HUP0201637A2 - Savval szemben labilis vegyületet tartalmazó új készítmény és adagolási forma - Google Patents

Savval szemben labilis vegyületet tartalmazó új készítmény és adagolási forma

Info

Publication number
HUP0201637A2
HUP0201637A2 HU0201637A HUP0201637A HUP0201637A2 HU P0201637 A2 HUP0201637 A2 HU P0201637A2 HU 0201637 A HU0201637 A HU 0201637A HU P0201637 A HUP0201637 A HU P0201637A HU P0201637 A2 HUP0201637 A2 HU P0201637A2
Authority
HU
Hungary
Prior art keywords
acid
active compound
administration form
mixture containing
novel preparation
Prior art date
Application number
HU0201637A
Other languages
English (en)
Inventor
Rango Dietrich
Rudolf Linder
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of HUP0201637A2 publication Critical patent/HUP0201637A2/hu
Publication of HUP0201637A3 publication Critical patent/HUP0201637A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány savérzékeny hatóanyagok új adagolási formáira éskészítményeire vonatkozik. Az új adagolási forma egyedihatóanyagegységeket tartalmaz; a hatóanyag a hatóanyagegységekbenlegalább egy zsíralkoholt és legalább egy szilárd paraffint tartalmazókeverékből, legalább egy trigliceridet és legalább egy szilárdparaffint tartalmazó keverékből vagy legalább egy zsírsav-észtert éslegalább egy szilárd paraffint tartalmazó keverékből készült mátrixbanvan jelen. Ahatóanyagegységek előnyösen dermesztéssel előállíthatómikrogömböcskék. Ó
HU0201637A 1999-06-07 2000-05-31 Novel preparation and administration form comprising an acid-labile active compound HUP0201637A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99110865 1999-06-07

Publications (2)

Publication Number Publication Date
HUP0201637A2 true HUP0201637A2 (hu) 2002-11-28
HUP0201637A3 HUP0201637A3 (en) 2004-05-28

Family

ID=8238296

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201637A HUP0201637A3 (en) 1999-06-07 2000-05-31 Novel preparation and administration form comprising an acid-labile active compound

Country Status (31)

