JP2005534684A5 - - Google Patents

Download PDF

Info

Publication number
JP2005534684A5
JP2005534684A5 JP2004524185A JP2004524185A JP2005534684A5 JP 2005534684 A5 JP2005534684 A5 JP 2005534684A5 JP 2004524185 A JP2004524185 A JP 2004524185A JP 2004524185 A JP2004524185 A JP 2004524185A JP 2005534684 A5 JP2005534684 A5 JP 2005534684A5
Authority
JP
Japan
Prior art keywords
group
substituted
unsubstituted
alkyl
independently selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2004524185A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005534684A (ja
Filing date
Publication date
Priority claimed from US10/208,412 external-priority patent/US20040097547A1/en
Priority claimed from US10/241,326 external-priority patent/US20040106794A1/en
Application filed filed Critical
Publication of JP2005534684A publication Critical patent/JP2005534684A/ja
Publication of JP2005534684A5 publication Critical patent/JP2005534684A5/ja
Pending legal-status Critical Current

Links

JP2004524185A 2002-07-30 2003-07-30 Ｃｘｃケモカインレセプタ配位子としての３，４−二置換シクロブテン−１，２−ジオン Pending JP2005534684A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/208,412 US20040097547A1 (en) 2001-04-16 2002-07-30 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US10/241,326 US20040106794A1 (en) 2001-04-16 2002-09-11 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
PCT/US2003/023785 WO2004011418A1 (en) 2002-07-30 2003-07-30 3,4-di-substituted cyclobutene-1, 2-diones as cxc-chemokine receptor ligands

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010217953A Division JP2011063591A (ja) 2002-07-30 2010-09-28 Ｃｘｃケモカインレセプタ配位子としての３，４−二置換シクロブテン−１，２−ジオン

Publications (2)

Publication Number Publication Date
JP2005534684A JP2005534684A (ja) 2005-11-17
JP2005534684A5 true JP2005534684A5 (enExample) 2006-09-14

Family

ID=31190690

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004524185A Pending JP2005534684A (ja) 2002-07-30 2003-07-30 Ｃｘｃケモカインレセプタ配位子としての３，４−二置換シクロブテン−１，２−ジオン

Country Status (15)

