JP6728163B2 - B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 - Google Patents
B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 Download PDFInfo
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- JP6728163B2 JP6728163B2 JP2017525073A JP2017525073A JP6728163B2 JP 6728163 B2 JP6728163 B2 JP 6728163B2 JP 2017525073 A JP2017525073 A JP 2017525073A JP 2017525073 A JP2017525073 A JP 2017525073A JP 6728163 B2 JP6728163 B2 JP 6728163B2
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- 0 *C(C1O)C(OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCOC(C(*)C2O)OC(CO)C2O)=O)=O)(COCCC(NCCCNC(CCCCOC(C(*)C2O)O[C@@](CO)C2O)=O)=O)N)=O)=O)OC(CO)C1O Chemical compound *C(C1O)C(OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCOC(C(*)C2O)OC(CO)C2O)=O)=O)(COCCC(NCCCNC(CCCCOC(C(*)C2O)O[C@@](CO)C2O)=O)=O)N)=O)=O)OC(CO)C1O 0.000 description 1
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/35—Nature of the modification
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- C12N2310/3521—Methyl
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- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3533—Halogen
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020113784A JP6947880B2 (ja) | 2014-11-10 | 2020-07-01 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462077799P | 2014-11-10 | 2014-11-10 | |
| US201462077672P | 2014-11-10 | 2014-11-10 | |
| US62/077,799 | 2014-11-10 | ||
| US62/077,672 | 2014-11-10 | ||
| US201562137464P | 2015-03-24 | 2015-03-24 | |
| US62/137,464 | 2015-03-24 | ||
| PCT/US2015/059916 WO2016077321A1 (en) | 2014-11-10 | 2015-11-10 | Hepatitis b virus (hbv) irna compositions and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020113784A Division JP6947880B2 (ja) | 2014-11-10 | 2020-07-01 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017538679A JP2017538679A (ja) | 2017-12-28 |
| JP2017538679A5 JP2017538679A5 (enExample) | 2018-12-20 |
| JP6728163B2 true JP6728163B2 (ja) | 2020-07-22 |
Family
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Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525073A Active JP6728163B2 (ja) | 2014-11-10 | 2015-11-10 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2017525059A Pending JP2017534290A (ja) | 2014-11-10 | 2015-11-10 | D型肝炎ウイルス(HDV)iRNA組成物及びその使用方法 |
| JP2020113784A Active JP6947880B2 (ja) | 2014-11-10 | 2020-07-01 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2021150898A Active JP7426973B2 (ja) | 2014-11-10 | 2021-09-16 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2024007963A Pending JP2024056714A (ja) | 2014-11-10 | 2024-01-23 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2025133429A Pending JP2025183208A (ja) | 2014-11-10 | 2025-08-08 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525059A Pending JP2017534290A (ja) | 2014-11-10 | 2015-11-10 | D型肝炎ウイルス(HDV)iRNA組成物及びその使用方法 |
| JP2020113784A Active JP6947880B2 (ja) | 2014-11-10 | 2020-07-01 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2021150898A Active JP7426973B2 (ja) | 2014-11-10 | 2021-09-16 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2024007963A Pending JP2024056714A (ja) | 2014-11-10 | 2024-01-23 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
| JP2025133429A Pending JP2025183208A (ja) | 2014-11-10 | 2025-08-08 | B型肝炎ウイルス(HBV)iRNA組成物及びその使用方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US10640770B2 (enExample) |
| EP (4) | EP3647424B1 (enExample) |
| JP (6) | JP6728163B2 (enExample) |
| KR (3) | KR102827682B1 (enExample) |
| CN (4) | CN113801882A (enExample) |
| AU (4) | AU2015346566B2 (enExample) |
| BR (2) | BR112017008868B1 (enExample) |
| CA (2) | CA2967408C (enExample) |
| CY (1) | CY1122520T1 (enExample) |
| DK (1) | DK3218489T3 (enExample) |
| ES (1) | ES2761912T3 (enExample) |
| HR (1) | HRP20192177T1 (enExample) |
| HU (1) | HUE047535T2 (enExample) |
| JO (2) | JOP20200092A1 (enExample) |
| MA (2) | MA40851A (enExample) |
| MX (2) | MX421406B (enExample) |
| PL (1) | PL3218489T3 (enExample) |
| PT (1) | PT3218489T (enExample) |
| SG (3) | SG11201703638XA (enExample) |
| SI (1) | SI3218489T1 (enExample) |
| TW (4) | TWI834187B (enExample) |
| WO (2) | WO2016077349A1 (enExample) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575327B2 (en) | 2003-06-12 | 2013-11-05 | Alnylam Pharmaceuticals, Inc. | Conserved HBV and HCV sequences useful for gene silencing |
| SG194751A1 (en) | 2011-06-30 | 2013-12-30 | Arrowhead Res Corp | Compositions and methods for inhibiting gene expression of hepatitis b virus |
