HUP0302956A2 - Tioflavinszármazékok az Alzheimer-kór antemortem diagnózisában történő alkalmazásra, eljárás a vegyületek előállítására és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Tioflavinszármazékok az Alzheimer-kór antemortem diagnózisában történő alkalmazásra, eljárás a vegyületek előállítására és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0302956A2
HUP0302956A2 HU0302956A HUP0302956A HUP0302956A2 HU P0302956 A2 HUP0302956 A2 HU P0302956A2 HU 0302956 A HU0302956 A HU 0302956A HU P0302956 A HUP0302956 A HU P0302956A HU P0302956 A2 HUP0302956 A2 HU P0302956A2
Authority
HU
Hungary
Prior art keywords
atom
compounds
preparation
group
alzheimer
Prior art date
Application number
HU0302956A
Other languages
English (en)
Inventor
William E. Klunk
Chester A. Mathis
Yanming Wang
Original Assignee
University Of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Pittsburgh filed Critical University Of Pittsburgh
Publication of HUP0302956A2 publication Critical patent/HUP0302956A2/hu
Publication of HUP0302956A3 publication Critical patent/HUP0302956A3/hu
Publication of HU230375B1 publication Critical patent/HU230375B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Abstract

Az (A)-(E) általános képletű amiloidkötő vegyületek vagy azokvízoldékony, nem toxikus sói, ahol a képletben Z jelentése - egyebekmellett - S-atom, Y jelentése NR1R2-, OR2- vagy SR2-csoport, Zjelentése egyebek mellett -C(R')2-csoport, ahol a képletben R'jelentése H-atom vagy rövid szénláncú alkilcsoport, Y jelentéseNR1R2-, OR2- vagy SR2-csoport, mind R1, mind R2 jelentése egymástólfüggetlenül - egyebek mellett - H-atom, és ahol az R3-R14 csoportokjelentése egymástól függetlenül - egyebek mellett - H-atom, Atalálmány tárgya továbbá eljárás azon vegyületek előállítására,amelyek az R1-R14 szubsztituensek közül legalább egy esetében 131I-,125I-, 123I-, 76Br-, 75Br-, 18F- vagy 19F-izotópot tartalmaznak, amelyszerint az amiloidkötő vegyületet radioaktív jelzéssel látják el (aholaz R1-R14 szubsztituensek közül legalább egy jelentése trialkil-ón) avegyületnek egy 131I-, 125I-, 123I-, 76Br-, 75Br-, 18F- vagy 19F-atomot tartalmazó anyaggal történő reagáltatása útján. A találmánytárgya továbbá egy gyógyászati készítmény amiloid-lerakódások in vivoleképezésére, amely (a) találmány szerinti vegyületet és (b)gyógyászatilag elfogadható vivőanyagot tartalmaz. Ó
HU0302956A 2000-08-24 2001-08-24 Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében HU230375B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22760100P 2000-08-24 2000-08-24
US60/227,601 2000-08-24
PCT/US2001/026427 WO2002016333A2 (en) 2000-08-24 2001-08-24 Thioflavin derivatives and their use in diagnosis and theraphy of alzheimer's disease

Publications (3)

Publication Number Publication Date
HUP0302956A2 true HUP0302956A2 (hu) 2003-12-29
HUP0302956A3 HUP0302956A3 (en) 2006-05-29
HU230375B1 HU230375B1 (hu) 2016-03-29

Family

ID=22853739

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0302956A HU230375B1 (hu) 2000-08-24 2001-08-24 Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében
HU1500560A HU230581B1 (hu) 2000-08-24 2001-08-24 Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében

Family Applications After (1)

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HU1500560A HU230581B1 (hu) 2000-08-24 2001-08-24 Tioflavin-származékok és alkalmazásuk az Alzheimer-kór diagnózisában és kezelésében

Country Status (19)

Country Link
US (5) US20020133019A1 (hu)
EP (2) EP1334091B1 (hu)
JP (2) JP5022554B2 (hu)
CN (1) CN1285582C (hu)
AU (3) AU8670201A (hu)
BR (1) BRPI0113470B8 (hu)
CA (1) CA2419420C (hu)
CY (1) CY1113311T1 (hu)
DK (2) DK1334091T3 (hu)
ES (2) ES2536449T3 (hu)
HK (2) HK1058041A1 (hu)
HU (2) HU230375B1 (hu)
LT (1) LTC1334091I2 (hu)
NO (1) NO330176B1 (hu)
PL (1) PL215711B1 (hu)
PT (2) PT2264018E (hu)
RU (1) RU2324686C2 (hu)
SI (1) SI1334091T1 (hu)
WO (1) WO2002016333A2 (hu)

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