JP2001081042A5 - - Google Patents
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- JP2001081042A5 JP2001081042A5 JP2000227474A JP2000227474A JP2001081042A5 JP 2001081042 A5 JP2001081042 A5 JP 2001081042A5 JP 2000227474 A JP2000227474 A JP 2000227474A JP 2000227474 A JP2000227474 A JP 2000227474A JP 2001081042 A5 JP2001081042 A5 JP 2001081042A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polynucleotide
- vaccine
- amino acid
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
- 108010017842 Telomerase Proteins 0.000 claims description 3
- 108010057210 telomerase RNA Proteins 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000003197 catalytic effect Effects 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 description 15
- 102000039446 nucleic acids Human genes 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 239000013598 vector Substances 0.000 description 3
- 101000655352 Homo sapiens Telomerase reverse transcriptase Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102100032938 Telomerase reverse transcriptase Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72464396A | 1996-10-01 | 1996-10-01 | |
| US08/724,643 | 1996-10-01 | ||
| US84441997A | 1997-04-18 | 1997-04-18 | |
| US08/844,419 | 1997-04-18 | ||
| US84601797A | 1997-04-25 | 1997-04-25 | |
| US08/846,017 | 1997-04-25 | ||
| US08/851,843 | 1997-05-06 | ||
| US08/851,843 US6093809A (en) | 1996-10-01 | 1997-05-06 | Telomerase |
| US08/854,050 | 1997-05-09 | ||
| US08/854,050 US6261836B1 (en) | 1996-10-01 | 1997-05-09 | Telomerase |
| US91131297A | 1997-08-14 | 1997-08-14 | |
| US91550397A | 1997-08-14 | 1997-08-14 | |
| US08/911,312 | 1997-08-14 | ||
| US08/912,951 | 1997-08-14 | ||
| US08/915,503 | 1997-08-14 | ||
| US08/912,951 US6475789B1 (en) | 1996-10-01 | 1997-08-14 | Human telomerase catalytic subunit: diagnostic and therapeutic methods |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP28618297A Division JP3869092B2 (ja) | 1996-10-01 | 1997-10-01 | ヒトテロメラーゼ触媒性サブユニット |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008194208A Division JP4852576B2 (ja) | 1996-10-01 | 2008-07-28 | ヒトテロメラーゼ触媒性サブユニット |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001081042A JP2001081042A (ja) | 2001-03-27 |
| JP2001081042A5 true JP2001081042A5 (enExample) | 2005-12-08 |
Family
ID=27575511
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP28618297A Expired - Lifetime JP3869092B2 (ja) | 1996-10-01 | 1997-10-01 | ヒトテロメラーゼ触媒性サブユニット |
| JP51680298A Pending JP2001523947A (ja) | 1996-10-01 | 1997-10-01 | テロメラーゼ逆転写酵素 |
| JP51690998A Pending JP2001510985A (ja) | 1996-10-01 | 1997-10-01 | ヒトテロメラーゼ触媒性サブユニット |
| JP32016998A Expired - Lifetime JP4070331B2 (ja) | 1996-10-01 | 1998-10-15 | ヒトテロメラーゼ触媒性サブユニットプロモーター |
| JP11042410A Pending JPH11313689A (ja) | 1996-10-01 | 1999-02-19 | ヒトテロメラ―ゼ触媒性サブユニット |
| JP2000227474A Withdrawn JP2001081042A (ja) | 1996-10-01 | 2000-07-27 | ヒトテロメラーゼ触媒性サブユニット |
| JP2008194208A Expired - Lifetime JP4852576B2 (ja) | 1996-10-01 | 2008-07-28 | ヒトテロメラーゼ触媒性サブユニット |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP28618297A Expired - Lifetime JP3869092B2 (ja) | 1996-10-01 | 1997-10-01 | ヒトテロメラーゼ触媒性サブユニット |
| JP51680298A Pending JP2001523947A (ja) | 1996-10-01 | 1997-10-01 | テロメラーゼ逆転写酵素 |
| JP51690998A Pending JP2001510985A (ja) | 1996-10-01 | 1997-10-01 | ヒトテロメラーゼ触媒性サブユニット |
| JP32016998A Expired - Lifetime JP4070331B2 (ja) | 1996-10-01 | 1998-10-15 | ヒトテロメラーゼ触媒性サブユニットプロモーター |
