JP6728163B2 - B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 - Google Patents
B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 Download PDFInfo
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- JP6728163B2 JP6728163B2 JP2017525073A JP2017525073A JP6728163B2 JP 6728163 B2 JP6728163 B2 JP 6728163B2 JP 2017525073 A JP2017525073 A JP 2017525073A JP 2017525073 A JP2017525073 A JP 2017525073A JP 6728163 B2 JP6728163 B2 JP 6728163B2
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- 0 *C(C1O)C(OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCOC(C(*)C2O)OC(CO)C2O)=O)=O)(COCCC(NCCCNC(CCCCOC(C(*)C2O)O[C@@](CO)C2O)=O)=O)N)=O)=O)OC(CO)C1O Chemical compound *C(C1O)C(OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCOC(C(*)C2O)OC(CO)C2O)=O)=O)(COCCC(NCCCNC(CCCCOC(C(*)C2O)O[C@@](CO)C2O)=O)=O)N)=O)=O)OC(CO)C1O 0.000 description 1
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- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3533—Halogen
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020113784A JP6947880B2 (ja) | 2014-11-10 | 2020-07-01 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462077799P | 2014-11-10 | 2014-11-10 | |
| US201462077672P | 2014-11-10 | 2014-11-10 | |
| US62/077,672 | 2014-11-10 | ||
| US62/077,799 | 2014-11-10 | ||
| US201562137464P | 2015-03-24 | 2015-03-24 | |
| US62/137,464 | 2015-03-24 | ||
| PCT/US2015/059916 WO2016077321A1 (en) | 2014-11-10 | 2015-11-10 | Hepatitis b virus (hbv) irna compositions and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020113784A Division JP6947880B2 (ja) | 2014-11-10 | 2020-07-01 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017538679A JP2017538679A (ja) | 2017-12-28 |
| JP2017538679A5 JP2017538679A5 (enExample) | 2018-12-20 |
| JP6728163B2 true JP6728163B2 (ja) | 2020-07-22 |
Family
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Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525073A Active JP6728163B2 (ja) | 2014-11-10 | 2015-11-10 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2017525059A Pending JP2017534290A (ja) | 2014-11-10 | 2015-11-10 | D型肝炎ウイルス(HDV)iRNA組成物及びその使用方法 |
| JP2020113784A Active JP6947880B2 (ja) | 2014-11-10 | 2020-07-01 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2021150898A Active JP7426973B2 (ja) | 2014-11-10 | 2021-09-16 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2024007963A Pending JP2024056714A (ja) | 2014-11-10 | 2024-01-23 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2025133429A Pending JP2025183208A (ja) | 2014-11-10 | 2025-08-08 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525059A Pending JP2017534290A (ja) | 2014-11-10 | 2015-11-10 | D型肝炎ウイルス(HDV)iRNA組成物及びその使用方法 |
| JP2020113784A Active JP6947880B2 (ja) | 2014-11-10 | 2020-07-01 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2021150898A Active JP7426973B2 (ja) | 2014-11-10 | 2021-09-16 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2024007963A Pending JP2024056714A (ja) | 2014-11-10 | 2024-01-23 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2025133429A Pending JP2025183208A (ja) | 2014-11-10 | 2025-08-08 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US10513703B2 (enExample) |
| EP (4) | EP3218487B1 (enExample) |
| JP (6) | JP6728163B2 (enExample) |
| KR (3) | KR102827682B1 (enExample) |
| CN (4) | CN113801882A (enExample) |
| AU (4) | AU2015346566B2 (enExample) |
| BR (2) | BR122021001218B1 (enExample) |
| CA (2) | CA2967408C (enExample) |
| CY (1) | CY1122520T1 (enExample) |
| DK (1) | DK3218489T3 (enExample) |
| ES (1) | ES2761912T3 (enExample) |
| HR (1) | HRP20192177T1 (enExample) |
| HU (1) | HUE047535T2 (enExample) |
| JO (2) | JOP20200092A1 (enExample) |
| MA (2) | MA40851A (enExample) |
| MX (2) | MX383315B (enExample) |
| PL (1) | PL3218489T3 (enExample) |
| PT (1) | PT3218489T (enExample) |
| SG (3) | SG10202007323VA (enExample) |
| SI (1) | SI3218489T1 (enExample) |
| TW (4) | TWI710633B (enExample) |
| WO (2) | WO2016077321A1 (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8575327B2 (en) | 2003-06-12 | 2013-11-05 | Alnylam Pharmaceuticals, Inc. | Conserved HBV and HCV sequences useful for gene silencing |
| WO2013003520A1 (en) | 2011-06-30 | 2013-01-03 | Arrowhead Research Corporation | Compositions and methods for inhibiting gene expression of hepatitis b virus |
