JP2003515623A5 - - Google Patents
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- Publication number
- JP2003515623A5 JP2003515623A5 JP2001541070A JP2001541070A JP2003515623A5 JP 2003515623 A5 JP2003515623 A5 JP 2003515623A5 JP 2001541070 A JP2001541070 A JP 2001541070A JP 2001541070 A JP2001541070 A JP 2001541070A JP 2003515623 A5 JP2003515623 A5 JP 2003515623A5
- Authority
- JP
- Japan
- Prior art keywords
- per
- cyclodextrin
- deoxy
- thio
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000858 Cyclodextrin Polymers 0.000 description 14
- -1 carboxyphenyl Chemical group 0.000 description 14
- 239000001116 FEMA 4028 Substances 0.000 description 8
- 229960004853 betadex Drugs 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 229940080345 gamma-cyclodextrin Drugs 0.000 description 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 description 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 1
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 description 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 1
- 229910000024 caesium carbonate Inorganic materials 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- YRIAPEVGKLRGHX-UHFFFAOYSA-N methyl 4-sulfanylbutanoate Chemical compound COC(=O)CCCS YRIAPEVGKLRGHX-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99309558 | 1999-11-29 | ||
| EP99309558.7 | 1999-11-29 | ||
| PCT/EP2000/011789 WO2001040316A1 (en) | 1999-11-29 | 2000-11-23 | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006195089A Division JP4563972B2 (ja) | 1999-11-29 | 2006-07-18 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003515623A JP2003515623A (ja) | 2003-05-07 |
| JP2003515623A5 true JP2003515623A5 (https=) | 2006-09-07 |
| JP3880041B2 JP3880041B2 (ja) | 2007-02-14 |
Family
ID=8241767
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001541070A Expired - Lifetime JP3880041B2 (ja) | 1999-11-29 | 2000-11-23 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
| JP2006195089A Expired - Lifetime JP4563972B2 (ja) | 1999-11-29 | 2006-07-18 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006195089A Expired - Lifetime JP4563972B2 (ja) | 1999-11-29 | 2006-07-18 | ６−メルカプト−シクロデキストリン誘導体：薬物誘導神経筋遮断回復薬 |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | USRE44733E1 (https=) |
| EP (1) | EP1259550B1 (https=) |
| JP (2) | JP3880041B2 (https=) |
| KR (1) | KR100716524B1 (https=) |
| CN (1) | CN1188428C (https=) |
| AR (1) | AR026605A1 (https=) |
| AT (1) | ATE288450T1 (https=) |
| AU (1) | AU776536B2 (https=) |
| BE (1) | BE2008C047I2 (https=) |
| BR (1) | BRPI0015947B8 (https=) |
| CA (1) | CA2390463C (https=) |
| CO (1) | CO5251450A1 (https=) |
| CY (1) | CY2008018I2 (https=) |
| CZ (1) | CZ298206B6 (https=) |
| DE (2) | DE122008000068I2 (https=) |
| DK (1) | DK1259550T3 (https=) |
| ES (1) | ES2237496T3 (https=) |
| FR (1) | FR08C0052I2 (https=) |
| HU (1) | HU227451B1 (https=) |
| IL (1) | IL149423A0 (https=) |
| LU (1) | LU91501I2 (https=) |
| MX (1) | MXPA02004940A (https=) |
| NL (1) | NL300356I2 (https=) |
| NO (2) | NO328790B1 (https=) |
| NZ (1) | NZ518752A (https=) |
| PE (1) | PE20010902A1 (https=) |
| PL (1) | PL203012B1 (https=) |
| PT (1) | PT1259550E (https=) |
| RU (1) | RU2260013C2 (https=) |
| SK (1) | SK286282B6 (https=) |
| TW (1) | TWI242015B (https=) |
| WO (1) | WO2001040316A1 (https=) |
| ZA (1) | ZA200203538B (https=) |
Families Citing this family (78)
