ES8200871A1 - Procedimiento para la obtencion de derivados de 2-amino-3,4-dihidropiridina - Google Patents

Procedimiento para la obtencion de derivados de 2-amino-3,4-dihidropiridina

Info

Publication number
ES8200871A1
ES8200871A1 ES497579A ES497579A ES8200871A1 ES 8200871 A1 ES8200871 A1 ES 8200871A1 ES 497579 A ES497579 A ES 497579A ES 497579 A ES497579 A ES 497579A ES 8200871 A1 ES8200871 A1 ES 8200871A1
Authority
ES
Spain
Prior art keywords
amino
substituted
medicaments
preparation
dihydropyridine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497579A
Other languages
English (en)
Other versions
ES497579A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19792949701 external-priority patent/DE2949701A1/de
Priority claimed from DE19803016874 external-priority patent/DE3016874A1/de
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8200871A1 publication Critical patent/ES8200871A1/es
Publication of ES497579A0 publication Critical patent/ES497579A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE 2-AMINO-3, 4-DIHIDROPIRIDINA DE FORMULA (I), DONDE R ES HIDROGENO, ALQUILO O UN GRUPO DE FORMULA (II), SIENDO R'' Y R'''' HIDROGENO, ALQUILO O ARALQUILO; R1 Y R2 SON ARILO O HEROARILO Y R3 Y R4 HIDROGENO, ALQUILO, ARALQUILO, ALQUENILO O ALQUINILO. SE HACE REACCIONAR, A TEMPERATURA DE 20-150 C, CANTIDADES EQUIMOLARES DE UN COMPUESTO OXO, -B-INSATURADO, DE FORMULA (III), Y DE UN ESTER DE ACIDO 3,3-DIAMINO-ACRILICO DE FORMULA (IV); O BIEN, CON SU FORMA IMINO TAUTOMERA, SIENDO R7 UN RESTO ALQUILO O ARALQUILO. LA REACCION SE EFECTUA EN UN DISOLVENTE ORGANICO INERTE Y OPCIONALMENTE EN PRESENCIA DE CATALIZADORES ACIDOS O BASICOS. DE APLICACION EN EL TRATAMIENTO DE LA HIPERLIPOPROTEINEMIAS, ARTEROESCLEROSIS, ADIPOSITAS Y TRASTORNOS DEL METABOLISMO.
ES497579A 1979-12-11 1980-12-10 Procedimiento para la obtencion de derivados de 2-amino-3,4-dihidropiridina Granted ES497579A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792949701 DE2949701A1 (de) 1979-12-11 1979-12-11 Substituierte 2-amino-3,4-dihydropyridinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE19803016874 DE3016874A1 (de) 1980-05-02 1980-05-02 Substituierte 2-amino-3,4-dihydropyridinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES8200871A1 true ES8200871A1 (es) 1981-11-16
ES497579A0 ES497579A0 (es) 1981-11-16

Family

ID=25782339

Family Applications (1)

Application Number Title Priority Date Filing Date
ES497579A Granted ES497579A0 (es) 1979-12-11 1980-12-10 Procedimiento para la obtencion de derivados de 2-amino-3,4-dihidropiridina

Country Status (9)

Country Link
US (1) US4442100A (es)
EP (1) EP0030343B1 (es)
AU (1) AU540498B2 (es)
CA (1) CA1181402A (es)
DE (1) DE3064716D1 (es)
DK (1) DK527180A (es)
ES (1) ES497579A0 (es)
GR (1) GR70670B (es)
NO (1) NO154840C (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3212736A1 (de) * 1982-04-06 1983-10-13 Bayer Ag, 5090 Leverkusen Verwendung von dihydropyridinen in arzneimitteln mit salidiuretischer wirkung
GB8431119D0 (en) * 1984-12-10 1985-01-16 Fujisawa Pharmaceutical Co Anti-arteriosclerotic composition
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
US5200522A (en) * 1991-06-11 1993-04-06 Boehringer Ingelheim Pharmaceuticals, Inc. Method for preparing 3-amino-2-chloro-4-alkylpyridines
AU652656B2 (en) * 1991-06-11 1994-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the preparation of 3-amino-2-chloro-4-alkylpyridines
US8946434B2 (en) 2010-07-16 2015-02-03 N30 Pharmaceuticals, Inc. Dihydropyridin-2(1H)-one compound as S-nirtosoglutathione reductase inhibitors and neurokinin-3 receptor antagonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136187A (en) * 1972-08-12 1979-01-23 Bayer Aktiengesellschaft Antihypertensive 2-amino-4,5-dihydropyridine derivatives
DE2239815C2 (de) * 1972-08-12 1983-02-10 Bayer Ag, 5090 Leverkusen 2-Alkylamino-dihydropyridine, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel

Also Published As

Publication number Publication date
EP0030343A1 (de) 1981-06-17
DK527180A (da) 1981-06-12
GR70670B (es) 1982-12-06
DE3064716D1 (en) 1983-10-06
AU6527980A (en) 1981-06-18
NO154840B (no) 1986-09-22
AU540498B2 (en) 1984-11-22
NO154840C (no) 1987-01-07
ES497579A0 (es) 1981-11-16
EP0030343B1 (de) 1983-08-31
US4442100A (en) 1984-04-10
CA1181402A (en) 1985-01-22
NO803551L (no) 1981-06-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519