ATE554394T1 - Cross-beta-struktur-bindende verbindungen - Google Patents

Cross-beta-struktur-bindende verbindungen

Info

Publication number
ATE554394T1
ATE554394T1 AT06783842T AT06783842T ATE554394T1 AT E554394 T1 ATE554394 T1 AT E554394T1 AT 06783842 T AT06783842 T AT 06783842T AT 06783842 T AT06783842 T AT 06783842T AT E554394 T1 ATE554394 T1 AT E554394T1
Authority
AT
Austria
Prior art keywords
cross
beta structure
structure binding
binding connections
cross beta
Prior art date
Application number
AT06783842T
Other languages
English (en)
Inventor
Martijn Gebbink
Barend Bouma
Original Assignee
Crossbeta Biosciences Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crossbeta Biosciences Bv filed Critical Crossbeta Biosciences Bv
Application granted granted Critical
Publication of ATE554394T1 publication Critical patent/ATE554394T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06783842T 2005-07-13 2006-07-13 Cross-beta-struktur-bindende verbindungen ATE554394T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05076613 2005-07-13
PCT/NL2006/000364 WO2007008072A2 (en) 2005-07-13 2006-07-13 CROSS-ß STRUCTURE BINDING COMPOUNDS

Publications (1)

Publication Number Publication Date
ATE554394T1 true ATE554394T1 (de) 2012-05-15

Family

ID=34938373

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06783842T ATE554394T1 (de) 2005-07-13 2006-07-13 Cross-beta-struktur-bindende verbindungen

Country Status (7)

