1 CY1110231 T1 CY 1110231T1
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- CY
- Cyprus
- Prior art keywords
- methods
- dosing regimen
- antibody
- treating
- binding fragment
- Prior art date
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Abstract
Παρέχονται μέθοδοι θεραπείας ενός ατόμου για έναν καρκίνο που περιλαμβάνει νεοπλαστικά κύτταρα τα οποία εκφράζουν το CD40 αντιγόνο κυτταρικής επιφάνειας. Οι μέθοδοι περιλαμβάνουν συνδυαστική θεραπεία με ιντερλευκίνη-2 (IL-2) ή βιολογικά δραστική παραλλαγή αυτής και τουλάχιστον ένα αντι-CD40 αντίσωμα ανταγωνιστή ή θραύσμα αυτού που προσδένει αντιγόνο. Σε ορισμένες υλοποιήσεις αυτοί οι δύο θεραπευτικοί παράγοντες χορηγούνται συγχρόνως σαν δύο χωριστές φαρμακευτικές συνθέσεις , που η μία περιέχει IL-2 ή βιολογικά δραστική παραλλαγή αυτής η οποία χορηγείται σύμφωνα με μία σταθερή αγωγή χορήγησης δόσεων της IL-2 ή με μία αγωγή χορήγησης IL-2 δόσεων δύο επιπέδων, και η άλλη περιέχει το αντι-CD40 αντίσωμα ανταγωνιστή ή ένα κατάλληλο θραύσμα αυτού που προσδένει αντιγόνο, η οποία χορηγείται σύμφωνα με μία αγωγή χορήγηση δόσεων εβδομαδιαίως ή εναλλακτικά μία φορά κάθε δύο, τρεις ή τέσσερις εβδομάδες. Η χορήγηση αυτών των δύο παραγόντων μαζί δυναμώνει την αποτελεσματικότητά τους στο να προάγουν μία θετική θεραπευτική απόκριση. Οι μέθοδοι μπορούν να χρησιμοποιηθούν στην θεραπεία καρκίνων που εκφράζουν CD40, συμπεριλαμβανομένων των καρκίνων που σχετίζονται με Β κύτταρα και των στερεών όγκων.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51733703P | 2003-11-04 | 2003-11-04 | |
US52557903P | 2003-11-26 | 2003-11-26 | |
US56571004P | 2004-04-27 | 2004-04-27 | |
EP04810510A EP1682180B1 (en) | 2003-11-04 | 2004-11-04 | Antagonist anti-cd40 monoclonal antibodies and methods for their use |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110231T1 true CY1110231T1 (el) | 2015-01-14 |
Family
ID=34577667
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100045T CY1110231T1 (el) | 2003-11-04 | 2010-01-15 | Anti-cd40 μονοκλωνικα αντισωματα antαγωνιστες και μεθοδοι για τη χρηση αυτων |
CY20101100869T CY1110803T1 (el) | 2003-11-04 | 2010-09-28 | Μεθοδοι θεραπειας για καρκινους που εκφραζουν to cd40 αντιγονο |
CY20101100931T CY1110839T1 (el) | 2003-11-04 | 2010-10-18 | Χρηση anti-cd40 αντισωματων ανταγωνιστων για θεραπευτικη αγωγη αυτοανοσων και φλεγμονωδων νοσηματων και απορριψης μοσχευματος οργανου |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100869T CY1110803T1 (el) | 2003-11-04 | 2010-09-28 | Μεθοδοι θεραπειας για καρκινους που εκφραζουν to cd40 αντιγονο |
CY20101100931T CY1110839T1 (el) | 2003-11-04 | 2010-10-18 | Χρηση anti-cd40 αντισωματων ανταγωνιστων για θεραπευτικη αγωγη αυτοανοσων και φλεγμονωδων νοσηματων και απορριψης μοσχευματος οργανου |
Country Status (23)
Country | Link |
---|---|
EP (6) | EP2248830A1 (el) |
JP (6) | JP4746552B2 (el) |
KR (2) | KR101403910B1 (el) |
CN (2) | CN1905897B (el) |
AT (3) | ATE476448T1 (el) |
AU (3) | AU2004287482B2 (el) |
CA (3) | CA2544949C (el) |
CY (3) | CY1110231T1 (el) |
DE (3) | DE602004023961D1 (el) |
DK (4) | DK1682180T3 (el) |
EC (2) | ECSP066607A (el) |
ES (3) | ES2346977T3 (el) |
HK (4) | HK1095270A1 (el) |
HR (2) | HRP20100066T1 (el) |
IL (1) | IL175225A (el) |
MA (1) | MA28331A1 (el) |
PL (4) | PL1682178T3 (el) |
PT (4) | PT1682180E (el) |
RS (2) | RS53073B (el) |
SG (1) | SG148143A1 (el) |
SI (3) | SI1682180T1 (el) |
WO (3) | WO2005044854A2 (el) |
ZA (1) | ZA200604419B (el) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7658924B2 (en) | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
EP2248830A1 (en) * | 2003-11-04 | 2010-11-10 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-CD40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection |
US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
EP2236172A1 (en) * | 2003-11-04 | 2010-10-06 | Novartis Vaccines and Diagnostics, Inc. | Combination therapy comprising anti-CD20 and anti-CD40 antibodies for the treatment of B cell-related cancers |
US20050281815A1 (en) * | 2004-02-26 | 2005-12-22 | Dani Eshel | CD40 splice variants and their uses |
EP1889065B1 (en) | 2005-05-18 | 2013-07-10 | Novartis AG | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
AU2006247067B2 (en) * | 2005-05-18 | 2012-06-07 | Novartis Ag | Methods for diagnosis and treatment of proliferative disorders mediated by CD40 signaling |
US20080311078A1 (en) | 2005-06-14 | 2008-12-18 | Gokarn Yatin R | Self-Buffering Protein Formulations |
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DK1682177T3 (da) * | 2003-11-04 | 2010-11-01 | Novartis Vaccines & Diagnostic | Anvendelse af antagonist-anti-CD40-antistoffer til behandling af kronisk lymfocytisk leukæmi |
EP1680141B8 (en) * | 2003-11-04 | 2011-01-12 | Novartis Vaccines and Diagnostics, Inc. | Methods of therapy for solid tumors expressing the cd40 cell-surface antigen |
WO2005044855A2 (en) * | 2003-11-04 | 2005-05-19 | Chiron Corporation | Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma |
EP2248830A1 (en) * | 2003-11-04 | 2010-11-10 | Novartis Vaccines and Diagnostics, Inc. | Use of antagonist anti-CD40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection |
JP6039343B2 (ja) | 2012-10-04 | 2016-12-07 | キヤノン株式会社 | 電子機器、電子機器の制御方法、プログラム、記憶媒体 |
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