JP2007526880A5 - - Google Patents
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- JP2007526880A5 JP2007526880A5 JP2006517620A JP2006517620A JP2007526880A5 JP 2007526880 A5 JP2007526880 A5 JP 2007526880A5 JP 2006517620 A JP2006517620 A JP 2006517620A JP 2006517620 A JP2006517620 A JP 2006517620A JP 2007526880 A5 JP2007526880 A5 JP 2007526880A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- toxin
- auristatin
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003053 toxin Substances 0.000 claims 33
- 231100000765 toxin Toxicity 0.000 claims 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 125000003275 alpha amino acid group Chemical group 0.000 claims 24
- 229920001184 polypeptide Polymers 0.000 claims 24
- 102000004196 processed proteins & peptides Human genes 0.000 claims 24
- WOWDZACBATWTAU-FEFUEGSOSA-N (2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-n-[(3r,4s,5s)-1-[(2s)-2-[(1r,2r)-3-[[(1s,2r)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical compound CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1 WOWDZACBATWTAU-FEFUEGSOSA-N 0.000 claims 20
- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 20
- 108010093470 monomethyl auristatin E Proteins 0.000 claims 20
- 108010084592 Saporins Proteins 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 8
- 108010087914 epidermal growth factor receptor VIII Proteins 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 210000002165 glioblast Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 238000002864 sequence alignment Methods 0.000 description 2
Images
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48314503P | 2003-06-27 | 2003-06-27 | |
| US60/483,145 | 2003-06-27 | ||
| US52557003P | 2003-11-26 | 2003-11-26 | |
| US60/525,570 | 2003-11-26 | ||
| US56245304P | 2004-04-15 | 2004-04-15 | |
| US60/562,453 | 2004-04-15 | ||
| PCT/US2004/020295 WO2005010151A2 (en) | 2003-06-27 | 2004-06-25 | Antibodies directed to the deletion mutants of epidermal growth factor receptor and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010252825A Division JP5583557B2 (ja) | 2003-06-27 | 2010-11-11 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007526880A JP2007526880A (ja) | 2007-09-20 |
| JP2007526880A5 true JP2007526880A5 (enExample) | 2009-10-22 |
| JP4808614B2 JP4808614B2 (ja) | 2011-11-02 |
Family
ID=34108807
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517700A Expired - Lifetime JP4800210B2 (ja) | 2003-06-27 | 2004-06-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2006517620A Expired - Lifetime JP4808614B2 (ja) | 2003-06-27 | 2004-06-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2010252825A Expired - Lifetime JP5583557B2 (ja) | 2003-06-27 | 2010-11-11 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2010262796A Expired - Lifetime JP5583560B2 (ja) | 2003-06-27 | 2010-11-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2013272028A Expired - Lifetime JP6328928B2 (ja) | 2003-06-27 | 2013-12-27 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2013272029A Expired - Lifetime JP6328929B2 (ja) | 2003-06-27 | 2013-12-27 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2017163089A Pending JP2017210486A (ja) | 2003-06-27 | 2017-08-28 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2017175574A Pending JP2017222711A (ja) | 2003-06-27 | 2017-09-13 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2019107945A Expired - Lifetime JP7062616B2 (ja) | 2003-06-27 | 2019-06-10 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517700A Expired - Lifetime JP4800210B2 (ja) | 2003-06-27 | 2004-06-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010252825A Expired - Lifetime JP5583557B2 (ja) | 2003-06-27 | 2010-11-11 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2010262796A Expired - Lifetime JP5583560B2 (ja) | 2003-06-27 | 2010-11-25 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2013272028A Expired - Lifetime JP6328928B2 (ja) | 2003-06-27 | 2013-12-27 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2013272029A Expired - Lifetime JP6328929B2 (ja) | 2003-06-27 | 2013-12-27 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2017163089A Pending JP2017210486A (ja) | 2003-06-27 | 2017-08-28 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2017175574A Pending JP2017222711A (ja) | 2003-06-27 | 2017-09-13 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
| JP2019107945A Expired - Lifetime JP7062616B2 (ja) | 2003-06-27 | 2019-06-10 | 上皮成長因子受容体の欠失型変異体を認識する抗体、およびそれらの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (9) | US7736644B2 (enExample) |
| EP (7) | EP1638606B1 (enExample) |
| JP (9) | JP4800210B2 (enExample) |
| KR (11) | KR101581040B1 (enExample) |
| CN (4) | CN104059147A (enExample) |
| AU (4) | AU2004259398A1 (enExample) |
| BR (2) | BRPI0411852A (enExample) |
| CA (2) | CA2530172A1 (enExample) |
| HK (2) | HK1201861A1 (enExample) |
| IN (1) | IN2012DN00313A (enExample) |
| MX (2) | MXPA05014152A (enExample) |
| WO (2) | WO2005012479A2 (enExample) |
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