Country Link
US (4) US20040106794A1 (enExample)
EP (1) EP1539678B1 (enExample)
JP (1) JP2005534684A (enExample)
KR (1) KR20050026060A (enExample)
AU (1) AU2003259302B2 (enExample)
BR (1) BR0313109A (enExample)
CA (1) CA2496676C (enExample)
IL (1) IL166427A0 (enExample)
MX (1) MXPA05001274A (enExample)
NO (1) NO20051036L (enExample)
NZ (1) NZ538521A (enExample)
PL (1) PL374876A1 (enExample)
RU (1) RU2005105692A (enExample)
TW (1) TW200716520A (enExample)
WO (1) WO2004011418A1 (enExample)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040106794A1 (en) * 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
MXPA05011183A (es) 2003-04-18 2005-12-14 Schering Corp Sintesis de 2-hidroxi-n, n-dimetil- 3-[[2-[1(r) -(5-metil -2-furanil) propil]amino]-3, 4-dioxo-1 -ciclobuten-1 -il]amino] benzamida.
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
US7230022B2 (en) 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
US7288563B2 (en) 2004-02-19 2007-10-30 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7479496B2 (en) 2004-02-19 2009-01-20 Bristol-Myers Squibb Company Substituted spiro azabicyclics as modulators of chemokine receptor activity
US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
CN1946690A (zh) * 2004-02-27 2007-04-11 先灵公司 用作丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的含环丁烯二酮基团化合物
CA2565519A1 (en) * 2004-05-12 2005-12-01 Schering Corporation Cxcr1 and cxcr2 chemokine antagonists
TW200626155A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CN101084211A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为治疗剂的用途
AU2005286728A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
JP4958785B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼインヒビターとしてのそれらの使用
BRPI0515483A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase
WO2006034441A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
WO2007130075A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
CN101253180B (zh) 2005-06-29 2011-08-03 先灵公司 作为cxc-化学活素受体配体的5，6-二取代的*二唑吡嗪和噻二唑吡嗪
MX2008015004A (es) * 2006-05-26 2008-12-05 Abbott Lab Inhibidores de cinasas de tipo polo.
CN101500544B (zh) * 2006-06-12 2012-08-08 先灵公司 Cxcr2或cxcr1与cxcr2两者的选择性拮抗剂的药物制剂和组合物及其用于治疗炎性疾病的使用方法
KR20090028811A (ko) * 2006-07-07 2009-03-19 쉐링 코포레이션 Ｃｘｃ-케모카인 수용체 리간드로서의 3,4-이치환된 사이클로부텐-1,2-디온
KR20100031718A (ko) 2007-06-06 2010-03-24 노파르티스 아게 항-염증성 치환된 시클로부텐디온 화합물
WO2009005801A1 (en) * 2007-07-03 2009-01-08 Schering Corporation Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds
WO2009012375A2 (en) * 2007-07-19 2009-01-22 Wyeth Squarate kinase inhibitors
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
EP2344446A4 (en) 2008-10-17 2012-04-04 Akaal Pharma Pty Ltd S1P RECEPTOR MODULATORS
CN102186845B (zh) * 2008-10-17 2016-09-07 阿卡制药有限公司 S1p受体调节剂以及它们的用途
WO2010063802A1 (en) * 2008-12-05 2010-06-10 Novartis Ag 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists
WO2010091543A1 (en) * 2009-02-10 2010-08-19 Merck Sharp & Dohme Corp. Novel hydrazino-cyclobut-3-ene-1, 2-dione derivatives as cxcr2 antagonists
US20120263701A1 (en) 2009-08-24 2012-10-18 Volker Schellenberger Coagulation factor vii compositions and methods of making and using same
HUE043894T2 (hu) 2011-06-10 2019-09-30 Bioverativ Therapeutics Inc Koagulációt elõsegítõ vegyületek és alkalmazásuk módszerei
