UA74339C2 - Форма для введення, що включає інгібітор протонної помпи у вигляді окремих одиниць, та спосіб їх одержання - Google Patents

Форма для введення, що включає інгібітор протонної помпи у вигляді окремих одиниць, та спосіб їх одержання

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Publication number
UA74339C2
UA74339C2 UA2002010191A UA200210191A UA74339C2 UA 74339 C2 UA74339 C2 UA 74339C2 UA 2002010191 A UA2002010191 A UA 2002010191A UA 200210191 A UA200210191 A UA 200210191A UA 74339 C2 UA74339 C2 UA 74339C2
Authority
UA
Ukraine
Prior art keywords
manufacture
dosage form
proton pump
pump inhibitor
active compound
Prior art date
Application number
UA2002010191A
Other languages
English (en)
Russian (ru)
Inventor
Ранго Дитріх
Рудольф Ліндер
Рудольф Линдер
Original Assignee
Алтана Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алтана Фарма Аг filed Critical Алтана Фарма Аг
Publication of UA74339C2 publication Critical patent/UA74339C2/uk

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009Sachets, pouches characterised by the material or function of the envelope
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1635Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007Effervescent

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Винахід належить до галузі фармацевтичної технології й у ньому описана форма для введення нестійких у кислому середовищі діючих речовин, вибраних з групи, що включає нестійкий у кислому середовищі інгібітор протонної помпи, сіль нестійкого у кислому середовищі інгібітору протонної помпи з основою та гідрат солі нестійкого у кислому середовищі інгібітору протонної помпи з основою. Форма для введення включає велику кількість окремих одиниць діючої речовини, що мають форму мікросфер, які можуть бути одержані грануляцією розбризкуванням, та фармацевтичні ексципієнти, при цьому нестійка у кислому середовищі речовина присутня у вигляді окремих одиниць діючої речовини в матриці, що включає суміш щонайменше одного спирту жирного ряду і щонайменше одного твердого парафіну, у матриці, що включає суміш щонайменше одного тригліцериду і щонайменше одного твердого парафіну, або в матриці, що включає суміш щонайменше одного ефіру кислоти жирного ряду і щонайменше одного твердого парафіну.
UA2002010191A 1999-06-07 2000-05-31 Форма для введення, що включає інгібітор протонної помпи у вигляді окремих одиниць, та спосіб їх одержання UA74339C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99110865 1999-06-07
PCT/EP2000/004958 WO2000074654A1 (en) 1999-06-07 2000-05-31 Novel preparation and administration form comprising an acid-labile active compound

Publications (1)

Publication Number Publication Date
UA74339C2 true UA74339C2 (uk) 2005-12-15

Family

ID=8238296

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2002010191A UA74339C2 (uk) 1999-06-07 2000-05-31 Форма для введення, що включає інгібітор протонної помпи у вигляді окремих одиниць, та спосіб їх одержання

Country Status (31)

Country Link
US (3) US7794752B1 (uk)
EP (2) EP1616562A1 (uk)
JP (1) JP4980527B2 (uk)
KR (1) KR100833633B1 (uk)
CN (1) CN1361683A (uk)
AT (1) ATE300285T1 (uk)
AU (1) AU775995B2 (uk)
BG (1) BG106165A (uk)
BR (1) BR0011347A (uk)
CA (1) CA2376202C (uk)
CZ (1) CZ20014405A3 (uk)
DE (1) DE60021570T2 (uk)
DK (1) DK1187601T3 (uk)
EA (2) EA006899B1 (uk)
EE (1) EE200100660A (uk)
ES (1) ES2246238T3 (uk)
HK (1) HK1046643A1 (uk)
HR (1) HRP20020006A2 (uk)
HU (1) HUP0201637A3 (uk)
IL (2) IL146504A0 (uk)
MX (1) MXPA01012659A (uk)
NO (1) NO20015980L (uk)
PL (1) PL352882A1 (uk)
PT (1) PT1187601E (uk)
SI (1) SI1187601T1 (uk)
SK (1) SK285247B6 (uk)
TR (1) TR200103527T2 (uk)
UA (1) UA74339C2 (uk)
WO (1) WO2000074654A1 (uk)
YU (1) YU86001A (uk)
ZA (1) ZA200110000B (uk)

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HUP0201637A3 (en) 2004-05-28
KR100833633B1 (ko) 2008-05-30
IL146504A (en) 2007-02-11
US7785630B2 (en) 2010-08-31
US7794752B1 (en) 2010-09-14
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US20060127477A1 (en) 2006-06-15
CN1361683A (zh) 2002-07-31
PT1187601E (pt) 2005-11-30
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PL352882A1 (en) 2003-09-22
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ES2246238T3 (es) 2006-02-16
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