ES8102096A1 - Procedimiento para la obtencion de derivados de 3,4,5-trihi-droxipiperidina - Google Patents

Procedimiento para la obtencion de derivados de 3,4,5-trihi-droxipiperidina

Info

Publication number
ES8102096A1
ES8102096A1 ES492143A ES492143A ES8102096A1 ES 8102096 A1 ES8102096 A1 ES 8102096A1 ES 492143 A ES492143 A ES 492143A ES 492143 A ES492143 A ES 492143A ES 8102096 A1 ES8102096 A1 ES 8102096A1
Authority
ES
Spain
Prior art keywords
trihydroxypiperidine
medicines
derivatives
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492143A
Other languages
English (en)
Other versions
ES492143A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES492143A0 publication Critical patent/ES492143A0/es
Publication of ES8102096A1 publication Critical patent/ES8102096A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 3,4,5-TRIHIDROXIPIPERIDINA DE FORMULA (I), DONDE R1, R''1, R3 Y R''3 SON HIDROGENO O UN ENLACE DIRECTO X; R2 Y R''2 SON HIDROGENO, C1-C4-ALQUILO O UN ENALCE DIRECTO CON X, SIENDO X UN MIEMBRO PUENTE. EN ESTE TIPO DE DERIVADOS SE DEBE CUMPLIR QUE UNO Y SOLO UNO DE LOS RESTOS R1, R2 Y R3 REPRESENTAN UN ENLACE DIRECTO CON X, CONDICION QUE DEBEN DE CUMPLIR TAMBIEN LOS RESTOS R''1, R''2, R''3. DICHA OBTENCION EN SU PLANTEAMIENTO BASICO, PERO NO UNICO, SE FUNDAMENTA EN LA REACCION, EN PRESENCIA DE UN DADOR DE HIDROGENO Y EN PROPORCION 2:1 EN PESO, DEL COMPUESTO DE FORMULA (II), DONDE R''''1 Y R''''2 SON HIDROGENO O CH2-NH2, Y R''''2 ES HIDROGENO O C-C-ALQUILO, Y DIALDEHIDOS DE FORMULA (III), EN LA QUE Z ES EL RESTO QUE FALTA PARA EL MIEMBRO PUENTE X. ESTOS COMPUESTOS SON ESPECIALMENTE INDICADOS PARA SU EMPLEO COMO MEDICAMENTO CONTRA LA DIABETES, LA HIPERLIPEMIA Y LA ADIPOSIDAD, ASI COMO EN LA ALIMENTACION DE ANIMALES. *FORMULA*
ES492143A 1979-06-05 1980-06-04 Procedimiento para la obtencion de derivados de 3,4,5-trihi-droxipiperidina Expired ES8102096A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792922760 DE2922760A1 (de) 1979-06-05 1979-06-05 Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung

Publications (2)

Publication Number Publication Date
ES492143A0 ES492143A0 (es) 1980-12-16
ES8102096A1 true ES8102096A1 (es) 1980-12-16

Family

ID=6072499

Family Applications (1)

Application Number Title Priority Date Filing Date
ES492143A Expired ES8102096A1 (es) 1979-06-05 1980-06-04 Procedimiento para la obtencion de derivados de 3,4,5-trihi-droxipiperidina

Country Status (18)

Country Link
US (1) US4465684A (es)
EP (1) EP0019899B1 (es)
JP (1) JPS55164676A (es)
AT (1) ATE8500T1 (es)
AU (1) AU539847B2 (es)
CA (1) CA1146558A (es)
DE (2) DE2922760A1 (es)
DK (1) DK243280A (es)
ES (1) ES8102096A1 (es)
FI (1) FI801787A (es)
GR (1) GR69267B (es)
HU (1) HU182143B (es)
IE (1) IE50258B1 (es)
IL (1) IL60210A (es)
NO (2) NO801553L (es)
PT (1) PT71308A (es)
SU (2) SU1017168A3 (es)
ZA (1) ZA803330B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56108767A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Bismoranoline derivative
ATE79555T1 (de) * 1987-11-16 1992-09-15 Medicorp Holding Vorrichtung zum spenden von fluessigen stoffen.
EP0344383A1 (en) * 1988-06-02 1989-12-06 Merrell Dow Pharmaceuticals Inc. Novel alpha-Glucosidase inhibitors
DE3936295A1 (de) * 1989-11-01 1991-05-02 Bayer Ag Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine
US5252587A (en) * 1990-04-27 1993-10-12 Merrell Dow Pharmaceuticals, Inc. N-derivatives of 1-deoxy nojirimycin
US5536732A (en) * 1990-04-27 1996-07-16 Merrell Pharmaceuticals Inc. N-derivatives of 1-deoxy nojirimycin
JPH0688963B2 (ja) * 1990-08-15 1994-11-09 工業技術院長 ジ（フェニル）スルホンスルホニルフルオライド化合物
AUPP942599A0 (en) * 1999-03-24 1999-04-15 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
EP1575587A1 (en) * 2002-10-29 2005-09-21 Ranbaxy Laboratories, Ltd. Iminosugar derivatives as glucosidase inhibitors
WO2022011211A1 (en) * 2020-07-10 2022-01-13 Emergent Product Development Gaithersburg Inc. Deoxynojirimycin derivatives as glucosidase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
JPS56108767A (en) * 1980-01-28 1981-08-28 Nippon Shinyaku Co Ltd Bismoranoline derivative

Also Published As

Publication number Publication date
ZA803330B (en) 1981-06-24
AU539847B2 (en) 1984-10-18
NO852778L (no) 1980-12-08
IL60210A0 (en) 1980-09-16
PT71308A (en) 1980-06-01
ES492143A0 (es) 1980-12-16
JPS64949B2 (es) 1989-01-10
CA1146558A (en) 1983-05-17
DE3068585D1 (en) 1984-08-23
ATE8500T1 (de) 1984-08-15
DE2922760A1 (de) 1980-12-11
US4465684A (en) 1984-08-14
IL60210A (en) 1983-11-30
NO801553L (no) 1980-12-08
SU1017168A3 (ru) 1983-05-07
HU182143B (en) 1983-12-28
JPS55164676A (en) 1980-12-22
FI801787A (fi) 1980-12-06
EP0019899A1 (de) 1980-12-10
EP0019899B1 (de) 1984-07-18
SU1050563A3 (ru) 1983-10-23
IE50258B1 (en) 1986-03-19
DK243280A (da) 1980-12-06
IE801149L (en) 1980-12-05
AU5852580A (en) 1980-12-11
GR69267B (es) 1982-05-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603