IL302917A - Compositions and methods for t-cell receptors reprogramming using fusion proteins - Google Patents
Compositions and methods for t-cell receptors reprogramming using fusion proteinsInfo
- Publication number
- IL302917A IL302917A IL302917A IL30291723A IL302917A IL 302917 A IL302917 A IL 302917A IL 302917 A IL302917 A IL 302917A IL 30291723 A IL30291723 A IL 30291723A IL 302917 A IL302917 A IL 302917A
- Authority
- IL
- Israel
- Prior art keywords
- cell
- cells
- tfp
- domain
- mesothelin
- Prior art date
Links
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| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
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| JP7291396B2 (ja) | 2016-11-22 | 2023-06-15 | ティーシーアール2 セラピューティクス インク. | 融合タンパク質を用いたtcrの再プログラミングのための組成物及び方法 |
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| US11535668B2 (en) | 2017-02-28 | 2022-12-27 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
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| SG11202007606QA (en) | 2018-02-17 | 2020-09-29 | Flagship Pioneering Innovations V Inc | Compositions and methods for membrane protein delivery |
| WO2019222283A1 (en) | 2018-05-14 | 2019-11-21 | Harpoon Therapeutics, Inc. | Binding moiety for conditional activation of immunoglobulin molecules |
| WO2019222275A2 (en) * | 2018-05-14 | 2019-11-21 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using inducible fusion proteins |
| JP7447388B2 (ja) * | 2018-07-13 | 2024-03-12 | ナンジン レジェンド バイオテック カンパニー,リミテッド | 感染性疾患の治療のための共受容体システム |
| US12240915B2 (en) | 2018-08-30 | 2025-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Chimeric antigen receptor cells for treating solid tumor |
| US20210253666A1 (en) * | 2018-08-30 | 2021-08-19 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CN109097396B (zh) * | 2018-09-10 | 2022-10-11 | 上海细胞治疗集团有限公司 | 一种制备靶向间皮素的car-t细胞的方法 |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| EP3856771A4 (en) | 2018-09-25 | 2022-06-29 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
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| US20200289568A1 (en) * | 2019-03-11 | 2020-09-17 | The Regents Of The University Of California | Deterministic mechanoporation for cell engineering |
| EP3941494A4 (en) * | 2019-03-22 | 2022-12-21 | TCR2 Therapeutics Inc. | COMPOSITIONS AND METHODS OF TCR REPROGRAMMING USING FUSION PROTEINS |
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| BR112021022795A2 (pt) * | 2019-05-16 | 2022-01-18 | Memorial Sloan Kettering Cancer Center | Composição polipeptídica compreendendo cars de mesotelina , células imunorresponsivas e seu método de produção, composição farmacêutica, composição de ácido nucleico, vetor e kit compreendendo composição de polipeptídeo |
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| JP2022542051A (ja) * | 2019-07-23 | 2022-09-29 | ウェン ヤン, | 養子免疫療法のための組成物および方法 |
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| US20210060069A1 (en) * | 2019-08-23 | 2021-03-04 | Innovative Cellular Therapeutics Holdings, Ltd. | Coupled redirected cells and uses thereof |
| WO2021050948A1 (en) * | 2019-09-12 | 2021-03-18 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| CN112500492B (zh) * | 2019-09-13 | 2023-08-04 | 中国科学院分子细胞科学卓越创新中心 | 一种嵌合抗原受体及其用途 |
| EP3795583A1 (en) * | 2019-09-19 | 2021-03-24 | Ecole Polytechnique Federale de Lausanne (EPFL) | Il10/fc fusion proteins useful as enhancers of immunotherapies |
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| CN110903401A (zh) * | 2019-11-20 | 2020-03-24 | 浙江大学 | 一种靶向cd19的二代嵌合抗原受体及其表达载体与应用 |
| US20230069322A1 (en) * | 2019-12-24 | 2023-03-02 | TCR2 Therapeutics Inc. | Compositions and methods for gamma delta tcr reprogramming using fusion proteins |
| US20230338421A1 (en) * | 2020-01-10 | 2023-10-26 | TCR2 Therapeutics Inc. | Compositions and methods for autoimmunity regulation |
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