| JP11042410A Pending JPH11313689A (ja) | 1996-10-01 | 1999-02-19 | ヒトテロメラ―ゼ触媒性サブユニット |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008194208A Expired - Lifetime JP4852576B2 (ja) | 1996-10-01 | 2008-07-28 | ヒトテロメラーゼ触媒性サブユニット |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US6166178A (enExample) |
| EP (6) | EP0932686A2 (enExample) |
| JP (7) | JP3869092B2 (enExample) |
| KR (2) | KR20000048820A (enExample) |
| CN (3) | CN1291231B (enExample) |
| AT (3) | ATE449851T1 (enExample) |
| AU (2) | AU4803697A (enExample) |
| BR (3) | BR9711844A (enExample) |
| CA (3) | CA2266752A1 (enExample) |
| DE (5) | DE69723531T3 (enExample) |
| EA (2) | EA199900349A1 (enExample) |
| ES (1) | ES2205132T5 (enExample) |
| FI (1) | FI990655A7 (enExample) |
| FR (1) | FR2757177A1 (enExample) |
| GB (2) | GB2321642B8 (enExample) |
| IL (2) | IL129222A0 (enExample) |
| NO (2) | NO319982B1 (enExample) |
| NZ (1) | NZ334709A (enExample) |
| SG (1) | SG94355A1 (enExample) |
| WO (2) | WO1998014593A2 (enExample) |
Families Citing this family (178)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5958680A (en) | 1994-07-07 | 1999-09-28 | Geron Corporation | Mammalian telomerase |
| US6545133B1 (en) | 1995-08-04 | 2003-04-08 | Geron Corporation | Methods for purifying telomerase |
| US6517834B1 (en) | 1995-08-04 | 2003-02-11 | Geron Corporation | Purified telomerase |
| US6582904B2 (en) | 1995-11-16 | 2003-06-24 | Michael W. Dahm | Method of quantifying tumour cells in a body fluid and a suitable test kit |
| US6881571B1 (en) * | 1998-03-11 | 2005-04-19 | Exonhit Therapeutics S.A. | Qualitative differential screening |
| US6607898B1 (en) | 1996-03-26 | 2003-08-19 | Oncomedx, Inc. | Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum |
| US7585622B1 (en) | 1996-10-01 | 2009-09-08 | Geron Corporation | Increasing the proliferative capacity of cells using telomerase reverse transcriptase |
| US6610839B1 (en) | 1997-08-14 | 2003-08-26 | Geron Corporation | Promoter for telomerase reverse transcriptase |
| US6777203B1 (en) * | 1997-11-19 | 2004-08-17 | Geron Corporation | Telomerase promoter driving expression of therapeutic gene sequences |
| US6261836B1 (en) * | 1996-10-01 | 2001-07-17 | Geron Corporation | Telomerase |
| US6093809A (en) | 1996-10-01 | 2000-07-25 | University Technology Corporation | Telomerase |
| FI990655A7 (fi) | 1996-10-01 | 1999-06-01 | Geron Corp | Ihmistelomeraasin katalyyttinen alayksikkö |
| US6808880B2 (en) | 1996-10-01 | 2004-10-26 | Geron Corporation | Method for detecting polynucleotides encoding telomerase |
| US6475789B1 (en) | 1996-10-01 | 2002-11-05 | University Technology Corporation | Human telomerase catalytic subunit: diagnostic and therapeutic methods |
| US6444650B1 (en) * | 1996-10-01 | 2002-09-03 | Geron Corporation | Antisense compositions for detecting and inhibiting telomerase reverse transcriptase |
| US7390891B1 (en) * | 1996-11-15 | 2008-06-24 | Amgen Inc. | Polynucleotides encoding a telomerase component TP2 |
| EP0942991A2 (en) * | 1996-11-26 | 1999-09-22 | Baylor College Of Medicine | Identification of inhibitors that prevent access of telomerase to chromosomal terminus |
| WO1998037181A2 (en) * | 1997-02-20 | 1998-08-27 | Whitehead Institute For Biomedical Research | Telomerase catalytic subunit gene and encoded protein |
| US7622549B2 (en) | 1997-04-18 | 2009-11-24 | Geron Corporation | Human telomerase reverse transcriptase polypeptides |