Country Link
US (1) US8067187B2 (de)
EP (2) EP2386861A3 (de)
AT (1) ATE554394T1 (de)
AU (1) AU2006267176A1 (de)
CA (1) CA2615028A1 (de)
WO (1) WO2007008072A2 (de)
ZA (1) ZA200800862B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1820806A1 (de) * 2006-02-16 2007-08-22 Crossbeta Biosciences B.V. Affinitätsbereiche
US20070003552A1 (en) * 2002-07-09 2007-01-04 Gebbink Martijn F B Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation
EP1380290A1 (de) * 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-Beta-Strukturweg und seine therapeutische Relevanz
US20090202980A1 (en) * 2005-03-21 2009-08-13 Crossbeta Biosciences B.V. Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation
CA2615028A1 (en) 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. Cross-.beta. structure binding compounds
EP1907864A2 (de) * 2005-07-13 2008-04-09 Crossbeta Biosciences B.V. Verfahren zur bestimmung der auswirkung einer behandlung auf den cross-beta struktur-gehalt eines proteins; auswahl von behandlungen und verwendungen davon
US8114832B2 (en) * 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
WO2007008070A2 (en) * 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. ADJUVATION THROUGH CROSS-β STRUCTURE
EP2007800A1 (de) * 2006-03-17 2008-12-31 Crossbeta Biosciences B.V. Verfahren zur bindung von kreuz-beta-strukturen durch chaperone
EP2058001A1 (de) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Steigerung der Immunogenizität von Antigenen
EP2058000A1 (de) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Zur Aktivierung von T-Zellen fähige immunogene Zusammensetzung
US20150291547A1 (en) * 2011-09-26 2015-10-15 Nanyang Polytechnic Small molecules for extending the well being of cells and methods of use thereof
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700447A (en) 1992-05-21 1997-12-23 The Picowder Institute For Medical Research Methods and materials for the diagnosis and treatment of conditions such as stroke
US5869534A (en) 1992-05-21 1999-02-09 The Picower Institute For Medical Research Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom
US5733524A (en) 1984-03-19 1998-03-31 The Picower Institute For Medical Research Methods and materials for the diagnosis and treatment of conditions such as stroke
US5733933A (en) 1984-03-19 1998-03-31 The Picower Institute For Medical Research Methods and materials for the diagnosis and treatment of conditions such as stroke
US5801200A (en) 1984-03-19 1998-09-01 The Picower Institute For Medical Research Methods and materials for the diagnosis and treatment of conditions such as stroke
DE3682891D1 (de) 1986-02-17 1992-01-23 Stichting Centraal Lab Gewebeplasminogen-aktivator-mutant, dafuer kodierende rekombinante genetische information und verfahren zur herstellung dieser mutanten, deren verwendung und pharmazeutische zusammensetzungen.
EP0319144A1 (de) 1987-11-06 1989-06-07 Asahi Kasei Kogyo Kabushiki Kaisha Sorbentmittel für beta-2-Mikroglobulin
US5216127A (en) 1987-11-20 1993-06-01 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Adsorbent for serum amyloid protein
EP0321703B1 (de) 1987-11-20 1993-04-28 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Sorbentmittel für Serum-Amyloid-Proteine
US5151082A (en) 1988-08-05 1992-09-29 Heathdyne, Inc. Apparatus and method for kidney dialysis using plasma in lieu of blood
CA1335361C (en) 1989-05-24 1995-04-25 Andrei Z. Budzynski Thrombus-targeted complexes of plasminogen activator and fibrin fragments
US5180615A (en) 1989-12-13 1993-01-19 W.R. Grace & Co.-Conn. Metallized bag for static protection of electronic components
US5591431A (en) 1990-03-09 1997-01-07 G.D. Searle & Co. Enhancement of clot lysis
US5753624A (en) 1990-04-27 1998-05-19 Milkhaus Laboratory, Inc. Materials and methods for treatment of plaquing disease
US5650418A (en) 1990-06-04 1997-07-22 Therapy 2000 Therapeutic lysine salt composition and method of use
US5230996A (en) 1990-06-04 1993-07-27 Therapy 2000 Use of ascorbate and tranexamic acid solution for organ and blood vessel treatment prior to transplantation
US5278189A (en) 1990-06-04 1994-01-11 Rath Matthias W Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
US5780587A (en) 1990-08-24 1998-07-14 President And Fellows Of Harvard College Compounds and methods for inhibiting β-protein filament formation and neurotoxicity
SE468881B (sv) 1991-01-09 1993-04-05 Kabi Pharmacia Ab Anvaendning av vissa foereningar foer framstaellning av laekemedel foer behandling av endotoxininducerade effekter samt saett att avlaegsna endotoxiner ur diverse loesningar
US5221628A (en) 1991-03-19 1993-06-22 Northwestern University Binding of aggregated immunoglobulin or immune complexes by serum amyloid P component
US5276059A (en) 1992-07-10 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of diseases associated with amyloid formation
HUT64977A (en) 1992-07-30 1994-03-28 Yeda Res & Dev Synthetical peptone derivatives of vitronectine and pharmaceutical preparaties containing them
US5958883A (en) 1992-09-23 1999-09-28 Board Of Regents Of The University Of Washington Office Of Technology Animal models of human amyloidoses
DE4242736A1 (de) 1992-12-17 1994-06-23 Behringwerke Ag Synthetische Peptide, Antikörper dagegen und ihre Verwendung
