JPS5533497A - Silaasubstituted 1*44dihydropyridine derivative - Google Patents

Silaasubstituted 1*44dihydropyridine derivative

Info

Publication number
JPS5533497A
JPS5533497A JP10899679A JP10899679A JPS5533497A JP S5533497 A JPS5533497 A JP S5533497A JP 10899679 A JP10899679 A JP 10899679A JP 10899679 A JP10899679 A JP 10899679A JP S5533497 A JPS5533497 A JP S5533497A
Authority
JP
Japan
Prior art keywords
derivatives
silaasubstituted
derivative
methods
sila
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10899679A
Other languages
English (en)
Other versions
JPS6217595B2 (ja
Inventor
Tatsuke Rainhoruto
Bentoraage Anke
Tobaruto Roberutoson
Fuataa Burufu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of JPS5533497A publication Critical patent/JPS5533497A/ja
Publication of JPS6217595B2 publication Critical patent/JPS6217595B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP10899679A 1978-08-28 1979-08-27 Silaasubstituted 1*44dihydropyridine derivative Granted JPS5533497A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782837477 DE2837477A1 (de) 1978-08-28 1978-08-28 Sila-substituierte 1,4-dihydropyridin- derivate

Publications (2)

Publication Number Publication Date
JPS5533497A true JPS5533497A (en) 1980-03-08
JPS6217595B2 JPS6217595B2 (ja) 1987-04-18

Family

ID=6048072

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10899679A Granted JPS5533497A (en) 1978-08-28 1979-08-27 Silaasubstituted 1*44dihydropyridine derivative

Country Status (8)

Country Link
US (1) US4237137A (ja)
EP (1) EP0010130B1 (ja)
JP (1) JPS5533497A (ja)
AT (1) ATE489T1 (ja)
CA (1) CA1135699A (ja)
DE (2) DE2837477A1 (ja)
ES (1) ES483661A1 (ja)
IL (1) IL58103A (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2915355A1 (de) * 1979-04-14 1980-10-23 Nattermann A & Cie Neue 1,4-dihydropyridin-bderivate mit antihypertensiver wirkung
US4325389A (en) * 1980-09-22 1982-04-20 Cordis Corporation Tip assembly for a carbon fiber implantable lead
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
DE3433239A1 (de) * 1984-09-11 1986-03-20 Bayer Ag, 5090 Leverkusen Feste arzneizubereitung enthaltend nitrendipin und verfahren zu ihrer herstellung
US4593033A (en) * 1985-04-24 1986-06-03 Merck & Co., Inc. Substituted indeno[2,1-c] pyridines useful as calcium channel blockers
US4605660A (en) * 1985-06-03 1986-08-12 Merck & Co., Inc. Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers
US4670443A (en) * 1985-07-02 1987-06-02 Merck & Co., Inc. Benzo(f)isoquinoline compounds useful as calcium entry blockers
US4735956A (en) * 1985-09-13 1988-04-05 Merck & Co., Inc. Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers
DE3677319D1 (de) * 1985-10-22 1991-03-07 Sanwa Kagaku Kenkyusho Co Pharmazeutische 1,4-dihydropyridinderivate, ihre salze und herstellung.
US4721708A (en) * 1985-11-26 1988-01-26 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use
US4788203A (en) * 1985-11-26 1988-11-29 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders
JPH01501144A (ja) * 1986-10-21 1989-04-20 インスティテュト　オルガニチェスコゴ　シンテザ　アカデミイ　ナウク　ラトビースコイ　エスエスアール ２，６―ジメチル―３，５―ジメトキシカルボニル―４―（５’―トリメチルシリル―２’―フリル）―１，４―ジヒドロピリジン
DE102005056050A1 (de) * 2005-11-24 2007-05-31 Wacker Chemie Ag Alpha-(beta-Ketocarbonyl)-funktionelle Organosiliciumverbindungen und deren Herstellung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355455A (en) * 1964-08-06 1967-11-28 Dow Corning Certain pyridyl silane derivatives
US3816439A (en) * 1970-06-19 1974-06-11 Monsanto Co Substituted 1,2-dihydropyridines and process for preparing same
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3781291A (en) * 1971-05-26 1973-12-25 R Sulzbach Silylated 1,4-dihydropyridines
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
DE2248150A1 (de) * 1972-09-30 1974-04-04 Bayer Ag Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
US4237137A (en) 1980-12-02
IL58103A (en) 1983-06-15
EP0010130B1 (de) 1981-12-23
EP0010130A1 (de) 1980-04-30
ES483661A1 (es) 1980-04-16
DE2961609D1 (en) 1982-02-11
JPS6217595B2 (ja) 1987-04-18
IL58103A0 (en) 1979-12-30
DE2837477A1 (de) 1980-03-13
CA1135699A (en) 1982-11-16
ATE489T1 (de) 1982-01-15

Similar Documents

Publication Publication Date Title
DE2963183D1 (en) 1,4-dihydropyridine compounds, their preparation, pharmaceutical compositions containing said compounds and preparation of these compositions
NZ192196A (en) 1-phenyl-2-azolyl-ethanols pharmaceutical compositions
FI831230A0 (fi) N-glykosylerade karboxylsyraamidderivat, foerfarande foer deras framstaellning samt deras anvaendnifoer att paoverka kroppens eget foersvar
NZ192195A (en) 1-triazolyl-2-hydroxy-2-phenyl-3-aryl-propanes and pharmaceutical compositions
IL58299A (en) Fluorine-containing 1,4-dihydropyridine derivatives,their production and their medicinal use
JPS5533497A (en) Silaasubstituted 1*44dihydropyridine derivative
IL64292A (en) D-homoandrostane-17alpha-carboxylic acids,derivatives thereof and 17alpha-spiroethers,their manufacture and pharmaceutical compositions containing them
NO921382D0 (no) Amidinofenylalaninderivater, samt fremstilling, anvendelse og preparater inneholdende forbindelsene
JPS567763A (en) 22hydroxymethyll3*4*55trihydroxyypiperidine derivative* its manufacture and use
AU539847B2 (en) 3,4,5-trihydroxypiperidine compounds
IL61989A (en) 1-(1,3,4-oxadiazolyl-phenoxy)-3-(phenylpiperazino)propan-2-ols and their derivatives,their preparation and pharmaceutical compositions containing them
FI800350A (fi) Dehydropeptider foerfarande foer framstaellning av dessa samt anvaendningen av dessa som laekemedel
DE58909244D1 (de) Verwendung von 1,4-Dihydropyridin-Derivaten in der Behandlung von Alkoholsucht.
JPS5536484A (en) Novel 1*44dihydropyridazinee33carboxylic acid derivative
DE3879709T2 (de) Platin-arzneimittel.
ES474052A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridazinas 1-n-sustituidas.
ATE42743T1 (de) Thiochromanderivat, verfahren zu seiner herstellung und dieses enthaltende pharmazeutische zusammensetzungen.