| JOP20200092A1 (ar) | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
| WO2016161388A1 (en) | 2015-04-03 | 2016-10-06 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| WO2017027350A2 (en) | 2015-08-07 | 2017-02-16 | Arrowhead Pharmaceuticals, Inc. | Rnai therapy for hepatitis b virus infection |
| EP3334499A4 (en) | 2015-08-14 | 2019-04-17 | University of Massachusetts | BIOACTIVE CONJUGATES FOR THE RELEASE OF OLIGONUCLEOTIDES |
| US10478503B2 (en) | 2016-01-31 | 2019-11-19 | University Of Massachusetts | Branched oligonucleotides |
| MA45478A (fr) | 2016-04-11 | 2019-02-20 | Arbutus Biopharma Corp | Compositions de conjugués d'acides nucléiques ciblés |
| JOP20190015A1 (ar) | 2016-08-04 | 2019-02-04 | Arrowhead Pharmaceuticals Inc | عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب |
| CN107703197B (zh) * | 2016-08-08 | 2020-01-17 | 西南医科大学附属中医医院 | 一种快速检测乙肝环状dna的方法 |
| MX2019002960A (es) | 2016-09-14 | 2019-09-18 | Janssen Biopharma Inc | Oligonucleótidos modificados y métodos de uso. |
| JP2019533472A (ja) * | 2016-11-11 | 2019-11-21 | ヤンセン バイオファーマ インク. | Hbv cccdnaのオリゴヌクレオチド標的化戦略 |
| WO2018102397A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| MX2019008252A (es) * | 2017-01-10 | 2019-09-06 | Arrowhead Pharmaceuticals Inc | Agentes de interferencia de acido ribonucleico (iarn) de alfa-1 antitripsina (aat), composiciones que incluyen agentes de iarn aat y metodos de uso. |
| MA52546A (fr) * | 2017-04-11 | 2020-02-19 | Arbutus Biopharma Corp | Compositions ciblées |
| US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
| JP7688480B2 (ja) * | 2017-04-18 | 2025-06-04 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | B型肝炎ウイルス(hbv)感染を有する対象を処置する方法 |
| CN118384268A (zh) * | 2017-04-18 | 2024-07-26 | 阿尔尼拉姆医药品有限公司 | 具有乙肝病毒(hbv)感染的受试者的治疗方法 |
| WO2018222910A1 (en) * | 2017-05-31 | 2018-12-06 | Arbutus Biopharma Corporation | Therapeutic compositions and methods for treating hepatitis b |
| CN110799647A (zh) | 2017-06-23 | 2020-02-14 | 马萨诸塞大学 | 双尾自递送sirna及相关的方法 |
| CN111527207B (zh) | 2017-09-14 | 2024-04-26 | 詹森生物制药有限公司 | GalNAc衍生物 |
| MY201698A (en) | 2017-10-20 | 2024-03-13 | Dicerna Pharmaceuticals Inc | Methods for treating hepatitis b infection |
| JP7273417B2 (ja) | 2017-12-01 | 2023-05-15 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 |
| WO2019105419A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| US11414661B2 (en) | 2017-12-01 | 2022-08-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| KR20250107294A (ko) * | 2017-12-01 | 2025-07-11 | 쑤저우 리보 라이프 사이언스 컴퍼니, 리미티드 | 핵산, 이를 포함하는 조성물과 컨쥬게이트, 및 그의 제조 방법과 용도 |
| WO2019105418A1 (zh) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 |
| EP3728281A1 (en) * | 2017-12-21 | 2020-10-28 | Alnylam Pharmaceuticals Inc. | Chirally-enriched double-stranded rna agents |
| DK3732185T3 (da) * | 2017-12-29 | 2025-03-31 | Suzhou Ribo Life Science Co Ltd | Konjugater og fremstilling og anvendelse heraf |
| SG11202009680XA (en) | 2018-04-05 | 2020-10-29 | Hoffmann La Roche | Use of fubp1 inhibitors for treating hepatitis b virus infection |
| CN108588097B (zh) * | 2018-04-28 | 2021-07-13 | 北京锦篮基因科技有限公司 | 改造后的hbv基因组和相关组合物及其应用 |
| MX2020011570A (es) | 2018-05-07 | 2020-11-24 | Alnylam Pharmaceuticals Inc | Administracion extrahepatica. |
| BR112021000538A2 (pt) | 2018-07-13 | 2021-04-06 | F. Hoffmann-La Roche Ag | Oligonucleotídeos para modular a expressão de rtel1 |
| MX2021001056A (es) | 2018-08-13 | 2021-04-12 | Alnylam Pharmaceuticals Inc | Composiciones de agente de acido ribonucleico bicatenario (arnbc) de virus de la hepatitis b (vhb) y metodos de uso de las mismas. |
| EP3842534A4 (en) * | 2018-08-21 | 2022-07-06 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND CONJUGATE WITH NUCLEIC ACID AND THEIR USE |
| EP3840759A4 (en) | 2018-08-23 | 2022-06-01 | University Of Massachusetts | O-METHYL RICH FULLY STABILIZED OLIGONUCLEOTIDES |
| WO2020063198A1 (zh) * | 2018-09-30 | 2020-04-02 | 苏州瑞博生物技术有限公司 | 一种siRNA缀合物及其制备方法和用途 |
| AU2019373090B2 (en) * | 2018-10-31 | 2023-05-25 | The University Of Sydney | Compositions and methods for treating viral infections |
| WO2020093053A1 (en) * | 2018-11-02 | 2020-05-07 | Arbutus Biopharma Corporation | Bivalent targeted conjugates |
| CA3118537A1 (en) * | 2018-11-09 | 2020-05-14 | Alnylam Pharmaceuticals, Inc. | Modified double stranded oligonucleotides |
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