JP2003515623A5 - - Google Patents
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- Publication number
- JP2003515623A5 JP2003515623A5 JP2001541070A JP2001541070A JP2003515623A5 JP 2003515623 A5 JP2003515623 A5 JP 2003515623A5 JP 2001541070 A JP2001541070 A JP 2001541070A JP 2001541070 A JP2001541070 A JP 2001541070A JP 2003515623 A5 JP2003515623 A5 JP 2003515623A5
- Authority
- JP
- Japan
- Prior art keywords
- per
- cyclodextrin
- deoxy
- thio
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000858 Cyclodextrin Polymers 0.000 description 14
- -1 carboxyphenyl Chemical group 0.000 description 14
- 239000001116 FEMA 4028 Substances 0.000 description 8
- 229960004853 betadex Drugs 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 229940080345 gamma-cyclodextrin Drugs 0.000 description 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 description 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 1
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 description 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 1
- 229910000024 caesium carbonate Inorganic materials 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- YRIAPEVGKLRGHX-UHFFFAOYSA-N methyl 4-sulfanylbutanoate Chemical compound COC(=O)CCCS YRIAPEVGKLRGHX-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99309558.7 | 1999-11-29 | ||
| EP99309558 | 1999-11-29 | ||
| PCT/EP2000/011789 WO2001040316A1 (en) | 1999-11-29 | 2000-11-23 | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006195089A Division JP4563972B2 (ja) | 1999-11-29 | 2006-07-18 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003515623A JP2003515623A (ja) | 2003-05-07 |
| JP2003515623A5 true JP2003515623A5 (https=) | 2006-09-07 |
| JP3880041B2 JP3880041B2 (ja) | 2007-02-14 |
Family
ID=8241767
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541070A Expired - Lifetime JP3880041B2 (ja) | 1999-11-29 | 2000-11-23 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
| JP2006195089A Expired - Lifetime JP4563972B2 (ja) | 1999-11-29 | 2006-07-18 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006195089A Expired - Lifetime JP4563972B2 (ja) | 1999-11-29 | 2006-07-18 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US6670340B1 (https=) |
| EP (1) | EP1259550B1 (https=) |
| JP (2) | JP3880041B2 (https=) |
| KR (1) | KR100716524B1 (https=) |
| CN (1) | CN1188428C (https=) |
| AR (1) | AR026605A1 (https=) |
| AT (1) | ATE288450T1 (https=) |
| AU (1) | AU776536B2 (https=) |
| BE (1) | BE2008C047I2 (https=) |
| BR (1) | BRPI0015947B8 (https=) |
| CA (1) | CA2390463C (https=) |
| CO (1) | CO5251450A1 (https=) |
| CY (1) | CY2008018I2 (https=) |
| CZ (1) | CZ298206B6 (https=) |
| DE (2) | DE60017947T2 (https=) |
| DK (1) | DK1259550T3 (https=) |
| ES (1) | ES2237496T3 (https=) |
| FR (1) | FR08C0052I2 (https=) |
| HU (1) | HU227451B1 (https=) |
| IL (1) | IL149423A0 (https=) |
| LU (1) | LU91501I2 (https=) |
| MX (1) | MXPA02004940A (https=) |
| NL (1) | NL300356I2 (https=) |
| NO (2) | NO328790B1 (https=) |
| NZ (1) | NZ518752A (https=) |
| PE (1) | PE20010902A1 (https=) |
| PL (1) | PL203012B1 (https=) |
| PT (1) | PT1259550E (https=) |
| RU (1) | RU2260013C2 (https=) |
| SK (1) | SK286282B6 (https=) |
| TW (1) | TWI242015B (https=) |
| WO (1) | WO2001040316A1 (https=) |
| ZA (1) | ZA200203538B (https=) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6744471B1 (en) * | 1997-12-05 | 2004-06-01 | Olympus Optical Co., Ltd | Electronic camera that synthesizes two images taken under different exposures |
| TWI242015B (en) | 1999-11-29 | 2005-10-21 | Akzo Nobel Nv | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
| AU2002220654A1 (en) * | 2000-11-02 | 2002-05-15 | Akzo Nobel N.V. | Use of cortisol-sequestering agents for the treatment of hypercortisolaemia related disorders |
