ES483661A1 - Procedimiento para la obtencion de derivados de 1,4-dihidro-piridina sila-sustituidos - Google Patents
Procedimiento para la obtencion de derivados de 1,4-dihidro-piridina sila-sustituidosInfo
- Publication number
- ES483661A1 ES483661A1 ES483661A ES483661A ES483661A1 ES 483661 A1 ES483661 A1 ES 483661A1 ES 483661 A ES483661 A ES 483661A ES 483661 A ES483661 A ES 483661A ES 483661 A1 ES483661 A1 ES 483661A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- sila
- substituted
- processes
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Los nuevos derivados de 1,4-dihidropiridina sila-sustituidos se pueden transformar en forma conocida en las formulaciones usuales tales como tabletas, cápsulas, grageas, píldoras, granulados, aerosoles, jarabes, emulsiones, suspensiones o soluciones empleando excipientes o disolventes inertes, no tóxicos, farmacéuticamente adecuados. Aquí deberá encontrarse el compuesto terapéuticamente activo, en cada caso presente en una concentración de aproximadamente de unos 0,5 hasta 90% en peso de la mezcla total, es decir, en cantidades que sean suficientes para alcanzar el margen de dosificación indicado. Las formulaciones se preparan, por ejemplo, mediante alargamiento de las sustancias activas con disolventes y/o excipientes, en caso dado empleando emulsionantes y/o agentes de dispersión donde, por ejemplo, en el caso de emplear agua como diluyente se pueden emplear en caso dado disolventes orgánicos como disolventes auxiliares.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782837477 DE2837477A1 (de) | 1978-08-28 | 1978-08-28 | Sila-substituierte 1,4-dihydropyridin- derivate |
Publications (1)
Publication Number | Publication Date |
---|---|
ES483661A1 true ES483661A1 (es) | 1980-04-16 |
Family
ID=6048072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES483661A Expired ES483661A1 (es) | 1978-08-28 | 1979-08-27 | Procedimiento para la obtencion de derivados de 1,4-dihidro-piridina sila-sustituidos |
Country Status (8)
Country | Link |
---|---|
US (1) | US4237137A (es) |
EP (1) | EP0010130B1 (es) |
JP (1) | JPS5533497A (es) |
AT (1) | ATE489T1 (es) |
CA (1) | CA1135699A (es) |
DE (2) | DE2837477A1 (es) |
ES (1) | ES483661A1 (es) |
IL (1) | IL58103A (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2915355A1 (de) * | 1979-04-14 | 1980-10-23 | Nattermann A & Cie | Neue 1,4-dihydropyridin-bderivate mit antihypertensiver wirkung |
US4325389A (en) * | 1980-09-22 | 1982-04-20 | Cordis Corporation | Tip assembly for a carbon fiber implantable lead |
DE3339236A1 (de) * | 1983-10-28 | 1985-05-09 | Bayer Ag | Arzneimittelzubereitung |
DE3433239A1 (de) * | 1984-09-11 | 1986-03-20 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitung enthaltend nitrendipin und verfahren zu ihrer herstellung |
US4593033A (en) * | 1985-04-24 | 1986-06-03 | Merck & Co., Inc. | Substituted indeno[2,1-c] pyridines useful as calcium channel blockers |
US4605660A (en) * | 1985-06-03 | 1986-08-12 | Merck & Co., Inc. | Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers |
US4670443A (en) * | 1985-07-02 | 1987-06-02 | Merck & Co., Inc. | Benzo(f)isoquinoline compounds useful as calcium entry blockers |
US4735956A (en) * | 1985-09-13 | 1988-04-05 | Merck & Co., Inc. | Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers |
EP0220917B1 (en) * | 1985-10-22 | 1991-01-30 | Sanwa Kagaku Kenkyusho Co., Ltd. | 1,4-dihydropyridine pharmaceutical derivatives and their salts, and the preparation thereof |
US4721708A (en) * | 1985-11-26 | 1988-01-26 | Merck & Co., Inc. | Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use |
US4788203A (en) * | 1985-11-26 | 1988-11-29 | Merck & Co., Inc. | Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders |
US4841054A (en) * | 1986-10-21 | 1989-06-20 | Lukevits Edmund Y | 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(5'-trimethylsilyl-2'-furyl)-1,4-dihydropyridine |
DE102005056050A1 (de) * | 2005-11-24 | 2007-05-31 | Wacker Chemie Ag | Alpha-(beta-Ketocarbonyl)-funktionelle Organosiliciumverbindungen und deren Herstellung |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3355455A (en) * | 1964-08-06 | 1967-11-28 | Dow Corning | Certain pyridyl silane derivatives |
US3816439A (en) * | 1970-06-19 | 1974-06-11 | Monsanto Co | Substituted 1,2-dihydropyridines and process for preparing same |
DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
US3781291A (en) * | 1971-05-26 | 1973-12-25 | R Sulzbach | Silylated 1,4-dihydropyridines |
US4031104A (en) * | 1972-04-18 | 1977-06-21 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters |
DE2248150A1 (de) * | 1972-09-30 | 1974-04-04 | Bayer Ag | Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
-
1978
- 1978-08-28 DE DE19782837477 patent/DE2837477A1/de not_active Withdrawn
-
1979
- 1979-08-08 US US06/064,936 patent/US4237137A/en not_active Expired - Lifetime
- 1979-08-20 DE DE7979102963T patent/DE2961609D1/de not_active Expired
- 1979-08-20 EP EP79102963A patent/EP0010130B1/de not_active Expired
- 1979-08-20 AT AT79102963T patent/ATE489T1/de not_active IP Right Cessation
- 1979-08-24 CA CA000334434A patent/CA1135699A/en not_active Expired
- 1979-08-24 IL IL58103A patent/IL58103A/xx unknown
- 1979-08-27 JP JP10899679A patent/JPS5533497A/ja active Granted
- 1979-08-27 ES ES483661A patent/ES483661A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IL58103A0 (en) | 1979-12-30 |
DE2961609D1 (en) | 1982-02-11 |
JPS5533497A (en) | 1980-03-08 |
IL58103A (en) | 1983-06-15 |
EP0010130B1 (de) | 1981-12-23 |
US4237137A (en) | 1980-12-02 |
CA1135699A (en) | 1982-11-16 |
ATE489T1 (de) | 1982-01-15 |
JPS6217595B2 (es) | 1987-04-18 |
DE2837477A1 (de) | 1980-03-13 |
EP0010130A1 (de) | 1980-04-30 |
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