Country Link
US (3) US7794752B1 (hu)
EP (2) EP1187601B1 (hu)
JP (1) JP4980527B2 (hu)
KR (1) KR100833633B1 (hu)
CN (1) CN1361683A (hu)
AT (1) ATE300285T1 (hu)
AU (1) AU775995B2 (hu)
BG (1) BG106165A (hu)
BR (1) BR0011347A (hu)
CA (1) CA2376202C (hu)
CZ (1) CZ20014405A3 (hu)
DE (1) DE60021570T2 (hu)
DK (1) DK1187601T3 (hu)
EA (2) EA006899B1 (hu)
EE (1) EE200100660A (hu)
ES (1) ES2246238T3 (hu)
HK (1) HK1046643A1 (hu)
HR (1) HRP20020006A2 (hu)
HU (1) HUP0201637A3 (hu)
IL (2) IL146504A0 (hu)
MX (1) MXPA01012659A (hu)
NO (1) NO20015980L (hu)
PL (1) PL352882A1 (hu)
PT (1) PT1187601E (hu)
SI (1) SI1187601T1 (hu)
SK (1) SK285247B6 (hu)
TR (1) TR200103527T2 (hu)
UA (1) UA74339C2 (hu)
WO (1) WO2000074654A1 (hu)
YU (1) YU86001A (hu)
ZA (1) ZA200110000B (hu)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9600070D0 (sv) * 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
SE0100823D0 (sv) * 2001-03-09 2001-03-09 Astrazeneca Ab Method I to obtain microparticles
US7357943B2 (en) 2000-12-07 2008-04-15 Nycomed Gmbh Pharmaceutical preparation in the form of a suspension comprising an acid-labile active ingredient
WO2002045694A1 (en) 2000-12-07 2002-06-13 Altana Pharma Ag Rapidly disintegrating tablet comprising an acid-labile active ingredient
EP1341524B1 (en) * 2000-12-07 2011-10-19 Nycomed GmbH Pharmaceutical preparation in the form of a paste comprising an acid-labile active ingredient
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
JP4310605B2 (ja) * 2001-05-25 2009-08-12 大塚製薬株式会社 医薬用組成物
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US20040005362A1 (en) * 2002-07-03 2004-01-08 Rajneesh Taneja Liquid dosage forms of acid labile drugs
KR101179012B1 (ko) 2003-03-10 2012-09-03 니코메드 게엠베하 로플루미라스트 신규한 제조 방법
TW200503783A (en) * 2003-04-11 2005-02-01 Altana Pharma Ag Oral pharmaceutical preparation for proton pump antagonists
PE20050150A1 (es) 2003-05-08 2005-03-22 Altana Pharma Ag Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo
CL2004000983A1 (es) 2003-05-08 2005-03-04 Altana Pharma Ag Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
WO2005074898A2 (en) * 2004-01-28 2005-08-18 Altana Pharma Ag Composition comprising (s) pantoprazole and an antibiotic for treating helicobacter pylori
US20060134210A1 (en) * 2004-12-22 2006-06-22 Astrazeneca Ab Solid dosage form comprising proton pump inhibitor and suspension made thereof
AU2006224619B2 (en) 2005-03-16 2012-06-07 Takeda Gmbh Taste masked dosage form containing roflumilast
SI1937642T1 (sl) 2005-10-19 2015-01-30 Teva Pharmaceutical Industries Ltd. Kristali natrijevega lakvinimoda in postopek za njihovo pripravo
ATE532515T1 (de) 2006-06-12 2011-11-15 Teva Pharma Stabile laquinimod-zubereitungen
AU2007279442A1 (en) * 2006-08-03 2008-02-07 Prosensa Technologies B.V. Antibiotic composition
CN101516334B (zh) 2006-09-26 2013-07-10 塔罗制药北美有限公司 用于抗生素的稳定组合物以及应用方法
ES2600920T3 (es) 2007-12-20 2017-02-13 Teva Pharmaceutical Industries, Ltd. Preparaciones estables de laquinimod
KR101094231B1 (ko) 2008-02-18 2011-12-14 하나제약 주식회사 서방성 고형 제제 및 그의 제조방법
WO2009120885A2 (en) * 2008-03-26 2009-10-01 Taro Pharmaceuticals U.S.A., Inc. Stabilizing lipid compositions for oral pharmaceutical agents
WO2010018593A2 (en) * 2008-07-03 2010-02-18 Torrent Pharmaceuticals Ltd. Gastric acid resistant benzimidazole multiple unit tablet composition
CN104311486A (zh) 2008-09-03 2015-01-28 泰华制药工业有限公司 2-羰基-1,2-二氢喹啉免疫功能调节剂
KR101107609B1 (ko) * 2009-09-21 2012-01-25 주식회사 한양비이에스티교육 태양에너지 발전 및 응용 교육을 위한 보트형 학습교재
EP2338477A1 (en) 2009-12-15 2011-06-29 bene-Arzneimittel GmbH Suppository comprising pantoprazole
