JOP20200092A1 - تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها - Google Patents

تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها

Info

Publication number
JOP20200092A1
JOP20200092A1 JOP/2020/0092A JOP20200092A JOP20200092A1 JO P20200092 A1 JOP20200092 A1 JO P20200092A1 JO P20200092 A JOP20200092 A JO P20200092A JO P20200092 A1 JOP20200092 A1 JO P20200092A1
Authority
JO
Jordan
Prior art keywords
hbv
hepatitis
virus
methods
irna compositions
Prior art date
Application number
JOP/2020/0092A
Other languages
Arabic (ar)
English (en)
Inventor
G Rajeev Kallanthottathil
Manoharan Muthiah
Jadhav Vasant
Sepp-Lorenzino Laura
Maier Martin
Milstein Stuart
Hinkle Gregory
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54542627&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JOP20200092(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of JOP20200092A1 publication Critical patent/JOP20200092A1/ar

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Virology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JOP/2020/0092A 2014-11-10 2014-11-10 تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها JOP20200092A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077672P 2014-11-10 2014-11-10
US201462077799P 2014-11-10 2014-11-10
US201562137464P 2015-03-24 2015-03-24

Publications (1)

Publication Number Publication Date
JOP20200092A1 true JOP20200092A1 (ar) 2017-06-16

Family

ID=54542627

Family Applications (2)

Application Number Title Priority Date Filing Date
JOP/2020/0092A JOP20200092A1 (ar) 2014-11-10 2014-11-10 تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
JOP/2015/0278A JO3573B1 (ar) 2014-11-10 2015-11-10 تركيبات iRNA لفيروس الكبد (HBV) B وطرق لاستخدامها

Family Applications After (1)

Application Number Title Priority Date Filing Date
JOP/2015/0278A JO3573B1 (ar) 2014-11-10 2015-11-10 تركيبات iRNA لفيروس الكبد (HBV) B وطرق لاستخدامها

Country Status (22)

Country Link
US (4) US10513703B2 (enExample)
EP (4) EP3218489B1 (enExample)
JP (5) JP2017534290A (enExample)
KR (3) KR102545316B1 (enExample)
CN (4) CN108064293A (enExample)
AU (4) AU2015346566B2 (enExample)
BR (2) BR112017008868B1 (enExample)
CA (2) CA3233743A1 (enExample)
CY (1) CY1122520T1 (enExample)
DK (1) DK3218489T3 (enExample)
ES (1) ES2761912T3 (enExample)
HR (1) HRP20192177T1 (enExample)
HU (1) HUE047535T2 (enExample)
JO (2) JOP20200092A1 (enExample)
MA (2) MA40843A (enExample)
MX (2) MX383315B (enExample)
PL (1) PL3218489T3 (enExample)
PT (1) PT3218489T (enExample)
SG (3) SG11201703638XA (enExample)
SI (1) SI3218489T1 (enExample)
TW (4) TWI834187B (enExample)
WO (2) WO2016077349A1 (enExample)

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