|
US20040009166A1
(en)
*
|
1997-04-30 |
2004-01-15 |
Filpula David R. |
Single chain antigen-binding polypeptides for polymer conjugation
|
|
AU7266698A
(en)
|
1997-04-30 |
1998-11-24 |
Enzon, Inc. |
Polyalkylene oxide-modified single chain polypeptides
|
|
US6333396B1
(en)
|
1998-10-20 |
2001-12-25 |
Enzon, Inc. |
Method for targeted delivery of nucleic acids
|
|
CA2353082A1
(en)
*
|
1998-11-03 |
2000-05-11 |
Centocor Inc. |
Modified antibodies and antibody fragments with increased duration of activity
|
|
US6610286B2
(en)
|
1999-12-23 |
2003-08-26 |
Zymogenetics, Inc. |
Method for treating inflammation using soluble receptors to interleukin-20
|
|
US7122632B2
(en)
|
1999-12-23 |
2006-10-17 |
Zymogenetics, Inc. |
Soluble Interleukin-20 receptor
|
|
CA2395713C
(en)
|
2000-01-10 |
2012-04-10 |
Maxygen, Inc. |
G-csf conjugates
|
|
EP1982732A3
(en)
|
2000-02-11 |
2011-06-08 |
Bayer HealthCare LLC |
Factor VII or VIIA-like conjugates
|
|
US20030027207A1
(en)
*
|
2000-02-29 |
2003-02-06 |
Filpula David Ray |
Anti-platelet binding proteins and polymer conjugates containing the same
|
|
CA2414076A1
(en)
|
2000-06-08 |
2001-12-13 |
La Jolla Pharmaceutical Company |
Multivalent platform molecules comprising high molecular weight polyethylene oxide
|
|
US6410271B1
(en)
*
|
2000-06-23 |
2002-06-25 |
Genetastix Corporation |
Generation of highly diverse library of expression vectors via homologous recombination in yeast
|
|
US6410246B1
(en)
*
|
2000-06-23 |
2002-06-25 |
Genetastix Corporation |
Highly diverse library of yeast expression vectors
|
|
ATE500838T1
(de)
*
|
2000-09-08 |
2011-03-15 |
Amylin Pharmaceuticals Inc |
ßPSEUDOß-NATIVE CHEMISCHE LIGATION
|
|
US7118737B2
(en)
*
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
|
US8110218B2
(en)
*
|
2000-11-30 |
2012-02-07 |
The Research Foundation Of State University Of New York |
Compositions and methods for less immunogenic protein-lipid complexes
|
|
WO2002044197A2
(en)
*
|
2000-12-01 |
2002-06-06 |
Fish Eleanor N |
Cytokine receptor binding peptides
|
|
US6979556B2
(en)
|
2000-12-14 |
2005-12-27 |
Genentech, Inc. |
Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
|
|
US7195923B2
(en)
*
|
2001-01-31 |
2007-03-27 |
Scripps Laboratories, Inc. |
Ratiometric determination of glycated protein
|
|
PL367154A1
(en)
|
2001-02-27 |
2005-02-21 |
Maxygen Aps |
New interferon beta-like molecules
|
|
CN100513414C
(zh)
|
2001-08-27 |
2009-07-15 |
杰南技术公司 |
进行抗体表达和装配的系统
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7795210B2
(en)
*
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US8008252B2
(en)
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
|
IL161978A0
(en)
|
2001-12-17 |
2005-11-20 |
Zymogenetics Inc |
Method for treating cervical cancer
|
|
NZ534399A
(en)
|
2002-01-25 |
2008-08-29 |
G2 Therapies Ltd |
Monoclonal antibodies against extracellular loops of C5aR
|
|
BR0311978A
(pt)
|
2002-06-21 |
2005-03-22 |
Novo Nordisk Healthcare Ag |
Preparação, método para preparar a mesma, formulação farmacêutica, métodos para tratar de uma sìndrome responsiva ao fator vii, para prevenir hemorragias indesejáveis, para prevenir coagulação sanguìnea indesejável e para prevenir as reações mediadas pelo fator tecidual, e, uso de uma preparação
|
|
MXPA04012496A
(es)
|
2002-06-21 |
2005-09-12 |
Novo Nordisk Healthcare Ag |
Glicoformos del factor vii pegilados.
|
|
US9321832B2
(en)
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
|
US20050026866A1
(en)
*
|
2002-08-02 |
2005-02-03 |
Pawelek John M. |
Agents and methods for treatment of disease by oligosaccharide targeting agents
|
|
US20040067532A1
(en)
|
2002-08-12 |
2004-04-08 |
Genetastix Corporation |
High throughput generation and affinity maturation of humanized antibody
|
|
US7759055B2
(en)
*
|
2002-08-28 |
2010-07-20 |
Millipore Corporation |
Compositions of solution for sequencing reaction clean-up
|
|
US8129330B2
(en)
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
WO2004061094A1
(en)
|
2002-12-30 |
2004-07-22 |
Gryphon Therapeutics, Inc. |
Water-soluble thioester and selenoester compounds and methods for making and using the same
|
|
US20040229793A1
(en)
*
|
2003-02-05 |
2004-11-18 |
Balasubramanian Sathyamangalam V. |
Compositions and methods for less immunogenic protein formulations
|
|
US7351688B2
(en)
*
|
2003-02-05 |
2008-04-01 |
The Research Foundation Of State University Of New York |
Compositions and methods for less immunogenic protein formulations
|
|
JP2006523211A
(ja)
|
2003-03-14 |
2006-10-12 |
ネオス テクノロジーズ インコーポレイテッド |
分岐水溶性ポリマーとその複合物
|
|
WO2006127896A2
(en)
|
2005-05-25 |
2006-11-30 |
Neose Technologies, Inc. |
Glycopegylated factor ix
|
|
NZ542586A
(en)
|
2003-04-09 |
2009-11-27 |
Biogenerix Ag |
Method of forming a covalent conjugate between a G-CSF peptide and PEG
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
AU2004240553A1
(en)
*
|
2003-05-09 |
2004-12-02 |
Neose Technologies, Inc. |
Compositions and methods for the preparation of human growth hormone glycosylation mutants
|
|
SI1639011T1
(sl)
*
|
2003-06-30 |
2009-04-30 |
Domantis Ltd |
Pegilirana protitelesa z enojno domeno (dAb)
|
|
US9005625B2
(en)
*
|
2003-07-25 |
2015-04-14 |
Novo Nordisk A/S |
Antibody toxin conjugates
|
|
WO2005017526A1
(en)
*
|
2003-08-05 |
2005-02-24 |
The Research Foundation Of State University Of New York |
Reconstitution medium for protein and peptide formulations
|
|
US20050055024A1
(en)
*
|
2003-09-08 |
2005-03-10 |
James Anthony H. |
Orthopaedic implant and screw assembly
|
|
EP2263684A1
(en)
|
2003-10-10 |
2010-12-22 |
Novo Nordisk A/S |
IL-21 derivatives
|
|
ES2428358T3
(es)
|
2003-10-17 |
2013-11-07 |
Novo Nordisk A/S |
Terapia de combinación
|
|
EP2143733A1
(en)
*
|
2003-11-21 |
2010-01-13 |
ZymoGenetics, Inc. |
ANTI-IL-20 antibodies and binding partners and methods of using in inflammation
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