AR082150A1 (es) 2010-07-09 2012-11-14 Teva Pharma N-etil-n-fenil-1,2-dihidro-4-hidroxi-5-cloro-1-metil-2-oxoquinolin-3-carboxamida deuterada, sales y usos de la misma, metodo de tratamiento, mezcla compuestos, composicion farmaceutica, proceso de preparacion, compuesto enriquecido con deuterio
WO2012171540A1 (en) 2011-06-15 2012-12-20 Bene-Arzneimittel Gmbh Suppository comprising pantoprazole comprised in pellets with a cellulose core
EP2744498A4 (en) 2012-02-16 2014-12-03 Teva Pharma N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-CHINOLINE CARBOXAMIDE AND THE PREPARATION AND USE THEREOF
TW201350467A (zh) 2012-05-08 2013-12-16 Teva Pharma Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
EA201590788A1 (ru) 2012-11-07 2015-12-30 Тева Фармасьютикал Индастриз Лтд. Аминные соли лахинимода
KR20160085269A (ko) * 2013-11-13 2016-07-15 틸로츠 파마 아게 다중-미립자 약물전달 시스템
CN107007561B (zh) * 2017-04-21 2019-12-03 湖南赛隆药业有限公司 一种左旋泮托拉唑钠缓释微球及其制备方法
CN107412171B (zh) * 2017-04-21 2020-04-17 湖南赛隆药业有限公司 注射用左旋泮托拉唑钠长效微球冻干制剂及其制备方法
WO2019161175A1 (en) 2018-02-15 2019-08-22 Boston Scientific Scimed, Inc. Introducer with expandable capabilities
CA3130704A1 (en) * 2019-02-21 2020-08-27 ChromaDex Inc. Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE27C (de) * 1877-08-02 GRAHL und HÖHL zu Dresden Akkumulator zum Betriebe von Hutpressen
US3065142A (en) * 1958-07-30 1962-11-20 Armour Pharma Gastric resistant medicinal preparation
US3800038A (en) * 1972-04-21 1974-03-26 Biolog Concepts Inc Uterine administraton of eutectic solid solutions of steroid hormones in a steroidal lipid carrier
DE2725924C3 (de) 1977-06-08 1980-11-06 Hobeg Hochtemperaturreaktor-Brennelement Gmbh, 6450 Hanau Verfahren zur Herstellung kugelförmiger Teilchen aus niedrigschmelzenden organischen Substanzen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
EP0031134B1 (en) 1979-12-19 1984-07-18 Goudsche Machinefabriek B.V. Continuously working crystallizer
JPS58116471A (ja) 1981-12-29 1983-07-11 Nippon Kayaku Co Ltd ４−ヒドロキシメチル−１−フタラゾンエステル誘導体およびその塩
US4637966A (en) * 1983-10-21 1987-01-20 Gates Energy Products, Inc. Sealed lead-acid cell
US4876094A (en) * 1984-01-13 1989-10-24 Battelle Development Corporation Controlled release liquid dosage formulation
JPS60248618A (ja) * 1984-05-24 1985-12-09 Nippon Zoki Pharmaceut Co Ltd ジペプチドを含有する潰瘍治療剤
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU4640985A (en) 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
JO1406B1 (en) 1984-11-02 1986-11-30 سميث كلاين اند فرينش لابوراتوريز ليمتد Chemical compounds
DE3524572A1 (de) * 1985-07-10 1987-01-15 Thomae Gmbh Dr K Feste arzneimittelformen zur peroralen anwendung enthaltend 9-deoxo-11-deoxy-9,11-(imino(2-(2-methoxyethoxy)ethyliden)-oxy)-(9s)-erythromycin und verfahren zu ihrer herstellung
ES2032394T3 (es) * 1986-02-20 1993-02-16 Hoechst Aktiengesellschaft Procedimiento para preparar derivados de tienoimidazol sustituidos.
GB2189699A (en) 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
CA1256109A (en) 1986-09-10 1989-06-20 Franz Rovenszky Process for the preparation of derivatives of 4, 5-dihydrooxazoles
FI90544C (fi) 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
US5026560A (en) 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
JPH0768125B2 (ja) 1988-05-18 1995-07-26 エーザイ株式会社 酸不安定化合物の内服用製剤
JP2681373B2 (ja) 1988-07-18 1997-11-26 塩野義製薬株式会社 徐放性製剤の製造法
ES2057338T3 (es) 1989-11-29 1994-10-16 Toa Eiyo Ltd Derivados de cicloheptenopiridina, procedimiento para su preparacion y agentes antiulcerosos que los contienen.
