ES2185179T3 - Preparacion de composiciones farmaceuticas. - Google Patents

Preparacion de composiciones farmaceuticas.

Info

Publication number
ES2185179T3
ES2185179T3 ES98930903T ES98930903T ES2185179T3 ES 2185179 T3 ES2185179 T3 ES 2185179T3 ES 98930903 T ES98930903 T ES 98930903T ES 98930903 T ES98930903 T ES 98930903T ES 2185179 T3 ES2185179 T3 ES 2185179T3
Authority
ES
Spain
Prior art keywords
ethanol
preparation
composition
pharmaceutical compositions
dissolved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98930903T
Other languages
English (en)
Inventor
Steven Leigh
Mathew Louis Steven Leigh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phares Pharmaceutical Research NV
Original Assignee
Phares Pharmaceutical Research NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phares Pharmaceutical Research NV filed Critical Phares Pharmaceutical Research NV
Application granted granted Critical
Publication of ES2185179T3 publication Critical patent/ES2185179T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Una composición sustancialmente homogénea en una forma de dosificación para entregar un compuesto biológicamente activo por vía oral a un organismo vivo, conteniendo la citada composición no más de 10% en peso de agua y constando de una cantidad biológicamente efectiva del compuesto lipófilo biológicamente activo disuelto en o asociado con al menos un lípido formador micelas, que es un monoacil derivado de un fosfolípido, de un glicolípido, de un esfingolípido o es un monoacil fosfolípido derivado de polietilenglicol, formando la citada composición al ponerse en contacto con un fluido acuoso agregados lipídicos que portan el compuesto lipófilo en dispersión molecular y hacen biodisponibles a los citados compuestos.
ES98930903T 1997-06-20 1998-06-19 Preparacion de composiciones farmaceuticas. Expired - Lifetime ES2185179T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9713140A GB2326337A (en) 1997-06-20 1997-06-20 Homogeneous lipid compositions for drug delivery

Publications (1)

Publication Number Publication Date
ES2185179T3 true ES2185179T3 (es) 2003-04-16

Family

ID=10814725

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98930903T Expired - Lifetime ES2185179T3 (es) 1997-06-20 1998-06-19 Preparacion de composiciones farmaceuticas.

Country Status (12)

Country Link
US (1) US6599527B1 (es)
EP (1) EP1011634B1 (es)
JP (1) JP2002507966A (es)
AT (1) ATE226815T1 (es)
AU (1) AU731397B2 (es)
CA (1) CA2294337C (es)
DE (1) DE69809074T2 (es)
DK (1) DK1011634T3 (es)
ES (1) ES2185179T3 (es)
GB (1) GB2326337A (es)
PT (1) PT1011634E (es)
WO (1) WO1998058629A2 (es)

Families Citing this family (35)

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GB2326337A (en) 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
GB2331924A (en) * 1997-12-08 1999-06-09 Phares Pharm Res Nv Lipid compositions and their use
AU2845599A (en) * 1998-03-05 1999-09-20 Phares Pharmaceutical Research N.V. Pharmaceutical compositions and their use
CA2352178A1 (en) * 1998-12-08 2000-06-15 Mathew Louis Steven Leigh Phospholipid compositions
GB9908309D0 (en) * 1999-04-12 1999-06-02 Phares Pharm Res Nv Lipid aggregate forming compositions and their use
WO2002062316A1 (de) * 2001-02-08 2002-08-15 Vectron Therapeutics Ag Invasomen zur therapie von erkrankungen, ihre herstellung und verwendung
US7306819B2 (en) 2002-06-12 2007-12-11 The Coca-Cola Company Beverages containing plant sterols
ATE413820T1 (de) 2002-06-12 2008-11-15 Coca Cola Co Pflanzliches sterol enthaltende getränke
DE10233632A1 (de) * 2002-07-24 2004-02-05 Wilex Ag Formulierungen von Phenylalanin-Derivaten
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
US20050196370A1 (en) * 2003-03-18 2005-09-08 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
GB0317869D0 (en) * 2003-07-30 2003-09-03 Disperse Ltd Improved drug delivery system
EP1748759B1 (en) * 2004-04-27 2013-03-27 Javeri, Indu Methods of enhancing solubility in water of hydrophobic compounds by micellar dispersions
US7659310B2 (en) * 2004-04-27 2010-02-09 Formatech, Inc. Methods of enhancing solubility of agents
US20050255154A1 (en) 2004-05-11 2005-11-17 Lena Pereswetoff-Morath Method and composition for treating rhinitis
WO2005110360A2 (en) * 2004-05-18 2005-11-24 Phares Pharmaceutical Research N.V. Compositions for injection
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
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EP2008651A1 (en) 2007-06-26 2008-12-31 Drug Delivery Solutions Limited A bioerodible patch
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
US20110070293A1 (en) 2009-09-23 2011-03-24 Javeri Indu Methods for the Preparation of Liposomes Comprising Docetaxel
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
US9144575B2 (en) 2010-07-28 2015-09-29 Life Technologies Corporation Anti-viral azide containing compounds
US20120028335A1 (en) 2010-07-28 2012-02-02 Life Technologies Corporation Anti-viral azide-containing compounds
HUE045467T2 (hu) 2011-03-14 2020-01-28 Drug Delivery Solutions Ltd Szemészeti készítmény
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
KR20140129054A (ko) 2012-01-26 2014-11-06 라이프 테크놀로지스 코포레이션 바이러스의 감염성을 증가시키는 방법
DE102012008822A1 (de) 2012-05-07 2013-11-07 GM Global Technology Operations LLC (n.d. Ges. d. Staates Delaware) Verstellvorrichtung, Kraftfahrzeugsitz, Kraftfahrzeug und Verfahren hierzu
EP2846773A4 (en) 2012-05-10 2015-12-30 Painreform Ltd DEPOT FORMULATIONS OF A LOCAL ANESTHETICS AND METHOD FOR THE MANUFACTURE THEREOF
WO2017044899A1 (en) 2015-09-11 2017-03-16 Lawrence Livermore National Security, Llc Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation
EP3426304A4 (en) * 2016-03-07 2019-11-27 Lawrence Livermore National Security, LLC NANOLIPOPROTEIN PARTICLES AND ASSOCIATED COMPOSITIONS, METHODS AND SYSTEMS FOR ENHANCED MEDICATION LOADING
US11207422B2 (en) 2017-05-02 2021-12-28 Lawrence Livermore National Security, Llc MOMP telonanoparticles, and related compositions, methods and systems
EP3542788A1 (en) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Topical composition comprising calcipotriol and betamethasone dipropionate

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GB2326337A (en) 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery

Also Published As

Publication number Publication date
CA2294337C (en) 2007-05-15
CA2294337A1 (en) 1998-12-30
GB2326337A (en) 1998-12-23
DE69809074D1 (de) 2002-12-05
WO1998058629A2 (en) 1998-12-30
DK1011634T3 (da) 2003-03-03
AU8118498A (en) 1999-01-04
ATE226815T1 (de) 2002-11-15
GB9713140D0 (en) 1997-08-27
EP1011634A1 (en) 2000-06-28
JP2002507966A (ja) 2002-03-12
AU731397B2 (en) 2001-03-29
DE69809074T2 (de) 2003-06-26
EP1011634B1 (en) 2002-10-30
WO1998058629A3 (en) 1999-03-18
US6599527B1 (en) 2003-07-29
PT1011634E (pt) 2003-03-31

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