| WO2005042584A2 (en) | 2003-10-31 | 2005-05-12 | The University Of Kansas | Sulfoalkyl ether-alkyl ether cyclodextrin derivatives |
| EP1735326A4 (en) | 2004-01-29 | 2011-04-20 | Pinnacle Pharmaceuticals | BETA-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST LETHAL ANTHRAX TOXIN |
| PL2708225T3 (pl) | 2004-04-23 | 2019-07-31 | Cydex Pharmaceuticals, Inc. | Formulacja DPI zawierająca eter sulfoalkilowy cyklodekstryny |
| CN101151037A (zh) | 2005-01-28 | 2008-03-26 | 平纳克尔医药股份有限公司 | 作为抗菌剂的β-环糊精衍生物 |
| US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| DK1945228T4 (da) | 2005-10-26 | 2015-01-12 | Cydex Pharmaceuticals Inc | Sulfoalkyl-ether-cyclodextrin-sammensætninger og fremgangsmåder til fremstilling deraf |
| US20090069412A1 (en) * | 2007-09-09 | 2009-03-12 | Protia, Llc | Deuterium-enriched sugammadex |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| US7938283B2 (en) * | 2008-06-20 | 2011-05-10 | Grainpro, Inc. | System and method for hermetic storage of agricultural commodities during shipping |
| US10463677B2 (en) | 2008-11-07 | 2019-11-05 | Cydex Pharmaceuticals, Inc. | Composition containing sulfoalkyl ether cyclodextrin and latanoprost |
| CN101591402B (zh) * | 2009-05-05 | 2011-11-30 | 杭州奥默医药技术有限公司 | 6-脱氧砜类环糊精衍生物及其制备方法 |
| US8492538B1 (en) | 2009-06-04 | 2013-07-23 | Jose R. Matos | Cyclodextrin derivative salts |
| DE102010012281A1 (de) * | 2010-03-22 | 2011-09-22 | Fresenius Medical Care Deutschland Gmbh | Pharmazeutische Zusammensetzungen enthaltend substituiertes 6-Deoxy-6-sulfanylcyclodextrin |
| CN101864003B (zh) * | 2010-06-11 | 2012-05-02 | 漆又毛 | 一种6-脱氧硫醚氨基酸环糊精衍生物的合成方法 |
| PL2609120T3 (pl) * | 2010-08-25 | 2016-03-31 | Davuluri Ramamohan Rao | Ulepszony sposób wytwarzania sugammadeksu |
| CN102060941B (zh) * | 2010-11-26 | 2012-12-26 | 漆又毛 | 6-脱氧α-氨基酸衍生物环糊精及制备和应用 |
| DK3702374T3 (da) | 2012-02-15 | 2022-06-27 | Cydex Pharmaceuticals Inc | Fremsgangsmåde til fremstilling for cyclodextrin-derivater |
| HK1211311A1 (en) | 2012-02-28 | 2016-05-20 | 锡德克斯药物公司 | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| JP5892847B2 (ja) * | 2012-04-27 | 2016-03-23 | Ｄｏｗａホールディングス株式会社 | シクロデキストリンとシリカ含有物質との複合材料、及びその製造方法、並びにガス吸着剤 |
| GB201211153D0 (en) * | 2012-06-22 | 2012-08-08 | Farmhispania | Pharmaceutical compositions |
| WO2014066274A1 (en) | 2012-10-22 | 2014-05-01 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| WO2014125501A1 (en) | 2013-02-14 | 2014-08-21 | Neuland Laboratories Limited | An improved process for preparation of sugammadex sodium |
| CA2950610A1 (en) | 2014-05-29 | 2015-12-03 | Uti Limited Partnership | Cyclodextrin-based polyanionic and non-ionic dendrimers |
| WO2015198456A1 (ja) | 2014-06-26 | 2015-12-30 | 丸石製薬株式会社 | 安定性を改善したロクロニウム製剤 |
| CN105348412B (zh) * | 2014-08-22 | 2018-06-05 | 江苏恩华药业股份有限公司 | 一种舒更葡糖钠的纯化方法 |
| JP6914188B2 (ja) | 2014-08-22 | 2021-08-04 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | 分画アルキル化シクロデキストリン組成物ならびにその調製方法および使用方法 |
| CN108348560A (zh) | 2015-03-19 | 2018-07-31 | 锡德克斯药物公司 | 包含水飞蓟素和磺烃基醚环糊精的组合物及其使用方法 |
| CN104844732B (zh) * | 2015-03-27 | 2017-05-03 | 山东滨州智源生物科技有限公司 | 一种舒更葡糖钠的制备方法 |
| EP3280740A4 (en) * | 2015-04-08 | 2019-03-27 | Ling, Chang-Chun | PHARMACEUTICAL COMPOSITIONS OF POLYANIONIC AND NONIONIC CYCLODEXTRIN BASED DENDRIMERS AND USES THEREOF |
| WO2016194001A1 (en) * | 2015-05-29 | 2016-12-08 | Alaparthi Lakshmi Prasad | Processes for preparation of sugammadex and intermediates thereof |
| CN104922693A (zh) * | 2015-06-19 | 2015-09-23 | 南开大学 | 一种阴离子型环糊精与抗癌药物包合物及制备方法 |
| JP2018530653A (ja) * | 2015-10-07 | 2018-10-18 | ユーティアイ リミテッド パートナーシップＵｔｉ Ｌｉｍｉｔｅｄ Ｐａｒｔｎｅｒｓｈｉｐ | 多官能性ポリアニオン性シクロデキストリンデンドリマー |
