ES8106304A1 - Un procedimiento para la preparacion de fenil-quinolicidinas - Google Patents

Un procedimiento para la preparacion de fenil-quinolicidinas

Info

Publication number
ES8106304A1
ES8106304A1 ES493199A ES493199A ES8106304A1 ES 8106304 A1 ES8106304 A1 ES 8106304A1 ES 493199 A ES493199 A ES 493199A ES 493199 A ES493199 A ES 493199A ES 8106304 A1 ES8106304 A1 ES 8106304A1
Authority
ES
Spain
Prior art keywords
phenyl
preparation
pharmaceutical compositions
compositions containing
treating diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493199A
Other languages
English (en)
Other versions
ES493199A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES493199A0 publication Critical patent/ES493199A0/es
Publication of ES8106304A1 publication Critical patent/ES8106304A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE FENIL-QUINOLICIDINAS DE FORMULA (I), DONDE X E Y SON HIDROGENO, FLUOR, CLORO, ALCOXILO O ALQUILO INFERIOR, PUDIENDO SER X ADEMAS TRIFLUOROMETILO; A ES UN GRUPO DE FORMULA (II) O (III), DONDE R3 ES OXIGENO O AZUFRE; R4, HIDROGENO O ALQUILO INFERIOR; R5 Y R6, HIDROGENO, METILO, FLUOR, CLORO, ETC. SE HACE REACCIONAR UN COMPUESTO DE FORMULA (IV), DONDE Z ES UN GRUPO DISOCIABLE COMO MESILOXILO O TOXILOXILO, CON UN COMPUESTO DE FORMULA (V) EN FORMA DE SAL DE METAL ALCALINO. SE AISLAN LOS ENANTIOMEROS MEDIANTE DISOCIACION DE LOS RACEMATOS CORRESPONDIENTES. OPCIONALMENTE SE OBTIENE UNA SAL DE ADICION DE ACIDO, HACIENDO REACCIONAR UNA BASE DEL COMPUESTO OBTENIDO, CON UN ACIDO MINERAL U ORGANICO. DE APLICACION COMO ANTIPSICOTICOS, ANTIEMETICOS Y ANALGESICOS EN EL CONTROL DE PSICOSIS, NEUROSIS, NAUSEAS Y DOLOR. *FORMULA* A
ES493199A 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas Expired ES8106304A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1065478 1978-10-13
CH715679 1979-08-03

Publications (2)

Publication Number Publication Date
ES493199A0 ES493199A0 (es) 1981-06-16
ES8106304A1 true ES8106304A1 (es) 1981-06-16

Family

ID=25700857

Family Applications (7)

Application Number Title Priority Date Filing Date
ES484930A Granted ES484930A0 (es) 1978-10-13 1979-10-11 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493198A Expired ES8105997A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493199A Expired ES8106304A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493195A Granted ES493195A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493204A Granted ES493204A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493202A Granted ES493202A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493196A Expired ES8105992A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES484930A Granted ES484930A0 (es) 1978-10-13 1979-10-11 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493198A Expired ES8105997A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES493195A Granted ES493195A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493204A Granted ES493204A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493202A Granted ES493202A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas
ES493196A Expired ES8105992A1 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas

Country Status (22)

Country Link
US (6) US4236010A (es)
EP (2) EP0044573B1 (es)
AR (3) AR230446A1 (es)
AT (1) ATE877T1 (es)
AU (1) AU533075B2 (es)
BR (1) BR7906543A (es)
CA (1) CA1140927A (es)
CS (2) CS613879A2 (es)
CU (1) CU35149A (es)
DE (2) DE2966740D1 (es)
DK (1) DK433779A (es)
ES (7) ES484930A0 (es)
FI (2) FI66611C (es)
GR (1) GR73144B (es)
HU (1) HU180249B (es)
IE (1) IE49082B1 (es)
IL (1) IL58415A (es)
MC (1) MC1289A1 (es)
NO (1) NO152787C (es)
NZ (1) NZ191763A (es)
PH (1) PH16131A (es)
PT (1) PT70309A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191763A (en) * 1978-10-13 1984-05-31 Hoffmann La Roche 7-beta-phenyl-quinolidines, intermediates and pharmaceutical compositions
DK116181A (da) * 1980-04-11 1981-10-12 Hoffmann La Roche Fremgangsmaade til fremstilling af quinolizidinderivater
ZW17385A1 (en) * 1984-11-06 1986-02-19 Hoffmann La Roche Tricyclic pyridine derivatives
US4889848A (en) * 1984-11-06 1989-12-26 Hoffmann-La Roche Inc. Tricyclic pyridine derivatives
CA1317945C (en) * 1985-12-13 1993-05-18 Ulf Fischer Tricyclic pyridazopyridone derivatives
DE3614005A1 (de) * 1986-04-25 1987-10-29 Westfael Elekt Werke Verfahren zur rauchgasentschwefelung
EP0294599A3 (de) * 1987-06-12 1990-05-09 F. Hoffmann-La Roche Ag Tricyclische Pyridonderivate
US6992090B2 (en) * 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
US7538110B2 (en) * 2005-10-27 2009-05-26 Adolor Corporation Opioid antagonists
US20100311782A1 (en) * 2009-06-08 2010-12-09 Adolor Corporation Substituted piperidinylpropanoic acid compounds and methods of their use
US8143273B2 (en) 2010-06-22 2012-03-27 Hoffman-La Roche Inc. Quinolizidine and indolizidine derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA668487A (en) * 1963-08-13 H. Tilford Charles Hexahydro quinolizines
US3031454A (en) * 1962-04-24 Hexahydro quinolizeses
GB1096589A (en) * 1964-03-31 1967-12-29 Chugai Pharmaceutical Co Ltd Novel quinolizidine derivatives or salts thereof and process for preparing the same
DE1470084A1 (de) * 1964-08-19 1969-05-29 Merck Ag E Verfahren zur Herstellung von substituierten Piperidin-derivaten
US3394141A (en) * 1965-11-12 1968-07-23 Fabio Sparatore Z-benzyaminobenzimidazoles
US3852452A (en) * 1970-02-10 1974-12-03 Ayerst Mckenna & Harrison Benzocycloheptaisoquinoline derivatives as cns depressants
NZ191763A (en) * 1978-10-13 1984-05-31 Hoffmann La Roche 7-beta-phenyl-quinolidines, intermediates and pharmaceutical compositions