|
US7956032B2
(en)
|
2003-12-03 |
2011-06-07 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
US20080220049A1
(en)
*
|
2003-12-05 |
2008-09-11 |
Adnexus, A Bristol-Myers Squibb R&D Company |
Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins
|
|
WO2005056764A2
(en)
*
|
2003-12-05 |
2005-06-23 |
Compound Therapeutics, Inc. |
Inhibitors of type 2 vascular endothelial growth factor receptors
|
|
US7338933B2
(en)
|
2004-01-08 |
2008-03-04 |
Neose Technologies, Inc. |
O-linked glycosylation of peptides
|
|
AU2005319099B2
(en)
|
2004-02-02 |
2010-09-16 |
Ambrx, Inc. |
Modified human growth hormone
|
|
CN103755800B
(zh)
|
2004-02-02 |
2016-02-24 |
Ambrx公司 |
经修饰的人类生长激素多肽与其用途
|
|
CN102532321B
(zh)
|
2004-06-18 |
2018-10-12 |
Ambrx公司 |
新颖抗原结合多肽和其用途
|
|
WO2006010143A2
(en)
|
2004-07-13 |
2006-01-26 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
|
|
US7638299B2
(en)
|
2004-07-21 |
2009-12-29 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
|
US20090292110A1
(en)
*
|
2004-07-23 |
2009-11-26 |
Defrees Shawn |
Enzymatic modification of glycopeptides
|
|
US20060045866A1
(en)
*
|
2004-09-01 |
2006-03-02 |
Chris Chappelow |
Novel high purity and high molecular weight mPEG alcohol compositions
|
|
EP1799249A2
(en)
|
2004-09-10 |
2007-06-27 |
Neose Technologies, Inc. |
Glycopegylated interferon alpha
|
|
EP3061461A1
(en)
|
2004-10-29 |
2016-08-31 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
NZ555425A
(en)
|
2004-12-22 |
2010-04-30 |
Ambrx Inc |
Compositions of aminoacyl-tRNA synthetase and uses thereof
|
|
AU2005323106B2
(en)
|
2004-12-22 |
2010-07-29 |
Ambrx, Inc. |
Methods for expression and purification of recombinant human growth hormone
|
|
KR101224781B1
(ko)
|
2004-12-22 |
2013-01-21 |
암브룩스, 인코포레이티드 |
비천연적으로 코딩된 아미노산을 포함하는 인간 성장호르몬의 조제물
|
|
US9029331B2
(en)
|
2005-01-10 |
2015-05-12 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
NZ556726A
(en)
|
2005-01-25 |
2011-04-29 |
Cell Therapeutics Inc |
Conjugates of biologically active proteins having a modified in vivo half-life
|
|
JP2008533114A
(ja)
*
|
2005-03-18 |
2008-08-21 |
ユーシーエル ビジネス パブリック リミテッド カンパニー |
メカノ成長因子ペプチドおよびその使用
|
|
WO2006102659A2
(en)
*
|
2005-03-23 |
2006-09-28 |
Nektar Therapeutics Al, Corporation |
CONJUGATES OF AN hGH MOIETY AND A POLYMER
|
|
EP2314320A2
(en)
|
2005-04-05 |
2011-04-27 |
Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. |
Method for shielding functional sites or epitopes on proteins
|
|
EP1871795A4
(en)
|
2005-04-08 |
2010-03-31 |
Biogenerix Ag |
COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE
|
|
WO2006127910A2
(en)
|
2005-05-25 |
2006-11-30 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin formulations
|
|
US20110003744A1
(en)
*
|
2005-05-25 |
2011-01-06 |
Novo Nordisk A/S |
Glycopegylated Erythropoietin Formulations
|
|
WO2006133088A2
(en)
|
2005-06-03 |
2006-12-14 |
Ambrx, Inc. |
Improved human interferon molecules and their uses
|
|
US8028453B2
(en)
*
|
2005-06-16 |
2011-10-04 |
Hold That Thought, Inc. |
Apparatus and methods for displaying a card
|
|
WO2006134173A2
(en)
|
2005-06-17 |
2006-12-21 |
Novo Nordisk Health Care Ag |
Selective reduction and derivatization of engineered proteins comprising at least one non-native cysteine
|
|
US7695710B2
(en)
*
|
2005-06-20 |
2010-04-13 |
Pepgen Corporation |
Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs
|
|
CN101257925A
(zh)
*
|
2005-06-20 |
2008-09-03 |
派普根公司 |
人干扰素α类似物和干扰素τ的低毒长循环的嵌合体
|
|
WO2007002886A2
(en)
*
|
2005-06-29 |
2007-01-04 |
The Research Foundation Of State University Of New York |
Compositions and methods for less immunogenic pr0tein-lip1d complexes
|
|
WO2007021822A2
(en)
*
|
2005-08-09 |
2007-02-22 |
The Research Foundation Of State Of University Of New York At Buffalo |
Compositions and methods of preparation of liposomal microparticulate il-12
|
|
CA2618878C
(en)
|
2005-08-18 |
2016-06-28 |
Ambrx, Inc. |
Compositions of trna and uses thereof
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
WO2007026972A2
(en)
*
|
2005-09-01 |
2007-03-08 |
Canon Kabushiki Kaisha |
Binding protein molecule
|
|
US8168592B2
(en)
|
2005-10-21 |
2012-05-01 |
Amgen Inc. |
CGRP peptide antagonists and conjugates
|
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
|
EP1951890A4
(en)
|
2005-11-16 |
2009-06-24 |
Ambrx Inc |
PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
|
|
JP5160534B2
(ja)
*
|
2006-03-30 |
2013-03-13 |
ザ リサーチ ファウンデイション オブ ステイト ユニバーシティー オブ ニューヨーク |
低免疫原性および長時間循環性タンパク質−脂質複合体の組成物
|
|
US7875288B2
(en)
*
|
2006-03-30 |
2011-01-25 |
The Research Foundation Of State University Of New York |
Method for treating blood coagulation disorders
|
|
US7985839B2
(en)
*
|
2006-03-31 |
2011-07-26 |
Baxter International Inc. |
Factor VIII polymer conjugates
|
|
US7982010B2
(en)
*
|
2006-03-31 |
2011-07-19 |
Baxter International Inc. |
Factor VIII polymer conjugates
|
|
US7645860B2
(en)
*
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
|
KR20080108147A
(ko)
|
2006-03-31 |
2008-12-11 |
백스터 인터내셔널 인코포레이티드 |
페질화된 인자 viii
|
|
WO2007117685A2
(en)
|
2006-04-07 |
2007-10-18 |
Nektar Therapeutics Al, Corporation |
Conjugates of an anti-tnf-alpha antibody
|
|
EP2581450B1
(en)
|
2006-05-02 |
2018-08-15 |
MedImmune Limited |
Non-natural amino acid substituted polypeptides
|
|
US20080096819A1
(en)
*
|
2006-05-02 |
2008-04-24 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
US20090252720A1
(en)
|
2006-05-24 |
2009-10-08 |
Novo Nordisk Health Care Ag |
Prolonged FIX Analogues and Derivatives
|
|
ES2656359T3
(es)
|
2006-06-30 |
2018-02-26 |
Novo Nordisk A/S |
Anticuerpos anti-NKG2A y usos de los mismos
|
|
US20080242607A1
(en)
|
2006-07-21 |
2008-10-02 |
Neose Technologies, Inc. |
Glycosylation of peptides via o-linked glycosylation sequences
|
|
WO2008030558A2
(en)
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and their uses
|
|
ES2457527T3
(es)
