BR0313109A - Ciclobuteno-1,2-dionas 3,4-dissubstituìdas como ligandos de receptor de quimiocina de cxc - Google Patents
Ciclobuteno-1,2-dionas 3,4-dissubstituìdas como ligandos de receptor de quimiocina de cxcInfo
- Publication number
- BR0313109A BR0313109A BR0313109-2A BR0313109A BR0313109A BR 0313109 A BR0313109 A BR 0313109A BR 0313109 A BR0313109 A BR 0313109A BR 0313109 A BR0313109 A BR 0313109A
- Authority
- BR
- Brazil
- Prior art keywords
- diones
- cyclobutene
- disubstituted
- chemokine receptor
- receptor ligands
- Prior art date
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- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
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- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- Organic Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
"CICLOBUTENO-1,2-DIONAS 3,4-DISSUBSTITUìDAS COMO LIGANDOS DE RECEPTOR DE QUIMIOCINA DE CXC". Revelados são os novos compostos da fórmula (I) ou um sal farmaceuticamente aceitável ou solvato destes. Também revelado é o tratamento de doenças mediadas por quimiocina usando os compostos da fórmula (II).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/208,412 US20040097547A1 (en) | 2001-04-16 | 2002-07-30 | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
US10/241,326 US20040106794A1 (en) | 2001-04-16 | 2002-09-11 | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
PCT/US2003/023785 WO2004011418A1 (en) | 2002-07-30 | 2003-07-30 | 3,4-di-substituted cyclobutene-1, 2-diones as cxc-chemokine receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0313109A true BR0313109A (pt) | 2005-06-21 |
Family
ID=31190690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0313109-2A BR0313109A (pt) | 2002-07-30 | 2003-07-30 | Ciclobuteno-1,2-dionas 3,4-dissubstituìdas como ligandos de receptor de quimiocina de cxc |
Country Status (15)
Country | Link |
---|---|
US (4) | US20040106794A1 (pt) |
EP (1) | EP1539678B1 (pt) |
JP (1) | JP2005534684A (pt) |
KR (1) | KR20050026060A (pt) |
AU (1) | AU2003259302B2 (pt) |
BR (1) | BR0313109A (pt) |
CA (1) | CA2496676C (pt) |
IL (1) | IL166427A0 (pt) |
MX (1) | MXPA05001274A (pt) |
NO (1) | NO20051036L (pt) |
NZ (1) | NZ538521A (pt) |
PL (1) | PL374876A1 (pt) |
RU (1) | RU2005105692A (pt) |
TW (1) | TW200716520A (pt) |
WO (1) | WO2004011418A1 (pt) |
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-
2002
- 2002-09-11 US US10/241,326 patent/US20040106794A1/en not_active Abandoned
-
2003
- 2003-07-30 EP EP03772075A patent/EP1539678B1/en not_active Expired - Lifetime
- 2003-07-30 KR KR1020057001672A patent/KR20050026060A/ko not_active Application Discontinuation
- 2003-07-30 MX MXPA05001274A patent/MXPA05001274A/es active IP Right Grant
- 2003-07-30 PL PL03374876A patent/PL374876A1/xx not_active Application Discontinuation
- 2003-07-30 TW TW095140972A patent/TW200716520A/zh unknown
- 2003-07-30 WO PCT/US2003/023785 patent/WO2004011418A1/en active Application Filing
- 2003-07-30 RU RU2005105692/04A patent/RU2005105692A/ru not_active Application Discontinuation
- 2003-07-30 BR BR0313109-2A patent/BR0313109A/pt not_active IP Right Cessation
- 2003-07-30 JP JP2004524185A patent/JP2005534684A/ja active Pending
- 2003-07-30 CA CA2496676A patent/CA2496676C/en not_active Expired - Fee Related
- 2003-07-30 NZ NZ538521A patent/NZ538521A/en unknown
- 2003-07-30 IL IL16642703A patent/IL166427A0/xx unknown
- 2003-07-30 AU AU2003259302A patent/AU2003259302B2/en not_active Ceased
-
2005
- 2005-02-25 NO NO20051036A patent/NO20051036L/no not_active Application Discontinuation
-
2006
- 2006-08-08 US US11/500,739 patent/US7964646B2/en not_active Expired - Fee Related
-
2009
- 2009-01-13 US US12/352,781 patent/US7947720B2/en not_active Expired - Fee Related
-
2011
- 2011-05-06 US US13/102,554 patent/US20110213029A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1539678A1 (en) | 2005-06-15 |
RU2005105692A (ru) | 2005-12-10 |
US7964646B2 (en) | 2011-06-21 |
US20090306079A1 (en) | 2009-12-10 |
NZ538521A (en) | 2008-02-29 |
EP1539678B1 (en) | 2012-09-05 |
PL374876A1 (en) | 2005-11-14 |
TW200716520A (en) | 2007-05-01 |
US20040106794A1 (en) | 2004-06-03 |
US20110213029A1 (en) | 2011-09-01 |
JP2005534684A (ja) | 2005-11-17 |
IL166427A0 (en) | 2006-01-15 |
CA2496676C (en) | 2011-06-14 |
KR20050026060A (ko) | 2005-03-14 |
NO20051036L (no) | 2005-04-20 |
US20070021494A1 (en) | 2007-01-25 |
MXPA05001274A (es) | 2005-09-08 |
US7947720B2 (en) | 2011-05-24 |
AU2003259302A1 (en) | 2004-02-16 |
AU2003259302B2 (en) | 2008-06-26 |
CA2496676A1 (en) | 2004-02-05 |
WO2004011418A1 (en) | 2004-02-05 |
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