HK1250146A1 - 抗前-bcr拮抗劑和方法 - Google Patents

抗前-bcr拮抗劑和方法

Info

Publication number
HK1250146A1
HK1250146A1 HK18109616.5A HK18109616A HK1250146A1 HK 1250146 A1 HK1250146 A1 HK 1250146A1 HK 18109616 A HK18109616 A HK 18109616A HK 1250146 A1 HK1250146 A1 HK 1250146A1
Authority
HK
Hong Kong
Prior art keywords
methods
bcr
antagonists
bcr antagonists
Prior art date
Application number
HK18109616.5A
Other languages
English (en)
Inventor
Bridget S Wilson
Stuart S Winter
Michael Frank Erasmus
Michael Horowitz
Original Assignee
Stc Unm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stc Unm filed Critical Stc Unm
Publication of HK1250146A1 publication Critical patent/HK1250146A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
HK18109616.5A 2015-02-05 2018-07-25 抗前-bcr拮抗劑和方法 HK1250146A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562112339P 2015-02-05 2015-02-05
PCT/US2016/016753 WO2016127043A1 (en) 2015-02-05 2016-02-05 Anti-pre-bcr antagonists and methods

Publications (1)

Publication Number Publication Date
HK1250146A1 true HK1250146A1 (zh) 2018-11-30

Family

ID=56564737

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18109616.5A HK1250146A1 (zh) 2015-02-05 2018-07-25 抗前-bcr拮抗劑和方法

Country Status (6)

Country Link
US (1) US10988533B2 (zh)
EP (1) EP3253408A4 (zh)
CN (1) CN107635578A (zh)
AU (1) AU2016215110A1 (zh)
HK (1) HK1250146A1 (zh)
WO (1) WO2016127043A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3185253A1 (en) * 2015-02-02 2016-08-11 Children's Health Care D/B/A Children's Minnesota Anti-surrogate light chain antibodies
WO2016127043A1 (en) 2015-02-05 2016-08-11 Stc.Unm Anti-pre-bcr antagonists and methods
CN107995913B (zh) 2015-05-18 2022-02-11 T细胞受体治疗公司 使用融合蛋白对tcr重编程的组合物和方法
CA3032498A1 (en) 2016-08-02 2018-02-08 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
IL302917A (en) 2016-10-07 2023-07-01 Tcr2 Therapeutics Inc Preparations and methods for reprogramming T-cell receptors using fusion proteins
EP3544996A2 (en) 2016-11-22 2019-10-02 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
US20220265821A1 (en) * 2019-07-19 2022-08-25 Pascal Biosciences Inc. Composition and methods of targeting the pre-b cell receptor for the treatment of leukemias and lymphomas
CA3208358A1 (en) 2021-02-16 2022-08-25 Stuart Sheldon Winter Methods for treating b-all by administering a pre-bcr complex antagonist

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1142087A (ja) * 1997-07-29 1999-02-16 Sumitomo Electric Ind Ltd 抗ヒトプレｂ細胞レセプター抗体およびその活性フラグメントならびにヒトプロｂ細胞の検出方法
JPH11133028A (ja) * 1997-10-29 1999-05-21 Sumitomo Electric Ind Ltd 抗ヒトプレｂ細胞レセプター抗体
EP1001020A4 (en) * 1997-07-29 2005-03-02 Sumitomo Electric Industries NON-HUMAN PRE-B CELL RECEPTOR ANTIBODIES
US6335157B1 (en) 1999-05-07 2002-01-01 The European Molecular Biology Laboratory Method based on localization of Hsp90 to the centrosome
US20030215453A1 (en) * 2002-05-14 2003-11-20 Dedera Douglas A. Methods of therapy and diagnosis using immunotargeting of cells expressing VpreB1 protein
US7635472B2 (en) * 2003-05-31 2009-12-22 Micromet Ag Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
JP5779350B2 (ja) 2007-03-27 2015-09-16 シー レーン バイオテクノロジーズ， エルエルシー 抗体代替軽鎖配列を含む構築物およびライブラリー
PT3330293T (pt) 2008-11-07 2019-10-18 Amgen Res Munich Gmbh Tratamento da leucemia linfoblástica aguda pediátrica com anticorpos biespecíficos contra cd3xcd19
AU2014248119B2 (en) * 2013-04-03 2019-06-20 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted T-cells derived from pluripotent stem cells
CA3185253A1 (en) 2015-02-02 2016-08-11 Children's Health Care D/B/A Children's Minnesota Anti-surrogate light chain antibodies
WO2016127043A1 (en) 2015-02-05 2016-08-11 Stc.Unm Anti-pre-bcr antagonists and methods

Also Published As

Publication number Publication date
EP3253408A4 (en) 2018-09-26
US10988533B2 (en) 2021-04-27
EP3253408A1 (en) 2017-12-13
CN107635578A (zh) 2018-01-26
AU2016215110A1 (en) 2017-09-21
WO2016127043A1 (en) 2016-08-11
US20180022805A1 (en) 2018-01-25

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