|
2006-09-08 |
2014-04-28 |
Ambrx, Inc. |
ARNt Supresor hibrido en células de vertebrados
|
|
JP2008069073A
(ja)
*
|
2006-09-12 |
2008-03-27 |
Yokohama Tlo Co Ltd |
ラクトフェリン複合体及びその製造方法
|
|
EP2073820A4
(en)
*
|
2006-09-15 |
2014-07-16 |
Belrose Pharma Inc |
TARGETED POLYMER PRODRUGS WITH MULTIFUNCTIONAL CONNECTORS
|
|
US8367065B2
(en)
*
|
2006-09-15 |
2013-02-05 |
Enzon Pharmaceuticals, Inc. |
Targeted polymeric prodrugs containing multifunctional linkers
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
JP5537946B2
(ja)
|
2006-11-22 |
2014-07-02 |
ブリストル−マイヤーズ スクイブ カンパニー |
Igf−irを含むチロシンキナーゼ受容体に対する改変タンパク質に基づく標的治療薬
|
|
AU2007333049B2
(en)
|
2006-12-15 |
2014-02-20 |
Takeda Pharmaceutical Company Limited |
Factor VIIa-(poly)sialic acid conjugate having prolonged in vivo half-life
|
|
EP2423219B1
(en)
*
|
2007-01-30 |
2015-04-29 |
Epivax, Inc. |
Regulatory T cell epitopes, compositions and uses thereof
|
|
US20100144599A1
(en)
*
|
2007-02-02 |
2010-06-10 |
Bristol-Myers Squibb Company |
Vegf pathway blockade
|
|
KR101476472B1
(ko)
|
2007-03-30 |
2015-01-05 |
암브룩스, 인코포레이티드 |
변형된 fgf-21 폴리펩티드 및 그 용도
|
|
CN101796063B
(zh)
|
2007-04-03 |
2017-03-22 |
拉蒂奥法姆有限责任公司 |
使用糖聚乙二醇化g‑csf的治疗方法
|
|
KR20100019467A
(ko)
|
2007-05-02 |
2010-02-18 |
암브룩스, 인코포레이티드 |
변형된 인터페론 베타 폴리펩티드 및 그의 용도
|
|
US9493499B2
(en)
|
2007-06-12 |
2016-11-15 |
Novo Nordisk A/S |
Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
|
|
US7968811B2
(en)
*
|
2007-06-29 |
2011-06-28 |
Harley-Davidson Motor Company Group, Inc. |
Integrated ignition and key switch
|
|
CA2693771A1
(en)
*
|
2007-07-13 |
2009-01-22 |
Abbott Biotechnology Ltd. |
Methods and compositions for pulmonary administration of a tnf.alpha. inhibitor
|
|
CA2707840A1
(en)
*
|
2007-08-20 |
2009-02-26 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
US20090304719A1
(en)
|
2007-08-22 |
2009-12-10 |
Patrick Daugherty |
Activatable binding polypeptides and methods of identification and use thereof
|
|
US8207112B2
(en)
|
2007-08-29 |
2012-06-26 |
Biogenerix Ag |
Liquid formulation of G-CSF conjugate
|
|
US12529164B2
(en)
|
2007-09-14 |
2026-01-20 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
EP3124497B1
(en)
|
2007-09-14 |
2020-04-15 |
Adimab, LLC |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
MX2010004872A
(es)
*
|
2007-11-15 |
2010-06-02 |
Nestec Sa |
Produccion de productos alimenticios con efecto refrescante mejorado en boca y mente.
|
|
ES2632504T3
(es)
|
2007-11-20 |
2017-09-13 |
Ambrx, Inc. |
Polipéptidos de insulina modificados y sus usos
|
|
DK2222706T4
(en)
|
2007-12-14 |
2016-11-21 |
Novo Nordisk As |
Antibodies that bind to NKG2D and its use
|
|
WO2009078970A1
(en)
|
2007-12-14 |
2009-06-25 |
Biotium, Inc. |
Fluorescent compounds
|
|
CN101952317B
(zh)
|
2008-01-24 |
2015-07-22 |
诺沃-诺迪斯克有限公司 |
人化抗-人nkg2a单克隆抗体
|
|
NZ602170A
(en)
|
2008-02-08 |
2014-03-28 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
|
JP2011517314A
(ja)
|
2008-02-14 |
2011-06-02 |
ブリストル−マイヤーズ スクイブ カンパニー |
Egfrに結合する操作されたタンパク質に基づく標的化された治療薬
|
|
CN104193824A
(zh)
|
2008-02-20 |
2014-12-10 |
G2炎症私人有限公司 |
人源化抗-C5aR抗体
|
|
DK2257311T3
(da)
|
2008-02-27 |
2014-06-30 |
Novo Nordisk As |
Konjugerede Faktor VIII-Molekyler
|
|
PE20091931A1
(es)
|
2008-05-22 |
2009-12-31 |
Bristol Myers Squibb Co |
Proteinas de dominio de armazon basadas en fibronectina multivalentes
|
|
MX2011000859A
(es)
|
2008-07-23 |
2011-02-24 |
Ambrx Inc |
Polipeptidos g-csf bovinos modificados y sus usos.
|
|
NO2337846T3
(OSRAM)
|
2008-09-26 |
2018-06-16 |
|
|
|
PL2342223T3
(pl)
|
2008-09-26 |
2017-09-29 |
Ambrx, Inc. |
Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania
|
|
CN102282168A
(zh)
|
2008-11-18 |
2011-12-14 |
梅里麦克制药股份有限公司 |
人血清白蛋白接头以及其结合物
|
|
TWI496582B
(zh)
*
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之egfr/igfir結合分子
|
|
CN102325795B
(zh)
|
2008-12-22 |
2015-03-25 |
诺沃—诺迪斯克有限公司 |
针对组织因子途径抑制剂的抗体
|
|
WO2010081173A2
(en)
*
|
2009-01-12 |
2010-07-15 |
Cytomx Therapeutics, Llc |
Modified antibody compositions, methods of making and using thereof
|
|
ES2539045T3
(es)
|
2009-01-19 |
2015-06-25 |
Innate Pharma |
Anticuerpos anti-KIR3D
|
|
US8399219B2
(en)
|
2009-02-23 |
2013-03-19 |
Cytomx Therapeutics, Inc. |
Protease activatable interferon alpha proprotein
|
|
US8067201B2
(en)
*
|
2009-04-17 |
2011-11-29 |
Bristol-Myers Squibb Company |
Methods for protein refolding
|
|
KR20120103431A
(ko)
*
|
2009-06-25 |
2012-09-19 |
대니스코 에이/에스 |
단백질
|
|
JP5946766B2
(ja)
|
2009-07-03 |
2016-07-06 |
ビオノール イミュノ エーエスBionor Immuno As |
Hivワクチン組成物における使用又は診断手段としての使用のためのhiv関連ペプチドの組合せ又は融合物
|
|
US8809501B2
(en)
|
2009-07-27 |
2014-08-19 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
US8637640B2
(en)
*
|
2009-07-27 |
2014-01-28 |
Baxter International Inc. |
Blood coagulation protein conjugates
|
|
WO2011012850A2
(en)
|
2009-07-27 |
2011-02-03 |
Lipoxen Technologies Limited |
Glycopolysialylation of non-blood coagulation proteins
|
|
RU2744370C2
(ru)
|
2009-07-27 |
2021-03-05 |
Баксалта Инкорпорейтед |
Конъюгаты белков свертывания крови
|
|
US8642737B2
(en)
|
2010-07-26 |
2014-02-04 |
Baxter International Inc. |
Nucleophilic catalysts for oxime linkage
|
|
ES2667258T3
(es)
|
2009-09-10 |
2018-05-10 |
Ucb Biopharma Sprl |
Anticuerpos multivalentes
|
|
US8658434B2
(en)
*
|
2009-10-28 |
2014-02-25 |
Biotium, Inc. |
Fluorescent pyrene compounds
|
|
GB0920127D0
(en)
*
|
2009-11-17 |
2009-12-30 |
Ucb Pharma Sa |
Antibodies
|
|
EP2516455A4
(en)
|
2009-12-21 |
2013-05-22 |
Ambrx Inc |
MODIFIED SWINE SOMATOTROPIN POLYPEPTIDES AND THEIR USES
|
|
NZ600361A
(en)
|
2009-12-21 |
2014-06-27 |
Ambrx Inc |
Modified bovine somatotropin polypeptides and their uses
|
|
TWI513466B
(zh)
|
2010-01-20 |
2015-12-21 |
Boehringer Ingelheim Int |
抗凝血劑解毒劑
|
|
WO2011100508A2
(en)
*
|
2010-02-12 |
2011-08-18 |
Arizona Board Of Regents For And On Behalf Of Arizona State University |