PT2760821T (pt) 2011-09-02 2018-01-11 Novartis Ag Sal de colina de um composto anti-inflamatório de ciclobutenodiona substituída
FR2981936B1 (fr) 2011-10-28 2013-12-20 Galderma Res & Dev Nouveaux composes di-substitues de la diamino-3,4-cyclobutene-3-dione-1,2 utiles dans le traitement de pathologies mediees par des chimiokines.
MX369862B (es) 2012-02-15 2019-11-25 Bioverativ Therapeutics Inc Composiciones del factor viii y metodos para hacerlas y usarlas.
NZ628014A (en) 2012-02-15 2016-09-30 Biogen Ma Inc Recombinant factor viii proteins
JP6120941B2 (ja) 2012-03-16 2017-04-26 アクシキン ファーマシューティカルズ インコーポレーテッド ３，５−ジアミノピラゾールキナーゼ阻害剤
AU2013270682A1 (en) 2012-06-08 2014-12-11 Biogen Ma Inc. Procoagulant compounds
CA2875247A1 (en) 2012-06-08 2013-12-12 Biogen Idec Ma Inc. Chimeric clotting factors
EP2908847B1 (en) 2012-10-18 2022-03-30 Bioverativ Therapeutics Inc. Methods of using a fixed dose of a clotting factor
ES2959747T3 (es) 2013-02-15 2024-02-28 Bioverativ Therapeutics Inc Gen del factor VIII optimizado
WO2015023894A1 (en) 2013-08-14 2015-02-19 Biogen Idec Ma Inc. Recombinant factor viii proteins
EP3033097B1 (en) 2013-08-14 2021-03-10 Bioverativ Therapeutics Inc. Factor viii-xten fusions and uses thereof
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
EP3048899B1 (en) 2013-09-25 2021-09-08 Bioverativ Therapeutics Inc. On-column viral inactivation methods
EP3197481A1 (en) 2014-09-26 2017-08-02 Bayer Pharma Aktiengesellschaft Stabilized adrenomedullin derivatives and use thereof
EA201700181A1 (ru) 2014-10-14 2017-09-29 Галозим, Инк. Композиции аденозиндеаминазы-2 (ада-2), их варианты и способы использования
KR102034202B1 (ko) 2014-12-23 2019-10-18 에스엠에이 세라퓨틱스 아이엔씨. 3,5-디아미노피라졸 키나제 억제제
EP3309146A4 (en) 2015-06-12 2019-02-27 University of Tsukuba SULPHONAMID DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITIVE SALT THEREOF
CA2994547A1 (en) 2015-08-03 2017-02-09 Bioverativ Therapeutics Inc. Factor ix fusion proteins and methods of making and using same
TWI724056B (zh) * 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
EP3411478B1 (en) 2016-02-01 2022-06-08 Bioverativ Therapeutics Inc. Optimized factor viii genes
WO2018102743A1 (en) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
GB201708856D0 (en) * 2017-06-02 2017-07-19 Ucb Biopharma Sprl Seletalisib crystalline forms
EP3668832A1 (en) 2017-08-14 2020-06-24 Allergan, Inc. 3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof
JP7322036B2 (ja) 2018-01-08 2023-08-07 ケモセントリックス，インコーポレイティド Ｃｃｒ６またはｃｘｃｒ２のアンタゴニストを用いて汎発性膿疱性乾癬を治療する方法
SG11202010767SA (en) 2018-05-18 2020-11-27 Bioverativ Therapeutics Inc Methods of treating hemophilia a
CN110577472B (zh) * 2018-06-11 2023-06-02 重庆博腾制药科技股份有限公司 一种(1r,3s)-3-氨基-1-环戊醇盐酸盐的制备方法
US12226451B2 (en) 2018-07-03 2025-02-18 Bristol-Myers Squibb Company FGF-21 formulations
EP3852879A1 (en) 2018-09-21 2021-07-28 Pfizer Inc. N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides useful as ccr6 inhibitors
EP4015501A1 (en) * 2020-12-16 2022-06-22 Consejo Superior de Investigaciones Científicas (CSIC) N-benzyl-alpha-aminoamides as anaphase-promoting complex/cyclosome (apc/c) inhibitors
WO2024222865A1 (zh) * 2023-04-28 2024-10-31 武汉朗来科技发展有限公司 作为ccr6拮抗剂的化合物、其药物组合物和用途
WO2025092968A1 (zh) * 2023-11-03 2025-05-08 武汉朗来科技发展有限公司 作为ccr6拮抗剂的化合物、其药物组合物和用途

