ES8106003A1 - Procedimiento para la obtencion de acido fosfonohidroxiace- tico - Google Patents

Procedimiento para la obtencion de acido fosfonohidroxiace- tico

Info

Publication number
ES8106003A1
ES8106003A1 ES495826A ES495826A ES8106003A1 ES 8106003 A1 ES8106003 A1 ES 8106003A1 ES 495826 A ES495826 A ES 495826A ES 495826 A ES495826 A ES 495826A ES 8106003 A1 ES8106003 A1 ES 8106003A1
Authority
ES
Spain
Prior art keywords
phosphono
salts
autiviral
hydroxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495826A
Other languages
English (en)
Other versions
ES495826A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6083349&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8106003(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES495826A0 publication Critical patent/ES495826A0/es
Publication of ES8106003A1 publication Critical patent/ES8106003A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDO FOSFONOHIDROXIACETICO DE FORMULA (I). CONSISTE EN LA HIDROLISIS DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1 Y R2 SON RADICALES ALQUILICOS, EN MEDIO ACIDO, O BIEN EN LA REACCION DE SILIZACION DEL MISMO COMPUESTO CON HALURO DE TRIALQUILISILILO, EN DISOLVENTES ORGANICOS INERTES, SEGUIDA DE HIDROLISIS ACIDA O BASICA. TAMBIEN SE PUEDE OBTENER EL COMPUESTO DE FORMULA (I) POR REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1 Y R2 SON RADICALES ARALQUILO, CON HIDROGENO EN PRESENCIA DE PALADIO FINAMENTE DIVIDIDO COMO CATALIZADOR. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS POR SU EFICACIA AUTIVIRAL, ESPECIALMENTE CONTRA VIRUS DE HERPES. *FORMULA*
ES495826A 1979-10-12 1980-10-10 Procedimiento para la obtencion de acido fosfonohidroxiace- tico Expired ES8106003A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792941384 DE2941384A1 (de) 1979-10-12 1979-10-12 Phosphono-hydroxy-essigsaeure, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES495826A0 ES495826A0 (es) 1981-07-01
ES8106003A1 true ES8106003A1 (es) 1981-07-01

Family

ID=6083349

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495826A Expired ES8106003A1 (es) 1979-10-12 1980-10-10 Procedimiento para la obtencion de acido fosfonohidroxiace- tico

Country Status (10)

Country Link
US (1) US4340599A (es)
EP (1) EP0027199B2 (es)
JP (1) JPS56115793A (es)
AT (1) ATE3552T1 (es)
AU (1) AU530678B2 (es)
CA (1) CA1163200A (es)
DE (2) DE2941384A1 (es)
DK (1) DK429480A (es)
ES (1) ES8106003A1 (es)
FI (1) FI803202L (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3039997A1 (de) * 1980-10-23 1982-06-03 Bayer Ag, 5090 Leverkusen Phosphonohydroxyacetonitril, ein verfahren zu seiner herstellung und seine verwendung als zwischenprodukt fuer die herstellung von arzneimitteln
DE3039998A1 (de) * 1980-10-23 1982-06-03 Bayer Ag, 5090 Leverkusen Phosphonoformaldehyd, ein verfahren zu seiner herstellung und seine verwendung als zwischenprodukt fuer die herstellung von arzneimittel
US5059591B1 (en) * 1983-05-26 2000-04-25 Liposome Co Inc Drug preparations of reduced toxicity
PT78628B (en) * 1984-05-02 1986-06-18 Liposome Co Inc Pharmaceutical composition with reduced toxicity
FR2596393B1 (fr) * 1986-04-01 1988-06-03 Sanofi Sa Derives de l'acide hydroxy-3 dihydroxyoxophosphorio-4 butanoique, leur procede de preparation, leur application comme medicament et les compositions les renfermant
US5760021A (en) * 1992-05-29 1998-06-02 The Procter & Gamble Company Phosphonocarboxylate compounds pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
CN1042427C (zh) * 1994-04-15 1999-03-10 大连理工大学 2－羟基－2膦酸基乙酸的合成方法
AU5034899A (en) * 1998-07-15 2000-02-07 Jomaa Hassan Drugs containing phosphoric acid derivatives as active ingredient and their use
FR2995900B1 (fr) 2012-09-27 2014-10-17 Chryso Copolymeres a groupements gem-acetophosphones
CN103435644B (zh) * 2013-09-09 2015-07-08 山东省泰和水处理有限公司 一种低氯2-羟基膦酰基乙酸的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3032500A (en) * 1959-12-31 1962-05-01 American Cyanamid Co Sequestration of metal ions
US3159537A (en) * 1960-12-20 1964-12-01 American Cyanamid Co Potentiation of tetracycline by phosphinic acid
US3767795A (en) * 1971-02-25 1973-10-23 Abbott Lab Method for combating certain virus infection
DE2217692C3 (de) * 1972-04-13 1984-10-18 Henkel KGaA, 4000 Düsseldorf Komplexbildner mit mehrwertigen Metallionen
US3965254A (en) * 1973-05-23 1976-06-22 The Procter & Gamble Company Compositions for the treatment of calcific tumors
DE2360797C2 (de) * 1973-12-06 1985-05-23 Henkel KGaA, 4000 Düsseldorf Pharmazeutische Präparate
US4016264A (en) * 1975-07-14 1977-04-05 The University Of Utah Wart treatment with phosphonoacetic acid or derivatives thereof
US4092412A (en) * 1976-04-30 1978-05-30 Abbott Laboratories Treatment of herpes simplex infections
US4052439A (en) * 1976-04-30 1977-10-04 Abbott Laboratories Carboxylic esters of phosphonoacetic acid
SE7607496L (sv) * 1976-07-01 1978-01-02 Astra Laekemedel Ab Sett for bekempning av virusinfektioner
JPS542336A (en) * 1977-06-06 1979-01-09 Meiji Seika Kaisha Ltd Preventive and remedy for viral diseases
US4150125A (en) * 1977-09-30 1979-04-17 Abbott Laboratories Triglyceride ester of phosphonoacetic acid having antiviral activity

Also Published As

Publication number Publication date
DE3063525D1 (en) 1983-07-07
AU530678B2 (en) 1983-07-28
ATE3552T1 (de) 1983-06-15
EP0027199B2 (de) 1985-06-19
ES495826A0 (es) 1981-07-01
FI803202L (fi) 1981-04-13
CA1163200A (en) 1984-03-06
DE2941384A1 (de) 1981-04-23
EP0027199B1 (de) 1983-05-25
US4340599A (en) 1982-07-20
JPS56115793A (en) 1981-09-11
DK429480A (da) 1981-04-13
AU6250680A (en) 1981-04-16
EP0027199A1 (de) 1981-04-22

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