Methods and compositions related to glycoprotein-immunoglobulin fusions
|
|
EP3409289B1
(en)
|
2010-02-26 |
2020-09-30 |
Novo Nordisk A/S |
Stable antibody containing compositions
|
|
US9815876B2
(en)
|
2010-03-05 |
2017-11-14 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
|
TW201138808A
(en)
|
2010-05-03 |
2011-11-16 |
Bristol Myers Squibb Co |
Serum albumin binding molecules
|
|
US20120135912A1
(en)
|
2010-05-10 |
2012-05-31 |
Perseid Therapeutics Llc |
Polypeptide inhibitors of vla4
|
|
US9562089B2
(en)
|
2010-05-26 |
2017-02-07 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold proteins having improved stability
|
|
RU2012153786A
(ru)
|
2010-05-28 |
2014-07-10 |
Ново Нордиск А/С |
Стабильные многодозовые композиции, содержащие антитело и консервант
|
|
US9127052B2
(en)
|
2010-06-29 |
2015-09-08 |
Centre National De La Recherche Scientifique |
LLT-1 antibodies with new functional properties
|
|
US9260518B2
(en)
|
2010-06-30 |
2016-02-16 |
Novo Nordisk A/S |
Antibodies that are capable of specifically binding tissue factor pathway inhibitor
|
|
KR102024922B1
(ko)
|
2010-07-16 |
2019-09-25 |
아디맵 엘엘씨 |
항체 라이브러리
|
|
SMT201900495T1
(it)
|
2010-08-17 |
2019-11-13 |
Ambrx Inc |
Polipeptidi di relaxina modificati e loro usi
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
PL2654794T3
(pl)
|
2010-12-22 |
2020-07-27 |
Baxalta GmbH |
Materiały i sposoby sprzęgania rozpuszczalnej w wodzie pochodnej kwasu tłuszczowego z białkiem
|
|
PE20140964A1
(es)
|
2011-03-30 |
2014-08-17 |
Boehringer Ingelheim Int |
Antidotos anticoagulantes
|
|
AU2012245073B2
(en)
|
2011-04-21 |
2016-02-11 |
Garvan Institute Of Medical Research |
Modified variable domain molecules and methods for producing and using them b
|
|
US20140170153A1
(en)
|
2011-05-31 |
2014-06-19 |
Novo Nordisk A/S |
Il-21 epitope and il-21 ligands
|
|
PL2718322T3
(pl)
|
2011-06-06 |
2019-07-31 |
Novo Nordisk A/S |
Lecznicze przeciwciała
|
|
CA2838220C
(en)
|
2011-06-17 |
2020-07-21 |
Novo Nordisk A/S |
Use of nkg2a antibodies for treatment of bone loss
|
|
US9382305B2
(en)
|
2011-07-01 |
2016-07-05 |
Bayer Intellectual Property Gmbh |
Relaxin fusion polypeptides and uses thereof
|
|
PT2717917T
(pt)
|
2011-07-05 |
2016-07-27 |
Bioasis Technologies Inc |
Conjugados de anticorpos p97
|
|
WO2013011061A1
(en)
|
2011-07-18 |
2013-01-24 |
Novo Nordisk A/S |
Antagonistic antibodies against oscar
|
|
WO2013011059A1
(en)
|
2011-07-18 |
2013-01-24 |
Novo Nordisk A/S |
Antagonist antibodies against oscar
|
|
WO2013011063A1
(en)
|
2011-07-18 |
2013-01-24 |
Novo Nordisk A/S |
Antagonistic antibodies against oscar
|
|
WO2013011062A2
(en)
|
2011-07-18 |
2013-01-24 |
Novo Nordisk A/S |
Oscar antagonists
|
|
AU2012356894B2
(en)
|
2011-12-23 |
2018-01-18 |
Araris Biotech Ltd. |
Enzymatic conjugation of polypeptides
|
|
ES2640268T3
(es)
|
2012-02-15 |
2017-11-02 |
Novo Nordisk A/S |
Anticuerpos que se unen a y bloquean un receptor desencadenante expresado en células mieloides 1 (TREM-1)
|
|
LT2814842T
(lt)
|
2012-02-15 |
2018-11-12 |
Novo Nordisk A/S |
Antikūnai, kurie suriša peptidoglikaną atpažįstantį baltymą 1
|
|
US9550830B2
(en)
|
2012-02-15 |
2017-01-24 |
Novo Nordisk A/S |
Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
|
|
CA2875624A1
(en)
|
2012-06-06 |
2013-12-12 |
Bionor Immuno As |
Hiv vaccine
|
|
JP6498600B2
(ja)
|
2012-06-08 |
2019-04-10 |
ストロ バイオファーマ インコーポレーテッド |
部位特異的な非天然アミノ酸残基を含む抗体、その調製方法、及びその使用方法
|
|
EP2863955B1
(en)
|
2012-06-26 |
2016-11-23 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
|
WO2014006230A1
(en)
|
2012-07-06 |
2014-01-09 |
Novo Nordisk A/S |
Il-20 epitopes and il-20 ligands
|
|
WO2014009426A2
(en)
|
2012-07-13 |
2014-01-16 |
Innate Pharma |
Screening of conjugated antibodies
|
|
US9932565B2
(en)
|
2012-07-31 |
2018-04-03 |
Bioasis Technologies, Inc. |
Dephosphorylated lysosomal storage disease proteins and methods of use thereof
|
|
WO2014036520A1
(en)
|
2012-08-30 |
2014-03-06 |
Merrimack Pharmaceuticals, Inc. |
Combination therapies comprising anti-erbb3 agents
|
|
DK2890402T3
(da)
|
2012-08-31 |
2019-07-15 |
Sutro Biopharma Inc |
Modificerede aminosyrer omfattende en azidogruppe
|
|
EP2916872B1
(en)
|
2012-11-09 |
2019-02-27 |
Innate Pharma |
Recognition tags for tgase-mediated conjugation
|
|
WO2014074218A1
(en)
|
2012-11-12 |
2014-05-15 |
Redwood Bioscience, Inc. |
Compounds and methods for producing a conjugate
|
|
US9310374B2
(en)
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
|
EP2920148B1
(en)
|
2012-11-16 |
2019-06-12 |
The Regents of the University of California |
Pictet-spengler ligation for protein chemical modification
|
|
US9963513B2
(en)
|
2013-02-05 |
2018-05-08 |
Engmab Sàrl |
Method for the selection of antibodies against BCMA
|
|
EP2762496A1
(en)
|
2013-02-05 |
2014-08-06 |
EngMab AG |
Method for the selection of antibodies against BCMA
|
|
EP2970433B1
(en)
|
2013-03-13 |
2019-09-18 |
Bioasis Technologies Inc. |
Fragments of p97 and uses thereof
|
|
WO2014140300A1
(en)
|
2013-03-15 |
2014-09-18 |
Innate Pharma |
Solid phase tgase-mediated conjugation of antibodies
|
|
ES2926773T3
(es)
|
2013-03-15 |
2022-10-28 |
Novo Nordisk As |
Anticuerpos capaces de unirse específicamente a dos epítopos en el inhibidor de la ruta del factor tisular
|
|
EP2789630A1
(en)
|
2013-04-09 |
2014-10-15 |
EngMab AG |
Bispecific antibodies against CD3e and ROR1
|
|
WO2014202773A1
(en)
|
2013-06-20 |
2014-12-24 |
Innate Pharma |
Enzymatic conjugation of polypeptides
|
|
JP6744212B2
(ja)
|
2013-06-21 |
2020-08-19 |
イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. |
ポリペプチドの酵素的結合
|
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
WO2015007337A1
(en)
|
2013-07-19 |
2015-01-22 |
Bionor Immuno As |
Method for the vaccination against hiv
|
|
EP3038657A2
(en)
|
2013-08-28 |
2016-07-06 |
Bioasis Technologies Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
|
US9840493B2
(en)