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| US6744471B1 (en) * | 1997-12-05 | 2004-06-01 | Olympus Optical Co., Ltd | Electronic camera that synthesizes two images taken under different exposures |
| TWI242015B (en) | 1999-11-29 | 2005-10-21 | Akzo Nobel Nv | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
| AU2002220654A1 (en) * | 2000-11-02 | 2002-05-15 | Akzo Nobel N.V. | Use of cortisol-sequestering agents for the treatment of hypercortisolaemia related disorders |
| CN101039682A (zh) | 2003-10-31 | 2007-09-19 | 堪萨斯大学 | 磺基烷基醚－烷基醚环糊精衍生物 |
| US7851457B2 (en) | 2004-01-29 | 2010-12-14 | Innovative Biologics, Inc. | β-Cyclodextrin derivatives |
| CN101098678A (zh) | 2004-04-23 | 2008-01-02 | 锡德克斯公司 | 含有磺基烷基醚环糊精的dpi制剂 |
| WO2006083678A2 (en) | 2005-01-28 | 2006-08-10 | Pinnacle Pharmaceuticals, Inc. | β-CYCLODEXTRIN DERIVATIVES AS ANTIBACTERIAL AGENTS |
| US7629331B2 (en) | 2005-10-26 | 2009-12-08 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof |
| PT2583668E (pt) | 2005-10-26 | 2015-01-05 | Cydex Pharmaceuticals Inc | Composições de éter sulfoalquílico de ciclodextrina e métodos para a sua preparação |
| US20090069412A1 (en) * | 2007-09-09 | 2009-03-12 | Protia, Llc | Deuterium-enriched sugammadex |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| US7938283B2 (en) * | 2008-06-20 | 2011-05-10 | Grainpro, Inc. | System and method for hermetic storage of agricultural commodities during shipping |
| US10463677B2 (en) | 2008-11-07 | 2019-11-05 | Cydex Pharmaceuticals, Inc. | Composition containing sulfoalkyl ether cyclodextrin and latanoprost |
| CN101591402B (zh) * | 2009-05-05 | 2011-11-30 | 杭州奥默医药技术有限公司 | 6-脱氧砜类环糊精衍生物及其制备方法 |
| US8492538B1 (en) | 2009-06-04 | 2013-07-23 | Jose R. Matos | Cyclodextrin derivative salts |
| DE102010012281A1 (de) * | 2010-03-22 | 2011-09-22 | Fresenius Medical Care Deutschland Gmbh | Pharmazeutische Zusammensetzungen enthaltend substituiertes 6-Deoxy-6-sulfanylcyclodextrin |
| CN101864003B (zh) * | 2010-06-11 | 2012-05-02 | 漆又毛 | 一种6-脱氧硫醚氨基酸环糊精衍生物的合成方法 |
| US9120876B2 (en) | 2010-08-25 | 2015-09-01 | Ramamohan Rao Davuluri | Process for preparation of Sugammadex |
| CN102060941B (zh) | 2010-11-26 | 2012-12-26 | 漆又毛 | 6-脱氧α-氨基酸衍生物环糊精及制备和应用 |
| WO2013123254A1 (en) | 2012-02-15 | 2013-08-22 | Cydex Pharmaceuticals, Inc. | Manufacturing process for cyclodextrin derivatives |
| RU2615385C2 (ru) | 2012-02-28 | 2017-04-04 | Сидекс Фармасьютикалс, Инк. | Композиции алкилированного циклодекстрина и способы их получения и применения |
| JP5892847B2 (ja) * | 2012-04-27 | 2016-03-23 | Ｄｏｗａホールディングス株式会社 | シクロデキストリンとシリカ含有物質との複合材料、及びその製造方法、並びにガス吸着剤 |
| GB201211153D0 (en) * | 2012-06-22 | 2012-08-08 | Farmhispania | Pharmaceutical compositions |
| KR102112119B1 (ko) | 2012-10-22 | 2020-05-19 | 사이덱스 파마슈티칼스, 인크. | 알킬화된 시클로덱스트린 조성물 및 이의 제조 및 사용 방법 |
| EP2956486B1 (en) | 2013-02-14 | 2020-09-30 | Neuland Laboratories Ltd | An improved process for preparation of sugammadex sodium |
| CA2950610A1 (en) | 2014-05-29 | 2015-12-03 | Uti Limited Partnership | Cyclodextrin-based polyanionic and non-ionic dendrimers |
| MX2016016148A (es) | 2014-06-26 | 2017-04-25 | Maruishi Pharma | Preparacion de rocuronio con estabilidad mejorada. |
| CN105348412B (zh) * | 2014-08-22 | 2018-06-05 | 江苏恩华药业股份有限公司 | 一种舒更葡糖钠的纯化方法 |
| PT3183295T (pt) | 2014-08-22 | 2023-11-03 | Cydex Pharmaceuticals Inc | Composições de ciclodextrina alquilada fracionada e processos para preparação e utilização das mesmas |
