WO2002024227A1 - Inhibiteurs de proliferation de cellules tumorales - Google Patents

Inhibiteurs de proliferation de cellules tumorales Download PDF

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Publication number
WO2002024227A1
WO2002024227A1 PCT/JP2001/008139 JP0108139W WO0224227A1 WO 2002024227 A1 WO2002024227 A1 WO 2002024227A1 JP 0108139 W JP0108139 W JP 0108139W WO 0224227 A1 WO0224227 A1 WO 0224227A1
Authority
WO
WIPO (PCT)
Prior art keywords
cell proliferation
tumor cell
proliferation inhibitors
proliferation
inhibiting
Prior art date
Application number
PCT/JP2001/008139
Other languages
English (en)
Japanese (ja)
Inventor
Yasuji Yamashita
Yoshinori Yamashita
Original Assignee
Kyowa Hakko Kogyo Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co., Ltd. filed Critical Kyowa Hakko Kogyo Co., Ltd.
Priority to AU2001290241A priority Critical patent/AU2001290241A1/en
Priority to JP2002528297A priority patent/JPWO2002024227A1/ja
Publication of WO2002024227A1 publication Critical patent/WO2002024227A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

L'invention concerne une substance qui inhibe la prolifération de cellules tumorales due à la production excessive de la protéine HNF4α d'un récepteur nucléaire. Elle concerne également des inhibiteurs de prolifération de cellules tumorales contenant cette substance comme ingrédient actif; et une méthode qui met en oeuvre des inhibiteurs de prolifération de cellules tumorales.
PCT/JP2001/008139 2000-09-20 2001-09-19 Inhibiteurs de proliferation de cellules tumorales WO2002024227A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001290241A AU2001290241A1 (en) 2000-09-20 2001-09-19 Tumor cell proliferation inhibitors
JP2002528297A JPWO2002024227A1 (ja) 2000-09-20 2001-09-19 腫瘍細胞増殖抑制剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-285371 2000-09-20
JP2000285371 2000-09-20

Publications (1)

Publication Number Publication Date
WO2002024227A1 true WO2002024227A1 (fr) 2002-03-28

Family

ID=18769455

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/008139 WO2002024227A1 (fr) 2000-09-20 2001-09-19 Inhibiteurs de proliferation de cellules tumorales

Country Status (3)

Country Link
JP (1) JPWO2002024227A1 (fr)
AU (1) AU2001290241A1 (fr)
WO (1) WO2002024227A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006008008A2 (fr) * 2004-07-23 2006-01-26 Bayer Healthcare Ag Agents diagnostiques et therapeutiques pour pathologies associees au facteur nucleaire d'hepatocyte 4, alpha (hnf4a)
JPWO2006006583A1 (ja) * 2004-07-12 2008-04-24 株式会社ペルセウスプロテオミクス ＨＮＦ４αアイソフォーム検出による癌等の診断及び原発巣の特定
US9795586B2 (en) 2015-01-05 2017-10-24 National Cancer Center HNF4-α antagonist and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023780A1 (fr) * 1996-11-26 1998-06-04 Joslin Diabetes Center, Inc. Procedes de diagnostic et de traitement du diabete
WO1999000116A2 (fr) * 1997-06-26 1999-01-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Acides carboxyliques, leurs derives, et compositions pharmaceutiques les contenant

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023780A1 (fr) * 1996-11-26 1998-06-04 Joslin Diabetes Center, Inc. Procedes de diagnostic et de traitement du diabete
WO1999000116A2 (fr) * 1997-06-26 1999-01-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Acides carboxyliques, leurs derives, et compositions pharmaceutiques les contenant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GALSON DEBORAH L. ET AL.: "The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antoginized by EAR3/COUP-TF1", MOLECULAR AND CELLULAR BIOLOGY, vol. 15, no. 4, 1995, pages 2135 - 2144, XP000960963 *
SEL SAADETTIN ET AL.: "Human renal cell carcinogenesis is accompanied by a coordinate loss of the tissue specific transcription factors HNF4alpha and HNF1alpha", CANCER LETTERS, vol. 101, no. 2, 1996, pages 205 - 210, XP002907437 *
VARGA E.V. ET AL.: "Decrease of HNF4alpha mRNA level correlates with rapid progression of HCC", MOLECULAR AND CELL BIOLOGY, vol. 30, no. SUPPL. 1, 1999, pages 209, XP002907438 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2006006583A1 (ja) * 2004-07-12 2008-04-24 株式会社ペルセウスプロテオミクス ＨＮＦ４αアイソフォーム検出による癌等の診断及び原発巣の特定
WO2006008008A2 (fr) * 2004-07-23 2006-01-26 Bayer Healthcare Ag Agents diagnostiques et therapeutiques pour pathologies associees au facteur nucleaire d'hepatocyte 4, alpha (hnf4a)
WO2006008008A3 (fr) * 2004-07-23 2006-06-22 Bayer Healthcare Ag Agents diagnostiques et therapeutiques pour pathologies associees au facteur nucleaire d'hepatocyte 4, alpha (hnf4a)
US9795586B2 (en) 2015-01-05 2017-10-24 National Cancer Center HNF4-α antagonist and use thereof

Also Published As

Publication number Publication date
AU2001290241A1 (en) 2002-04-02
JPWO2002024227A1 (ja) 2004-01-29

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