FR2657257B1 (fr) * 1990-01-19 1994-09-02 Rhone Poulenc Sante Procede de preparation de medicaments sous forme de perles.
US5213810A (en) * 1990-03-30 1993-05-25 American Cyanamid Company Stable compositions for parenteral administration and method of making same
DE4018642C2 (de) 1990-06-11 1993-11-25 Byk Gulden Lomberg Chem Fab Neue Salzform des 5-Difluormethoxy-2-[(3,4-dimethoxy-2-pyridyl) methylsulfinyl]-1H-benzimitazol-Natriumsalzes
DE4022648C2 (de) 1990-07-17 1994-01-27 Nukem Gmbh Verfahren und Vorrichtung zur Herstellung von kugelförmigen Teilchen aus flüssiger Phase
TW209174B (hu) * 1991-04-19 1993-07-11 Takeda Pharm Industry Co Ltd
YU48263B (sh) 1991-06-17 1997-09-30 Byk Gulden Lomberg Chemische Fabrik Gmbh. Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola
KR0141909B1 (ko) * 1991-11-08 1998-06-15 보조 다꾸로 액정 표시 디바이스 제조 방법
JP2973751B2 (ja) * 1991-12-04 1999-11-08 大正製薬株式会社 矯味経口組成物の製造方法
TW272942B (hu) * 1993-02-10 1996-03-21 Takeda Pharm Industry Co Ltd
FR2707184B1 (fr) * 1993-07-08 1995-08-11 Rhone Poulenc Nutrition Animal Procédé de préparation de sphérules contenant un principe actif alimentaire ou pharmaceutique.
EP0642797B1 (en) * 1993-09-09 2000-05-17 Takeda Chemical Industries, Ltd. Formulation comprising antibacterial substance and antiulcer substance
NL9400618A (nl) 1994-04-18 1995-12-01 Goudsche Machinefabriek Bv Inrichting voor het koelen en verwerken van een gesmolten produkt tot een granulaatprodukt.
BR9506018A (pt) 1994-07-08 1997-09-02 Astra Ab Forma farmacêutica oral de múltipla dosagem unitária em tablete processos para a preparação da mesma para a inibição da secreção de ácido gástrico em mamiferos e no homem e para o tratamento das doenças inflamatórias gastrointestinais em mamiferos e no homem e embalagem de ampola de pressão transversal
SE9402431D0 (sv) 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE512835C2 (sv) 1996-01-08 2000-05-22 Astrazeneca Ab Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
FR2754177B1 (fr) * 1996-10-07 1999-08-06 Sanofi Sa Microspheres pharmaceutiques d'acide valproique pour administration orale
WO1998020858A1 (en) * 1996-11-12 1998-05-22 Pharmacia & Upjohn Ab COMPACT MEMBER COMPRISING A PLURALITY OF POROUS CELLULOSE MATRICES, (PCMs), METHOD OF MANUFACTURING AND USE THEREOF
GB9710800D0 (en) 1997-05-23 1997-07-23 Cipla Limited Pharmaceutical composition and method of preparing it
ID20812A (id) * 1997-07-09 1999-03-11 Takeda Chemical Industries Ltd Senyawa polyol, produk dan penggunaannya
PT1003476E (pt) * 1997-08-11 2005-05-31 Alza Corp Forma de dosagem de agente activo de libertacao prolongada adaptada para retencao gastrica
US6174548B1 (en) * 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
ATE303809T1 (de) * 1997-12-08 2005-09-15 Altana Pharma Ag Orale verabreichungsform enthaltend einen protonenpumpeninhbitor (z.b. pantoprazole)
NL1007904C2 (nl) 1997-12-24 1999-06-25 Goudsche Machinefabriek Bv Werkwijze en inrichting voor het vormen van granulaat uit een smelt van chemische producten.
DK173431B1 (da) 1998-03-20 2000-10-23 Gea Farmaceutisk Fabrik As Farmaceutisk formulering omfattende en 2-[[(2-pyridinyl)methyl]sulfinyl]benzimidazol med anti-ulcusaktivitet samt fremgangs
EA003512B1 (ru) * 1998-03-20 2003-06-26 Кова Ко., Лтд. Желудочная и/или дуоденальная клейкая лекарственная форма
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
JP4370429B2 (ja) 1998-09-10 2009-11-25 東和薬品株式会社 徐放性マイクロスフエアの製造法
DE19848849A1 (de) 1998-10-22 2000-04-27 Knoll Ag Verfahren zur Herstellung von festen, sphärischen Formen, enthaltend eine biologisch aktive Substanz