| CA2980170A1 (en) | 2015-03-19 | 2016-09-22 | Cydex Pharmaceuticals, Inc. | Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same |
| CN104844732B (zh) * | 2015-03-27 | 2017-05-03 | 山东滨州智源生物科技有限公司 | 一种舒更葡糖钠的制备方法 |
| AU2015390471A1 (en) * | 2015-04-08 | 2017-11-09 | John KLASSEN | Pharmaceutical compositions of polyanionic and non-ionic cyclodextrin-based dendrimers and uses thereof |
| US10494450B2 (en) * | 2015-05-29 | 2019-12-03 | Lakshmi Prasad ALAPARTHI | Processes for preparation of Sugammadex and intermediates thereof |
| CN104922693A (zh) * | 2015-06-19 | 2015-09-23 | 南开大学 | 一种阴离子型环糊精与抗癌药物包合物及制备方法 |
| EP3359578A4 (en) * | 2015-10-07 | 2019-05-15 | UTI Limited Partnership | MULTIFUNCTIONAL POLYANIONIC CYCLODEXTRINDDRIMERE |
| SI3380554T2 (sl) * | 2015-11-25 | 2024-01-31 | Fresenius Kabi Ipsum S.R.L. | Kristalne oblike per-kloro-gama-ciklodekstrinov |
| ES2829236T3 (es) | 2015-11-25 | 2021-05-31 | Fresenius Kabi Ipsum S R L | Procedimiento mejorado para la preparación de sugammadex y sus productos intermedios |
| EP3433285B1 (en) * | 2016-03-22 | 2020-06-03 | Fresenius Kabi iPSUM S.r.l. | An improved process for the preparation of sugammadex |
| AU2017256640B2 (en) * | 2016-04-29 | 2020-07-30 | Alveron Pharma B.V. | Cyclodextrins as Procoagulants |
| ES2915423T3 (es) * | 2016-06-23 | 2022-06-22 | Synthon Bv | Proceso de preparación de sugammadex |
| WO2017084401A1 (zh) | 2016-06-29 | 2017-05-26 | 北京睿创康泰医药研究院有限公司 | 舒更葡糖钠的制备及纯化方法 |
| US10526422B2 (en) | 2016-06-29 | 2020-01-07 | Beijing Creatron Institute Of Pharmaceutical Research Co., Ltd. | Process for preparation and purification of Sugammades sodium |
| CN107778383B (zh) * | 2016-08-24 | 2020-03-10 | 王炳永 | 一种舒更葡糖钠的精制方法 |
| US10385142B2 (en) | 2017-01-23 | 2019-08-20 | Scinopharm Taiwan, Ltd. | Method for preparing sugammadex sodium |
| JP7204670B2 (ja) | 2017-05-03 | 2023-01-16 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | シクロデキストリン及びブスルファンを含有する組成物 |
| CN109021148B (zh) * | 2017-06-08 | 2020-11-10 | 天津科伦药物研究有限公司 | 一种制备舒更葡糖钠的方法 |
| US10442871B2 (en) | 2017-06-22 | 2019-10-15 | Lawrence Livermore National Security, Llc | Modified cyclodextrins for the selective sequestration of fentanyl related compounds and uses thereof |
| ES2761899T3 (es) | 2017-06-30 | 2020-05-21 | Synthon Bv | Proceso para preparar Sugammadex |
| US10233263B1 (en) * | 2017-08-23 | 2019-03-19 | Formosa Laboratories, Inc. | Method for preparation of sugammadex sodium |
| TWI703163B (zh) * | 2017-08-23 | 2020-09-01 | 台耀化學股份有限公司 | 舒更葡糖鈉之製備方法及其晶型 |
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| CN111978435B (zh) | 2019-05-22 | 2021-05-25 | 合肥博思科创医药科技有限公司 | 一种高纯度舒更葡糖钠的制备方法 |
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| CN111714459B (zh) * | 2020-06-18 | 2022-06-14 | 广州瑞尔医药科技有限公司 | 一种注射用舒更葡糖钠粉针剂及其制备方法 |
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| US11446325B2 (en) * | 2020-09-30 | 2022-09-20 | Cyclolab Cyclodextrin Research And Development Laboratory Ltd. | Cyclodextrin derivatives in the treatment or prevention of lysosomal neurodegenerative diseases |
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| CN113637097A (zh) * | 2021-08-10 | 2021-11-12 | 北京恒创星远医药科技有限公司 | 6-全脱氧-6-全碘代-γ-环糊精晶体及其制备方法和应用 |
| CN115708777A (zh) * | 2021-08-19 | 2023-02-24 | 北京费森尤斯卡比医药有限公司 | 包含巯基环糊精衍生物或其可药用盐的包装药品和保存方法 |
| CN119679816A (zh) * | 2023-09-15 | 2025-03-25 | 杭州奥默医药股份有限公司 | 一种用于逆转苄异喹啉类肌松药的肌松拮抗药物 |
