ES2057338T3 - Derivados de cicloheptenopiridina, procedimiento para su preparacion y agentes antiulcerosos que los contienen. - Google Patents

Derivados de cicloheptenopiridina, procedimiento para su preparacion y agentes antiulcerosos que los contienen.

Info

Publication number
ES2057338T3
ES2057338T3 ES90122644T ES90122644T ES2057338T3 ES 2057338 T3 ES2057338 T3 ES 2057338T3 ES 90122644 T ES90122644 T ES 90122644T ES 90122644 T ES90122644 T ES 90122644T ES 2057338 T3 ES2057338 T3 ES 2057338T3
Authority
ES
Spain
Prior art keywords
group
atom
hydrogen atom
halogen atom
optionally containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90122644T
Other languages
English (en)
Inventor
Shin-Ichi Yamada
Takao Goto
Rie Yorita
Eizi Shimanuki
Takaji Yamaguchi
Kentaro Kogi
Senichi Narita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toa Eiyo Ltd
Original Assignee
Toa Eiyo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toa Eiyo Ltd filed Critical Toa Eiyo Ltd
Application granted granted Critical
Publication of ES2057338T3 publication Critical patent/ES2057338T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

SE PROPORCIONAN DERIVADOS DE CICLOHEPTEROPIRIDINA REPRESENTADOS POR LA FORMULA GENERAL. [ EN DONDE R REPRESENTA A UN ATOMO DE HIDROGENO O UN ALQUILO INFERIOR; R'' REPRESENTA UN ATOMO DE HIDROGENO, ATOMO HALOGENO, GRUPO ALCOXI INFERIOR, GRUPO CICLOALCOXI INFERIOR, GRUPO AMIDO, GRUPO PHEROXI SUSTITUIDO , GRUPO BENCILOXI SUSTITUIDO, GRUPO ALCOXI INFERIOR QUE DE MANERA OPCIONAL CONTIENE ATOMO (S) HALOGENO (S), GRUPO NITRO, GRUPO HIDROXIL, GRUPO ALQUENILOXY INFERIOR, GRUPO ALQUILIO INFERIOR, O GRUPO NR ELEVADO 4 R ELEVADO 4 (EN DONDE R ELEVADO 4 Y R ELEVADO 5 PUEDEN SE IGUALES O DIFERENTES Y CADA UNA REPRESENTA UN ATOMO DE HIDROGENO O GRUPO ALQUILO INFERIOR, O R ELEVADO 4 Y R ELEVADO 5 SE COMBINAN ENTRE SI CON EL ATOMO DE HIDROGENO ADYACENTE A EL PARA FORMAR UN CICLO DE 5 DRADO) REPRESENTA UN ATOMO DE HIDROGENO, ATOMO HALOGENO, GRUPO ALQUILO INFERIOR QUE OPCIONALMENTE PUEDE CONTENER UN ATOMO HALOGENO, GRUPO ALCOXI INFERIOR QUE DE MANERA OPCIONAL CONTIENE UN ATOMO HALOGENO, GRUPO HIDROXIL, GRUPO ACILO, GRUPO ALCOXICARBONICO, GRUPO NITRO O GRUPO AMINO;R ELEVADO 3 REPRESENTA UN GRUPO ALQUILO INFERIOR, GRUPO ALCOXIMETILO INFERIOR, GRUPO ALQUILOCARBONILO INFERIOR, GRUPO ALCOXICARBONILO INFERIOR, GRUPO CARBANILO, GRUPO ALCILOCARBONILO INFERIOR, GRUPO ALQUILOCARBONILMETILO INFERIOR, GRUPO ALCOXICARBONILMETILO INFERIO, GRUPO ACILOXIMETILO INFERIOR, GRUPO ALQUILSUFONITO INFERIOR, O UN GRUPO PROTECTOR FISIOLOGICAMENTE ACEPTABLE QUE SE PUEDE ELIMINAR EN UN ACIDO MEDIO O BAJO UNA CONDICION FISIOLOGICA ; N REPRESENTA 0 O 1; Y A REPRESENTA UN CARBON METINO O ATOMO DE HIDROGENO] O SUS SALES. ESTOS DERIVADOS Y SUS SALES SON UTILES COMO AGENTES ANTIULCERA.
ES90122644T 1989-11-29 1990-11-27 Derivados de cicloheptenopiridina, procedimiento para su preparacion y agentes antiulcerosos que los contienen. Expired - Lifetime ES2057338T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30763089 1989-11-29

Publications (1)

Publication Number Publication Date
ES2057338T3 true ES2057338T3 (es) 1994-10-16

Family

ID=17971348

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90122644T Expired - Lifetime ES2057338T3 (es) 1989-11-29 1990-11-27 Derivados de cicloheptenopiridina, procedimiento para su preparacion y agentes antiulcerosos que los contienen.

Country Status (5)

Country Link
US (1) US5149702A (es)
EP (1) EP0434999B1 (es)
AT (1) ATE110069T1 (es)
DE (1) DE69011645T2 (es)
ES (1) ES2057338T3 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
JP2002510293A (ja) * 1997-05-30 2002-04-02 ドクター・レディーズ・リサーチ・ファウンデーション 抗潰瘍剤として新規なベンゾイミダゾール誘導体、それらの製造方法、及びそれらを含有する薬学的組成物
WO1999004816A1 (en) 1997-07-25 1999-02-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Proton pump inhibitor in therapeutic combination with antibacterial substances
JP4988088B2 (ja) 1998-08-12 2012-08-01 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング ピリジン−２−イルメチルスルフィニル−１ｈ−ベンズイミダゾール、もしくはピリジン−２−イルメチルスルフィニル−１ｈ−ベンズイミダゾールの骨格を有する化合物、またはその薬学的に許容される塩の経口投与形組成物を固定的に組み合わせた組成物
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
CA2376202C (en) 1999-06-07 2008-11-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel preparation and administration form comprising an acid-labile active compound
CA2493618A1 (en) * 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
US8802139B2 (en) 2003-06-26 2014-08-12 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
TWI372066B (en) 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CA2648280C (en) 2006-04-03 2014-03-11 Isa Odidi Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
WO2010042785A1 (en) * 2008-10-10 2010-04-15 Celtaxsys, Inc. Method of inducing negative chemotaxis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
GB8417194D0 (en) * 1984-07-05 1984-08-08 Boots Co Plc Therapeutic agents
DK585485A (da) * 1984-12-18 1986-08-08 Utsuka Pharm Co Ltd Tetrahydroquinolinderivat, imidazopyridinderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat med mindst en saadan forbindelse
GB8526154D0 (en) * 1985-02-06 1985-11-27 Kotobuki Seiyaku Co Ltd 2-substituted cyclo-heptoimidazoles
GB8505492D0 (en) * 1985-03-04 1985-04-03 Roussel Lab Ltd Chemical compounds
US4824856A (en) * 1985-08-14 1989-04-25 Nippon Chemiphar Co., Ltd. Method of protecting gastrointestinal tract

Also Published As

Publication number Publication date
EP0434999A1 (en) 1991-07-03
ATE110069T1 (de) 1994-09-15
US5149702A (en) 1992-09-22
EP0434999B1 (en) 1994-08-17
DE69011645D1 (de) 1994-09-22
DE69011645T2 (de) 1995-01-12

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