| US20050013825A1 (en) * | 1997-04-18 | 2005-01-20 | Geron Corporation | Vaccine containing the catalytic subunit of telomerase for treating cancer |
| US7413864B2 (en) | 1997-04-18 | 2008-08-19 | Geron Corporation | Treating cancer using a telomerase vaccine |
| EP0990037A2 (de) * | 1997-06-20 | 2000-04-05 | Bayer Ag | Humane katalytische telomerase-untereinheit und deren diagnostische und therapeutische verwendung |
| CA2294782A1 (en) * | 1997-07-01 | 1999-01-14 | Cambia Biosystems Llc | Vertebrate telomerase genes and proteins and uses thereof |
| EP1571215A3 (en) * | 1997-07-01 | 2007-10-31 | Cambia Biosystems LLC | Vertebrate telomerase genes and proteins and uses thereof |
| US7378244B2 (en) | 1997-10-01 | 2008-05-27 | Geron Corporation | Telomerase promoters sequences for screening telomerase modulators |
| WO1999027113A1 (en) * | 1997-11-26 | 1999-06-03 | Geron Corporation | Mouse telomerase reverse transcriptase |
| DE19757984A1 (de) * | 1997-12-24 | 1999-07-01 | Bayer Ag | Regulatorische DNA-Sequenzen aus der 5'-Region vom Gen der humanen katalytischen Telomerase-Untereinheit udn deren diagnostische und therapeutische Verwendung |
| DE19804372A1 (de) * | 1998-02-04 | 1999-08-05 | Michael W Dr Dr Dahm | Verfahren zur quantitativen Bestimmung von Tumorzellen in einer Körperflüssigkeit und dazu geeignete Testkits |
| AU754278B2 (en) * | 1998-03-26 | 2002-11-07 | Kyowa Hakko Kogyo Co. Ltd. | Monoclonal antibody against human telomerase catalytic subunit |
| US6337200B1 (en) * | 1998-03-31 | 2002-01-08 | Geron Corporation | Human telomerase catalytic subunit variants |
| CA2347067C (en) | 1998-03-31 | 2013-09-17 | Geron Corporation | Dendritic cell vaccine containing telomerase reverse transcriptase for the treatment of cancer |
| US7402307B2 (en) | 1998-03-31 | 2008-07-22 | Geron Corporation | Method for identifying and killing cancer cells |
| US20030105315A1 (en) * | 1998-04-09 | 2003-06-05 | Metagen Pharmaceuticals Gmbh | Human nucleic acid sequences from ovarian tumor tissue |
| US7030211B1 (en) | 1998-07-08 | 2006-04-18 | Gemvax As | Antigenic peptides derived from telomerase |
| US6900049B2 (en) | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| ATE347904T1 (de) | 1998-10-29 | 2007-01-15 | Dana Farber Cancer Inst Inc | Krebsimmuntherapie und krebsdiagnose unter verwendung universeller tumorassoziierter antigene einschliesslich htert |
| GB9900298D0 (en) * | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| EP1149161A2 (de) * | 1999-01-22 | 2001-10-31 | Humboldt-Universität zu Berlin Universitätsklinikum Charite; | GEGEN DIE KATALYTISCHE UNTEREINHEIT DER HUMANEN TELOMERASE (hTERT) GERICHTETE RIBOZYME |
| ES2220448T3 (es) * | 1999-02-04 | 2004-12-16 | Geron Corporation | Secuencias reguladoras de la transcripcion de la telomerasa transcriptasa inversa. |
| US7314926B1 (en) | 1999-04-08 | 2008-01-01 | Antisoma Research Limited | Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin |
| US7960540B2 (en) | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
| US8114850B2 (en) | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
| EP1171612A2 (en) * | 1999-04-09 | 2002-01-16 | Biomira, Inc. | Telomerase-specific cancer vaccine |
| US6358739B1 (en) * | 1999-04-12 | 2002-03-19 | Modex Therapeutiques, S.A. | Transiently immortalized cells |
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