| EP4656660A1 (en) * | 2024-05-31 | 2025-12-03 | Universidad de Almeria | Alfa-, beta-, and gamma- cyclodextrin derivatives decorated with (2-mercaptoethyl)phosphonic acid branches, synthesis and applications |
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| US5840881A (en) | 1992-11-27 | 1998-11-24 | Takeda Chemical Industries, Ltd. | Composition containing a water-insoluble or slightly water-soluble compound with enhanced water-solubility |
| US5767112A (en) | 1994-10-21 | 1998-06-16 | Poli Industria Chimica, S.P.A. | Muscle relaxant pharmaceutical compositions |
| AU708107B2 (en) | 1994-11-04 | 1999-07-29 | Commonwealth Scientific And Industrial Research Organisation | Method for treating animals |
| GB2307176A (en) * | 1995-11-15 | 1997-05-21 | Todd Selwyn Everest | Anti-inflammatory clathrating agents for topical use |
| US5935941A (en) | 1997-10-24 | 1999-08-10 | Pitha; Josef | Alkylations of cyclodextrins leading to derivatives which have a ridgidly extended cavity |
| US5834446A (en) * | 1996-06-21 | 1998-11-10 | Queen's University At Kingston | Nerve process growth modulators |
| JP4249282B2 (ja) | 1998-02-27 | 2009-04-02 | 日本食品化工株式会社 | 新規シクロデキストリン誘導体及びその製造方法 |
| US6348498B1 (en) | 1998-05-29 | 2002-02-19 | Neurosciences Research Foundation, Inc. | Control of pain with endogenous cannabinoids |
| JP4782334B2 (ja) | 1999-08-13 | 2011-09-28 | ナームローゼ・フエンノートチヤツプ・オルガノン | 薬物起因性神経筋遮断のための拮抗薬としての化学的キレート化剤の使用 |
| TWI242015B (en) | 1999-11-29 | 2005-10-21 | Akzo Nobel Nv | 6-mercapto-cyclodextrin derivatives: reversal agents for drug-induced neuromuscular block |
| US20020111377A1 (en) | 2000-12-22 | 2002-08-15 | Albany College Of Pharmacy | Transdermal delivery of cannabinoids |
| DE60211132T2 (de) | 2001-02-14 | 2006-09-28 | Akzo Nobel N.V. | 2-alkylierte cyclodextrin-derivate : umkehrungsmittel von medikament-induzierter neuromuskulärer blockierung |
| TW200402417A (en) | 2002-06-21 | 2004-02-16 | Akzo Nobel Nv | 1-[(Indol-3-yl)carbonyl]piperazine derivatives |
-
2000
- 2000-11-08 TW TW089123585A patent/TWI242015B/zh not_active IP Right Cessation
- 2000-11-23 KR KR1020027006871A patent/KR100716524B1/ko not_active Expired - Lifetime
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- 2000-11-23 WO PCT/EP2000/011789 patent/WO2001040316A1/en not_active Ceased
- 2000-11-23 CN CNB00816360XA patent/CN1188428C/zh not_active Expired - Lifetime
- 2000-11-23 PT PT00993261T patent/PT1259550E/pt unknown
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- 2000-11-23 ES ES00993261T patent/ES2237496T3/es not_active Expired - Lifetime
- 2000-11-23 US US13/432,742 patent/USRE44733E1/en active Active
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- 2000-11-23 PL PL356097A patent/PL203012B1/pl unknown
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- 2000-11-23 MX MXPA02004940A patent/MXPA02004940A/es active IP Right Grant
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- 2000-11-23 US US10/148,307 patent/US6670340B1/en not_active Ceased
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- 2000-11-23 JP JP2001541070A patent/JP3880041B2/ja not_active Expired - Lifetime
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2002
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- 2002-05-28 NO NO20022522A patent/NO328790B1/no not_active IP Right Cessation
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2003
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