ES468525A1 - Procedimiento para la obtencion de nuevas 2-alquilenaminodi-hidropiridinas - Google Patents
Procedimiento para la obtencion de nuevas 2-alquilenaminodi-hidropiridinasInfo
- Publication number
- ES468525A1 ES468525A1 ES468525A ES468525A ES468525A1 ES 468525 A1 ES468525 A1 ES 468525A1 ES 468525 A ES468525 A ES 468525A ES 468525 A ES468525 A ES 468525A ES 468525 A1 ES468525 A1 ES 468525A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyleneaminodihydropyridines
- compounds
- production
- medicinal use
- provision
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedimiento para la obtención de 2-alquilen- aminodihidropiridinas de fórmula **(Fórmula)** don R1 significa hidrógeno, alquilo, alcoxi-alquilo ó aralquilo, donde los mencionados grupos alquilo y arilo están en caso dado sustituidos, A significa un resto alquileno, de cadena recta o ramificada, Y y Z son iguales o diferentes y significan a) una agrupación COOR2 ó COR2. b) un resto ciano o c) un resto SO(n)-R3- n representa 0, 1 ó 2, R4 significa hidrógeno o alquilo X significa un resto arilo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19772715182 DE2715182A1 (de) | 1977-04-05 | 1977-04-05 | 2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE19772740080 DE2740080A1 (de) | 1977-09-06 | 1977-09-06 | 2-alkylenaminodihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ES468525A1 true ES468525A1 (es) | 1979-07-01 |
Family
ID=25771839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES468525A Expired ES468525A1 (es) | 1977-04-05 | 1978-04-04 | Procedimiento para la obtencion de nuevas 2-alquilenaminodi-hidropiridinas |
Country Status (8)
Country | Link |
---|---|
US (1) | US4177278A (es) |
JP (1) | JPS53124274A (es) |
AT (1) | AT361478B (es) |
ES (1) | ES468525A1 (es) |
FR (1) | FR2386527A1 (es) |
GB (1) | GB1585978A (es) |
IL (1) | IL54429A (es) |
NL (1) | NL7803626A (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ193167A (en) * | 1979-03-27 | 1984-08-24 | Boots Co Plc | Quinoline derivatives and pharmaceutical compositions |
US4365063A (en) * | 1981-08-31 | 1982-12-21 | American Home Products Corporation | Antihypertensive agents |
US4321384A (en) * | 1981-02-27 | 1982-03-23 | American Home Products Corporation | Antihypertensive agents |
CS228917B2 (en) | 1981-03-14 | 1984-05-14 | Pfizer | Method of preparing substituted derivatives of 1,4-dihydropyridine |
JPS597163A (ja) * | 1982-07-02 | 1984-01-14 | Yamanouchi Pharmaceut Co Ltd | 抗動脈硬化剤 |
EP0100189B1 (en) * | 1982-07-22 | 1986-05-28 | Pfizer Limited | Dihydropyridine anti-ischaemic and antihypertensive agents |
EP0107293A3 (en) * | 1982-09-04 | 1984-06-06 | Pfizer Limited | Dihydropyridines |
PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
PT77842B (en) * | 1982-12-21 | 1986-05-05 | Pfizer | Process for preparing dihydropyridines |
US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
US4520131A (en) * | 1983-03-03 | 1985-05-28 | Usv Pharmaceutical | Antihypertensive N-substituted 1,4-dihydropyridines |
GB8306666D0 (en) * | 1983-03-10 | 1983-04-13 | Pfizer Ltd | Therapeutic agents |
JPS60156671A (ja) * | 1984-01-25 | 1985-08-16 | Yamanouchi Pharmaceut Co Ltd | ジヒドロピリジン誘導体およびその製造法 |
JPS60214778A (ja) * | 1984-03-08 | 1985-10-28 | Suntory Ltd | Ν置換3,4−ジヒドロピリミジン誘導体ならびにその製造法および用途 |
GR851819B (es) * | 1984-08-17 | 1985-11-26 | Wyeth John & Brother Ltd | |
US4833150A (en) * | 1985-03-14 | 1989-05-23 | Nelson Research & Development Co. | 1,4-dihydropyridines |
IT1215298B (it) * | 1985-08-06 | 1990-01-31 | Boehringer Biochemia Srl | 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione. |
DE3544211A1 (de) * | 1985-12-13 | 1987-06-19 | Bayer Ag | Neue, fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4849436A (en) * | 1986-03-11 | 1989-07-18 | Nelson Research & Development Co. | 1,4-dihydropyridines |
GB8608335D0 (en) * | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
FR2602231B1 (fr) * | 1986-08-04 | 1988-10-28 | Adir | Nouveaux derives de la dihydro-1,4 pyridine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
US5234959A (en) * | 1988-04-08 | 1993-08-10 | Whitby Research, Inc. | Penetration enhancers for transdermal delivery of systemic agents |
US5472946A (en) * | 1988-04-08 | 1995-12-05 | Peck; James V. | Transdermal penetration enhancers |
US6653481B2 (en) * | 2000-12-29 | 2003-11-25 | Synthon Bv | Process for making amlodipine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2210674C3 (de) * | 1972-03-06 | 1981-09-24 | Bayer Ag, 5090 Leverkusen | 2-Amino-6-methyl-1,4-dihydropyridine, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
-
1978
- 1978-03-15 US US05/886,971 patent/US4177278A/en not_active Expired - Lifetime
- 1978-03-31 FR FR7809642A patent/FR2386527A1/fr active Granted
- 1978-03-31 GB GB12685/78A patent/GB1585978A/en not_active Expired
- 1978-04-03 JP JP3820278A patent/JPS53124274A/ja active Granted
- 1978-04-03 IL IL54429A patent/IL54429A/xx unknown
- 1978-04-04 ES ES468525A patent/ES468525A1/es not_active Expired
- 1978-04-05 NL NL7803626A patent/NL7803626A/xx not_active Application Discontinuation
- 1978-04-05 AT AT240378A patent/AT361478B/de active
Also Published As
Publication number | Publication date |
---|---|
IL54429A (en) | 1981-07-31 |
ATA240378A (de) | 1980-08-15 |
NL7803626A (nl) | 1978-10-09 |
FR2386527B1 (es) | 1980-07-18 |
JPS53124274A (en) | 1978-10-30 |
AT361478B (de) | 1981-03-10 |
FR2386527A1 (fr) | 1978-11-03 |
US4177278A (en) | 1979-12-04 |
JPS6126783B2 (es) | 1986-06-21 |
GB1585978A (en) | 1981-03-11 |
IL54429A0 (en) | 1978-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Patent lapsed |
Effective date: 19960604 |