| EP3741801A1 (en) | 2015-11-25 | 2020-11-25 | Fresenius Kabi iPSUM S.r.l. | Crystalline forms of per-chloro-gamma-cyclodextrines |
| AU2016359420B2 (en) | 2015-11-25 | 2020-10-01 | Fresenius Kabi Ipsum S.R.L. | An improved process for the preparation of sugammadex and its intermediates |
| EP3433285B1 (en) * | 2016-03-22 | 2020-06-03 | Fresenius Kabi iPSUM S.r.l. | An improved process for the preparation of sugammadex |
| CN109414452B (zh) * | 2016-04-29 | 2024-02-02 | 阿弗隆制药有限公司 | 作为促凝血剂的环糊精 |
| US10894839B2 (en) | 2016-06-23 | 2021-01-19 | Synthon B.V. | Process for making Sugammadex |
| US20180016359A1 (en) | 2016-06-29 | 2018-01-18 | Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. | Sugammadex preparation and purification method |
| US10526422B2 (en) | 2016-06-29 | 2020-01-07 | Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. | Process for preparation and purification of Sugammades sodium |
| CN107778383B (zh) | 2016-08-24 | 2020-03-10 | 王炳永 | 一种舒更葡糖钠的精制方法 |
| US10385142B2 (en) | 2017-01-23 | 2019-08-20 | Scinopharm Taiwan, Ltd. | Method for preparing sugammadex sodium |
| JP7204670B2 (ja) | 2017-05-03 | 2023-01-16 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | シクロデキストリン及びブスルファンを含有する組成物 |
| CN109021148B (zh) * | 2017-06-08 | 2020-11-10 | 天津科伦药物研究有限公司 | 一种制备舒更葡糖钠的方法 |
| US10442871B2 (en) * | 2017-06-22 | 2019-10-15 | Lawrence Livermore National Security, Llc | Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof |
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| JP2556236B2 (ja) | 1991-08-29 | 1996-11-20 | 田辺製薬株式会社 | β−シクロデキストリン誘導体のポリ硫酸エステル及びその製法 |
| US5840881A (en) | 1992-11-27 | 1998-11-24 | Takeda Chemical Industries, Ltd. | Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility |
| US5767112A (en) | 1994-10-21 | 1998-06-16 | Poli Industria Chimica, S.P.A. | Muscle relaxant pharmaceutical compositions |
| AU708107B2 (en) | 1994-11-04 | 1999-07-29 | Commonwealth Scientific And Industrial Research Organisation | Method for treating animals |
| GB2307176A (en) * | 1995-11-15 | 1997-05-21 | Todd Selwyn Everest | Anti-inflammatory clathrating agents for topical use |
| US5935941A (en) | 1997-10-24 | 1999-08-10 | Pitha; Josef | Alkylations of cyclodextrins leading to derivatives which have a ridgidly extended cavity |
| US5834446A (en) * | 1996-06-21 | 1998-11-10 | Queen's University At Kingston | Nerve process growth modulators |
| JP4249282B2 (ja) | 1998-02-27 | 2009-04-02 | 日本食品化工株式会社 | 新規シクロデキストリン誘導体及びその製造方法 |
| CA2330681C (en) | 1998-05-29 | 2008-08-26 | Andrea Giuffrida | Control of pain with endogenous cannabinoids |
| US7265099B1 (en) | 1999-08-13 | 2007-09-04 | Organon N.V. | Use of chemical chelators as reversal agents for drug-induced neuromuscular block |
| TWI242015B (en) | 1999-11-29 | 2005-10-21 | Akzo Nobel Nv | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
| US20020111377A1 (en) | 2000-12-22 | 2002-08-15 | Albany College Of Pharmacy | Transdermal delivery of cannabinoids |
| DE60211132T2 (de) | 2001-02-14 | 2006-09-28 | Akzo Nobel N.V. | 2-alkylierte cyclodextrin-derivate : umkehrungsmittel von medikament-induzierter neuromuskulärer blockierung |
| TW200402417A (en) | 2002-06-21 | 2004-02-16 | Akzo Nobel Nv | 1-[(Indol-3-yl)carbonyl]piperazine derivatives |
-
2000
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- 2000-11-23 CZ CZ20021814A patent/CZ298206B6/cs not_active IP Right Cessation
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- 2000-11-23 AT AT00993261T patent/ATE288450T1/de active
- 2000-11-23 US US10/148,307 patent/US6670340B1/en not_active Ceased
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- 2000-11-23 KR KR1020027006871A patent/KR100716524B1/ko not_active Expired - Lifetime
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