AU2001286702B2 - Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease - Google Patents

Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease Download PDF

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Publication number
AU2001286702B2
AU2001286702B2 AU2001286702A AU2001286702A AU2001286702B2 AU 2001286702 B2 AU2001286702 B2 AU 2001286702B2 AU 2001286702 A AU2001286702 A AU 2001286702A AU 2001286702 A AU2001286702 A AU 2001286702A AU 2001286702 B2 AU2001286702 B2 AU 2001286702B2
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group
compound
amyloid
rph
tissue
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AU2001286702A1 (en
Inventor
William E. Klunk
Chester A. Mathis Jr.
Yanming Wang
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University of Pittsburgh
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University of Pittsburgh
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Priority to AU2008202626A priority Critical patent/AU2008202626B9/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nuclear Medicine (AREA)
AU2001286702A 2000-08-24 2001-08-24 Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease Expired AU2001286702B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2008202626A AU2008202626B9 (en) 2000-08-24 2008-06-13 Thioflavin derivatives and their use in diagnosis and therapy of Alzheimer's disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22760100P 2000-08-24 2000-08-24
US60/227,601 2000-08-24
PCT/US2001/026427 WO2002016333A2 (en) 2000-08-24 2001-08-24 Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease

Related Child Applications (1)

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AU2008202626A Division AU2008202626B9 (en) 2000-08-24 2008-06-13 Thioflavin derivatives and their use in diagnosis and therapy of Alzheimer's disease

Publications (2)

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AU2001286702A1 AU2001286702A1 (en) 2002-05-30
AU2001286702B2 true AU2001286702B2 (en) 2008-03-13

Family

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Application Number Title Priority Date Filing Date
AU2001286702A Expired AU2001286702B2 (en) 2000-08-24 2001-08-24 Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease
AU8670201A Pending AU8670201A (en) 2000-08-24 2001-08-24 Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition
AU2008202626A Expired AU2008202626B9 (en) 2000-08-24 2008-06-13 Thioflavin derivatives and their use in diagnosis and therapy of Alzheimer's disease

Family Applications After (2)

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AU8670201A Pending AU8670201A (en) 2000-08-24 2001-08-24 Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition
AU2008202626A Expired AU2008202626B9 (en) 2000-08-24 2008-06-13 Thioflavin derivatives and their use in diagnosis and therapy of Alzheimer's disease

Country Status (18)

Country Link
US (5) US20020133019A1 (enExample)
EP (2) EP2264018B1 (enExample)
JP (2) JP5022554B2 (enExample)
CN (1) CN1285582C (enExample)
AU (3) AU2001286702B2 (enExample)
BR (1) BRPI0113470B8 (enExample)
CA (1) CA2419420C (enExample)
CY (1) CY1113311T1 (enExample)
DK (2) DK2264018T3 (enExample)
ES (2) ES2536449T3 (enExample)
HU (2) HU230581B1 (enExample)
LT (1) LTC1334091I2 (enExample)
NO (1) NO330176B1 (enExample)
PL (1) PL215711B1 (enExample)
PT (2) PT2264018E (enExample)
RU (1) RU2324686C2 (enExample)
SI (1) SI1334091T1 (enExample)
WO (1) WO2002016333A2 (enExample)

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