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1669798A1 (de) * 1966-07-28 1971-08-26 Huels Chemische Werke Ag Verfahren zum Stabilisieren markomolekularer Polyacetale
CS214745B2 (en) * 1976-08-28 1982-05-28 Huels Chemische Werke Ag Shaped and non-shaped products from plastic materials
DE3309655A1 (de) 1983-03-17 1984-09-20 Bayer Ag, 5090 Leverkusen 1,2,5-thiadiazol-1-oxide und 1,1-dioxide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS60255756A (ja) * 1984-06-01 1985-12-17 Ikeda Mohandou:Kk アミノアルキルフエノキシ誘導体
US4978665A (en) 1987-01-20 1990-12-18 Nissan Chemical Industries Ltd. 3(2H)pyridazinone, and antagonistic agent against SRS-A containing it
JPH02256668A (ja) 1988-12-20 1990-10-17 Nissan Chem Ind Ltd ピリダジノン誘導体
CA2074864A1 (en) * 1991-07-30 1993-01-31 Carmen Almansa Tetralones with pharmacological activity
US5206252A (en) * 1992-05-08 1993-04-27 American Home Products Corporation Thiadiazolyl-amino derivatives of benzopyrans and indanes
JPH0692915A (ja) * 1992-07-28 1994-04-05 Sumitomo Metal Ind Ltd １，２−ジアミノシクロブテン−３，４−ジオン誘導体及びその用途
GB9312210D0 (en) * 1993-06-14 1993-07-28 Smithkline Beecham Plc Chemical compounds
US5506252A (en) * 1993-11-17 1996-04-09 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5354763A (en) * 1993-11-17 1994-10-11 American Home Products Corporation Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones
US5466712A (en) * 1994-11-04 1995-11-14 American Home Products Corporation Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones
JPH10509145A (ja) 1994-11-16 1998-09-08 アメリカン・ホーム・プロダクツ・コーポレイション ジアミノシクロブテン−３，４−ジオン
US6709594B2 (en) 1995-11-02 2004-03-23 Dh20, L.L.C. Method for treating waste-activated sludge using electroporation
DE69717841T2 (de) * 1996-07-17 2003-05-28 Wyeth, Madison Substituierte n-arylmethylamino-cyclobuten-3,4-dion-derivate
US6174905B1 (en) * 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
JP3354090B2 (ja) * 1996-09-30 2002-12-09 シエーリング アクチエンゲゼルシャフト 分化誘導剤
UA52698C2 (uk) * 1996-10-04 2003-01-15 Х. Луннбек А/С Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі
CN1217660C (zh) * 1997-01-23 2005-09-07 史密丝克莱恩比彻姆公司 Il－8受体拮抗剂
US5840764A (en) * 1997-01-30 1998-11-24 American Home Products Corporation Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
WO1998033763A1 (en) * 1997-01-30 1998-08-06 American Home Products Corporation Substituted hydroxy-anilino derivatives of cyclobutene-3,4-diones
AR015425A1 (es) * 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
US6214877B1 (en) * 1998-05-12 2001-04-10 John A. Butera 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
DE69903053T2 (de) 1998-10-02 2003-05-22 Neurosearch A/S, Ballerup Diaminocyclobuten-3,4-dionderivate, deren herstellung und deren verwendung
WO2000021927A2 (en) 1998-10-08 2000-04-20 Smithkline Beecham Plc Pyrrole-2,5-diones as gsk-3 inhibitors
US6211220B1 (en) * 1998-11-23 2001-04-03 Cell Pathways, Inc. Method for treating neoplasia with amino or pyridylamino cyclobutene derivatives
US6376555B1 (en) * 1998-12-04 2002-04-23 American Home Products Corporation 4-substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones and analogs thereof as novel potassium channel openers
US6166050A (en) * 1998-12-14 2000-12-26 American Home Products Corporation 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by VLA-4
CA2351464A1 (en) * 1998-12-14 2000-06-22 Joan E. Sabalski 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by vla-4
US6420396B1 (en) * 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
DE69927050T2 (de) * 1998-12-16 2006-06-29 Bayer Healthcare Ag Biphenylverbindungen und biphenyl-analoge als intergrin-antagonisten
US6677360B2 (en) * 1998-12-16 2004-01-13 Bayer Aktiengesellschaft Biphenyl and biphenyl-analogous compounds as integrin antagonists
FR2792635B1 (fr) * 1999-04-20 2001-06-01 Synthelabo Derives de cyclobutene-3,4-dione leur preparation et leur application en therapeutique
US6518283B1 (en) * 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
CA2386049A1 (en) 1999-10-15 2001-04-26 Daniel S. Gardner Bicyclic and tricyclic amines as modulators of chemokine receptor activity
AR033803A1 (es) 2000-03-01 2004-01-07 Smithkline Beecham Corp Compuestos de dianilino escuarano, composiciones farmaceuticas que los comprenden, y el uso de los mismos en la fabricacion de medicamentos para tratar enfermedades mediadas por quimioquinas
WO2001064691A1 (en) 2000-03-01 2001-09-07 Smithkline Beecham Corporation Il-8 receptor antagonists
GB0006050D0 (en) 2000-03-14 2000-05-03 Johnson Matthey Plc Liquid gold compositions
EP1274415A4 (en) * 2000-03-14 2005-09-07 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
EP1284956A4 (en) * 2000-05-30 2005-08-24 Smithkline Beecham Corp ANTAGONISTS OF THE IL-8 RECEPTOR
JP2004505110A (ja) * 2000-08-02 2004-02-19 セルテック　アール　アンド　ディ　リミテッド ３位置換イソキノリン−１−イル誘導体
AU2002223492A1 (en) * 2000-11-14 2002-05-27 Neurosearch A/S Use of malaria parasite anion channel blockers for treating malaria
US20040048897A1 (en) 2001-01-16 2004-03-11 Mccleland Brent Il-8 receptor antagonists
US20040132694A1 (en) 2001-01-16 2004-07-08 Palovich Michael R. Il-8 receptor antagonists
RU2003126913A (ru) 2001-02-02 2005-03-10 Шеринг Корпорейшн (US) 3,4-дизамещенные циклобутен-1,2-дионы, как антагонисты хемокинового рецептора схс
US20030204085A1 (en) 2001-02-02 2003-10-30 Taveras Arthur G. 3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists
US20040097547A1 (en) * 2001-04-16 2004-05-20 Taveras Arthur G. 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
PT1818325E (pt) * 2001-04-16 2010-05-12 Schering Corp Ciclobuteno-1,2-dionas 3,4-di-substituídas como ligandos de receptor de quimoquina cxc
US7132445B2 (en) * 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US20040106794A1 (en) * 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
EP1434775A1 (en) 2001-10-12 2004-07-07 Schering Corporation 3,4-di-substituted maleimide compounds as cxc-chemokine receptor antagonists
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
BR0308739A (pt) * 2002-03-18 2005-01-11 Schering Corp Tratamentos em combinação para doenças mediadas por quimiocina
US20040186142A1 (en) 2002-10-09 2004-09-23 Schering Corporation Pharmacopeia, Inc. Thiadiazoledioxides and thiadiazoleoxides as CXC- and CC- chemokine receptor ligands
MXPA05011183A (es) * 2003-04-18 2005-12-14 Schering Corp Sintesis de 2-hidroxi-n, n-dimetil- 3-[[2-[1(r) -(5-metil -2-furanil) propil]amino]-3, 4-dioxo-1 -ciclobuten-1 -il]amino] benzamida.
DE602005022986D1 (de) 2004-01-30 2010-09-30 Schering Corp Kristalline polymorphe eines cxc-chemokinrezeptorliganden
US20080190441A1 (en) * 2007-02-13 2008-08-14 Michael Victor Vecchiola Ergonomic hair brush

