ES8200094A1 - Procedimiento para la obtencion de alquilureas - Google Patents

Procedimiento para la obtencion de alquilureas

Info

Publication number
ES8200094A1
ES8200094A1 ES496650A ES496650A ES8200094A1 ES 8200094 A1 ES8200094 A1 ES 8200094A1 ES 496650 A ES496650 A ES 496650A ES 496650 A ES496650 A ES 496650A ES 8200094 A1 ES8200094 A1 ES 8200094A1
Authority
ES
Spain
Prior art keywords
medicaments
preparation
alkyl
treatment
urea derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496650A
Other languages
English (en)
Other versions
ES496650A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19792945238 external-priority patent/DE2945238A1/de
Priority claimed from DE19803030024 external-priority patent/DE3030024A1/de
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8200094A1 publication Critical patent/ES8200094A1/es
Publication of ES496650A0 publication Critical patent/ES496650A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Abstract

PROCEDIMIENTO DE OBTENCION DE ALQUILUREAS DE FORMULA (I), DONDE Y ES UN RESTO DE FORMULA (II) O UN HIDROCARBURO ALIFATICO; R1 ES HIDROGENO O ALQUILO INFERIOR; R2 ES ALQUILO INFERIOR; R3, R4 Y R5 HIDROGENO, HALOGENO, HIDROXI, CIANO... Y OTROS; Y X, OXIGENO O AZUFRE. SE HACEN REACCIONAR A TEMPERATURA DE 20-120 C, CANTIDADES EQUIMOLECULARES DE UNA AMINA DE FORMULA (III) Y DE UN COMPUESTO DE FORMULA (IV), EN UN DISLVENTE ORGANICO INERTE Y EN PRESENCIA DE CATALIZADORES. SE DEJA REPOSAR LA MEZCLA, SE ENFRIA, Y EL PRECIPITADO RESULTANTE SE SEPARA POR SUCCION. LAS SUSTANCIAS ACTIVAS SE PRESENTAN EN EL PREPARADO FARMACEUTICO JUNTO CON EXCIPIENTES NO TOXICOS, INERTES Y FARMACEUTICAMENTE COMPATIBLES, Y OPCIONALMENTE, CON COLORANTES Y AGENTES DE CONSEVACION. DE APLICACION EN MEDICAMENTOS INFLUENCIADORES SOBRE EL METABOLISMO GRASO.
ES496650A 1979-11-09 1980-11-07 Procedimiento para la obtencion de alquilureas Granted ES496650A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19792945238 DE2945238A1 (de) 1979-11-09 1979-11-09 Verwendung von alkylharnstoffderivaten in arzneimitteln zur behandlung von fettstoffwechselstoerungen
DE19803030024 DE3030024A1 (de) 1980-08-08 1980-08-08 Alkylharnstoffderivate zur behandlung von erkrankungen des fettstoffwechsels, verfahren zu deren herstellung, deren verwendung in arzneimitteln zur behandlung von festtstoffwechselstoerungen, diese enthaltende arzneimittel und verfahren zur herstellung der arzneimittel

Publications (2)

Publication Number Publication Date
ES8200094A1 true ES8200094A1 (es) 1981-10-16
ES496650A0 ES496650A0 (es) 1981-10-16

Family

ID=25781919

Family Applications (1)

Application Number Title Priority Date Filing Date
ES496650A Granted ES496650A0 (es) 1979-11-09 1980-11-07 Procedimiento para la obtencion de alquilureas

Country Status (10)