Also Published As

Publication number Publication date
IL58415A (en) 1982-11-30
BR7906543A (pt) 1980-07-15
GR73144B (es) 1984-02-09
FI841359A0 (fi) 1984-04-05
IL58415A0 (en) 1980-01-31
CS241050B2 (en) 1986-03-13
ES8105993A1 (es) 1981-07-01
US4306067A (en) 1981-12-15
IE791943L (en) 1980-04-13
DK433779A (da) 1980-04-14
ES493198A0 (es) 1981-07-01
PT70309A (en) 1979-11-01
ES8105994A1 (es) 1981-07-01
ES493196A0 (es) 1981-07-01
ES8105992A1 (es) 1981-07-01
ES493199A0 (es) 1981-06-16
ES8200680A1 (es) 1981-11-16
US4329467A (en) 1982-05-11
MC1289A1 (fr) 1980-07-22
AR230636A1 (es) 1984-05-31
DE2966740D1 (de) 1984-04-05
CU35149A (en) 1983-04-06
NO152787C (no) 1985-11-20
AR230637A1 (es) 1984-05-31
ES8105997A1 (es) 1981-07-01
EP0044573B1 (de) 1984-02-29
ES484930A0 (es) 1981-11-16
ES493202A0 (es) 1981-07-01
ATE877T1 (de) 1982-05-15
FI66611C (fi) 1984-11-12
IE49082B1 (en) 1985-07-24
FI66611B (fi) 1984-07-31
FI70017C (fi) 1986-09-12
CS613879A2 (en) 1985-06-13
NZ191763A (en) 1984-05-31
FI841359A (fi) 1984-04-05
NO793300L (no) 1980-04-15
ES8105991A1 (es) 1981-07-01
PH16131A (en) 1983-07-08
NO152787B (no) 1985-08-12
EP0044573A1 (de) 1982-01-27
HU180249B (en) 1983-02-28
US4236010A (en) 1980-11-25
FI70017B (fi) 1986-01-31
US4316030A (en) 1982-02-16
CA1140927A (en) 1983-02-08
EP0012170A1 (de) 1980-06-25
FI793182A (fi) 1980-04-14
EP0012170B1 (de) 1982-04-21
ES493204A0 (es) 1981-07-01
AR230446A1 (es) 1984-04-30
ES493195A0 (es) 1981-07-01
AU5154579A (en) 1980-04-17
AU533075B2 (en) 1983-10-27
US4338444A (en) 1982-07-06
US4272627A (en) 1981-06-09
DE2962580D1 (en) 1982-06-03

Similar Documents

Publication Publication Date Title
ES8202798A1 (es) Procedimiento para la preparacion de sulfonilureas
AU529426B2 (en) 4-amino-2-ureido-pyrimidine-5-carboxylic acid anilides and their use in treating lipometabolism disturbances and adiposity
ES473451A1 (es) Un procedimiento para la preparacion de derivados de imida- zol.
SE8700498D0 (sv) Novel pharmaceologically active compounds
MY101791A (en) New benzimidazole derivatives
ES8402591A1 (es) Procedimiento para la obtencion de pirazolooxacinas, pirazolotiacinas y pirazoloquinolinas.
ES474592A1 (es) Procedimiento para la preparacion de derivados de imidazoli-nina
PT79840B (en) Process for the preparation of polipeptides with alpha-amilase inhibiting action and pharmaceutical compositions therewith
ES8102561A1 (es) Procedimiento de preparacion de los aril-1 arilsulfonil-4 a amino-propoxi-3 1h pirazoles
ES8702427A1 (es) Un procedimiento para preparar derivados de 1,3-difosfonato
ES8106304A1 (es) Un procedimiento para la preparacion de fenil-quinolicidinas
SE8405588D0 (sv) New compounds
AU530678B2 (en) Phosphono-hydroxy-acetic acid
ES8103112A1 (es) Procedimiento para la obtencion de pseudo-trisacaridos
DE3062340D1 (en) 1-n-alkylsisomicin derivatives, process for their preparation and their use as medicines
ES478795A1 (es) Procedimiento para fabricar dilignoles y compuestos simila- res al dilignol.
ZA874470B (en) New tetrahydrobenzothiazoles,and the preparation and use thereof
ES466493A1 (es) Procedimiento de fabricacion de acidos a-aril-a -oxo-isovalericos.
ES8106128A1 (es) Un procedimiento para la preparacion de derivados de ciclo- hexadieno
PT77285B (en) Process for preparing substituted benzenosulphonates and pharmaceutical compositions containing the same
ES8200684A1 (es) Procedimiento para la preparacion de sulfonilureas
ES469840A1 (es) Procedimiento para la obtencion de nuevos derivados de tria-zolotiadiacinas.
IL67400A0 (en) 3,7alpha-diazacyclohepta(j,k)fluorene derivatives,their preparation and pharmaceutical compositions containing them
IL60383A0 (en) Cyclophosphathiazene derivatives,their preparation and pharmaceutical compositions containing them