Similar Documents

Publication Publication Date Title
JP2005534684A5 (enExample)
CA2496676A1 (en) 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine receptor ligands
FI91151C (sv) Förfarande för framställning av farmaceutiskt aktiva bensimidazolföreningar
RU2344123C9 (ru) 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокинового рецептора
AU2018294254B2 (en) Synthesis of omecamtiv mecarbil
KR102702618B1 (ko) 면역조절제
HRP20161463T1 (hr) Dimerni spojevi kao agonisti receptora fgf (fgfr), postupak za njihovu pripravu i njihova terapijska uporaba
JP2012524053A5 (enExample)
JP2004535447A5 (enExample)
WO2000032606A1 (en) IMIDAZO[4,5-b]PYRIDINIUMMETHYL-CONTAINING CEPHEM COMPOUNDS HAVING BROAD ANTIBACTERIAL SPECTRUM
JP2020500869A5 (enExample)
JP2002526501A5 (enExample)
KR20050106392A (ko) 로플루미라스트 신규한 제조 방법
DE3888415T2 (de) Salpetersäureester-Derivate.
CA2575777A1 (en) Compositions and methods for treatment of colitis using methimazole and/or cyclic thione derivatives
JP2022541467A (ja) オーロラキナーゼ阻害剤およびその使用
EP4313302A1 (en) Inhibitors of nlrp3 inflammasome
RU2012136473A (ru) Кислородзамещенные производные 3-гетероароиламинопропионовых кислот и их применение в качестве фармацевтических средств
CN102627778A (zh) 制备交联的聚烯丙基胺或其药学上可接受的盐的方法
AU733043B2 (en) Cyanoguanidines as cell proliferation inhibitors
JP2007525503A5 (enExample)
US12054489B2 (en) Substituted amidrazones as intermediates in the process for preparing soluble guanylate cyclase stimulators
JP2022505827A (ja) 置換インドール二量体の化合物
JP2011500796A (ja) 新規前駆体
WO2004085422A1 (en) Water-soluble thalidomine derivatives