|
2013-10-11 |
2017-12-12 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
AU2014337555C1
(en)
|
2013-10-15 |
2021-01-28 |
Seagen Inc. |
PEGylated drug-linkers for improved Ligand-Drug Conjugate pharmacokinetics
|
|
CN105705517A
(zh)
|
2013-11-07 |
2016-06-22 |
诺和诺德股份有限公司 |
用于治疗凝血障碍的新方法和抗体
|
|
CN105744935B
(zh)
|
2013-11-27 |
2022-09-30 |
雷德伍德生物科技股份有限公司 |
肼基-吡咯并化合物及用于生成缀合物的方法
|
|
CA2935423C
(en)
|
2014-01-24 |
2023-11-07 |
Dana-Farber Cancer Institute, Inc. |
Antibody molecules to pd-1 and uses thereof
|
|
AU2015210750B2
(en)
|
2014-01-31 |
2020-08-20 |
Children's Medical Center Corporation |
Antibody molecules to TIM-3 and uses thereof
|
|
WO2015130997A1
(en)
|
2014-02-26 |
2015-09-03 |
Gdovin Matthew |
Nitrobenzaldehyde proton release for manipulation of cellular acidosis
|
|
WO2015138920A1
(en)
|
2014-03-14 |
2015-09-17 |
Novartis Ag |
Antibody molecules to lag-3 and uses thereof
|
|
EP3593812A3
(en)
|
2014-03-15 |
2020-05-27 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor
|
|
EP3129401B1
(en)
|
2014-03-20 |
2019-06-12 |
Bristol-Myers Squibb Company |
Serum albumin-binding fibronectin type iii domains
|
|
DK3160994T3
(da)
|
2014-06-27 |
2025-05-05 |
Innate Pharma |
Multispecifikke antigenbindende proteiner
|
|
WO2015197593A1
(en)
|
2014-06-27 |
2015-12-30 |
Innate Pharma |
MULTISPECIFIC NKp46 BINDING PROTEINS
|
|
EP2975056A1
(en)
|
2014-07-17 |
2016-01-20 |
Novo Nordisk A/S |
Site directed mutagenesis of TREM-1 antibodies for decreasing viscosity
|
|
KR102641268B1
(ko)
|
2014-07-17 |
2024-02-27 |
노보 노르디스크 에이/에스 |
점도를 감소시키기 위한 trem-1 항체의 부위 지정 돌연변이유발
|
|
EP3026061A1
(en)
|
2014-11-26 |
2016-06-01 |
Novo Nordisk A/S |
Site directed mutagenesis of trem-1 antibodies for decreasing viscosity.
|
|
WO2016014530A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
|
US11542488B2
(en)
|
2014-07-21 |
2023-01-03 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
|
MY181834A
(en)
|
2014-07-21 |
2021-01-08 |
Novartis Ag |
Treatment of cancer using humanized anti-bcma chimeric antigen receptor
|
|
US9777061B2
(en)
|
2014-07-21 |
2017-10-03 |
Novartis Ag |
Treatment of cancer using a CD33 chimeric antigen receptor
|
|
US20170209492A1
(en)
|
2014-07-31 |
2017-07-27 |
Novartis Ag |
Subset-optimized chimeric antigen receptor-containing t-cells
|
|
WO2016025880A1
(en)
|
2014-08-14 |
2016-02-18 |
Novartis Ag |
Treatment of cancer using gfr alpha-4 chimeric antigen receptor
|
|
SG11201700770PA
(en)
|
2014-08-19 |
2017-03-30 |
Novartis Ag |
Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
|
|
ES2891332T3
(es)
|
2014-09-17 |
2022-01-27 |
Novartis Ag |
Direccionamiento a células citotóxicas con receptores quiméricos para la inmunoterapia adoptiva
|
|
CA2963692A1
(en)
|
2014-10-09 |
2016-04-14 |
Engmab Ag |
Bispecific antibodies against cd3epsilon and ror1
|
|
WO2016061142A1
(en)
|
2014-10-14 |
2016-04-21 |
Novartis Ag |
Antibody molecules to pd-l1 and uses thereof
|
|
BR112017008157A2
(pt)
|
2014-10-24 |
2017-12-19 |
Bristol Myers Squibb Co |
polipeptídeos de fgf-21 modificados e usos dos mesmos
|
|
US20180334490A1
(en)
|
2014-12-03 |
2018-11-22 |
Qilong H. Wu |
Methods for b cell preconditioning in car therapy
|
|
WO2016102657A1
(en)
|
2014-12-23 |
2016-06-30 |
Novo Nordisk A/S |
Alpha-cell re-generation combined with conversion to beta cells
|
|
WO2016150845A1
(en)
*
|
2015-03-20 |
2016-09-29 |
Ablynx Nv |
Glycosylated immunoglobulin single variable domains
|
|
MX2017012939A
(es)
|
2015-04-08 |
2018-05-22 |
Novartis Ag |
Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
|
|
EP3286211A1
(en)
|
2015-04-23 |
2018-02-28 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
|
US10676723B2
(en)
|
2015-05-11 |
2020-06-09 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
EP3313876B1
(en)
|
2015-06-23 |
2025-01-22 |
Innate Pharma |
Multispecific antigen binding proteins
|
|
WO2016207278A1
(en)
|
2015-06-23 |
2016-12-29 |
Innate Pharma |
Multispecific nk engager proteins
|
|
ES2878188T3
(es)
|
2015-07-29 |
2021-11-18 |
Novartis Ag |
Terapias de combinación que comprenden moléculas de anticuerpos contra LAG-3
|
|
EP4378957A3
(en)
|
2015-07-29 |
2024-08-07 |
Novartis AG |
Combination therapies comprising antibody molecules to pd-1
|
|
WO2017019897A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
|
AU2016302881B2
(en)
|
2015-08-03 |
2022-09-15 |
Bristol-Myers Squibb Company |
Monoclonal antibodies against BCMA
|
|
ES2781207T3
(es)
|
2015-09-23 |
2020-08-31 |
Bristol Myers Squibb Co |
Dominios de fibronectina de tipo iii de unión a seroalbúmina con velocidad de disociación rápida
|
|
ES2908470T3
(es)
|
2015-11-09 |
2022-04-29 |
Scherer Technologies Llc R P |
Conjugados de anticuerpo anti-CD22-maitansina y métodos de uso de los mismos
|
|
US11793880B2
(en)
|
2015-12-04 |
2023-10-24 |
Seagen Inc. |
Conjugates of quaternized tubulysin compounds
|
|
TWI852735B
(zh)
|
2015-12-04 |
2024-08-11 |
美商思進公司 |
四級胺化妥布賴森(tubulysin)化合物之結合物
|
|
EP3389712B1
(en)
|
2015-12-17 |
2024-04-10 |
Novartis AG |
Antibody molecules to pd-1 and uses thereof
|
|
RU2018125603A
(ru)
|
2015-12-17 |
2020-01-21 |
Новартис Аг |
Комбинация ингибитора с-мет с молекулой антитела к pd-1 и ее применения
|
|
PT3393504T
(pt)
|
2015-12-22 |
2025-12-30 |
Novartis Ag |
Recetor de antigénio quimérico (car) de mesotelina e anticorpo contra o inibidor de pd-l1 para utilização combinada em terapia anticancerígena
|
|
EP3405492B1
(en)
|
2016-01-21 |
2020-10-21 |
Novartis AG |
Multispecific molecules targeting cll-1
|
|
CA3016287A1
(en)
|
2016-03-04 |
2017-09-08 |
Novartis Ag |
Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore
|
|
US11549099B2
(en)
|
2016-03-23 |
2023-01-10 |
Novartis Ag |
Cell secreted minibodies and uses thereof
|
|
KR102626498B1
(ko)
|
2016-03-25 |
2024-01-19 |
씨젠 인크. |
페길화된 약물-링커 및 그의 중간체의 제조를 위한 공정
|
|
ES3046711T3
(en)
|
2016-04-15 |
2025-12-02 |
Beckman Coulter Inc |