US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5750349A (en) 1993-01-25 1998-05-12 Takeda Chemical Industries Ltd. Antibodies to β-amyloids or their derivatives and use thereof
US5560418A (en) * 1993-04-02 1996-10-01 Advantage Office Systems, L.L.C. Attachment bar for partition panel
US5449663A (en) 1993-06-11 1995-09-12 Bicher; Haim I. Antineoplastic compositions
JP3537440B2 (ja) 1993-12-17 2004-06-14 持田製薬株式会社 可溶性トロンボモジュリンを長期保存安定化させる方法
US6410598B1 (en) 1994-02-03 2002-06-25 Michael P. Vitek Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis
JPH09511492A (ja) 1994-02-03 1997-11-18 ザ ピコワー インスティテュート フォア メディカル リサーチ アミロイドーシスの前進性グリコシル化終末産物仲介モジュレーション用組成物及び方法
KR0163563B1 (ko) 1994-03-23 1998-12-01 김종인 피부질환 치료용 의약조성물
US5786324A (en) 1994-03-24 1998-07-28 Regents Of The University Of Minnesota Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use
US5589154A (en) 1994-11-22 1996-12-31 Rutgers, The State University Of New Jersey Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
US6136548A (en) 1994-11-22 2000-10-24 Rutgers, The State University Of New Jersey Methods for identifying useful T-PA mutant derivatives for treatment of vascular hemorrhaging
US5888774A (en) 1994-12-19 1999-03-30 Cangene Corporation Recombinant DNA molecules and expression vectors for erythropoietin
WO1996028471A1 (en) 1995-03-14 1996-09-19 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
US5817626A (en) 1995-03-14 1998-10-06 Praecis Pharmaceuticals Incorporated Modulators of beta-amyloid peptide aggregation
US5854215A (en) 1995-03-14 1998-12-29 Praecis Pharmaceuticals Incorporated Modulators of β-amyloid peptide aggregation
US5948763A (en) 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
US6436969B1 (en) 1995-09-12 2002-08-20 Kansas University Medical Center Research Institute Inc. Dialysis solutions and methods
CA2233059A1 (en) 1995-10-02 1997-04-10 Mohammad W. Katoot Biologically-active polymers
US5985242A (en) 1995-10-27 1999-11-16 Praecis Pharmaceuticals, Inc. Modulators of β-amyloid peptide aggregation comprising D-amino acids
US6310046B1 (en) 1995-11-17 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Sequestrin of Plasmodium falciparum
AU1529297A (en) 1996-01-24 1997-08-20 Warner-Lambert Company Method of imaging amyloid deposits
US5785187A (en) 1996-04-29 1998-07-28 Lipman; Daniel Mechandising display assembly
US6034211A (en) 1996-06-03 2000-03-07 Kelly; Jeffery W. β-sheet nucleating peptidomimetics
US6929807B1 (en) 1996-08-09 2005-08-16 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
US6689275B1 (en) 1996-12-31 2004-02-10 Ajay Gupta Method and pharmaceutical composition for replacing iron losses in dialysis patients
US6372473B1 (en) 1997-05-28 2002-04-16 Human Genome Sciences, Inc. Tissue plasminogen activator-like protease
US20020122807A1 (en) 1998-07-07 2002-09-05 Dan Michael D. Antigen binding fragments, designated 4B5, that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
DE19735902A1 (de) 1997-08-19 1999-02-25 Imtec Immundiagnostika Gmbh Selektives Adsorbens für biologische Materialien
DE69815122T2 (de) 1997-08-28 2003-12-24 University Of Washington, Seattle Saccharid-enthaltende zubereitungen zur behandlung von alzheimerschen erkrankung und von weiteren amyloidosen
CA2306875C (en) 1997-10-24 2011-01-04 John P. Blass Nutritional supplement for cerebral metabolic insufficiencies
JP4037525B2 (ja) 1998-03-25 2008-01-23 生化学工業株式会社 新規抗菌性ペプチド
US7041287B2 (en) 1998-05-21 2006-05-09 Trustees Of The University Of Pennsylvania Compositions and methods for selective dissolution of nascent intravascular blood clots
US6416963B1 (en) 1998-08-12 2002-07-09 New York Blood Center Cleaved fragments of fibrinogen
JP2002525323A (ja) 1998-09-25 2002-08-13 スノル・モレキュラー・コーポレーション 医薬活性化合物及びその使用方法
IN190822B (de) 1998-12-24 2003-08-23 Council Scient Ind Res
US6242473B1 (en) 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US6161547A (en) 1999-01-15 2000-12-19 Coaxia, Inc. Medical device for flow augmentation in patients with occlusive cerebrovascular disease and methods of use
AU4316600A (en) 1999-04-30 2000-11-17 Akira Matsumoto Human brain carboxypeptidase b
AT500670A1 (de) 1999-05-19 2006-02-15 Bio & Bio Licensing Sa Arzneimittel zur lokalen anwendung
GB9917725D0 (en) 1999-07-28 1999-09-29 Medical Res Council Peptides
EP1307219A4 (de) 1999-08-13 2005-04-06 Univ Columbia Verfahren zur hemmung der bindung von beta-faltblattfibrillen an rage( advanced glycation endproduct receptor )
US20040013647A1 (en) 1999-09-03 2004-01-22 Ramot At Tel-Aviv University Ltd. Methods and compositions for treating a plaque-forming disease
BR0014615A (pt) 1999-09-14 2002-06-18 Meiji Seika Kaisha Derivado de ácido fosfÈnico que apresenta atividade inibidora contra carboxipeptidase b
US6399314B1 (en) 1999-12-29 2002-06-04 American Cyanamid Company Methods of detection of amyloidogenic proteins
EP1252181B1 (de) 2000-01-20 2006-01-18 Regents Of The University Of Minnesota Peptide mit antibakterieller wirkung
WO2001058476A2 (en) 2000-02-11 2001-08-16 The European Molecular Biology Laboratory Methods and compositions for treatment of alzheimer's disease by enhancing plasmin or plasmin-like activity
AU783144B2 (en) 2000-02-21 2005-09-29 H. Lundbeck A/S Novel method for down-regulation of amyloid
HK1054865B (zh) 2000-02-21 2007-06-01 H. Lundbeck A/S 下调淀粉状蛋白的新方法
