JP2004506723A5 - - Google Patents
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- Publication number
- JP2004506723A5 JP2004506723A5 JP2002521434A JP2002521434A JP2004506723A5 JP 2004506723 A5 JP2004506723 A5 JP 2004506723A5 JP 2002521434 A JP2002521434 A JP 2002521434A JP 2002521434 A JP2002521434 A JP 2002521434A JP 2004506723 A5 JP2004506723 A5 JP 2004506723A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- lower alkyl
- chelating
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 71
- 150000001875 compounds Chemical class 0.000 claims 58
- 239000002184 metal Substances 0.000 claims 45
- 229910052751 metal Inorganic materials 0.000 claims 45
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 31
- 229910052739 hydrogen Inorganic materials 0.000 claims 27
- 231100000252 nontoxic Toxicity 0.000 claims 17
- 230000003000 nontoxic effect Effects 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- 229910052702 rhenium Inorganic materials 0.000 claims 16
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 13
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 13
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 12
- 210000004556 brain Anatomy 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 208000024827 Alzheimer disease Diseases 0.000 claims 7
- 208000037259 Amyloid Plaque Diseases 0.000 claims 6
- 210000001638 cerebellum Anatomy 0.000 claims 6
- 239000000243 solution Substances 0.000 claims 6
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 150000001412 amines Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000001574 biopsy Methods 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 238000002372 labelling Methods 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 238000000386 microscopy Methods 0.000 claims 2
- 230000002194 synthesizing effect Effects 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 108010060159 Apolipoprotein E4 Proteins 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 239000012062 aqueous buffer Substances 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- 238000000339 bright-field microscopy Methods 0.000 claims 1
- 238000004624 confocal microscopy Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 claims 1
- 208000015756 familial Alzheimer disease Diseases 0.000 claims 1
- 238000000799 fluorescence microscopy Methods 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000011503 in vivo imaging Methods 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 230000010287 polarization Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 1
- 238000004611 spectroscopical analysis Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22760100P | 2000-08-24 | 2000-08-24 | |
| US60/227,601 | 2000-08-24 | ||
| PCT/US2001/026427 WO2002016333A2 (en) | 2000-08-24 | 2001-08-24 | Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011266396A Division JP2012102106A (ja) | 2000-08-24 | 2011-12-06 | アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004506723A JP2004506723A (ja) | 2004-03-04 |
| JP2004506723A5 true JP2004506723A5 (enExample) | 2005-12-22 |
| JP5022554B2 JP5022554B2 (ja) | 2012-09-12 |
Family
ID=22853739
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002521434A Expired - Lifetime JP5022554B2 (ja) | 2000-08-24 | 2001-08-24 | アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体 |
| JP2011266396A Pending JP2012102106A (ja) | 2000-08-24 | 2011-12-06 | アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011266396A Pending JP2012102106A (ja) | 2000-08-24 | 2011-12-06 | アルツハイマー病の生前診断ならびにアミロイド沈着物のインビボ画像化および予防に用いるためのチオフラビン誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US20020133019A1 (enExample) |
| EP (2) | EP2264018B1 (enExample) |
| JP (2) | JP5022554B2 (enExample) |
| CN (1) | CN1285582C (enExample) |
| AU (3) | AU8670201A (enExample) |
| BR (1) | BRPI0113470B8 (enExample) |
| CA (1) | CA2419420C (enExample) |
| CY (1) | CY1113311T1 (enExample) |
| DK (2) | DK2264018T3 (enExample) |
| ES (2) | ES2395721T3 (enExample) |
| HU (2) | HU230581B1 (enExample) |
| LT (1) | LTC1334091I2 (enExample) |
| NO (1) | NO330176B1 (enExample) |
| PL (1) | PL215711B1 (enExample) |
| PT (2) | PT2264018E (enExample) |
| RU (1) | RU2324686C2 (enExample) |
| SI (1) | SI1334091T1 (enExample) |
| WO (1) | WO2002016333A2 (enExample) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689753B1 (en) * | 1999-11-05 | 2004-02-10 | Axonyx, Inc. | β sheet breaker peptide analogs that inhibit β pleated sheet formation in amyloid β-peptide |