Photoactive macromolecules and uses thereof
|
|
EP3443096B1
(en)
|
2016-04-15 |
2023-03-01 |
Novartis AG |
Compositions and methods for selective expression of chimeric antigen receptors
|
|
UA127200C2
(uk)
|
2016-05-18 |
2023-06-07 |
Бьорінгер Інгельхайм Інтернаціональ Гмбх |
Молекула антитіла до pd1
|
|
US10556936B2
(en)
|
2016-05-27 |
2020-02-11 |
Alk Abelló |
Immunogenic proteins and fragments thereof from allergenic mites
|
|
US20210177896A1
(en)
|
2016-06-02 |
2021-06-17 |
Novartis Ag |
Therapeutic regimens for chimeric antigen receptor (car)- expressing cells
|
|
WO2018013563A1
(en)
|
2016-07-12 |
2018-01-18 |
Kite Pharma, Inc. |
Antigen binding molecules and methods of use thereof
|
|
SG11201900344YA
(en)
|
2016-07-15 |
2019-02-27 |
Novartis Ag |
Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor
|
|
CN110214150A
(zh)
|
2016-07-28 |
2019-09-06 |
诺华股份有限公司 |
嵌合抗原受体和pd-1抑制剂的组合疗法
|
|
EP3490590A2
(en)
|
2016-08-01 |
2019-06-05 |
Novartis AG |
Treatment of cancer using a chimeric antigen receptor in combination with an inhibitor of a pro-m2 macrophage molecule
|
|
WO2018067992A1
(en)
|
2016-10-07 |
2018-04-12 |
Novartis Ag |
Chimeric antigen receptors for the treatment of cancer
|
|
EP3535295A1
(en)
|
2016-11-02 |
2019-09-11 |
EngMab Sàrl |
Bispecific antibody against bcma and cd3 and an immunological drug for combined use in treating multiple myeloma
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
EP3551703A4
(en)
|
2016-12-12 |
2021-01-20 |
Becton, Dickinson and Company |
WATER-SOLUBLE POLYMERIC DYES
|
|
EP3360898A1
(en)
|
2017-02-14 |
2018-08-15 |
Boehringer Ingelheim International GmbH |
Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
|
|
US20190322767A1
(en)
|
2016-12-23 |
2019-10-24 |
Innate Pharma |
Heterodimeric antigen binding proteins
|
|
EP3574005B1
(en)
|
2017-01-26 |
2021-12-15 |
Novartis AG |
Cd28 compositions and methods for chimeric antigen receptor therapy
|
|
US10266578B2
(en)
|
2017-02-08 |
2019-04-23 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
|
US20200048359A1
(en)
|
2017-02-28 |
2020-02-13 |
Novartis Ag |
Shp inhibitor compositions and uses for chimeric antigen receptor therapy
|
|
US11730822B2
(en)
|
2017-03-24 |
2023-08-22 |
Seagen Inc. |
Process for the preparation of glucuronide drug-linkers and intermediates thereof
|
|
US20200179511A1
(en)
|
2017-04-28 |
2020-06-11 |
Novartis Ag |
Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
|
|
US20200055948A1
(en)
|
2017-04-28 |
2020-02-20 |
Novartis Ag |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
|
US11312783B2
(en)
|
2017-06-22 |
2022-04-26 |
Novartis Ag |
Antibody molecules to CD73 and uses thereof
|
|
US20200223924A1
(en)
|
2017-06-27 |
2020-07-16 |
Novartis Ag |
Dosage regimens for anti-tim-3 antibodies and uses thereof
|
|
EP3652209A2
(en)
|
2017-07-11 |
2020-05-20 |
Compass Therapeutics LLC |
Agonist antibodies that bind human cd137 and uses thereof
|
|
KR20200031659A
(ko)
|
2017-07-20 |
2020-03-24 |
노파르티스 아게 |
항-lag-3 항체의 투여 요법 및 그의 용도
|
|
US11718679B2
(en)
|
2017-10-31 |
2023-08-08 |
Compass Therapeutics Llc |
CD137 antibodies and PD-1 antagonists and uses thereof
|
|
CN111655288A
(zh)
|
2017-11-16 |
2020-09-11 |
诺华股份有限公司 |
组合疗法
|
|
EP3713961A2
(en)
|
2017-11-20 |
2020-09-30 |
Compass Therapeutics LLC |
Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
|
|
AU2018371114A1
(en)
|
2017-11-21 |
2020-05-07 |
Innate Pharma |
Multispecific antigen binding proteins
|
|
WO2019133399A1
(en)
|
2017-12-26 |
2019-07-04 |
Becton, Dickinson And Company |
Deep ultraviolet-excitable water-solvated polymeric dyes
|
|
WO2019139987A1
(en)
|
2018-01-09 |
2019-07-18 |
Elstar Therapeutics, Inc. |
Calreticulin binding constructs and engineered t cells for the treatment of diseases
|
|
AU2019215031C1
(en)
|
2018-01-31 |
2026-02-26 |
Novartis Ag |
Combination therapy using a chimeric antigen receptor
|
|
US12152073B2
(en)
|
2018-03-14 |
2024-11-26 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to calreticulin and uses thereof
|
|
CN119242071A
(zh)
|
2018-03-30 |
2025-01-03 |
贝克顿·迪金森公司 |
含侧基发色团的水溶性聚合染料
|
|
AU2019248547B2
(en)
|
2018-04-02 |
2025-07-17 |
Bristol-Myers Squibb Company |
Anti-TREM-1 antibodies and uses thereof
|
|
US20210147547A1
(en)
|
2018-04-13 |
2021-05-20 |
Novartis Ag |
Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
|
|
EP3784351A1
(en)
|
2018-04-27 |
2021-03-03 |
Novartis AG |
Car t cell therapies with enhanced efficacy
|
|
EP3569618A1
(en)
|
2018-05-19 |
2019-11-20 |
Boehringer Ingelheim International GmbH |
Antagonizing cd73 antibody
|
|
WO2019226658A1
(en)
|
2018-05-21 |
2019-11-28 |
Compass Therapeutics Llc |
Multispecific antigen-binding compositions and methods of use
|
|
WO2019226617A1
(en)
|
2018-05-21 |
2019-11-28 |
Compass Therapeutics Llc |
Compositions and methods for enhancing the killing of target cells by nk cells
|
|
WO2019227003A1
(en)
|
2018-05-25 |
2019-11-28 |
Novartis Ag |
Combination therapy with chimeric antigen receptor (car) therapies
|
|
US20210214459A1
(en)
|
2018-05-31 |
2021-07-15 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
|
AU2019284911B2
(en)
|
2018-06-13 |
2026-04-09 |
Novartis Ag |
BCMA chimeric antigen receptors and uses thereof
|
|
KR20210035173A
(ko)
|
2018-06-19 |
2021-03-31 |
아타르가, 엘엘씨 |
보체 성분 5에 대한 항체분자 및 이의 용도
|
|
WO2020010250A2
(en)
|
2018-07-03 |
2020-01-09 |
Elstar Therapeutics, Inc. |
Anti-tcr antibody molecules and uses thereof
|
|
AR116109A1
(es)
|
2018-07-10 |
2021-03-31 |
Novartis Ag |
Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
|
|
US20220162336A1
(en)
|
2018-07-22 |
2022-05-26 |
Bioasis Technologies, Inc. |
Treatment of lymphatic metastases
|
|
JP2021531306A
(ja)
|
2018-07-25 |
2021-11-18 |
アドバンスド アクセラレーター アプリケーションズ エスエー |
神経内分泌腫瘍の処置の方法
|
|
MX2021002575A
(es)
|
2018-09-11 |
2021-06-08 |
Ambrx Inc |
Conjugados de polipeptidos de interleucina-2 y sus usos.