| JOP20200092A1 (ar) | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
| JP6892433B2 (ja) | 2015-04-03 | 2021-06-23 | ユニバーシティ・オブ・マサチューセッツUniversity Of Massachusetts | 十分に安定化された非対称sirna |
| AU2016306275A1 (en) | 2015-08-07 | 2018-02-08 | Arrowhead Pharmaceuticals, Inc. | RNAi therapy for Hepatitis B virus infection |
| US10633653B2 (en) | 2015-08-14 | 2020-04-28 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| US10478503B2 (en) | 2016-01-31 | 2019-11-19 | University Of Massachusetts | Branched oligonucleotides |
| MA45478A (fr) | 2016-04-11 | 2019-02-20 | Arbutus Biopharma Corp | Compositions de conjugués d'acides nucléiques ciblés |
| JOP20170161A1 (ar) | 2016-08-04 | 2019-01-30 | Arrowhead Pharmaceuticals Inc | عوامل RNAi للعدوى بفيروس التهاب الكبد ب |
| CN107703197B (zh) * | 2016-08-08 | 2020-01-17 | 西南医科大学附属中医医院 | 一种快速检测乙肝环状dna的方法 |
| EP3512949A1 (en) * | 2016-09-14 | 2019-07-24 | Janssen BioPharma, Inc. | Modified oligonucleotides and methods of use |
| TW201831684A (zh) * | 2016-11-11 | 2018-09-01 | 美商艾洛斯生物製藥公司 | 用於cccDNA之寡核苷酸標靶策略 |
| JP2019535839A (ja) | 2016-11-29 | 2019-12-12 | ピュアテック ヘルス エルエルシー | 治療剤の送達のためのエクソソーム |
| CA3045045A1 (en) * | 2017-01-10 | 2018-07-19 | Zhen Li | Alpha-1 antitrypsin (aat) rnai agents, compositions including aat rnai agents, and methods of use |
| NZ757927A (en) * | 2017-04-11 | 2023-07-28 | Arbutus Biopharma Corp | Targeted compositions |
| JP7688480B2 (ja) * | 2017-04-18 | 2025-06-04 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | B型肝炎ウイルス(hbv)感染を有する対象を処置する方法 |
| US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
| CA3059446A1 (en) * | 2017-04-18 | 2018-10-25 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (hbv) infection |
| WO2018222910A1 (en) * | 2017-05-31 | 2018-12-06 | Arbutus Biopharma Corporation | Therapeutic compositions and methods for treating hepatitis b |
| CN110799647A (zh) | 2017-06-23 | 2020-02-14 | 马萨诸塞大学 | 双尾自递送sirna及相关的方法 |
| BR112020004955A2 (pt) | 2017-09-14 | 2020-10-06 | Janssen Biopharma, Inc. | derivados de galnac |
| LT3684377T (lt) * | 2017-10-20 | 2023-03-10 | Dicerna Pharmaceuticals, Inc. | Hepatito b infekcijos gydymo būdai |
| JP7273417B2 (ja) | 2017-12-01 | 2023-05-15 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 |
| US11414661B2 (en) | 2017-12-01 | 2022-08-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| US12083142B2 (en) * | 2017-12-01 | 2024-09-10 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| JP7365052B2 (ja) | 2017-12-01 | 2023-10-19 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用 |
| JP7727308B2 (ja) * | 2017-12-01 | 2025-08-21 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 二本鎖オリゴヌクレオチド、二本鎖オリゴヌクレオチドを含む組成物および複合体ならびに調製方法と使用 |
| WO2019126651A1 (en) * | 2017-12-21 | 2019-06-27 | Alnylam Pharmaceuticals, Inc. | Chirally-enriched double-stranded rna agents |
| DK3732185T3 (da) * | 2017-12-29 | 2025-03-31 | Suzhou Ribo Life Science Co Ltd | Konjugater og fremstilling og anvendelse heraf |
| RU2020135289A (ru) | 2018-04-05 | 2022-05-05 | Ф. Хоффманн-Ля Рош Аг | Применение ингибиторов fubp1 для лечения инфекции вирусом гепатита в |
| CN108588097B (zh) * | 2018-04-28 | 2021-07-13 | 北京锦篮基因科技有限公司 | 改造后的hbv基因组和相关组合物及其应用 |
| TW202016301A (zh) | 2018-05-07 | 2020-05-01 | 美商阿里拉姆製藥股份有限公司 | 肝外遞送技術 |
| KR20210033004A (ko) | 2018-07-13 | 2021-03-25 | 에프. 호프만-라 로슈 아게 | Rtel1의 발현을 조절하기 위한 올리고뉴클레오티드 |
| AU2019321375A1 (en) * | 2018-08-13 | 2021-03-11 | Alnylam Pharmaceuticals, Inc. | Hepatitis B virus (HBV) dsRNA agent compositions and methods of use thereof |
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| WO2020041769A1 (en) | 2018-08-23 | 2020-02-27 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
| CN111655297A (zh) | 2018-09-30 | 2020-09-11 | 苏州瑞博生物技术有限公司 | 一种siRNA缀合物及其制备方法和用途 |
| US20210395751A1 (en) * | 2018-10-31 | 2021-12-23 | The University Of Sydney | Compositions and methods for treating viral infections |
| US20220062323A1 (en) * | 2018-11-02 | 2022-03-03 | Arbutus Biopharma Corporation | Bivalent targeted conjugates |
| US20210388356A1 (en) * | 2018-11-09 | 2021-12-16 | Alnylam Pharmaceuticals, Inc. | Modified double stranded oligonucleotide |
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