Also Published As

Publication number Publication date
EP1616562A1 (en) 2006-01-18
AU5074100A (en) 2000-12-28
EP1187601B1 (en) 2005-07-27
ZA200110000B (en) 2002-12-24
PL352882A1 (en) 2003-09-22
PT1187601E (pt) 2005-11-30
SK285247B6 (sk) 2006-09-07
ES2246238T3 (es) 2006-02-16
YU86001A (sh) 2004-07-15
DK1187601T3 (da) 2005-11-21
NO20015980D0 (no) 2001-12-06
US20080069882A1 (en) 2008-03-20
DE60021570T2 (de) 2006-05-24
HK1046643A1 (zh) 2003-01-24
EA200401241A1 (ru) 2005-02-24
HRP20020006A2 (en) 2003-04-30
ATE300285T1 (de) 2005-08-15
EA006899B1 (ru) 2006-04-28
EA005803B1 (ru) 2005-06-30
TR200103527T2 (tr) 2002-04-22
CA2376202A1 (en) 2000-12-14
UA74339C2 (uk) 2005-12-15
BR0011347A (pt) 2002-03-19
CZ20014405A3 (cs) 2002-04-17
SK18022001A3 (sk) 2002-04-04
KR100833633B1 (ko) 2008-05-30
JP2003501377A (ja) 2003-01-14
US7785630B2 (en) 2010-08-31
DE60021570D1 (de) 2005-09-01
EP1187601A1 (en) 2002-03-20
US7794752B1 (en) 2010-09-14
AU775995B2 (en) 2004-08-19
NO20015980L (no) 2002-01-23
JP4980527B2 (ja) 2012-07-18
WO2000074654A1 (en) 2000-12-14
EE200100660A (et) 2003-04-15
EA200101266A1 (ru) 2002-06-27
US20060127477A1 (en) 2006-06-15
MXPA01012659A (es) 2003-09-04
SI1187601T1 (sl) 2005-12-31
BG106165A (bg) 2002-09-30
US7790198B2 (en) 2010-09-07
IL146504A (en) 2007-02-11
CN1361683A (zh) 2002-07-31
IL146504A0 (en) 2002-07-25
KR20020011997A (ko) 2002-02-09
HUP0201637A3 (en) 2004-05-28
CA2376202C (en) 2008-11-18

Similar Documents

Publication Publication Date Title
HUP0201637A2 (hu) Savval szemben labilis vegyületet tartalmazó új készítmény és adagolási forma
HUP0400566A2 (hu) Mátrixon diszpergált hatóanyagot tartalmazó gyógyászati készítmény
BR0115986A (pt) Comprimido de desintegração rápida contendo um ingrediente ativo instável aos ácidos
DE50104138D1 (de) Injizierbare pharmazeutische zusammensetzung zur systemischen verabreichung pharmakologisch aktiver wirkstoffe enthaltend mittelkettige triglyceride
ID26221A (id) Komposisi-komposisi farmasi yang dapat dijadikan gel
AP2397A (en) Matrix for sustained, invariant and independent release of active compounds.
AR032073A1 (es) Las nanoparticulas lipidas anfifilicas para la incorporacion de los peptidos y/o las proteinas
HUP0302452A2 (hu) Prosztaglandin E1-et tartalmazó topikus gyógyászati készítmények
ES2185179T3 (es) Preparacion de composiciones farmaceuticas.
MY138975A (en) Novel preparation and administration form comprising an acid-labile active compound
KR970705553A (ko) 디히드로벤조푸란, 및 항염증 약물로서 유용한 관련 화합물(dihydrobenzofuran and related compounds useful as anti-inflammatory agents)
GEP20053455B (en) Pharmaceutical Preparations
AR002972A1 (es) Pildoras que tienen una matriz farmaceutica que proporcionan un perfil apropiado de liberacion de la droga, composicion para la preparacion de dichamatriz, proceso para preparar dichas pildoras y formas de dosificacion de dicha composicion.
IT1293835B1 (it) Composizioni farmaceutiche orali in forma solida a cessione modulata contenenti nicorandil e procedimento per la loro preparazione
HUP0302027A2 (hu) Optikailag aktív 2-aminotetralin-származékok, eljárás ezek előállítására, és ezeket tartalmazó gyógyászati készítmények terápiás alkalmazása
TH16766A (th) ยาเตรียมที่ให้ผ่านทางผิวหนัง
CO4520304A1 (es) Dihidrato de eprosartano y un procedimiento para su produc- cion y formulacion

Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: ALTANA PHARMA AG, DE

Free format text: FORMER OWNER(S): BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH, DE

FD9A Lapse of provisional protection due to non-payment of fees