Country Link
US (4) US4510156A (es)
EP (1) EP0028765B1 (es)
AU (1) AU538478B2 (es)
CA (1) CA1191133A (es)
DE (1) DE3062981D1 (es)
DK (1) DK475380A (es)
ES (1) ES496650A0 (es)
GR (1) GR72127B (es)
HU (1) HU185018B (es)
NO (1) NO156087B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5003106A (en) * 1983-07-19 1991-03-26 American Cyanamid Company Antiatherosclerotic ureas and thioureas
DE3738237A1 (de) * 1987-11-11 1989-05-24 Bayer Ag Bis-indolyl-ethylen
DE3738238A1 (de) * 1987-11-11 1989-05-24 Bayer Ag Bis-indolyl-ethylen-aldehyde
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US6669926B1 (en) 2000-10-16 2003-12-30 Mallinckrodt, Inc. Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
US7066789B2 (en) * 2002-07-29 2006-06-27 Manoclean Technologies, Inc. Methods for resist stripping and other processes for cleaning surfaces substantially free of contaminants
US7297286B2 (en) * 2002-07-29 2007-11-20 Nanoclean Technologies, Inc. Methods for resist stripping and other processes for cleaning surfaces substantially free of contaminants
US7101260B2 (en) * 2002-07-29 2006-09-05 Nanoclean Technologies, Inc. Methods for resist stripping and other processes for cleaning surfaces substantially free of contaminants
US6764385B2 (en) * 2002-07-29 2004-07-20 Nanoclean Technologies, Inc. Methods for resist stripping and cleaning surfaces substantially free of contaminants
US7134941B2 (en) * 2002-07-29 2006-11-14 Nanoclean Technologies, Inc. Methods for residue removal and corrosion prevention in a post-metal etch process
TWI329102B (en) * 2006-08-15 2010-08-21 Nat Health Research Institutes Thiourea compounds and method for inhibiting hepatitis c virus infection
US7985763B2 (en) * 2007-04-10 2011-07-26 National Health Research Institutes Hepatitis C virus inhibitors
TW200848016A (en) * 2007-06-08 2008-12-16 Nat Health Research Institutes Thiourea compound and composition of treating hepatitis C virus infection
US8198284B2 (en) * 2008-04-30 2012-06-12 National Health Research Institutes Treatment of neurodegenerative disorders with thiourea compounds
EP3071205B1 (en) 2013-11-18 2020-02-05 Forma Therapeutics, Inc. Benzopiperazine compositions as bet bromodomain inhibitors
MX370535B (es) 2013-11-18 2019-12-17 Forma Therapeutics Inc Compuestos de tetrahidroquinolina como inhibidores del bromodominio extra terminal y bromo (bet) y el uso de los mismos en el tratamiento de cáncer.
EP4031540A1 (en) * 2019-09-17 2022-07-27 Bial-R&D Investments, S.A. Substituted, saturated and unsaturated n-heterocyclic carboxamides and related compounds for their use in the treatment of medical disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2364347A (en) * 1940-09-26 1944-12-05 Eastman Kodak Co Nitrogen heterocyclic compounds
US3143545A (en) * 1961-11-27 1964-08-04 Searle & Co 4-aminoalkanoyl-2-phenyl-3, 4-dihydro-2h-1, 4-benzothiazines
US3880847A (en) * 1969-04-05 1975-04-29 Bayer Ag Thiocarbamic acid derivatives
US3890348A (en) * 1973-03-26 1975-06-17 Sandoz Ag Indole-1 and indoline-1-carboxamides and thiocarboxamides
GB1574019A (en) * 1977-01-14 1980-09-03 Joullie International Sa Therapeutically useful 3,4,5-trimethoxybenzene derivatives
IL51342A (en) * 1977-01-27 1980-11-30 Abic Ltd Ethoxyquin derivatives,their preparation and pharmaceutical and veterinary compositions comprising them

Also Published As

Publication number Publication date
AU6418980A (en) 1981-05-14
NO803266L (no) 1981-05-11
EP0028765B1 (de) 1983-05-04
CA1191133A (en) 1985-07-30
NO156087B (no) 1987-04-13
AU538478B2 (en) 1984-08-16
EP0028765A1 (de) 1981-05-20
GR72127B (es) 1983-09-16
DK475380A (da) 1981-05-10
US4510156A (en) 1985-04-09
ES496650A0 (es) 1981-10-16
US4574124A (en) 1986-03-04
HU185018B (en) 1984-11-28
US4460607A (en) 1984-07-17
US4466964A (en) 1984-08-21
DE3062981D1 (en) 1983-06-09

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