EP1130031A1 (de) 2000-02-25 2001-09-05 Universitair Medisch Centrum Utrecht Verfahren zur Hemmung der Angiogenese unter Verwendung von Molekülen die die Plasminbildung steigern oder die Plasminaktivität verlängern
US6686144B2 (en) 2000-03-21 2004-02-03 The Research Foundation Of The State University Of New York Adsorption of polyampholytes to charged surfaces and assays incorporating same
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US20020133019A1 (en) 2000-08-24 2002-09-19 Klunk William E. Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and vivo imaging and prevention of amyloid deposition
EP1186299A1 (de) 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht Diagnose, Verbeugung und/oder Behandlung von Atherosklerose, Infectionen und Störungen des Immunsystems
ATE347376T1 (de) 2000-12-28 2006-12-15 Biomay Prod & Handel Behandlung von allergien
EP1383885A4 (de) 2001-04-04 2005-11-30 American Diagnostica Inc Verfahren zur herstellung eines stabilisierten, mit thrombin aktivierbaren fibrinolyseinhibitors (tafi) sowie verfahren zu dessen verwendung
EP1395833B1 (de) 2001-05-31 2013-02-27 Adlyfe, Inc. Verfahren zum erkennen von inkorrekt gefalteten proteinen
US6960465B1 (en) 2001-06-27 2005-11-01 Northwestern University Increased cell resistance to toxic organic substances
US6737401B2 (en) 2001-06-28 2004-05-18 Metronic Minimed, Inc. Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom
EP1414491A4 (de) 2001-07-09 2005-07-06 Elan Pharm Inc Verfahren zur hemmung der toxizität von amyloid
JP2003024080A (ja) 2001-07-19 2003-01-28 Univ Tokyo p53依存性アポトーシス誘導タンパク質、およびアポトーシス調節剤のスクリーニング方法
GB0202275D0 (en) 2002-01-31 2002-03-20 Hansa Medica Ab Peptide
EP1820806A1 (de) 2006-02-16 2007-08-22 Crossbeta Biosciences B.V. Affinitätsbereiche
BRPI0307976B8 (pt) 2002-02-28 2021-07-27 Microsens Biophage Ltd processo para a ligação seletiva de uma forma anormal agregativa de uma proteína, e, processo ou ensaio quanto à presença de uma forma agregativa anormal de uma proteína de uma amostra
WO2003094937A1 (en) 2002-05-09 2003-11-20 Medigenes A pharmaceutical composition for treatment of wounds containing blood plasma or serum
US20070003552A1 (en) 2002-07-09 2007-01-04 Gebbink Martijn F B Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation
EP1380290A1 (de) 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-Beta-Strukturweg und seine therapeutische Relevanz
US20050142611A1 (en) 2002-09-30 2005-06-30 Auburn University Method of isolation and self-assembly of small protein particles from blood and other biological materials
US7470667B2 (en) 2002-12-05 2008-12-30 Medgenn (Hong Kong) Ltd Methods of treating cancer using a modified endostatin protein
EP1449536A1 (de) 2003-02-14 2004-08-25 Prionics AG Prioproteine als therapeutische mittel zur behandlung von AP-1 assoziierten krankheiten
US7172875B2 (en) 2003-02-18 2007-02-06 The Ohio State University Research Foundation Identifying inhibitors of intracellular protein fibrillization
CA2536918A1 (en) 2003-08-26 2005-03-03 Leland Shapiro Compositions of, and methods for, alpha-1 antitrypsin fc fusion molecules
US7427659B2 (en) 2003-10-24 2008-09-23 Amgen Inc. Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
US20090156471A1 (en) 2004-07-15 2009-06-18 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
US20080299212A1 (en) 2005-02-25 2008-12-04 Medigenes Co., Ltd Pharmaceutical Composition for Treating Avellino Cornea Dystrophy Comprising Blood Plasma or Serum
EP1704867A1 (de) 2005-03-18 2006-09-27 Crossbeta Biosciences B.V. Cross-Beta Strukturen auf Mikrobenorganismen
US20090202980A1 (en) 2005-03-21 2009-08-13 Crossbeta Biosciences B.V. Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation
US8114832B2 (en) 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
EP1907864A2 (de) 2005-07-13 2008-04-09 Crossbeta Biosciences B.V. Verfahren zur bestimmung der auswirkung einer behandlung auf den cross-beta struktur-gehalt eines proteins; auswahl von behandlungen und verwendungen davon
CA2615028A1 (en) 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. Cross-.beta. structure binding compounds
US20070015133A1 (en) 2005-07-13 2007-01-18 Umc Utrecht Holding B.V. Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein
WO2007008070A2 (en) 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. ADJUVATION THROUGH CROSS-β STRUCTURE
JP2009504636A (ja) 2005-08-11 2009-02-05 メディジーンズ カンパニー リミテッド 血漿または血清を含む神経損傷治療用の医薬組成物
US8543424B2 (en) 2005-12-30 2013-09-24 Darryl Mark Hunsaker Vehicle insurance status display system
EP2007800A1 (de) 2006-03-17 2008-12-31 Crossbeta Biosciences B.V. Verfahren zur bindung von kreuz-beta-strukturen durch chaperone
EP2058000A1 (de) 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Zur Aktivierung von T-Zellen fähige immunogene Zusammensetzung
EP2058001A1 (de) 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Steigerung der Immunogenizität von Antigenen

Also Published As

Publication number Publication date
WO2007008072A2 (en) 2007-01-18
ZA200800862B (en) 2009-01-28
EP2386861A3 (de) 2012-07-18
AU2006267176A1 (en) 2007-01-18
CA2615028A1 (en) 2007-01-18
US8067187B2 (en) 2011-11-29
US20080267948A1 (en) 2008-10-30
EP1910844B1 (de) 2012-04-18
EP2386861A2 (de) 2011-11-16
WO2007008072A3 (en) 2007-05-18
EP1910844A2 (de) 2008-04-16

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