|
|
AU2019361206A1
(en)
|
2018-10-19 |
2021-06-03 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
|
US12016885B2
(en)
|
2018-11-06 |
2024-06-25 |
Alsatech, Inc. |
Method of solubilizing TDP-43 protein aggregates in amyotrophic lateral sclerosis using a microvascular endothelial cell expressing an anti-TDP-43 Fab
|
|
WO2020102387A1
(en)
|
2018-11-13 |
2020-05-22 |
Compass Therapeutics Llc |
Multispecific binding constructs against checkpoint molecules and uses thereof
|
|
GB201818477D0
(en)
|
2018-11-13 |
2018-12-26 |
Emstopa Ltd |
Tissue plasminogen activator antibodies and method of use thereof
|
|
JP2022514280A
(ja)
|
2018-12-20 |
2022-02-10 |
ノバルティス アーゲー |
Mdm2阻害剤のための延長低用量レジメン
|
|
WO2020128972A1
(en)
|
2018-12-20 |
2020-06-25 |
Novartis Ag |
Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
|
|
CN119455003A
(zh)
|
2019-02-12 |
2025-02-18 |
Ambrx公司 |
包含抗体-tlr激动剂缀合物的组合物、方法和用途
|
|
BR112021015672A2
(pt)
|
2019-02-15 |
2021-10-05 |
Novartis Ag |
Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona substituída e usos dos mesmos
|
|
ES3032659T3
(en)
|
2019-02-15 |
2025-07-23 |
Novartis Ag |
3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
US10871640B2
(en)
|
2019-02-15 |
2020-12-22 |
Perkinelmer Cellular Technologies Germany Gmbh |
Methods and systems for automated imaging of three-dimensional objects
|
|
GB2597851B
(en)
|
2019-02-21 |
2024-05-29 |
Marengo Therapeutics Inc |
Antibody molecules that bind to NKP30 and uses thereof
|
|
AU2020226893B2
(en)
|
2019-02-21 |
2025-02-27 |
Marengo Therapeutics, Inc. |
Multifunctional molecules that bind to T cell related cancer cells and uses thereof
|
|
US20220088075A1
(en)
|
2019-02-22 |
2022-03-24 |
The Trustees Of The University Of Pennsylvania |
Combination therapies of egfrviii chimeric antigen receptors and pd-1 inhibitors
|
|
JP2022527790A
(ja)
|
2019-03-29 |
2022-06-06 |
アターガ,エルエルシー |
抗fgf23抗体分子
|
|
JP7712210B2
(ja)
|
2019-04-01 |
2025-07-23 |
ノヴォ ノルディスク アー/エス |
リラグルチドに対する抗体およびその使用
|
|
CN114144435B
(zh)
|
2019-07-15 |
2024-06-25 |
百时美施贵宝公司 |
针对人trem-1的抗体及其用途
|
|
EP3999543A1
(en)
|
2019-07-15 |
2022-05-25 |
Bristol-Myers Squibb Company |
Anti-trem-1 antibodies and uses thereof
|
|
CN114765980A
(zh)
*
|
2019-09-06 |
2022-07-19 |
加利福尼亚大学董事会 |
用于治疗癌症的嵌合抗原受体及相关方法和组合物
|
|
CA3158298A1
(en)
|
2019-10-21 |
2021-04-29 |
Novartis Ag |
Combination therapies with venetoclax and tim-3 inhibitors
|
|
TW202128191A
(zh)
|
2019-10-21 |
2021-08-01 |
瑞士商諾華公司 |
Tim-3抑制劑及其用途
|
|
EP4065158A2
(en)
|
2019-11-26 |
2022-10-05 |
Novartis AG |
Chimeric antigen receptors binding bcma and cd19 and uses thereof
|
|
KR20220116257A
(ko)
|
2019-12-20 |
2022-08-22 |
노파르티스 아게 |
골수섬유증 및 골수이형성 증후군을 치료하기 위한, 데시타빈 또는 항 pd-1 항체 스파르탈리주맙을 포함하거나 또는 포함하지 않는, 항 tim-3 항체 mbg453 및 항 tgf-베타 항체 nis793의 조합물
|
|
AU2020416273A1
(en)
|
2020-01-03 |
2022-07-28 |
Marengo Therapeutics, Inc. |
Anti-TCR antibody molecules and uses thereof
|
|
CN113186185B
(zh)
*
|
2020-01-14 |
2023-05-26 |
东北林业大学 |
一种从哺乳动物粪便中高效富集宿主dna的方法
|
|
US20230058489A1
(en)
|
2020-01-17 |
2023-02-23 |
Novartis Ag |
Combination comprising a tim-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia
|
|
EP4090762A1
(en)
|
2020-01-17 |
2022-11-23 |
Becton, Dickinson and Company |
Methods and compositions for single cell secretomics
|
|
MX2022010685A
(es)
|
2020-02-27 |
2022-09-23 |
Novartis Ag |
Metodos de produccion de celulas que expresan receptores de antigeno quimericos.
|
|
WO2021183832A1
(en)
|
2020-03-11 |
2021-09-16 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
|
US20210355468A1
(en)
|
2020-05-18 |
2021-11-18 |
Bioasis Technologies, Inc. |
Compositions and methods for treating lewy body dementia
|
|
CA3180665A1
(en)
|
2020-05-19 |
2021-11-25 |
Boehringer Ingelheim International Gmbh |
Binding molecules for the treatment of cancer
|
|
CA3180556A1
(en)
|
2020-05-29 |
2021-12-02 |
Stephan Becker |
Neutralizing antibodies against sars-related coronavirus
|
|
US20210393787A1
(en)
|
2020-06-17 |
2021-12-23 |
Bioasis Technologies, Inc. |
Compositions and methods for treating frontotemporal dementia
|
|
CN115916199A
(zh)
|
2020-06-23 |
2023-04-04 |
诺华股份有限公司 |
包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案
|
|
US11524998B2
(en)
|
2020-07-16 |
2022-12-13 |
Novartis Ag |
Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules
|
|
WO2022026592A2
(en)
|
2020-07-28 |
2022-02-03 |
Celltas Bio, Inc. |
Antibody molecules to coronavirus and uses thereof
|
|
US20230271940A1
(en)
|
2020-08-03 |
2023-08-31 |
Novartis Ag |
Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
|
|
CN116547301A
(zh)
|
2020-08-10 |
2023-08-04 |
先天制药公司 |
使用抗体进行的细胞表面mica和micb检测
|
|
AU2021327396A1
(en)
|
2020-08-20 |
2023-03-23 |
Ambrx, Inc. |
Antibody-TLR agonist conjugates, methods and uses thereof
|
|
EP4204020A1
(en)
|
2020-08-31 |
2023-07-05 |
Advanced Accelerator Applications International S.A. |
Method of treating psma-expressing cancers
|
|
WO2022043557A1
(en)
|
2020-08-31 |
2022-03-03 |
Advanced Accelerator Applications International Sa |
Method of treating psma-expressing cancers
|
|
JP7633397B2
(ja)
|
2020-10-21 |
2025-02-19 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
眼の疾患の処置のための二重特異性抗VEGF及び抗TrkB結合分子
|
|
KR20230110523A
(ko)
|
2020-10-22 |
2023-07-24 |
얀센 바이오테크 인코포레이티드 |
델타-유사 리간드 3(dll3) 항원 결합 영역을 포함하는 단백질 및 그의 용도
|
|
JP2023547499A
(ja)
|
2020-11-06 |
2023-11-10 |
ノバルティス アーゲー |
抗体Fc変異体
|
|
MX2023005609A
(es)
|
2020-11-13 |
2023-05-29 |
Novartis Ag |
Terapias de combinacion con celulas que expresan receptores quimericos para el antigeno (car).