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| HU230581B1 (hu) * | 2000-08-24 | 2017-01-30 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében |
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| WO2003099206A2 (en) | 2002-05-21 | 2003-12-04 | Bristol-Myers Squibb Company | Indole compounds useful as impdh inhibitors |
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| US20070003552A1 (en) * | 2002-07-09 | 2007-01-04 | Gebbink Martijn F B | Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation |
| EP1380290A1 (en) * | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-beta structure pathway and its therapeutic relevance |
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| PT1988397E (pt) | 2002-12-19 | 2011-12-02 | Scripps Research Inst | Composições e utilizações para estabilização da transtirretina e inibição do enrolamento |
| GB0229686D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
| CN102532055B (zh) * | 2003-03-14 | 2016-05-11 | 匹兹堡大学联邦制高等教育 | 苯并噻唑衍生物化合物、组合物及用途 |
| CA2438032C (en) * | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| GB0307855D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Organic compounds |
| US20040223912A1 (en) * | 2003-05-07 | 2004-11-11 | Montalto Michael Christopher | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
| WO2004100998A2 (en) | 2003-05-07 | 2004-11-25 | General Electric Company | Compositions and methods for non-invasive imaging of soluble beta-amyloid |
| MXPA06001742A (es) * | 2003-08-13 | 2006-08-11 | Bf Res Inst Inc | Sondas para enfermedades en las cuales se acumula amiloide, agentes para tincion del amiloide, farmacos para tratamiento y profilaxis de enfermedades con amiloide acumulado, y sondas para diagnostico de ovillos neurofibrilares y agentes para tincion |
| WO2005016384A1 (ja) * | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤 |
| US8236282B2 (en) | 2003-08-22 | 2012-08-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Benzothiazole derivative compounds, compositions and uses |
| WO2005042461A1 (ja) * | 2003-10-30 | 2005-05-12 | Dojindo Laboratories | アミロイド親和性化合物 |
| JP4910695B2 (ja) * | 2004-02-25 | 2012-04-04 | アステラス製薬株式会社 | 血栓造影剤 |
| AU2005237520B2 (en) | 2004-04-27 | 2012-01-19 | Wyeth | Purification of progesterone receptor modulators |
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| CA2587253A1 (en) * | 2004-07-02 | 2006-02-09 | William E. Klunk | A method of diagnosing prodromal forms of diseases associated with amyloid deposition |
| CA2830939C (en) | 2004-07-02 | 2017-02-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of thioflavin radiolabelled derivatives in amyloid imaging for identifying patients prodromal to a disease associated with amyloid deposition |
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| KR100778888B1 (ko) * | 2005-11-29 | 2007-11-28 | 재단법인서울대학교산학협력재단 | 베타아밀로이드 펩타이드 플라크의 영상화를 위한벤질리덴아닐린 계열의 유도체 및 그의 방사성 동위원소표지화합물 |
| US8022075B2 (en) | 2005-11-30 | 2011-09-20 | Fujifilm Ri Pharma Co., Ltd. | Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition |
| EP1971584A2 (en) * | 2005-12-01 | 2008-09-24 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Isotopically-labeled benzothiazole compounds as imaging agents for amyloidogenic proteins |
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| JP5182747B2 (ja) * | 2006-03-28 | 2013-04-17 | 国立大学法人滋賀医科大学 | 神経難病の画像診断薬 |
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| JP5896739B2 (ja) * | 2008-06-09 | 2016-03-30 | ルートヴィヒ‐マクシミリアンズ‐ウニヴェルジテート・ミュンヘン | タンパク質凝集関連の疾患および／または神経変性性疾患に関係するタンパク質の凝集を阻害するための新規薬物 |
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| EP2619590A2 (de) | 2010-09-20 | 2013-07-31 | Technische Universität Darmstadt | Verbindungen für die diagnostik neurodegenerativer erkrankungen an der retina |
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- 2001-08-24 ES ES01966165T patent/ES2395721T3/es not_active Expired - Lifetime
- 2001-08-24 DK DK10185669.8T patent/DK2264018T3/en active
- 2001-08-24 SI SI200131017T patent/SI1334091T1/sl unknown
- 2001-08-24 US US09/935,767 patent/US20020133019A1/en not_active Abandoned
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- 2001-08-24 PT PT1966165T patent/PT1334091E/pt unknown
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