|
|
EP4284510A1
(en)
|
2021-01-29 |
2023-12-06 |
Novartis AG |
Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof
|
|
US20240230671A9
(en)
|
2021-02-24 |
2024-07-11 |
Alladapt Immunotherapeutics, Inc. |
Compositions and methods for identification of cross-reactive allergenic proteins and treatment of allergies
|
|
JP2024511465A
(ja)
|
2021-03-26 |
2024-03-13 |
イナート・ファルマ・ソシエテ・アノニム |
Nk細胞エンゲージングのためにサイトカインに融合したnkp46結合性部位、がん抗原結合性部位を含む多特異性タンパク質
|
|
IL307168A
(en)
|
2021-03-26 |
2023-11-01 |
Janssen Biotech Inc |
Humanized antibodies against paired helical strands of TAU protein and their uses
|
|
MX2023011480A
(es)
|
2021-04-03 |
2023-12-06 |
Ambrx Inc |
Conjugados anticuerpo anti-her2-fármaco y usos de estos.
|
|
CN117242093A
(zh)
|
2021-04-05 |
2023-12-15 |
先天制药公司 |
免疫组织化学方法和kir3dl2特异性试剂
|
|
TW202304979A
(zh)
|
2021-04-07 |
2023-02-01 |
瑞士商諾華公司 |
抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途
|
|
AR125874A1
(es)
|
2021-05-18 |
2023-08-23 |
Novartis Ag |
Terapias de combinación
|
|
EP4095156A1
(en)
|
2021-05-28 |
2022-11-30 |
Universität zu Köln |
Neutralizing antibodies against hepatitis c virus
|
|
WO2022258678A1
(en)
|
2021-06-09 |
2022-12-15 |
Innate Pharma |
Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
|
|
WO2022258691A1
(en)
|
2021-06-09 |
2022-12-15 |
Innate Pharma |
Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
|
|
US20250002601A1
(en)
|
2021-06-09 |
2025-01-02 |
Innate Pharma |
Multispecific antibodies binding to cd20, nkp46, cd16 and conjugated to il-2
|
|
MX2023014647A
(es)
|
2021-06-09 |
2024-01-31 |
Innate Pharma |
Proteinas de union a nkp46 multiespecificas.
|
|
TW202317625A
(zh)
|
2021-06-17 |
2023-05-01 |
德商百靈佳殷格翰國際股份有限公司 |
新穎三特異性結合分子
|
|
EP4405396A2
(en)
|
2021-09-20 |
2024-07-31 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of her2 positive cancer
|
|
EP4155349A1
(en)
|
2021-09-24 |
2023-03-29 |
Becton, Dickinson and Company |
Water-soluble yellow green absorbing dyes
|
|
US20250034559A1
(en)
|
2021-11-17 |
2025-01-30 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of tau-related disorders
|
|
EP4190810A1
(en)
|
2021-12-01 |
2023-06-07 |
Universität zu Köln |
Neutralizing antibodies against sars-related coronavirus
|
|
JP2024542793A
(ja)
|
2021-12-01 |
2024-11-15 |
ウニヴェルズィテート ツー ケルン |
Sars関連コロナウイルスに対する中和抗体
|
|
TW202342548A
(zh)
|
2022-02-07 |
2023-11-01 |
美商威特拉公司 |
抗獨特型(anti-idiotype)抗體分子及其用途
|
|
KR20240159846A
(ko)
|
2022-03-11 |
2024-11-06 |
얀센 파마슈티카 엔브이 |
다중특이적 항체 및 이의 용도
|
|
AU2023232448A1
(en)
|
2022-03-11 |
2024-10-24 |
Janssen Pharmaceutica Nv |
Multispecific antibodies and uses thereof
|
|
TW202346355A
(zh)
|
2022-03-11 |
2023-12-01 |
比利時商健生藥品公司 |
多特異性抗體及其用途(二)
|
|
EP4522757A2
(en)
|
2022-05-13 |
2025-03-19 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of her2 positive cancer
|
|
AU2023298234A1
(en)
|
2022-07-01 |
2025-01-16 |
Beckman Coulter, Inc. |
Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
|
|
EP4554677A1
(en)
|
2022-07-15 |
2025-05-21 |
Boehringer Ingelheim International GmbH |
Binding molecules for the treatment of cancer
|
|
JP2025528068A
(ja)
|
2022-08-03 |
2025-08-26 |
ボイジャー セラピューティクス インコーポレイテッド |
血液脳関門を通過させるための組成物及び方法
|
|
WO2024044327A1
(en)
|
2022-08-26 |
2024-02-29 |
Beckman Coulter, Inc. |
Dhnt monomers and polymer dyes with modified photophysical properties
|
|
EP4587123A1
(en)
|
2022-09-15 |
2025-07-23 |
Avidicure IP B.V. |
Multispecific antigen binding proteins for tumor-targeting of nk cells and use thereof
|
|
WO2024168061A2
(en)
|
2023-02-07 |
2024-08-15 |
Ayan Therapeutics Inc. |
Antibody molecules binding to sars-cov-2
|
|
EP4669667A2
(en)
|
2023-02-24 |
2025-12-31 |
Universität zu Köln |
SARS-CoV-2 Neutralizing Antibodies
|
|
WO2024196805A1
(en)
|
2023-03-17 |
2024-09-26 |
Beckman Coulter, Inc. |
Benzothienopyrrole cyanine dyes
|
|
WO2024208818A1
(en)
|
2023-04-04 |
2024-10-10 |
Innate Pharma |
Modular chimeric antigen receptor
|
|
WO2024251884A1
(en)
|
2023-06-09 |
2024-12-12 |
Innate Pharma |
Nk cell engager proteins comprising anti-cd20 and ant-nkp46 antibody, linked to il-2 in treatment of r/r b-nhl
|
|
EP4484445A1
(en)
|
2023-06-26 |
2025-01-01 |
Universität zu Köln |
Hcmv neutralizing antibodies
|
|
EP4735478A1
(en)
|
2023-06-28 |
2026-05-06 |
Universität zu Köln |
Neutralizing human monoclonal antibodies against p. aeruginosa
|
|
CN121866309A
(zh)
|
2023-09-21 |
2026-04-14 |
贝克曼库尔特有限公司 |
用于流式细胞术的二氢菲(dhp)桥接染料
|
|
WO2025122634A1
(en)
|
2023-12-05 |
2025-06-12 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of tau-related disorders
|
|
WO2025149633A1
(en)
|
2024-01-12 |
2025-07-17 |
Laigo Bio B.V. |
Bispecific antigen binding proteins
|
|
WO2025172924A1
(en)
|
2024-02-15 |
2025-08-21 |
Janssen Biotech, Inc. |
Anti-transferrin receptor compositions and methods thereof
|
|
WO2025191136A1
(en)
|
2024-03-15 |
2025-09-18 |
Avidicure Ip B.V. |
Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof
|
|
WO2025191137A1
(en)
|
2024-03-15 |
2025-09-18 |
Avidicure Ip B.V. |
Conjugates of trop2-specific antigen binding proteins and cytokines
|
|
WO2025191133A1
(en)
|
2024-03-15 |
2025-09-18 |
Avidicure Ip B.V. |
Il-21 muteins, fusion proteins comprising the same and uses thereof
|
|
WO2026036047A1
(en)
|
2024-08-08 |
2026-02-12 |
Altus Enterprises, Inc. |
Antibody molecules to fixa and fx and uses thereof
|
|
WO2026043823A2
(en)
|
2024-08-19 |
2026-02-26 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of preparation and uses thereof
|
|
WO2026058155A1
(en)
|
2024-09-11 |
2026-03-19 |
Novartis Ag |
Antibodies targeting il-31
|
|
WO2026087747A1
(en)
|
2024-10-24 |
2026-04-30 |
Avidicure Ip B.V. |
Multispecific antigen binding proteins for tumor-targeting of γδ1 t cells and use thereof
|
|
WO2026087748A1
(en)
|
2024-10-24 |
2026-04-30 |
Avidicure Ip B.V. |
Multispecific antigen binding proteins for the expansion of γδ t cells and use thereof
|